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2. Roxadustat for CKD-related Anemia in Non-dialysis Patients

Author

Coyne, Daniel W., Roger, Simon D., Shin, Sug Kyun, Kim, Sung Gyun, Cadena, Andres A., Moustafa, Moustafa A., Chan, Tak Mao, Besarab, Anatole, Chou, Willis, Bradley, Charles, Eyassu, Meraf, Leong, Robert, Lee, Tyson T., Saikali, Khalil G., Szczech, Lynda, and Yu, Kin-Hung P.

Published
2021
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5. Tenofovir Use and Urinary Biomarkers Among HIV-Infected Women in the Women's Interagency HIV Study (WIHS)

Author

Oboho, Ikwo, Abraham, Alison G, Benning, Lorie, Anastos, Kathryn, Sharma, Anjali, Young, Mary, Burian, Pamela, Gandhi, Monica, Cohen, Mardge, and Szczech, Lynda

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, HIV/AIDS, Clinical Research, Kidney Disease, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Renal and urogenital, Infection, Good Health and Well Being, Acetylglucosaminidase, Acute-Phase Proteins, Adenine, Adult, Biomarkers, Female, HIV Infections, Humans, Lipocalin-2, Lipocalins, Middle Aged, Organophosphonates, Prospective Studies, Proto-Oncogene Proteins, Reverse Transcriptase Inhibitors, Tenofovir, beta 2-Microglobulin, urinary biomarkers, HIV-infected women, Public Health and Health Services, Virology, Clinical sciences, Epidemiology, Public health
Abstract

BackgroundTenofovir (TDF) has been associated with renal tubular injury. Biomarkers that signal early tubular dysfunction are needed because creatinine rise lags behind TDF-associated kidney dysfunction. We examined several urinary biomarkers to determine if rises accompanying TDF initiation preceded creatinine changes.MethodsThree urinary biomarkers of tubular impairment--neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D-glucosaminidase (NAG), and β-2-microglobulin (β2MG)--were measured across 3 time points (one pre-TDF visit and 2 post-TDF visits) in 132 HIV-positive women from the Women's Interagency HIV Study. Women initiating highly active antiretroviral therapy (HAART) containing TDF were propensity score matched to women initiating HAART without TDF and women not on HAART.ResultsThere were no differences between groups for NGAL or NAG, but β2MG was 19 times more likely to be elevated among TDF users at the second post-TDF visit compared with non-TDF users at the pre-TDF visit (P < 0.01). History of proteinuria was associated with elevated NGAL (P < 0.01). Factors associated with elevated NAG were glomerular filtration rate 100,000 copies/mL, hepatitis C, boosted protease inhibitor use, and glomerular filtration rate

Published
2013

9. An Equation Based on Fuzzy Mathematics to Assess the Timing of Haemodialysis Initiation

Author

Liu, Ying, Wang, Degang, Chen, Xiangmei, Sun, Xuefeng, Song, Wenyan, Jiang, Hongli, Shi, Wei, Liu, Wenhu, Fu, Ping, Ding, Xiaoqiang, Chang, Ming, Yu, Xueqing, Cao, Ning, Chen, Menghua, Ni, Zhaohui, Cheng, Jing, Sun, Shiren, Wang, Huimin, Wang, Yunyan, Gao, Bihu, Wang, Jianqin, Hao, Lirong, Li, Suhua, He, Qiang, Liu, Hongmei, Shao, Fengmin, Li, Wei, Wang, Yang, Szczech, Lynda, Lv, Qiuxia, Han, Xianfeng, Wang, Luping, Fang, Ming, Odeh, Zach, Sun, Ximing, and Lin, Hongli

Published
2019
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15. Retraction notice to “Pooled Analysis of Roxadustat for Anemia in Patients With Kidney Failure Incident to Dialysis.” Kidney Int Rep. 2021;6:613–623

Author

Provenzano, Robert, primary, Fishbane, Steven, additional, Szczech, Lynda, additional, Leong, Robert, additional, Saikali, Khalil G., additional, Zhong, Ming, additional, Lee, Tyson T., additional, Houser, Mark T., additional, Frison, Lars, additional, Houghton, John, additional, Little, Dustin J., additional, Peony Yu, Kin-Hung, additional, and Neff, Thomas B., additional

Published
2022
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33. Roxadustat for anemia in patients with end-stage renal disease incident to dialysis

Author

Provenzano, Robert, primary, Shutov, Evgeny, additional, Eremeeva, Liubov, additional, Korneyeva, Svitlana, additional, Poole, Lona, additional, Saha, Gopal, additional, Bradley, Charles, additional, Eyassu, Meraf, additional, Besarab, Anatole, additional, Leong, Robert, additional, Liu, Cameron S, additional, Neff, Thomas B, additional, Szczech, Lynda, additional, and Yu, Kin-Hung P, additional

Published
2021
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35. Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible staphylococcus aureus bacteremia

Author

Stryjewski, Martin E., Szczech, Lynda A., Benjamin, Daniel K., Jr., Inrig, Jula K., Kanafani, Zeina A., Engemann, John J., Cu, Vivian H., Joyce, Maria J., Reller, L. Barth, Corey, G. Ralph, and Fowler, Vance G., Jr.

Subjects
Vancomycin -- Research, Cephaloridine -- Research, Cephalosporins -- Research, Moxalactam -- Research, Hemodialysis patients -- Drug therapy, Bacteremia -- Care and treatment, Bacteremia -- Research, Staphylococcus aureus -- Care and treatment, Health, Health care industry
Published
2007

38. Immunosuppression, Hepatitis C infection, and acute renal failure in HIV-infected patients

Author

Franceschini, Nora, Napravnik, Sonia, Finn, William F., Szczech, Lynda, and Eron, Joseph J., Jr.

Subjects
Immunosuppressive agents -- Research, HIV patients -- Health aspects, Hepatitis C virus -- Risk factors, Health
Abstract

The effect of CD4 cell count on the incidence rate (IR) of acute renal failure (ARF) in ambulatory HIV-infected patients with access to highly active antiretroviral therapy is estimated. Results reveal that immunosuppression and hepatitis C virus confection are associated with increased IRs of ARF in ambulatory HIV-I-infected patients.

Published
2006

39. Guidelines for the management of chronic kidney disease in HIV-infected patients: recommendations of the HIV medicine association of the Infectious Diseases Society of America

Author

Gupta, Samir K., Eustace, Joseph A., Winston, Jonathan A., Boydstun, Ivy I., Ahuja, Tejinder S., Rodriguez, Rudolph A., Tashima, Karen T., Roland, Michelle, Franceschini, Nora, Palella, Frank J., Lennox, Jeffrey L., Klotman, Paul E., Nachman, Sharon A., Hall, Stephen D., and Szczech, Lynda A.

Subjects
HIV infection -- Diagnosis, HIV infection -- Care and treatment, Kidney diseases -- Diagnosis, Kidney diseases -- Care and treatment, Health, Health care industry
Published
2005

41. Contributors

Author

Agarwal, Rajiv, primary, Andersen, Martin J., additional, Asplin, John R., additional, Bakris, George L., additional, Batlle, Daniel, additional, Berl, Tomas, additional, Bieber, Scott D., additional, Cattran, Daniel C., additional, Choudhury, Devasmita, additional, Granado, Rolando Claure-Del, additional, Croker, Byron P., additional, Denker, Bradley M., additional, Derebail, Vimal K., additional, Desnick, Robert J., additional, Drechsler, Christiane, additional, Eirin, Alfonso, additional, Eknoyan, Garabed, additional, Kossi, Mohsen El, additional, Nahas, Meguid El, additional, Elliott, William J., additional, Ellison, David H., additional, Erdbruegger, Uta, additional, Esteve, Angela Alonso, additional, Fervenza, Fernando C., additional, Figlin, Robert A., additional, Fraer, Mony, additional, Friedman, Eli A., additional, Gipson, Debbie S., additional, Gipson, Patrick E., additional, Goldfarb, Stanley, additional, Gonin, Joyce M., additional, Griffiths, Ryan S., additional, Halperin, Mitchell L., additional, Hogan, Marie C., additional, Horwitz, Edward J., additional, Hou, Susan, additional, Irish, Ashley B., additional, Jefferson, J. Ashley, additional, Kalantar-Zadeh, Kamyar, additional, Kamel, Kamel S., additional, Kamil, Elaine S., additional, Kawar, B.S., additional, Kirmse, Brian, additional, Kovesdy, Csaba P., additional, Kupin, Warren, additional, Lattanzio, Michael R., additional, Lerma, Edgar V., additional, Levi, Moshe, additional, Lewis, Edmund J., additional, Linas, Stuart L., additional, Macedo, Etienne, additional, Maddirala, Supriya, additional, Martins, David, additional, Mehrotra, Rajnish, additional, Mehta, Ravindra L., additional, Mira, Maria Valentina Irazabal, additional, Modi, Snesha, additional, Moore, Rebecca, additional, Nachman, Patrick H., additional, Negrea, Lavinia A., additional, Nicolle, Lindsay E., additional, Noris, Marina, additional, Norris, Keith C., additional, Oliveras, Anna, additional, Olyaei, Ali J., additional, Pal, Sumanta Kumar, additional, Palevsky, Paul M., additional, Palmer, Biff F., additional, Patel, Ami M., additional, Perazella, Mark A., additional, Prichard, Sarah, additional, Rahman, Mahboob, additional, Ram, C. Venkata S., additional, Rao, Madhav V., additional, Rao, Vijaykumar M., additional, Remuzzi, Guiseppe, additional, Rocco, Michael V., additional, Ronco, Claudio, additional, Rosen, Ally, additional, Rosner, Mitchell H., additional, Rudnick, Michael R., additional, Rudolph, Earl H., additional, Rueda, Jose F., additional, Sabath, Ernesto, additional, Sedor, John R., additional, Shah, Anuja Pradip, additional, Simpson, William L., additional, Sinniah, Rajalingam, additional, Sloand, James A., additional, Sorensen, Mathew D., additional, Sprague, Stuart M., additional, Stevens, Lesley A., additional, Stokes, John B., additional, Stoller, Marshall L., additional, Szczech, Lynda Anne M., additional, Thomas, Jeffrey, additional, Tisher, C. Craig, additional, Torres, Vicente, additional, Trachtman, Howard, additional, Tsien, Cynthia, additional, Tuncel, Meryem, additional, Turner, Neil, additional, Udani, Suneel M., additional, Vogt, Beth A., additional, Wanner, Christoph, additional, Weir, Matthew R., additional, Whittier, William L., additional, Williams, Eleri, additional, Wish, Jay B., additional, Wong, Florence, additional, and Woredekal, Yalemzewd, additional

Published
2012
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43. Contributors

Author

Altice, Frederick L., primary, Angelino, Andrew F., additional, Azis, Leyla, additional, Bartlett, John G., additional, Blount, Robert J., additional, Bruce, R. Douglas, additional, Chaisson, Richard, additional, Clifford, David B., additional, Coffey, Susa, additional, Cooper, David A., additional, Crowe, Suzanne M., additional, Davis, J. Lucian, additional, De Cock, Kevin M., additional, Dieterich, Douglas T., additional, Doby, Elizabeth H., additional, Drew, W. Lawrence, additional, Dunn, James P., additional, Ellner, Jerrold J., additional, Erlich, Kim S., additional, Flexner, Charles W., additional, Friedland, Gerald, additional, Gandhi, Monica, additional, Gerntholtz, Trevor E., additional, Gray, Clive M., additional, Greenblatt, Ruth M., additional, Greene, Warner C., additional, Greenspan, Deborah, additional, Greenspan, John S., additional, Grunfeld, Carl, additional, Gumbi, Pamela, additional, Han, Guan-Zhu, additional, Huang, Laurence, additional, Inrig, Jula K., additional, Jacobson, Mark A., additional, John, Malcolm, additional, Jones-López, Edward C., additional, Abdool Karim, Salim S., additional, Kelleher, Anthony D., additional, Kim, Jerome H., additional, Klausner, Jeffrey D., additional, Klotman, Paul E., additional, Koehler, Jane E., additional, Laeyendecker, Oliver, additional, Larson, Elysia, additional, Mallal, Simon, additional, Maurer, Toby, additional, Merry, Concepta, additional, Michael, Nelson L., additional, Mishra, Rakesh K., additional, Mitsuyasu, Ronald T., additional, Mofenson, Lynne M., additional, Moncado, Pablo A., additional, Montoya, Jose G., additional, Nolan, David, additional, Onyike, Chiadi U., additional, Overbaugh, Julie, additional, Page, Kathleen R., additional, Pavia, Andrew T., additional, Peterlin, B. Matija, additional, Peters, Marion G., additional, Powderly, William G., additional, Quinn, Thomas C., additional, Radebe, Mopo, additional, Reiss, Peter, additional, Sande, Merle A., additional, Sarkar, Monika, additional, Schambelan, Morris, additional, Schuitemaker, Hanneke, additional, Shepherd, James C., additional, Sirisanthana, Thira, additional, Stremlau, Matthew, additional, Supparatpinyo, Khuanchai, additional, Szczech, Lynda A., additional, Taylor, Steven A., additional, Teshome, Mengesha A., additional, Treisman, Glenn J., additional, Vachon, Marie-Louise, additional, van Manen, Daniëlle, additional, van 't Wout, Angélique B., additional, Volberding, Paul A., additional, Wainberg, Mark A., additional, Walker, Bruce, additional, Worobey, Michael, additional, Zaharatos, Gerasimos J., additional, Zaidi, Irum, additional, and Zembe, Lycias, additional

Published
2012
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46. Development of proteinuria or elevated serum creatinine and mortality in HIV-infected women

Author

Gardner, Lytt I., Holmberg, Scott D., Williamson, John M., Szczech, Lynda A., Carpenter, Charles C. J., Rompalo, Anne M., Schuman, Paula, and Klein, Robert S.

Subjects
Epidemiology -- Statistics, Epidemiology -- Research, HIV patients -- Demographic aspects, HIV patients -- Health aspects, HIV patients -- Care and treatment, HIV infection -- Demographic aspects, HIV infection -- Prevention, HIV infection -- Research, HIV infection -- Health aspects, Mortality -- Demographic aspects, Mortality -- Statistics, Mortality -- Causes of, Mortality -- Health aspects, Women -- Diseases, Women -- Health aspects, Proteinuria -- Prevention, Proteinuria -- Prognosis, Proteinuria -- Causes of, Proteinuria -- Health aspects, Serum -- Physiological aspects, Creatine -- Physiological aspects, AIDS (Disease) -- Research, Mortality -- United States, Health
Abstract

Research has been copnducted on proteinuria or elevated serum creatinine incidence in HIV-positive and HIV-negative women. The hypothesis that these abnormalities are mortality predictors has been tested, and the results suggest that proteinuria or elevated serum creatinine management should be a priority for HIV-infected people.

Published
2003

49. Association between pulse pressure and mortality in patients undergoing maintenance hemodialysis. (Original Contribution)

Author

Klassen, Preston S., Lowrie, Edmund C., Reddan, Donal N., DeLong, Elizabeth R., Coladonato, Joseph A., Szczech, Lynda A., Lazarus, J. Michael, and Owen, William F.

Subjects
Chronic kidney failure -- Patient outcomes, Blood pressure -- Health aspects, Hemodialysis patients -- Patient outcomes
Abstract

An increase in pulse pressure is a risk factor for death in patients with kidney failure who receive dialysis, according to a study of 37,069 hemodialysis patients. Pulse pressure is a different way of measuring blood pressure. It involves subtracting diastolic pressure from systolic pressure to measure the actual pulse of blood flow every time the heart contracts., Context: Although increased blood pressure is associated with adverse outcomes in the general population, elevated blood pressure is associated with decreased mortality in patients with end-stage renal disease undergoing maintenance hemodialysis. Recent investigations in the general population have demonstrated the predictive utility of pulse pressure (systolic minus diastolic blood pressure), a measure reflecting the pulsatile nature of the cardiac cycle. Objectives: To estimate the relationship between pulse pressure and mortality in patients undergoing maintenance hemodialysis and to test our hypothesis that an increasing pulse pressure would be associated with increased risk of death up to 1 year despite the inverse relationship between conventional blood pressure measures and mortality in patients with end-stage renal disease. Design, Setting, and Patients: Retrospective cohort investigation of patients with end-stage renal disease undergoing maintenance hemodialysis at 782 hemodialysis facilities throughout the United States. Of 44 069 eligible patients as of January 1, 1998, 37069 with complete demographic data were included in the analyses of clinical and laboratory data collected from October 1 through December 31, 1997. Patients were followed up through December 31, 1998. Main Outcome Measures: The primary study outcome was death at 1 year. A secondary outcome was the magnitude of the pulse pressure. Results: The final patient cohort was similar to national averages with respect to age, sex, race, and diabetic status. Mean (SD) pulse pressures before dialysis were 75.0 (15.0) mm Hg and 66.9 (13.9) mm Hg after dialysis. By the end of the 1-year follow-up, 5731 patients (18.4%) died. After adjusting for level of systolic blood pressure, multivariable Cox proportional hazards modeling showed a direct and consistent relationship between increasing pulse pressure and increasing death risk. Each incremental elevation of 10 mm Hg in postdialysis pulse pressure was associated with a 12% increase in the hazard for death (hazard ratio, 1.12; 95% confidence interval, 1.06-1.18). Postdialysis systolic blood pressure was inversely related to mortality with a 13% decreased hazard for death for each incremental elevation of 10 mm Hg (hazard ratio, 0.87; 95% confidence interval, 0.84-0.90). In a multivariable linear regression model, important variables directly associated with elevated pulse pressure included age, diabet es, white race, female sex, and number of years receiving dialysis (all P Conclusions: Pulse pressure is associated with risk of death in a large, nationally representative sample of patients undergoing maintenance hemodialysis. The recognition of pulse pressure as an important correlate of mortality in patients receiving dialysis highlights the need to investigate the relationship between potential therapeutic implications of conduit vessel function and clinical outcomes in patients with end-stage renal disease.

Published
2002

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