Search

Your search keyword '"Szendroedi J"' showing total 275 results
Start Over Author "Szendroedi J"
275 results on '"Szendroedi J"'

1. Association of dietary patterns with diabetes-related comorbidities varies among diabetes endotypes

Author

Roden, M., Al-Hasani, H., Belgardt, B., Lammert, E., Bönhof, G., Geerling, G., Herder, C., Icks, A., Jandeleit-Dahm, K., Kotzka, J., Kuß, O., Rathmann, W., Schlesinger, S., Schrauwen-Hinderling, V., Szendroedi, J., Trenkamp, S., Wagner, R., Weber, Katharina S., Schlesinger, Sabrina, Lang, Alexander, Straßburger, Klaus, Maalmi, Haifa, Zhu, Anna, Zaharia, Oana-Patricia, Strom, Alexander, Bönhof, Gidon J., Goletzke, Janina, Trenkamp, Sandra, Wagner, Robert, Buyken, Anette E., Lieb, Wolfgang, Roden, Michael, and Herder, Christian

Published
2024
Full Text
View/download PDF

3. Association of dietary patterns with diabetes-related comorbidities varies among diabetes endotypes

Author

Weber, Katharina S., primary, Schlesinger, Sabrina, additional, Lang, Alexander, additional, Straßburger, Klaus, additional, Maalmi, Haifa, additional, Zhu, Anna, additional, Zaharia, Oana-Patricia, additional, Strom, Alexander, additional, Bönhof, Gidon J., additional, Goletzke, Janina, additional, Trenkamp, Sandra, additional, Wagner, Robert, additional, Buyken, Anette E., additional, Lieb, Wolfgang, additional, Roden, Michael, additional, Herder, Christian, additional, Roden, M., additional, Al-Hasani, H., additional, Belgardt, B., additional, Lammert, E., additional, Bönhof, G., additional, Geerling, G., additional, Herder, C., additional, Icks, A., additional, Jandeleit-Dahm, K., additional, Kotzka, J., additional, Kuß, O., additional, Rathmann, W., additional, Schlesinger, S., additional, Schrauwen-Hinderling, V., additional, Szendroedi, J., additional, Trenkamp, S., additional, and Wagner, R., additional

Published
2024
Full Text
View/download PDF

5. Typ-2-Diabetes

Author

Ammon, H. P. T., Burchard, A., Drexel, H., Füchtenbusch, M., Häring, H.-U., Hauner, H., Joost, H.-G., Matthaei, S., Merkel, M., Müller-Wieland, D., Pfohl, M., Roden, M., Rustenbeck, I., Säly, C., Schatz, H., Schifferdecker, E., Schinner, S., Schwarz, P., Szendrödi, J., Vonbank, A., Wascher, T., Zeyfang, A., Schatz, Helmut, editor, and Pfeiffer, Andreas F. H., editor

Published
2014
Full Text
View/download PDF

10. Metabolic flexibility and oxidative capacity independently associate with insulin sensitivity in individuals with newly diagnosed type 2 diabetes

Author

Apostolopoulou, Maria, Strassburger, Klaus, Herder, Christian, Knebel, Birgit, Kotzka, Jörg, Szendroedi, Julia, Roden, Michael, Roden, M., Buyken, A. E., Eckel, J., Geerling, G., Al-Hasani, H., Herder, C., Icks, A., Kotzka, J., Kuss, O., Lammert, E., Lundbom, J., Müssig, K., Nowotny, P., Rathmann, W., Szendroedi, J., Ziegler, D., and for the GDS group

Published
2016
Full Text
View/download PDF

15. Human myocardial mitochondrial oxidative capacity is impaired in mild acute heart transplant rejection

Author

Scheiber, D., Zweck, E., Albermann, S., Jelenik, T., Spieker, M., Bönner, F., Horn, P., Schultheiss, H.P., Aleshcheva, G., Escher, F., Boeken, U., Akhyari, P., Roden, M., Kelm, M., Szendroedi, J., and Westenfeld, R.

Subjects
Heart Diseases, Heart failure, Original Articles, Mitochondria, Heart, Acute cellular heart transplant rejection, Oxidative Stress, Diabetes Mellitus, Type 2, Myocardial inflammation, RC666-701, Diseases of the circulatory (Cardiovascular) system, Heart Transplantation, Humans, Original Article, Acute Cellular Heart Transplant Rejection, Heart Failure, Mitochondrial Respiration, Myocardial Inflammation, Mitochondrial respiration
Abstract

AIMS: Acute cellular rejection (ACR) following heart transplantation (HTX) is associated with long-term graft loss and increased mortality. Disturbed mitochondrial bioenergetics have been identified as pathophysiological drivers in heart failure, but their role in ACR remains unclear. We aimed to prove functional disturbances of myocardial bioenergetics in human heart transplant recipients with mild ACR by assessing myocardial mitochondrial respiration using high-resolution respirometry, digital image analysis of myocardial inflammatory cell infiltration, and clinical assessment of HTX patients. We hypothesized that (i) mild ACR is associated with impaired myocardial mitochondrial respiration and (ii) myocardial inflammation, systemic oxidative stress, and myocardial oedema relate to impaired mitochondrial respiration and myocardial dysfunction. METHODS AND RESULTS: We classified 35 HTX recipients undergoing endomyocardial biopsy according International Society for Heart and Lung Transplantation criteria to have no (0R) or mild (1R) ACR. Additionally, we quantified immune cell infiltration by immunohistochemistry and digital image analysis. We analysed mitochondrial substrate utilization in myocardial fibres by high-resolution respirometry and performed cardiovascular magnetic resonance (CMR). ACR (1R) was diagnosed in 12 patients (34%), while the remaining 23 patients revealed no signs of ACR (0R). Underlying cardiomyopathies (dilated cardiomyopathy 50% vs. 65%; P=0.77), comorbidities (type 2 diabetes mellitus: 50% vs. 35%, P=0.57; chronic kidney disease stage 5: 8% vs. 9%, P>0.99; arterial hypertension: 59% vs. 30%, P=0.35), medications (tacrolimus: 100% vs. 91%, P=0.54; mycophenolate mofetil: 92% vs. 91%, P>0.99; prednisolone: 92% vs. 96%, P>0.99) and time post-transplantation (21.5±26.0months vs. 29.4±26.4months, P=0.40) were similar between groups. Mitochondrial respiration was reduced by 40% in ACR (1R) compared with ACR (0R) (77.8±23.0 vs. 128.0±33.0; P14 CD3+ -lymphocytes/mm2 (100% sensitivity, 82% specificity; P&nbsp

Published
2021

16. Erhöhte Prävalenz des Risiko-Allels des Patatin-like phospholipase domain-containing 3 Gen im schwer-insulinresistenten Diabetes (SIRD)-Cluster

Author

Zaharia, OP, additional, Strassburger, K, additional, Knebel, B, additional, Kupriyanova, Y, additional, Karusheva, Y, additional, Wolkersdorfer, M, additional, Bódis, K, additional, Markgraf, D, additional, Burkart, V, additional, Hwang, JH, additional, Kotzka, Jörg, additional, Al-Hasani, H, additional, Szendroedi, J, additional, and Rod, M, additional

Published
2021
Full Text
View/download PDF

17. Typ-2-Diabetes-induzierte NFκB-Expression im humanen Myokard korreliert mit eingeschränkter Komplex-I-assoziierter Mitochondrienfunktion

Author

Zweck, E, additional, Scheiber, D, additional, Jelenik, T, additional, Horn, P, additional, Pesta, D, additional, Lassner, D, additional, Schultheiss, HP, additional, Boeken, U, additional, Akhyari, P, additional, Lichtenberg, A, additional, Kelm, M, additional, Roden, M, additional, Westenfeld, R, additional, and Szendroedi, J, additional

Published
2021
Full Text
View/download PDF

19. Early changes in hepatic energy metabolism and lipid content in recent-onset type 1 and 2 diabetes mellitus

Author

Kupriyanova, Yuliya, primary, Zaharia, Oana Patricia, additional, Bobrov, Pavel, additional, Karusheva, Yanislava, additional, Burkart, Volker, additional, Szendroedi, Julia, additional, Hwang, Jong-Hee, additional, Roden, Michael, additional, Roden, M., additional, Al-Hasani, H., additional, Burkart, V., additional, Buyken, A.E., additional, Geerling, G., additional, Hwang, J.H., additional, Herder, C., additional, Icks, A., additional, Jandeleit-Dahm, K., additional, Kahl, S., additional, Kotzka, J., additional, Kuss, O., additional, Lammert, E., additional, Trenkamp, S., additional, Rathmann, W., additional, Szendroedi, J., additional, and Ziegler, D., additional

Published
2021
Full Text
View/download PDF

24. Ventricular endomyocardial mitochondrial impairment and inflammation accompany diastolic dysfunction in the type 2 diabetic human heart

Author

Zweck, E, primary, Scheiber, D, additional, Jelenik, T, additional, Bonner, F, additional, Horn, P, additional, Pesta, D, additional, Schultheiss, H.P, additional, Boeken, U, additional, Akhyari, P, additional, Lichtenberg, A, additional, Roden, M, additional, Kelm, M, additional, Szendroedi, J, additional, and Westenfeld, R, additional

Published
2020
Full Text
View/download PDF

25. Regional analysis of inflammation and contractile function in reperfused acute myocardial infarction by in vivo 19F cardiovascular magnetic resonance in pigs.

Author

Bönner, Florian, Gastl, M., Nienhaus, F., Rothe, M., Jahn, A., Pfeiler, S., Gross, U., Schultheiss, H.-P., Ibanez, B., Kozerke, S., Szendroedi, J., Roden, M., Westenfeld, R., Schrader, J., Flögel, U., Heusch, G., and Kelm, M.

Abstract

Inflammatory cell infiltration is central to healing after acute myocardial infarction (AMI). The relation of regional inflammation to edema, infarct size (IS), microvascular obstruction (MVO), intramyocardial hemorrhage (IMH), and regional and global LV function is not clear. Here we noninvasively characterized regional inflammation and contractile function in reperfused AMI in pigs using fluorine (19F) cardiovascular magnetic resonance (CMR). Adult anesthetized pigs underwent left anterior descending coronary artery instrumentation with either 90 min occlusion (n = 17) or without occlusion (sham, n = 5). After 3 days, in surviving animals a perfluorooctyl bromide nanoemulsion was infused intravenously to label monocytes/macrophages. At day 6, in vivo 1H-CMR was performed with cine, T2 and T2* weighted imaging, T2 and T1 mapping, perfusion and late gadolinium enhancement followed by 19F-CMR. Pigs were sacrificed for subsequent ex vivo scans and histology. Edema extent was 35 ± 8% and IS was 22 ± 6% of LV mass. Six of ten surviving AMI animals displayed both MVO and IMH (3.3 ± 1.6% and 1.9 ± 0.8% of LV mass). The 19F signal, reflecting the presence and density of monocytes/macrophages, was consistently smaller than edema volume or IS and not apparent in remote areas. The 19F signal-to-noise ratio (SNR) > 8 in the infarct border zone was associated with impaired remote systolic wall thickening. A whole heart value of 19F integral (19F SNR × milliliter) > 200 was related to initial LV remodeling independently of edema, IS, MVO, and IMH. Thus, 19F-CMR quantitatively characterizes regional inflammation after AMI and its relation to edema, IS, MVO, IMH and regional and global LV function and remodeling. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

30. Meal-derived glucagon responses are related to lower hepatic phosphate concentrations in obesity and type 2 diabetes

Author

Weber, K. S. Strassburger, K. Fritsch, M. Bierwagen, A. and Koliaki, C. Phielix, E. Pacini, G. Hwang, J-H Markgraf, D. F. Burkart, V Muessig, K. Szendroedi, J. Roden, M.

Subjects
endocrine system, digestive, oral, and skin physiology
Abstract

Aim. - Type 2 diabetes (T2D) alters glucagon, glucagon-like peptide (GLP)-1, glucose-dependent insulinotropic polypeptide (GIP) and hepatic energy metabolism, yet the possible relationships remain unclear. Methods. - In this observational study, lean insulin-sensitive control subjects (BMI: 23.2 +/- 1.5 kg/m(2)), age-matched insulin-resistant obese subjects (BMI: 34.3 +/- 1.7 kg/m(2)) and similarly obese elderly T2D patients (BMI: 32.0 +/- 2.4 kg/m(2)) underwent mixed-meal tolerance tests (MMTTs), and assessment of hepatic gamma ATP, inorganic phosphate (P-i) and lipids using P-31/H-1 magnetic resonance spectroscopy. Meal-induced secretion of glucagon and incretins was calculated from incremental areas under the concentration-time curves (iAUCs). Peripheral and adipose tissue insulin sensitivity were assessed from time courses of circulating glucose, insulin and free fatty acids. Results. - MMTT-derived peripheral insulin sensitivity was lowest in T2D patients (P < 0.001), while glucagon concentrations were comparable across all three groups. At 260 min, GLP-1 was lower in T2D patients than in controls, whereas GIP was lowest in obese individuals. Fasting glucagon concentrations correlated positively with fasting (r = 0.60) and postprandial hepatocellular lipid levels (160 min: r= 0.51, 240 min: r = 0.59), and negatively with adipose tissue insulin sensitivity (r = -0.73). Higher meal-induced glucagon release (iAUC(0)(-260) (min)) correlated with lower fasting (r = -0.62) and postprandial P(i )levels (160 min: r = -0.43, 240 min: r = -0.42; all P < 0.05). Higher meal-induced release of GIP (iAUC(0-260) (min)) correlated positively with fasting (r = 0.54) and postprandial serum triglyceride concentrations (iAUC(0-260 min, )r = 0.54; all P < 0.01). Conclusion. - Correlations between fasting glucagon and hepatic lipids and between meal-induced glucagon and hepatic P-i suggest a role for glucagon in hepatic energy metabolism. (C) 2018 Elsevier Masson SAS. All rights reserved.

Published
2018

31. Typ-2-Diabetes Patienten mit einer Transmembrane-6-Superfamily-Member-2-Protein (TM6SF2)-Mutation haben höhere Insulinsensitivität trotz höherem Leberfettgehalt

Author

Bódis, K, additional, Szendroedi, J, additional, Ahlers, J, additional, Zaharia, OP, additional, Karusheva, Y, additional, Knebel, B, additional, Kupriyanova, Y, additional, Hwang, JH, additional, Burkart, V, additional, Müssig, K, additional, Al-Hasani, H, additional, Roden, M, additional, and Markgraf, D, additional

Published
2019
Full Text
View/download PDF

33. Reduced insulin clearance relates to increased liver fat content in recent-onset type 2 diabetes and to impaired glucose control in recent-onset type 1 diabetes

Author

Antoniou, S, additional, Zaharia, OP, additional, Bobrov, P, additional, Strassburger, K, additional, Karusheva, Y, additional, Bodis, K, additional, Kupriyanova, Y, additional, Burkart, V, additional, Hwang, JH, additional, Müssig, K, additional, Gastaldelli, A, additional, Roden, M, additional, and Szendroedi, J, additional

Published
2019
Full Text
View/download PDF

34. Subphenotypen neu diagnostizierter Patienten mit Diabetes entwickeln unterschiedliche Risikoprofile für Diabetes-assoziierte Erkrankungen

Author

Zaharia, OP, additional, Strassburger, K, additional, Strom, A, additional, Kupriyanova, Y, additional, Bönhof, G, additional, Karusheva, Y, additional, Antoniou, S, additional, Bódis, K, additional, Markgraf, D, additional, Burkart, V, additional, Müssig, K, additional, Hwang, JH, additional, Asplund, O, additional, Groop, L, additional, Ahlqvist, E, additional, Seissler, J, additional, Nawroth, P, additional, Kopf, S, additional, Schmid, SM, additional, Stumvoll, M, additional, Pfeiffer, AFH, additional, Kabisch, S, additional, Tselmin, S, additional, Fritsche, A, additional, Ziegler, D, additional, Kuss, O, additional, Szendroedi, J, additional, and Roden, M, additional

Published
2019
Full Text
View/download PDF

35. Meal-derived glucagon responses are related to lower hepatic phosphate concentrations in obesity and type 2 diabetes

Author

Weber, K. S., Weber, K. S., Strassburger, K., Fritsch, M., Bierwagen, A., Koliaki, C., Phielix, E., Pacini, G., Hwang, J-H, Markgraf, D. F., Burkart, Roman, Muessig, K., Szendroedi, J., Roden, M., Weber, K. S., Weber, K. S., Strassburger, K., Fritsch, M., Bierwagen, A., Koliaki, C., Phielix, E., Pacini, G., Hwang, J-H, Markgraf, D. F., Burkart, Roman, Muessig, K., Szendroedi, J., and Roden, M.

Abstract

Aim. - Type 2 diabetes (T2D) alters glucagon, glucagon-like peptide (GLP)-1, glucose-dependent insulinotropic polypeptide (GIP) and hepatic energy metabolism, yet the possible relationships remain unclear.Methods. - In this observational study, lean insulin-sensitive control subjects (BMI: 23.2 +/- 1.5 kg/m(2)), age-matched insulin-resistant obese subjects (BMI: 34.3 +/- 1.7 kg/m(2)) and similarly obese elderly T2D patients (BMI: 32.0 +/- 2.4 kg/m(2)) underwent mixed-meal tolerance tests (MMTTs), and assessment of hepatic gamma ATP, inorganic phosphate (P-i) and lipids using P-31/H-1 magnetic resonance spectroscopy. Meal-induced secretion of glucagon and incretins was calculated from incremental areas under the concentration-time curves (iAUCs). Peripheral and adipose tissue insulin sensitivity were assessed from time courses of circulating glucose, insulin and free fatty acids.Results. - MMTT-derived peripheral insulin sensitivity was lowest in T2D patients (P <0.001), while glucagon concentrations were comparable across all three groups. At 260 min, GLP-1 was lower in T2D patients than in controls, whereas GIP was lowest in obese individuals. Fasting glucagon concentrations correlated positively with fasting (r = 0.60) and postprandial hepatocellular lipid levels (160 min: r= 0.51, 240 min: r = 0.59), and negatively with adipose tissue insulin sensitivity (r = -0.73). Higher meal-induced glucagon release (iAUC(0)(-260) (min)) correlated with lower fasting (r = -0.62) and postprandial P(i )levels (160 min: r = -0.43, 240 min: r = -0.42; all P <0.05). Higher meal-induced release of GIP (iAUC(0-260) (min)) correlated positively with fasting (r = 0.54) and postprandial serum triglyceride concentrations (iAUC(0-260 min, )r = 0.54; all P <0.01).Conclusion. - Correlations between fasting glucagon and hepatic lipids and between meal-induced glucagon and hepatic P-i suggest a role for glucagon in hepatic energy metabolism. (C) 2018 Elsevier

Published
2018

36. Informationsbedürfnisse von Menschen mit kürzlich diagnostiziertem Diabetes mellitus: Ergebnisse der Deutschen Diabetes-Studie

Author

Grobosch, S., Kuske, S., Linnenkamp, U., Ernstmann, N., Stephan, A., Genz, J., Begun, A., Haastert, B., Szendroedi, J., Müssig, K., Burkart, V., Roden, M., and Icks, A.

Subjects
Diabetes mellitus, ddc: 610, Patientenzentrierte Versorgung, Informationsbedürfnisse, 610 Medical sciences, Medicine
Abstract

Hintergrund: Menschen mit Diabetes mellitus haben im Vergleich zu Menschen mit anderen chronischen Erkrankungen ein höheres Informationsbedürfnis. Dennoch sind ihre Informationsbedürfnisse bisher kaum untersucht. Fragestellung: Ziele dieser Studie sind (1) die Informationsbedürfnisse[zum vollständigen Text gelangen Sie über die oben angegebene URL], 51. Kongress für Allgemeinmedizin und Familienmedizin

Published
2017

38. P4220Mild cellular heart transplant rejection is associated with decreased myocardial mitochondrial respiration and coupling efficiency

Author

Zweck, E, primary, Scheiber, D, additional, Jelenik, T, additional, Horn, P, additional, Albermann, S, additional, Boeken, U, additional, Saeed, D, additional, Schultheiss, H P, additional, Lassner, D, additional, Kelm, M, additional, Roden, M, additional, Szendroedi, J, additional, and Westenfeld, R, additional

Published
2018
Full Text
View/download PDF

39. P2781Sympathomimetic beta-1AR autoantibodies in patients after heart transplantation are associated with higher mitochondrial coupling efficiency

Author

Horn, P, primary, Haschemi, J, additional, Scheiber, D, additional, Szendroedi, J, additional, Zweck, E, additional, Sun, R, additional, Luppa, P B, additional, Saeed, D, additional, Boeken, U, additional, Kelm, M, additional, Roden, M, additional, Boege, F, additional, and Westenfeld, R, additional

Published
2018
Full Text
View/download PDF

45. Reduzierte Stearoyl-CoA-Desaturase-1 und hormonsensitive Lipase-Genexpression im oberflächlichen subkutanen Fettgewebe bei männlichen, aber nicht weiblichen Patienten mit Typ-2-Diabetes

Author

Bódis, K, additional, Lundbom, J, additional, Jelenik, T, additional, Markgraf, D, additional, Strom, A, additional, Zaharia, OP, additional, Karusheva, Y, additional, Burkart, V, additional, Müssig, K, additional, Kupriyanova, Y, additional, Ouni, M, additional, Hwang, JH, additional, Ziegler, D, additional, Schürmann, A, additional, Roden, M, additional, and Szendroedi, J, additional

Published
2018
Full Text
View/download PDF

49. Elevated markers of DNA damage and senescence are associated with the progression of albuminuria and restrictive lung disease in patients with type 2 diabetesResearch in context

Author

Kumar Varun, Kender Zoltan, Sulaj Alba, Blume Manuel, Kliemank Elisabeth, Tsilingiris Dimitrios, Groener Jan B, Brune Maik, Shahzad Khurrum, Isermann Berend, Herzig Stephen, Fleming Thomas, Szendroedi Julia, Nawroth Peter, and Kopf Stefan

Subjects
Type 2 diabetes mellitus, Diabetic complications, DNA-damage, Senescence, Senescence-associated secretory phenotype, Diabetic kidney disease, Medicine, Medicine (General), R5-920
Abstract

Summary: Background: This study was conducted to investigate the cascade involving DNA damage, senescence, and senescence-associated secretory phenotype (SASP) in experimental diabetes and in a four-year follow-up study in patients with pre-diabetes and type 2 diabetes. Methods: Kidney, lung, and liver were studied in 4 months diabetic db/db mice and age-matched controls for the presence of DNA damage and fibrosis. DNA damage (comet-tail-length and ɤH2Ax-positivity in white blood cells), urinary p21-excretion, and plasma IL-6 and TGF-β1 were determined from 115 healthy participants, 34 patients with pre-diabetes and 221 with type 2 diabetes. Urinary albumin-creatinine-ratio, lung function, and transient elastography of the liver were performed in a prospective follow-up study over 4 years. Findings: db/db mice showed an increased nuclear ɤH2AX signal in all tissues as compared to the background control. Markers for DNA damage, senescence, and SASP were increased in patients with diabetes. The presence of nephropathy, restrictive lung disease (RLD), and increased liver stiffness was in a cross-sectional design associated with increased markers for DNA damage, senescence, and SASP. The progression of nephropathy over 4 years was predicted by increased DNA damage, senescence, and SASP, while the progression of RLD was associated with increased DNA damage and IL-6 only. The progression of liver stiffness was not associated with any of these parameters. HbA1c was not predictive for progression. Interpretation: In db/db mice, the cascade of DNA damage is associated with diabetes-related complications. In patients with diabetes, the progression of complications in the kidney and lung is predicted by markers reflecting DNA damage, and senescence-triggered organ fibrosis. Funding: This work was supported by the German Research Foundation (DFG) in the CRC 1118 and CRC 1158, by the GRK DIAMICOM, by the German Center for Diabetes Research (DZD e.V.), and by the Ministry of Science, Research and the Arts, Baden-Württemberg (Kompetenznetzwerk Präventivmedizin).

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results