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22 results on '"Szabados, Tamara"'

6. Identification of New, Translatable ProtectomiRs against Myocardial Ischemia/Reperfusion Injury and Oxidative Stress: The Role of MMP/Biglycan Signaling Pathways.

Author

Szabados, Tamara, Molnár, Arnold, Kenyeres, Éva, Gömöri, Kamilla, Pipis, Judit, Pósa, Bence, Makkos, András, Ágg, Bence, Giricz, Zoltán, Ferdinandy, Péter, Görbe, Anikó, and Bencsik, Péter

Subjects
REPERFUSION injury, MYOCARDIAL ischemia, CELLULAR signal transduction, MYOCARDIAL infarction, LABORATORY rats, MYOCARDIAL perfusion imaging, OXIDATIVE stress, IDENTIFICATION
Abstract

Introduction: Ischemic conditionings (ICon) were intensively investigated and several protective signaling pathways were identified. Previously, we have shown the role of matrix metalloproteinases (MMP) in myocardial ischemia/reperfusion injury (MIRI) and the cardioprotective role of biglycan (BGN), a small leucine-rich proteoglycan in vitro. Here, we hypothesized that cardiac MMP and BGN signaling are involved in the protective effects of ICon. Methods: A reverse target-microRNA prediction was performed by using the miRNAtarget™ 2.0 software to identify human microRNAs with a possible regulatory effect on MMP and BGN, such as on related genes. To validate the identified 1289 miRNAs in the predicted network, we compared them to two cardioprotective miRNA omics datasets derived from pig and rat models of MIRI in the presence of ICons. Results: Among the experimentally measured miRNAs, we found 100% sequence identity to human predicted regulatory miRNAs in the case of 37 porcine and 24 rat miRNAs. Upon further analysis, 42 miRNAs were identified as MIRI-associated miRNAs, from which 24 miRNAs were counter-regulated due to ICons. Conclusions: Our findings highlight 24 miRNAs that potentially regulate cardioprotective therapeutic targets associated with MMPs and BGN in a highly translatable porcine model of acute myocardial infarction. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Cardioprotective efficacy of limb remote ischemic preconditioning in rats: discrepancy between meta-analysis and a three-centre in vivo study

Author

Sayour, Nabil V, primary, Brenner, Gábor B, additional, Makkos, András, additional, Kiss, Bernadett, additional, Kovácsházi, Csenger, additional, Gergely, Tamás G, additional, Aukrust, Sverre Groever, additional, Tian, Huimin, additional, Zenkl, Viktória, additional, Gömöri, Kamilla, additional, Szabados, Tamara, additional, Bencsik, Péter, additional, Heinen, Andre, additional, Schulz, Rainer, additional, Baxter, Gary F, additional, Zuurbier, Coert J, additional, Vokó, Zoltán, additional, Ferdinandy, Péter, additional, and Giricz, Zoltán, additional

Published
2023
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9. Altered Cellular Protein Quality Control System Modulates Cardiomyocyte Function in Volume Overload-Induced Hypertrophy

Author

Gömöri, Kamilla, primary, Herwig, Melissa, additional, Hassoun, Roua, additional, Budde, Heidi, additional, Mostafi, Nusratul, additional, Delalat, Simin, additional, Modi, Suvasini, additional, Begovic, Merima, additional, Szabados, Tamara, additional, Pipis, Judit, additional, Farkas-Morvay, Nikolett, additional, Leprán, István, additional, Kovács, Árpád, additional, Mügge, Andreas, additional, Ferdinandy, Péter, additional, Görbe, Anikó, additional, Bencsik, Péter, additional, and Hamdani, Nazha, additional

Published
2022
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10. Sex Difference in Cardioprotection against Acute Myocardial Infarction in MAO-B Knockout Mice In Vivo

Author

Heger, Jacqueline, Szabados, Tamara, Brosinsky, Paulin, Bencsik, Péter, Ferdinandy, Péter, Schulz, Rainer, and Justus Liebig University Giessen

Subjects
mitochondria, ddc:610, monoamine oxidase B, ischemia/reperfusion
Abstract

The cardiomyocyte-specific knockout (KO) of monoamine oxidase (MAO)-B, an enzyme involved in the formation of reactive oxygen species (ROS), reduced myocardial ischemia/reperfusion (I/R) injury in vitro. Because sex hormones have a strong impact on MAO metabolic pathways, we analyzed the myocardial infarct size (IS) following I/R in female and male MAO-B KO mice in vivo. Method and Results: To induce the deletion of MAO-B, MAO-B KO mice (Myh6 Cre+/MAO-Bfl/fl) and wild-type (WT, Cre-negative MAO-Bfl/fl littermates) were fed with tamoxifen for 2 weeks followed by 10 weeks of normal mice chow. Myocardial infarction (assessed by TTC staining and expressed as a percentage of the area at risk as determined by Evans blue staining)) was induced by 45 min coronary occlusion followed by 120 min of reperfusion. Results: The mortality following I/R was higher in male compared to female mice, with the lowest mortality found in MAO-B KO female mice. IS was significantly higher in male WT mice compared to female WT mice. MAO-B KO reduced IS in male mice but had no further impact on IS in female MAO-B KO mice. Interestingly, there was no difference in the plasma estradiol levels among the groups. Conclusion: The cardiomyocyte-specific knockout of MAO-B protects male mice against acute myocardial infarction but had no effect on the infarct size in female mice.

Published
2023
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11. Cardioprotective efficacy of limb remote ischaemic preconditioning in rats: discrepancy between a meta-analysis and a three-centre in vivo study.

Author

Sayour, Nabil V, Brenner, Gábor B, Makkos, András, Kiss, Bernadett, Kovácsházi, Csenger, Gergely, Tamás G, Aukrust, Sverre Groever, Tian, Huimin, Zenkl, Viktória, Gömöri, Kamilla, Szabados, Tamara, Bencsik, Péter, Heinen, Andre, Schulz, Rainer, Baxter, Gary F, Zuurbier, Coert J, Vokó, Zoltán, Ferdinandy, Péter, and Giricz, Zoltán

Subjects
ISCHEMIC preconditioning, IN vivo studies, MYOCARDIAL ischemia, REPERFUSION injury, LABORATORY rats
Abstract

Aims Remote ischaemic preconditioning (RIPC) is a robust cardioprotective intervention in preclinical studies. To establish a working and efficacious RIPC protocol in our laboratories, we performed randomized, blinded in vivo studies in three study centres in rats, with various RIPC protocols. To verify that our experimental settings are in good alignment with in vivo rat studies showing cardioprotection by limb RIPC, we performed a systematic review and meta-analysis. In addition, we investigated the importance of different study parameters. Methods and results Male Wistar rats were subjected to 20–45 min cardiac ischaemia followed by 120 min reperfusion with or without preceding RIPC by 3 or 4 × 5−5 min occlusion/reperfusion of one or two femoral vessels by clamping, tourniquet, or pressure cuff. RIPC did not reduce infarct size (IS), microvascular obstruction, or arrhythmias at any study centres. Systematic review and meta-analysis focusing on in vivo rat models of myocardial ischaemia/reperfusion injury with limb RIPC showed that RIPC reduces IS by 21.28% on average. In addition, the systematic review showed methodological heterogeneity and insufficient reporting of study parameters in a high proportion of studies. Conclusion We report for the first time the lack of cardioprotection by RIPC in rats, assessed in individually randomized, blinded in vivo studies, involving three study centres, using different RIPC protocols. These results are in discrepancy with the meta-analysis of similar in vivo rat studies; however, no specific methodological reason could be identified by the systematic review, probably due to the overall insufficient reporting of several study parameters that did not improve over the past two decades. These results urge for publication of more well-designed and well-reported studies, irrespective of the outcome, which are required for preclinical reproducibility, and the development of clinically translatable cardioprotective interventions. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Deletion but Not Inhibition of Extracellular PCSK9 Reduces Infarct Sizes Ex Vivo but Not In Vivo

Author

Schreckenberg, Rolf, primary, Wolf, Annemarie, additional, Szabados, Tamara, additional, Gömöri, Kamilla, additional, Szabó, István Adorján, additional, Ágoston, Gergely, additional, Brenner, Gábor, additional, Bencsik, Péter, additional, Ferdinandy, Péter, additional, Schulz, Rainer, additional, and Schlüter, Klaus-Dieter, additional

Published
2022
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13. Ca2+/calmodulin‐dependent protein kinase II and protein kinase G oxidation contributes to impaired sarcomeric proteins in hypertrophy model

Author

Gömöri, Kamilla, primary, Herwig, Melissa, additional, Budde, Heidi, additional, Hassoun, Roua, additional, Mostafi, Nusratul, additional, Zhazykbayeva, Saltanat, additional, Sieme, Marcel, additional, Modi, Suvasini, additional, Szabados, Tamara, additional, Pipis, Judit, additional, Farkas‐Morvay, Nikolett, additional, Leprán, István, additional, Ágoston, Gergely, additional, Baczkó, István, additional, Kovács, Árpád, additional, Mügge, Andreas, additional, Ferdinandy, Péter, additional, Görbe, Anikó, additional, Bencsik, Péter, additional, and Hamdani, Nazha, additional

Published
2022
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15. Tuning Activity and Selectivity of Co2 Hydrogenation by Using Different Interlayer Anions Over Mechanochemically Pretreated Gibbsite-Based, Nickel-Poor Layered Double Hydroxides

Author

Szabados, Márton, primary, Szabados, Tamara, additional, Mucsi, Róbert, additional, Baán, Kornélia, additional, Kiss, János, additional, Szamosvölgyi, Ákos, additional, Sápi, András, additional, Kukovecz, Ákos, additional, Kónya, Zoltán, additional, Pálinkó, István, additional, and Sipos, Pal, additional

Published
2022
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17. Chronic treatment with rofecoxib but not ischemic preconditioning of the myocardium ameliorates early intestinal damage following cardiac ischemia/reperfusion injury in rats

Author

László, Szilvia B., primary, Lázár, Bernadette, additional, Brenner, Gábor B., additional, Makkos, András, additional, Balogh, Mihály, additional, Al-Khrasani, Mahmoud, additional, Hutka, Barbara, additional, Mohammadzadeh, Amir, additional, Kemény, Ágnes, additional, László, Terézia, additional, Scheich, Bálint, additional, Szabados, Tamara, additional, Kenyeres, Éva, additional, Giricz, Zoltán, additional, Bencsik, Péter, additional, Varga, Zoltán V., additional, Novák, Julianna, additional, Helyes, Zsuzsanna, additional, Ferdinandy, Péter, additional, Gyires, Klára, additional, and Zádori, Zoltán S., additional

Published
2020
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20. The impact of age on cardiac function and extracellular matrix component expression in adverse post-infarction remodeling in mice

Author

Nagel, Felix, primary, Santer, David, additional, Stojkovic, Stefan, additional, Kaun, Christoph, additional, Schaefer, Anne-Kristin, additional, Krššák, Martin, additional, Abraham, Dietmar, additional, Bencsik, Péter, additional, Ferdinandy, Péter, additional, Kenyeres, Eva, additional, Szabados, Tamara, additional, Wojta, Johann, additional, Trescher, Karola, additional, Kiss, Attila, additional, and Podesser, Bruno K., additional

Published
2019
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21. Subantimicrobial Dose Doxycycline Worsens Chronic Arthritis-Induced Bone Microarchitectural Alterations in a Mouse Model: Role of Matrix Metalloproteinases?

Author

Horváth, Ádám, primary, Botz, Bálint, additional, Kiss, Tamás, additional, Csekő, Kata, additional, Kiss, Ibolya, additional, Felinger, Attila, additional, Szabados, Tamara, additional, Kenyeres, Éva, additional, Bencsik, Péter, additional, Mócsai, Attila, additional, Ferdinandy, Péter, additional, and Helyes, Zsuzsanna, additional

Published
2019
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22. Directed thermocatalytic CO2reduction over NiAl4layered double hydroxide precursors − activity and selectivity control using different interlayer anions

Author

Szabados, Márton, Szabados, Tamara, Mucsi, Róbert, Baán, Kornélia, Kiss, János, Szamosvölgyi, Ákos, Sápi, András, Kónya, Zoltán, Kukovecz, Ákos, and Sipos, Pál

Abstract

The use of rare nickel-poor and aluminum-rich layered double hydroxides (LDHs) as catalyst precursors in CO2hydrogenations has revealed the key importance of chemical quality of the interlayer anions for the achievable CO2conversion and CH4/CO selectivity. At atmospheric pressures between 300 and 700 °C, the obtained CH4and CO formation rates varied widely, reaching up to the remarkable 76.8 (LDH-NO3) and 47.7 μmol/gcats (LDH-NH2SO3), respectively, competing with Pt and Co containing catalysts. Depending on thermal stability of the interlayer anions, their partial or complete removal resulted in significant differences in LDH transformation and thus in reducibility of Ni(II) and specific surface area values of the resulting metal oxides. Moreover, clear correlation was found between the conversion, selectivity and the abundance, strength of base and acid sites presented in the calcined LDHs related to the nature of starting interlamellar anions. Incorporation of nitrate and perchlorate ions into the precursors helped the formation of weak basic sites, while sulphate and sulphamate ions resulted in a large number of strong acid and base sites. The high-resolution quasi in situX-ray photoelectron spectra revealed the effect of the anions on chemical composition of the forming catalytic interfaces. Meantime, the in situdiffuse reflectance infrared spectroscopy measurements indicated multifarious CO2hydrogenation pathways viaformate (LDH-NO3, -Br, -I), carboxylate (LDH-Cl, -ClO4) intermediates and CO2dissociation (LDH-SO4, -NH2SO3).

Published
2023
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