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3. Six-Month Outcomes After High-Risk Coronary Artery Bypass Graft Surgery and Preoperative Intra-aortic Balloon Counterpulsation Use: An Inception Cohort Study

Author

Bagshaw, Sean M., Keri-Anne Cowdrey, Heidi Buhr, Frengley, Rob, Ferrier, Janet, Gilder, Eileen, Henderson, Seton, Larobina, Marco, Merthens, Jan, Morgan, Matthew, Navarra, Lean, Rudas, Máté, Turner, Lisa, Reid, Kristen, Wise, Matthew, Young, Noel, Young, Paul, McGiffin, D, Duncan, J, Kaczmarek, M, Seevanayagam, S, Shaw, M, Shardey, G, Skillington, P, Chorley, T, Baker, L, Zhang, B, Bright, C, Baker, R, Canning, N, Gilfillan, I, Kruger, R, Fayers, T, Kyte, M, Doran, C, Smith, J, Baxter, H, Seah, P, Scaybrook, S, James, A, Goodwin, K, Dignan, R, Hewitt, N, Gerrard, K, Curtis, L, Tiruvoipati, R, Broukal, N, Wolfenden, H, Muir, V, Worthington, M, Wong, C, Tatoulis, J, Wynne, R, Marshman, D, Sze, D, Wilson, M, Turner, L, Passage, J, Kolybaba, M, Fermanis, G, Newbon, P, Newcomb, A, Mack, J, Duve, K, Jansz, P, Hunter, T, Bissaker, P, Dennis, N, Burke, N, Yadav, S, Cooper, K, Chard, R, Halaka, M, Tran, L, Huq, M, Billah, B, Reid, CM, Litton, Edward, Bass, Frances, Delaney, Anthony, Hillis, Graham, Marasco, Silvana, McGuinness, Shay, Myles, Paul S., Reid, Christopher M., and Smith, Julian A.

Published
2018
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5. Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver

Author

Au, T, Thorne, S, Korn, WM, Sze, D, Kirn, D, and Reid, TR

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Colo-Rectal Cancer, Liver Disease, Cancer, Gene Therapy, Genetics, Digestive Diseases, Adenoviridae, Cell Line, Tumor, Colorectal Neoplasms, Enterovirus, Genetic Vectors, Humans, Immunohistochemistry, Liver, Liver Neoplasms, Receptors, Virus, Tomography, X-Ray Computed, Viral Vaccines, Virus Replication, colon cancer, gene therapy, oncolytic virus, clinical trial, adenovirus, Onyx-015, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

We administered an adenoviral vector, Onyx-015, into the hepatic artery of patients with metastatic colorectal cancer involving the liver. Thirty-five patients enrolled in this multi-institutional phase I/II trial received up to eight arterial infusions of up to 2 x 10(12) viral particles. Hepatic toxicity was the primary dose-limiting toxicity observed in preclinical models. However, nearly 200 infusions of this adenoviral vector were administered directly into the hepatic artery without significant toxicity. Therefore, we undertook this analysis to determine the impact of repeated adenoviral exposure on hepatic function. Seventeen patients were treated at our institution, providing a detailed data set on the changes in hepatic function following repeated exposure to adenovirus. No changes in hepatic function occurred with the first treatment of Onyx-015 among these patients. Transient increases in transaminase levels occurred in one patient starting with the second infusion and transient increases in bilirubin was observed in two patients starting with the fifth treatment. These changes occurred too early to be explained by viral-mediated lysis of hepatocytes. In addition, viremia was observed starting 3-5 days after the viral infusion in half of the patient, but was not associated with hepatic toxicity. To further understand the basis for the minimal hepatic toxicity of adenoviral vectors, we evaluated the replication of adenovirus in primary hepatocytes and tumor cells in culture and the expression of the coxsackie-adenoviral receptor (CAR) in normal liver and colon cancer metastatic to the liver. We found that adenovirus replicates poorly in primary hepatocytes but replicates efficiently in tumors including tumors derived from hepatocytes. In addition, we found that CAR is localized at junctions between hepatocytes and is inaccessible to hepatic blood flow. CAR is not expressed on tumor vasculature but is expressed on tumor cells. Spatial restriction of CAR to the intercellular space in normal liver and diminished replication of adenovirus in hepatocytes may explain the minimal toxicity observed following repeated hepatic artery infusions with Onyx-015.

Published
2007

6. Abstract No. 79 Comparison of 90Y Radioembolization Outcomes for Hepatocellular Carcinoma (HCC) in TACE-Refractory (T-REF) vs Treatment Naïve (TN) Patients in the RESiN Registry (NCT: 02685631)

Author

Hund, H., primary, Du, L., additional, Matsuoka, L., additional, Sze, D., additional, Kennedy, A., additional, Vaheesan, K., additional, Petroziello, M., additional, Golzarian, J., additional, Wang, E., additional, Ghandi, R., additional, Collins, Z., additional, Brower, J., additional, Lee, J., additional, and Brown, D., additional

Published
2023
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7. Abstract No. 130 Comparing Survival Outcomes and Toxicities of 90Y Radioembolization of Colorectal Cancer Metastatic to the Liver Between Patients Older and Younger than 70: Analysis from the RESiN Registry (NCT02685631)

Author

Bishay, S., primary, Emmons, E., additional, Du, L., additional, Krebs, H., additional, Gandhi, R., additional, Collins, Z., additional, O'Hara, R., additional, Akhter, N., additional, Wang, E., additional, Grilli, C., additional, Brower, J., additional, Peck, S., additional, Petroziello, M., additional, Aal, A. Abdel, additional, Golzarian, J., additional, Kennedy, A., additional, Matsuoka, L., additional, Sze, D., additional, and Brown, D., additional

Published
2023
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9. Abstract No. 80 Progression and Survival Outcomes of Hepatocellular Carcinoma (HCC) Patients within Milan Criteria Following 90Y Radioembolization Using the Radiation-Emitting SIR-Spheres in Non-Resectable Tumor (RESiN) Registry NCT 02685631

Author

Park, S., primary, Du, L., additional, Petroziello, M., additional, Kouri, B., additional, Brower, J., additional, Lee, J., additional, Golzarian, J., additional, Vaheesan, K., additional, Sze, D., additional, Kennedy, A., additional, Matsuoka, L., additional, and Brown, D., additional

Published
2023
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10. Abstract No. 1 ▪ ABSTRACT OF THE YEAR Survival outcomes and toxicities following Y-90 radioembolization of colorectal cancer metastatic to the liver: 498-patient analysis from the RESiN registry (NCT: 02685631)

Author

Emmons, E., primary, Krebs, H., additional, Gandhi, R., additional, Collins, Z., additional, O’Hara, R., additional, Akhter, N., additional, Wang, E., additional, Grilli, C., additional, Brower, J., additional, Peck, S., additional, Petroziello, M., additional, Aal, A. Abdel, additional, Golzarian, J., additional, Kennedy, A., additional, Matsuoka, L., additional, Sze, D., additional, and Brown, D., additional

Published
2022
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11. Abstract No. 304 Evaluation of survival and toxicity of cholangiocarcinoma treated with Y-90 radioembolization: outcomes assessment from the radiation emitting SIR-Spheres in non-resectable tumor registry

Author

Robinson, T., primary, Zhang, K., additional, Matsuoka, L., additional, Sze, D., additional, Kennedy, A., additional, Gandhi, R., additional, Kouri, B., additional, Collins, Z., additional, O’Hara, R., additional, Kokabi, N., additional, Grilli, C., additional, Wang, E., additional, Lee, J., additional, and Brown, D., additional

Published
2022
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12. Abstract No. 196 Overall survival and toxicities of advanced hepatocellular carcinoma (HCC) Barcelona clinic liver cancer C (BCLC-C) patients following Y-90 radioembolization: assessment from the RESiN Registry (NCT: 02685631)

Author

Goswami, P., primary, Adeniran, O., additional, Frantz, S., additional, Matsuoka, L., additional, Du, L., additional, Gandhi, R., additional, Collins, Z., additional, Matrana, M., additional, Petroziello, M., additional, Brower, J., additional, Sze, D., additional, Kennedy, A., additional, Golzarian, J., additional, Wang, E., additional, and Brown, D., additional

Published
2022
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18. 3:45 PM Abstract No. 27 Neutrophil-lymphocyte ratio correlates with survival in MUlticenter Study of RAS Mutations (MURAS) in patients with colorectal liver metastases receiving Y90 radioembolization treatment

Author

Dendy Case, M., primary, Ghodadra, A., additional, Novelli, P., additional, Wu, V., additional, Ganguli, S., additional, Wildgruber, M., additional, Kohler, M., additional, Robinson, C., additional, Kim, C., additional, Wang, D., additional, Sze, D., additional, Kolbeck, K., additional, Russell, L., additional, Ludwig, J., additional, Uhlig, J., additional, and Kim, K., additional

Published
2020
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31. Predictors of Frequent Readmissions in Patients With Heart Failure

Author

Wang, N, Gallagher, R, Sze, D, Hales, S, and Tofler, G

Subjects
Aged, 80 and over, Male, Heart Failure, Cardiovascular System & Hematology, Risk Factors, Humans, Female, Length of Stay, New South Wales, Patient Readmission, Risk Assessment, Retrospective Studies, Follow-Up Studies
Abstract

© 2017 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ) Background: Patients with heart failure (HF) have a high incidence of hospital readmissions. However risk models that explore predictors of a single readmission may be less useful at identifying the patients with frequent readmissions who contribute to a disproportionately large proportion of morbidity and health care costs. Methods: A total of 6252 patients enrolled in the Management of Cardiac Failure Program (MACARF) in Northern Sydney Area Hospitals between 1998 and 2015 were randomly divided into derivation and validation cohorts to create and test a risk model for predictors of ≥2 readmissions or death within 1 year of initial hospitalisation for HF. Results: Multivariate predictors of frequent (≥2) readmissions or death were a history of ischaemic heart disease and chronic kidney disease, being unmarried, having anaemia, low serum albumin, elevated creatinine, prolonged hospital stay (>7 days), and not receiving beta blockers on discharge. Event rates increased with a higher risk score (p < 0.001) and the prediction was similar in the validation and derivation cohorts (p = 0.588). The C-statistic was 0.65. Conclusions: Our risk score may assist in focussing health care resources and interventions by identifying the subset of HF patients at increased risk for a disproportionately high burden of disease.

Published
2017

34. THE ARIES-I TOKAMAK REACTOR STUDY

Author

Najmabadi, F., primary, Conn, R.W., additional, Bathke, C.G., additional, Bromberg, L., additional, Cheng, E.T., additional, Cohn, D.R., additional, Cooke, P.I.H., additional, Creedon, R.L., additional, Ehst, D.A., additional, Evans, K., additional, Ghoniem, N.M., additional, Grotz, S.P., additional, Hasan, M.Z., additional, Hogan, J.T., additional, Herring, J.S., additional, Hyatt, A.W., additional, Ibrahim, E., additional, Jardin, S.A., additional, Kessel, C., additional, Klasky, M., additional, Krakowski, R.A., additional, Kunugi, T., additional, Leuer, J.A., additional, Mandrekas, J., additional, Martin, R.C., additional, Mau, T-K., additional, Miller, R.L., additional, Peng, Y-K.M., additional, Reid, R.L., additional, Santarius, J.F., additional, Schaffer, M.J., additional, Schultz, J., additional, Schultz, K.R., additional, Schwartz, J., additional, Sharafat, S., additional, Singer, C.E., additional, Snead, L., additional, Steiner, D., additional, Strickler, D.J., additional, Sze, D-K., additional, Valenti, M., additional, Ward, D.J., additional, Williams, J.E.C., additional, Wittenberg, L.J., additional, and Wong, C.P.C., additional

Published
1991
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35. On the exploration of innovative concepts for fusion chamber technology

Author

Abdou, M.A, TEAM, The APEX, Ying, A, Morley, N, Gulec, K, Smolentsev, S, Kotschenreuther, M, Malang, S, Zinkle, S, Rognlien, T, Fogarty, P, Nelson, B, Nygren, R, McCarthy, K, Youssef, M.Z, Ghoniem, N, Sze, D, Wong, C, Sawan, M, Khater, H, Woolley, R, Mattas, R, Moir, R, Sharafat, S, Brooks, J, Hassanein, A, Petti, D, Tillack, M, Ulrickson, M, and Uchimoto, T

Published
2001
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36. Abstract No. 115 Demographics and outcomes following Y90 radioembolization of hepatocellular carcinoma at transplant versus non-transplant centers: analysis of the radiation-emitting SIR-spheres in non-resectable liver tumor (RESiN) registry

Author

Frantz, S., Matsuoka, L., Shahin, I., Vaheesan, K., Petroziello, M., D’Souza, D., Golzarian, J., Matrana, M., Wang, E., Gandhi, R., Collins, Z., Brower, J., Du, Kennedy, A., Sze, D., Lee, J., Adeniran, O., Wong, T., O’Hara, R., Fidelman, N., Shrestha, R., Kouri, B., Hennemeyer, C., Meek, J., Mohan, P., Westcott, M., Siskin, G., and Brown, D.

Published
2021
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37. Tailoring Anti-Impact Properties of Ultra-High Performance Concrete by Incorporating Functionalized Carbon Nanotubes

Author

Jialiang Wang, Sufen Dong, Sze Dai Pang, Xun Yu, Baoguo Han, and Jinping Ou

Subjects
Functionalized carbon nanotubes, Concrete, Anti-impact properties, Reinforcing mechanisms, Engineering (General). Civil engineering (General), TA1-2040
Abstract

Replacing micro-reinforcing fibers with carbon nanotubes (CNTs) is beneficial for improving the impact properties of ultra-high performance concrete (UHPC); however, the weak wettability and dispersibility of CNTs and the weakly bonded interface between CNTs and UHPC limit their effectiveness as composites. Therefore, this study aims to enhance the reinforcement effect of CNTs on the impact properties of UHPC via functionalization. Unlike ordinary CNTs, functionalized CNTs with carboxyl or hydroxyl groups can break the Si–O–Ca–O–Si coordination bond in the C–S–H gel and form a new network in the UHPC matrix, effectively inhibiting the dislocation slip inside UHPC matrix. Furthermore, functionalized CNTs, particularly carboxyl-functionalized CNTs, control the crystallization process and microscopic morphology of the hydration products, significantly decreasing and even eliminating the width of the aggregate–matrix interface transition zone of the UHPC. Moreover, the functionalized CNTs further decrease the attraction of the negatively charged silicate tetrahedron to Ca2+ in the C–S–H gel, while modifying the pore structure (particularly the nanoscale pore structure) of UHPC, leading to the expansion of the intermediate C–S–H layer. The changes in the microstructures of UHPC brought about by the functionalized CNTs significantly enhance its dynamic compressive strength, peak strain, impact toughness, and impact dissipation energy at strain rates of 200–800 s−1. Impact performance of UHPC containing a small amount of carboxyl-functionalized CNTs (especially the short ones) is generally better than that of UHPC containing hydroxyl-functionalized and ordinary CNTs; it is even superior to that of UHPC with a high steel fiber content.

Published
2022
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38. ALPS–advanced limiter-divertor plasma-facing systems

Author

Mattas, R.F, Allain, J.P, Bastasz, R, Brooks, J.N, Evans, T, Hassanein, A, Luckhardt, S, McCarthy, K, Mioduszewski, P, Maingi, R, Mogahed, E, Moir, R, Molokov, S, Morely, N, Nygren, R, Rognlien, T, Reed, C, Ruzic, D, Sviatoslavsky, I, Sze, D, Tillack, M, Ulrickson, M, Wade, P.M, Wooley, R, and Wong, C

Published
2000
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40. Radioembolization with 90Y Resin Microspheres of Neuroendocrine Liver Metastases After Initial Peptide Receptor Radionuclide Therapy.

Author

Braat, A. J. A. T., Ahmadzadehfar, H., Kappadath, S. C., Stothers, C. L., Frilling, A., Deroose, C. M., Flamen, P., Brown, D. B., Sze, D. Y., Mahvash, A., and Lam, M. G. E. H.

Subjects
PEPTIDE receptors, RADIOEMBOLIZATION, LIVER metastasis, RADIOISOTOPES, MICROSPHERES, RADIOISOTOPE therapy, LATEX, LIVER tumors, CELL receptors, RETROSPECTIVE studies, TREATMENT effectiveness, NEUROENDOCRINE tumors, RADIOISOTOPE brachytherapy
Abstract

Purpose: Peptide receptor radionuclide therapy (PRRT) and radioembolization are increasingly used in neuroendocrine neoplasms patients. However, concerns have been raised on cumulative hepatotoxicity. The aim of this sub-analysis was to investigate hepatotoxicity of yttrium-90 resin microspheres radioembolization in patients who were previously treated with PRRT.Methods: Patients treated with radioembolization after systemic radionuclide treatment were retrospectively analysed. Imaging response according to response evaluation criteria in solid tumours (RECIST) v1.1 and clinical response after 3 months were collected. Clinical, biochemical and haematological toxicities according to common terminology criteria for adverse events (CTCAE) v4.03 were also collected. Specifics on prior PRRT, subsequent radioembolization treatments, treatments after radioembolization and overall survival (OS) were collected.Results: Forty-four patients were included, who underwent a total of 58 radioembolization procedures, of which 55% whole liver treatments, at a median of 353 days after prior PRRT. According to RECIST 1.1, an objective response rate of 16% and disease control rate of 91% were found after 3 months. Clinical response was seen in 65% (15/23) of symptomatic patients after 3 months. Within 3 months, clinical toxicities occurred in 26%. Biochemical and haematological toxicities CTCAE grade 3-4 occurred in ≤ 10%, apart from lymphocytopenia (42%). Radioembolization-related complications occurred in 5% and fatal radioembolization-induced liver disease in 2% (one patient). A median OS of 3.5 years [95% confidence interval 1.8-5.1 years] after radioembolization for the entire study population was found.Conclusion: Radioembolization after systemic radionuclide treatments is safe, and the occurrence of radioembolization-induced liver disease is rare.Level Of Evidence: 4, case series. [ABSTRACT FROM AUTHOR]

Published
2020
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43. 3:36 PM Abstract No. 125 Single-day outpatient yttrium-90 radioembolization using resin microspheres

Author

Abdelmaksoud, M., primary, Abuelsalheen, O., additional, Ibrahim, K., additional, AbdelRazek, M., additional, Abdelfattah, A., additional, Abdelaziz, A., additional, Darwish, A., additional, Hassanien, M., additional, Ismail, A., additional, Hosny, A., additional, Hazem, A., additional, Sami, A., additional, Fattah, Y.A., additional, and Sze, D., additional

Published
2018
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44. 3:09 PM Abstract No. 122 Lobar or whole-liver Yttrium-90 radioembolization using resin microspheres without prophylactic embolization of the gastroduodenal artery

Author

Abdelmaksoud, M., primary, Abuelsalheen, O., additional, Ibrahim, K., additional, AbdelRazek, M., additional, Abdelfattah, A., additional, Abdelaziz, A., additional, Darwish, A., additional, Hassanien, M., additional, Ismail, A., additional, Hosny, A., additional, Hazem, A., additional, Sami, A., additional, Fattah, Y.A., additional, and Sze, D., additional

Published
2018
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