Search

Your search keyword '"Szczepanski, Miroslaw J."' showing total 171 results
Start Over Author "Szczepanski, Miroslaw J."
171 results on '"Szczepanski, Miroslaw J."'

2. The role of tumor-derived exosomes in tumor angiogenesis and tumor progression

Author

Gluszko Alicja, Mirza Shafaq M., Piszczatowska Katarzyna, Kantor Ireneusz, Struga Marta, and Szczepanski Miroslaw J.

Subjects
tumor-derived exosomes, angiogenesis, endothelial cells, hypoxia, Medicine
Abstract

Exosomes, belonging to the group of extracellular bodies, are released by healthy as well as cancerous cells and serve as a communication pathway. Tumor-derived exosomes (TEX) possess the capacity to reprogram the function of normal cells owing to their genetic and molecular cargo. Such exosomes target endothelial cells (among others) in the tumor microenvironment to promote angiogenesis. Blood supply is essential in solid tumor growth and metastasis. The potential of pro-angiogenic changes is enhanced by an increased amount of circulating tumor-derived exosomes in the body fluids of cancer patients. A vascular network is important, since the proliferation, as well as the metastatic spread of cancer cells depends on an adequate supply of oxygen and nutrients, and the removal of waste products. New blood vessels and lymphatic vessels are formed through processes called angiogenesis and lymphangiogenesis, respectively. Angiogenesis is regulated by both activator and inhibitor molecules. Thousands of patients have received anti-angiogenic therapy to date. Despite their theoretical efficacy, anti-angiogenic treatments have not proved beneficial in terms of long-term survival. Tumor-derived exosomes carrying pro-angiogenic factors might be a target for new anti-cancer therapy.

Published
2019
Full Text
View/download PDF

4. Supplementary Figure 3 from Sheddase Activity of Tumor Necrosis Factor-α Converting Enzyme Is Increased and Prognostically Valuable in Head and Neck Cancer

Author

Ge, Lisheng, primary, Baskic, Dejan, primary, Basse, Per, primary, Vujanovic, Lazar, primary, Unlu, Sebnem, primary, Yoneyama, Toshie, primary, Vujanovic, Andrea, primary, Han, Jie, primary, Bankovic, Dragic, primary, Szczepanski, Miroslaw J., primary, Hunt, Jennifer L., primary, Herberman, Ronald B., primary, Gollin, Susanne M., primary, Ferris, Robert L., primary, Whiteside, Theresa L., primary, Myers, Eugene N., primary, and Vujanovic, Nikola L., primary

Published
2023
Full Text
View/download PDF

5. Supplementary Figure 2 from Sheddase Activity of Tumor Necrosis Factor-α Converting Enzyme Is Increased and Prognostically Valuable in Head and Neck Cancer

Author

Ge, Lisheng, primary, Baskic, Dejan, primary, Basse, Per, primary, Vujanovic, Lazar, primary, Unlu, Sebnem, primary, Yoneyama, Toshie, primary, Vujanovic, Andrea, primary, Han, Jie, primary, Bankovic, Dragic, primary, Szczepanski, Miroslaw J., primary, Hunt, Jennifer L., primary, Herberman, Ronald B., primary, Gollin, Susanne M., primary, Ferris, Robert L., primary, Whiteside, Theresa L., primary, Myers, Eugene N., primary, and Vujanovic, Nikola L., primary

Published
2023
Full Text
View/download PDF

7. Supplementary Table 3 from Targeting ALDHbright Human Carcinoma–Initiating Cells with ALDH1A1-Specific CD8+ T Cells

Author

Visus, Carmen, primary, Wang, Yangyang, primary, Lozano-Leon, Antonio, primary, Ferris, Robert L., primary, Silver, Susan, primary, Szczepanski, Miroslaw J., primary, Brand, Randall E., primary, Ferrone, Cristina R., primary, Whiteside, Theresa L., primary, Ferrone, Soldano, primary, DeLeo, Albert B., primary, and Wang, Xinhui, primary

Published
2023
Full Text
View/download PDF

8. Supplementary Figure 3b from Targeting ALDHbright Human Carcinoma–Initiating Cells with ALDH1A1-Specific CD8+ T Cells

Author

Visus, Carmen, primary, Wang, Yangyang, primary, Lozano-Leon, Antonio, primary, Ferris, Robert L., primary, Silver, Susan, primary, Szczepanski, Miroslaw J., primary, Brand, Randall E., primary, Ferrone, Cristina R., primary, Whiteside, Theresa L., primary, Ferrone, Soldano, primary, DeLeo, Albert B., primary, and Wang, Xinhui, primary

Published
2023
Full Text
View/download PDF

9. Supplementary Figure 1 from Sheddase Activity of Tumor Necrosis Factor-α Converting Enzyme Is Increased and Prognostically Valuable in Head and Neck Cancer

Author

Ge, Lisheng, primary, Baskic, Dejan, primary, Basse, Per, primary, Vujanovic, Lazar, primary, Unlu, Sebnem, primary, Yoneyama, Toshie, primary, Vujanovic, Andrea, primary, Han, Jie, primary, Bankovic, Dragic, primary, Szczepanski, Miroslaw J., primary, Hunt, Jennifer L., primary, Herberman, Ronald B., primary, Gollin, Susanne M., primary, Ferris, Robert L., primary, Whiteside, Theresa L., primary, Myers, Eugene N., primary, and Vujanovic, Nikola L., primary

Published
2023
Full Text
View/download PDF

13. Supplementary Figure Legend from Targeting ALDHbright Human Carcinoma–Initiating Cells with ALDH1A1-Specific CD8+ T Cells

Author

Visus, Carmen, primary, Wang, Yangyang, primary, Lozano-Leon, Antonio, primary, Ferris, Robert L., primary, Silver, Susan, primary, Szczepanski, Miroslaw J., primary, Brand, Randall E., primary, Ferrone, Cristina R., primary, Whiteside, Theresa L., primary, Ferrone, Soldano, primary, DeLeo, Albert B., primary, and Wang, Xinhui, primary

Published
2023
Full Text
View/download PDF

14. Supplementary Figure Legends from Sheddase Activity of Tumor Necrosis Factor-α Converting Enzyme Is Increased and Prognostically Valuable in Head and Neck Cancer

Author

Ge, Lisheng, primary, Baskic, Dejan, primary, Basse, Per, primary, Vujanovic, Lazar, primary, Unlu, Sebnem, primary, Yoneyama, Toshie, primary, Vujanovic, Andrea, primary, Han, Jie, primary, Bankovic, Dragic, primary, Szczepanski, Miroslaw J., primary, Hunt, Jennifer L., primary, Herberman, Ronald B., primary, Gollin, Susanne M., primary, Ferris, Robert L., primary, Whiteside, Theresa L., primary, Myers, Eugene N., primary, and Vujanovic, Nikola L., primary

Published
2023
Full Text
View/download PDF

16. Supplementary Table 1 from Targeting ALDHbright Human Carcinoma–Initiating Cells with ALDH1A1-Specific CD8+ T Cells

Author

Visus, Carmen, primary, Wang, Yangyang, primary, Lozano-Leon, Antonio, primary, Ferris, Robert L., primary, Silver, Susan, primary, Szczepanski, Miroslaw J., primary, Brand, Randall E., primary, Ferrone, Cristina R., primary, Whiteside, Theresa L., primary, Ferrone, Soldano, primary, DeLeo, Albert B., primary, and Wang, Xinhui, primary

Published
2023
Full Text
View/download PDF

18. Supplementary Figure 5 from Targeting ALDHbright Human Carcinoma–Initiating Cells with ALDH1A1-Specific CD8+ T Cells

Author

Visus, Carmen, primary, Wang, Yangyang, primary, Lozano-Leon, Antonio, primary, Ferris, Robert L., primary, Silver, Susan, primary, Szczepanski, Miroslaw J., primary, Brand, Randall E., primary, Ferrone, Cristina R., primary, Whiteside, Theresa L., primary, Ferrone, Soldano, primary, DeLeo, Albert B., primary, and Wang, Xinhui, primary

Published
2023
Full Text
View/download PDF

19. Supplementary Figure 2 from Targeting ALDHbright Human Carcinoma–Initiating Cells with ALDH1A1-Specific CD8+ T Cells

Author

Visus, Carmen, primary, Wang, Yangyang, primary, Lozano-Leon, Antonio, primary, Ferris, Robert L., primary, Silver, Susan, primary, Szczepanski, Miroslaw J., primary, Brand, Randall E., primary, Ferrone, Cristina R., primary, Whiteside, Theresa L., primary, Ferrone, Soldano, primary, DeLeo, Albert B., primary, and Wang, Xinhui, primary

Published
2023
Full Text
View/download PDF

20. Supplementary Figure 1 from Targeting ALDHbright Human Carcinoma–Initiating Cells with ALDH1A1-Specific CD8+ T Cells

Author

Visus, Carmen, primary, Wang, Yangyang, primary, Lozano-Leon, Antonio, primary, Ferris, Robert L., primary, Silver, Susan, primary, Szczepanski, Miroslaw J., primary, Brand, Randall E., primary, Ferrone, Cristina R., primary, Whiteside, Theresa L., primary, Ferrone, Soldano, primary, DeLeo, Albert B., primary, and Wang, Xinhui, primary

Published
2023
Full Text
View/download PDF

21. Supplementary Figure 4 from Targeting ALDHbright Human Carcinoma–Initiating Cells with ALDH1A1-Specific CD8+ T Cells

Author

Visus, Carmen, primary, Wang, Yangyang, primary, Lozano-Leon, Antonio, primary, Ferris, Robert L., primary, Silver, Susan, primary, Szczepanski, Miroslaw J., primary, Brand, Randall E., primary, Ferrone, Cristina R., primary, Whiteside, Theresa L., primary, Ferrone, Soldano, primary, DeLeo, Albert B., primary, and Wang, Xinhui, primary

Published
2023
Full Text
View/download PDF

22. Supplementary Table 2 from Targeting ALDHbright Human Carcinoma–Initiating Cells with ALDH1A1-Specific CD8+ T Cells

Author

Visus, Carmen, primary, Wang, Yangyang, primary, Lozano-Leon, Antonio, primary, Ferris, Robert L., primary, Silver, Susan, primary, Szczepanski, Miroslaw J., primary, Brand, Randall E., primary, Ferrone, Cristina R., primary, Whiteside, Theresa L., primary, Ferrone, Soldano, primary, DeLeo, Albert B., primary, and Wang, Xinhui, primary

Published
2023
Full Text
View/download PDF

23. Supplementary Figure 3 from Triggering of Toll-like Receptor 4 Expressed on Human Head and Neck Squamous Cell Carcinoma Promotes Tumor Development and Protects the Tumor from Immune Attack

Author

Szczepanski, Miroslaw J., primary, Czystowska, Malgorzata, primary, Szajnik, Marta, primary, Harasymczuk, Malgorzata, primary, Boyiadzis, Michael, primary, Kruk-Zagajewska, Aleksandra, primary, Szyfter, Witold, primary, Zeromski, Jan, primary, and Whiteside, Theresa L., primary

Published
2023
Full Text
View/download PDF

24. Supplementary Figure 2 from Triggering of Toll-like Receptor 4 Expressed on Human Head and Neck Squamous Cell Carcinoma Promotes Tumor Development and Protects the Tumor from Immune Attack

Author

Szczepanski, Miroslaw J., primary, Czystowska, Malgorzata, primary, Szajnik, Marta, primary, Harasymczuk, Malgorzata, primary, Boyiadzis, Michael, primary, Kruk-Zagajewska, Aleksandra, primary, Szyfter, Witold, primary, Zeromski, Jan, primary, and Whiteside, Theresa L., primary

Published
2023
Full Text
View/download PDF

25. Data from Triggering of Toll-like Receptor 4 Expressed on Human Head and Neck Squamous Cell Carcinoma Promotes Tumor Development and Protects the Tumor from Immune Attack

Author

Szczepanski, Miroslaw J., primary, Czystowska, Malgorzata, primary, Szajnik, Marta, primary, Harasymczuk, Malgorzata, primary, Boyiadzis, Michael, primary, Kruk-Zagajewska, Aleksandra, primary, Szyfter, Witold, primary, Zeromski, Jan, primary, and Whiteside, Theresa L., primary

Published
2023
Full Text
View/download PDF

26. Data from Biological Significance of Prolactin in Gynecologic Cancers

Author

Levina, Vera V., primary, Nolen, Brian, primary, Su, YunYun, primary, Godwin, Andrew K., primary, Fishman, David, primary, Liu, Jinsong, primary, Mor, Gil, primary, Maxwell, Larry G., primary, Herberman, Ronald B., primary, Szczepanski, Miroslaw J., primary, Szajnik, Marta E., primary, Gorelik, Elieser, primary, and Lokshin, Anna E., primary

Published
2023
Full Text
View/download PDF

27. Supplementary Figure Legends 1-3 from Triggering of Toll-like Receptor 4 Expressed on Human Head and Neck Squamous Cell Carcinoma Promotes Tumor Development and Protects the Tumor from Immune Attack

Author

Szczepanski, Miroslaw J., primary, Czystowska, Malgorzata, primary, Szajnik, Marta, primary, Harasymczuk, Malgorzata, primary, Boyiadzis, Michael, primary, Kruk-Zagajewska, Aleksandra, primary, Szyfter, Witold, primary, Zeromski, Jan, primary, and Whiteside, Theresa L., primary

Published
2023
Full Text
View/download PDF

28. Supplementary Figure 1 from Triggering of Toll-like Receptor 4 Expressed on Human Head and Neck Squamous Cell Carcinoma Promotes Tumor Development and Protects the Tumor from Immune Attack

Author

Szczepanski, Miroslaw J., primary, Czystowska, Malgorzata, primary, Szajnik, Marta, primary, Harasymczuk, Malgorzata, primary, Boyiadzis, Michael, primary, Kruk-Zagajewska, Aleksandra, primary, Szyfter, Witold, primary, Zeromski, Jan, primary, and Whiteside, Theresa L., primary

Published
2023
Full Text
View/download PDF

30. Arginase-1 in Plasma-Derived Exosomes as Marker of Metastasis in Patients with Head and Neck Squamous Cell Carcinoma.

Author

Hofmann, Linda, Harasymczuk, Malgorzata, Huber, Diana, Szczepanski, Miroslaw J., Dworacki, Grzegorz, Whiteside, Theresa L., and Theodoraki, Marie-Nicole

Subjects
PROTEIN metabolism, EXOSOMES, BLOOD plasma, IMMUNOHISTOCHEMISTRY, WESTERN immunoblotting, HEAD & neck cancer, METASTASIS, CANCER relapse, TUMOR classification, CANCER patients, ENZYME-linked immunosorbent assay, RESEARCH funding, TUMOR markers, PROGRESSION-free survival, CELL lines, SQUAMOUS cell carcinoma
Abstract

Simple Summary: Head and neck cancer creates a highly immunosuppressive microenvironment, to which the enzyme Arginase-1 contributes. The impact of Arginase-1 on the clinicopathology and prognosis of head and neck cancer, however, is not fully understood. We evaluated Arginase-1 protein levels in both the tumors and plasma of patients. Patients with high tumor Arginase-1 levels had better clinicopathology and prognosis, while patients with high plasma Arginase-1 levels had unfavorable clinicopathology. We attributed this difference to the presence of Arginase-1-positive exosomes in the blood of patients. Exosomes, small vesicles for intercellular communication, are released by cancer cells and can travel through the body. Patients with high Arginase-1 levels in these exosomes had lymph node metastasis and poor prognosis. We conclude that exosomes can export Arginase-1 from the tumor to the periphery for further immunosuppression. Exosomal Arginase-1 might be a better indicator of metastatic disease and prognosis than tissue or plasma Argianse-1. Immunoregulatory Arginase-1 (Arg-1) is present in the tumor microenvironment of solid tumors. Its association to clinicopathology and its prognostic impact are inconsistent among different tumor types and biological fluids. This study evaluated Arg-1 protein levels in tumors and the circulation of patients with head and neck squamous cell carcinoma (HNSCC) in relation to clinical stage and prognosis. Tumor Arg-1 expression was monitored via immunohistochemistry while plasma Arg-1 levels via ELISA in 37 HNSCC patients. Arg-1 presence in plasma-derived exosomes was assessed using Western blots in 20 HNSCC patients. High tumor Arg-1 expression correlated with favorable clinicopathology and longer recurrence-free survival (RFS), while high plasma Arg-1 levels were associated with unfavorable clinicopathology. All patients with low tumor and high plasma Arg-1 had nodal metastases and developed recurrence. This discrepancy was attributed to the presence of Arg-1-carrying exosomes. Arg-1 was found in plasma-derived exosomes from all HNSCC patients. High exosomal Arg-1 levels were associated with positive lymph nodes and short RFS. Circulating Arg-1+ exosomes represent a mechanism of active Arg-1 export from the tumor to the periphery. Exosomes reflected biologically relevant Arg-1 levels in metastatic HNSCC and emerged as potentially more accurate biomarkers of metastatic disease and RFS than tissue or plasma Arg-1 levels. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

31. PRAME expression in head and neck cancer correlates with markers of poor prognosis and might help in selecting candidates for retinoid chemoprevention in pre-malignant lesions

Author

Szczepanski, Miroslaw J., DeLeo, Albert B., Łuczak, Michał, Molinska-Glura, Marta, Misiak, Jan, Szarzynska, Bronislawa, Dworacki, Grzegorz, Zagor, Mariola, Rozwadowska, Natalia, Kurpisz, Maciej, Krzeski, Antoni, Kruk-Zagajewska, Aleksandra, Kopec, Tomasz, Banaszewski, Jacek, and Whiteside, Theresa L.

Published
2013
Full Text
View/download PDF

42. Internal Carotid Artery Aneurysm Mimicking Peritonsillar Abscess

Author

Brzost, Jacek, Cyran, Anna M., Waniewska, Martyna, and Szczepanski, Miroslaw J.

Subjects
Article Subject
Abstract

The extracranial internal carotid artery aneurysm (EICAA) is an uncommon arterial lesion. Patients typically present with neurologic symptoms resulting from impaired cerebral perfusion and compression symptoms of cranial nerves. Often EICAA presents as a pulsatile neck mass, which is otherwise asymptomatic. We present a case of an 84-year-old female, who was initially referred to the Emergency Department for Otolaryngology with suspected peritonsillar abscess. The patient had a history of recent upper airway infection and cardiovascular comorbidities, including hypertension and ischaemic stroke complicated by extensive neurologic deficits. Physical examination revealed a compact, nonpulsatile mass in the lateral parapharyngeal space and local erythema of the mucosa. Duplex Doppler Ultrasonography and Computed Tomography revealed an atherosclerotic aneurysm of the right internal carotid artery, measuring 63×55×88 mm, stretching from the skull base to the angle of the mandible.

Published
2015
Full Text
View/download PDF

46. Role of CCL11/eotaxin-1 signaling in ovarian cancer

Author

Levina, Vera, Nolen, Brian M., Marrangoni, Adele M., Cheng, Peng, Marks, Jeffrey R., Szczepanski, Miroslaw J., Szajnik, Marta E., Gorelik, Elieser, and Lokshin, Anna E.

Subjects
Chemokine CCL11, Ovarian Neoplasms, Receptors, CCR5, Receptors, CCR2, Receptors, CCR3, Phosphoproteins, Article, Cell Line, Tumor, Cytokines, Humans, Female, Cell Proliferation, Signal Transduction, Transcription Factors
Abstract

Tumor cell growth and migration can be directly regulated by chemokines. In the present study, the association of CCL11 with ovarian cancer has been investigated.Circulating levels of CCL11 in sera of patients with ovarian cancer were significantly lower than those in healthy women or women with breast, lung, liver, pancreatic, or colon cancer. Cultured ovarian carcinoma cells absorbed soluble CCL11, indicating that absorption by tumor cells could be responsible for the observed reduction of serum level of CCL11 in ovarian cancer. Postoperative CCL11 levels in women with ovarian cancer negatively correlated with relapse-free survival. Ovarian tumors overexpressed three known cognate receptors of CCL11, CC chemokine receptors (CCR) 2, 3, and 5. Strong positive correlation was observed between expression of individual receptors and tumor grade. CCL11 potently stimulated proliferation and migration/invasion of ovarian carcinoma cell lines, and these effects were inhibited by neutralizing antibodies against CCR2, CCR3, and CCR5. The growth-stimulatory effects of CCL11 were likely associated with activation of extracellular signal-regulated kinase 1/2, MEK1, and STAT3 phosphoproteins and with increased production of multiple cytokines, growth factors, and angiogenic factors. Inhibition of CCL11 signaling by the combination of neutralizing antibodies against the ligand and its receptors significantly increased sensitivity to cisplatin in ovarian carcinoma cells.We conclude that CCL11 signaling plays an important role in proliferation and invasion of ovarian carcinoma cells and CCL11 pathway could be targeted for therapy in ovarian cancer. Furthermore, CCL11 could be used as a biomarker and a prognostic factor of relapse-free survival in ovarian cancer.

Published
2009

47. Molecular signaling of the HMGB1/RAGE axis contributes to cholesteatoma pathogenesis

Author

Szczepanski, Miroslaw J., primary, Luczak, Michal, additional, Olszewska, Ewa, additional, Molinska-Glura, Marta, additional, Zagor, Mariola, additional, Krzeski, Antoni, additional, Skarzynski, Henryk, additional, Misiak, Jan, additional, Dzaman, Karolina, additional, Bilusiak, Mikolaj, additional, Kopec, Tomasz, additional, Leszczynska, Malgorzata, additional, Witmanowski, Henryk, additional, and Whiteside, Theresa L., additional

Published
2014
Full Text
View/download PDF

49. Antagonism of Tumoral Prolactin Receptor Promotes Autophagy-Related Cell Death

Author

Wen, Yunfei, primary, Zand, Behrouz, additional, Ozpolat, Bulent, additional, Szczepanski, Miroslaw J., additional, Lu, Chunhua, additional, Yuca, Erkan, additional, Carroll, Amy R., additional, Alpay, Neslihan, additional, Bartholomeusz, Chandra, additional, Tekedereli, Ibrahim, additional, Kang, Yu, additional, Rupaimoole, Rajesha, additional, Pecot, Chad V., additional, Dalton, Heather J., additional, Hernandez, Anadulce, additional, Lokshin, Anna, additional, Lutgendorf, Susan K., additional, Liu, Jinsong, additional, Hittelman, Walter N., additional, Chen, Wen Y., additional, Lopez-Berestein, Gabriel, additional, Szajnik, Marta, additional, Ueno, Naoto T., additional, Coleman, Robert L., additional, and Sood, Anil K., additional

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results