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Introduction: Hypophysitis is a rare condition, and as such, each case may exhibit a unique clinical course. Majority of literature identifies labor and immunotherapy as the two most common causes of hypophysitis, neither is applicable in this case. While there is currently no universal cure for hypophysitis, symptomatic management aimed at correcting dysfunctional pituitary axes can significantly improve patients' quality of life. Case Report: The 61-year-old male patient was admitted to the Endocrinology Clinic in February 2023 with complaints including fatigue, dizziness, flushing, hyperhidrosis, polyuria, nocturia, anorexia with a 5-kilogram weight loss, dry mouth, and dry skin persisting for 4 months. Laboratory results from January of that year indicated secondary hypothyroidism and secondary hypocorticoidism. Further endocrine diagnostics was inconclusive, showing an uncommon ho rmonal landscape. Conclusion: We present a case of an uncommon clinical and hormonal picture of hypophysitis in a course of pituitary stalk thickening. This case appoints the uniqueness of every case of this rare condition, underlining the role of hormonal and imaging tests. [ABSTRACT FROM AUTHOR]

Introduction: Gonadotropin-secreting pituitary tumors, constituting 10-30% of all adenomas, are typically hormonally inactive. They often present symptoms such as lethargy, loss of libido, or visual disturbances. They may induce pituitary insufficiency. Hormonally active tumors can lead to ovarian hyperstimulation in women or precocious puberty in boys. These tumors are usually benign, rarely becoming malignant. Case Report: A 28-year-old male complained of severe headaches. Additionally, the patient had numerous conditions, including depressive disorders. Results: MRI examination revealed the presence of pathological tissue mass suggesting a macro-adenoma of the pituitary gland. The tumor did not compress the optic chiasm, but the mass of the tumor caused a restriction of the suprasellar cisterns. Laboratory tests showed no abnormalities in the pituitary axis. After numerous planned hospitalizations and MRI examinations, the patient was qualified for endoscopic transsphenoidal resection of the pituitary tumor. Immunohistochemical examination, as well as histopathological analysis, indicated a hormonally inactive gonadotropinoma tumor. Following the surgery, the pain symptoms resolved, and pituitary function remained preserved. Conclusion: The case demonstrates that MRI is the best method for detecting pituitary tumors, and treatment typically involves transsphenoidal resection and hormonal substitution. It highlights the importance of regular screening examinations and paying attention to chronically occurring, seemingly benign symptoms. [ABSTRACT FROM AUTHOR]

Introduction: Acromegaly is a slow-progressing disease caused by excessive secretion of growth hormone, typically by pituitary adenomas. Ectopic tumors, such as those in the lungs or pancreas, are a rare cause. Acromegaly associated with ectopic GHRH secretion is more common in women. Case Report: The 48-year-old man underwent head contrast computed tomography (CT) and pituitary magnetic resonance imaging (MRI) due to persistent headaches, but no lesions were found. Outpatient tests showed elevated levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Physical examination revealed coarse facial features, enlarged hands and feet, hyperhidrosis, and snoring. During hospitalization, elevated levels of IGF-1 and serotonin were noted, along with paradoxical GH release during an oral glucose tolerance test and abnormal thyroid hormone levels. Chest X-ray showed opacity in the right lung. The patient, diagnosed with acromegaly, also had obesity, hypertension, left ventricular hypertrophy, impaired fasting glucose, and cholelithiasis. Treatment with liraglutide was initiated. Ectopic sites of GH secretion were investigated, revealing emphysematous bullae and nodules in the lungs, as well as suspicious findings in the anterior mediastinum. Subsequent hospitalization showed normal thyroid and gonadal function, and MRI showed no pituitary lesions. Conclusion: This case illustrates the difficulties in diagnosing acromegaly. Pituitary hyperplasia visualized on imaging studies does not always indicate pituitary acromegaly, as it could result from hypertrophy due to ectopic GHRH secretion. Although ectopic acromegaly is rare, it should always be considered in the differential diagnosis. [ABSTRACT FROM AUTHOR]

A 25-year-old woman was admitted to the Emergency Ward because of a severe allergic reaction. The clinical picture contained facial swelling, a rash of the face and neck (fig. 1.), skin itching and rumour, and dyspnoea with difficulties in swallowing. A detailed interview was collected, with particular emphasis on plausible allergens. The only substance that was new in the patient's surroundings was the intake of levothyroxine according to Hashimoto syndrome, which was diagnosed a few days before. Given the suspicion of hypersensitivity to levothyroxine, the patient was admitted to the Clinic of Endocrinology. At first, the substitution of L-thyroxine was interrupted. Then, the preparation of L-thyroxine was changed to the liquid form and the patient started to take this under the observation of the ward's medical personnel. After 5 days of novel preparation intake, no hypersensitivity reaction was observed - therefore the patient was discharged home with additional advice to attend the Allergology Ambulatory. [ABSTRACT FROM AUTHOR]