1. Early surgical resection for stage I high-grade neuroendocrine caricinoma of lung
- Author
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Kyohei Ooishi, Koshiro Ichijyo, Miyuki Nagaoka, Eisuke Mochizuki, Shinichiro Mikura, Syunya Furukawa, Syun Matsuura, Naoki Koshimizu, Koichi Miyashita, and Masaru Tsukui
- Subjects
Surgical resection ,medicine.medical_specialty ,Lung ,Adjuvant chemotherapy ,business.industry ,Clinical course ,Disease ,Neuroendocrine tumors ,medicine.disease ,Small-cell carcinoma ,Surgery ,medicine.anatomical_structure ,medicine ,Overall survival ,business - Abstract
RATIONALE: Since high-grade neuroendocrine tumors are rapidly progressive, most cases are inoperable when diagnosed. There are few reports about the prognosis of patients or the course of the disease after surgery. OBJECTIVES: To clarify the clinical course of the disease after surgery and factors influencing the prognosis. METHODS: We retrospectively assessed 27 patients receiving surgery for small cell carcinoma (22 cases) and large neuroendocrine carcinoma (5 cases) from January 2005 through January 2015 at our hospital. RESULTS: Patients were all male, with an average age of 70.9 years. Of the 27 patients, 22 had received postoperative adjuvant chemotherapy. Median progression-free survival (PFS) and overall survival (OS) were 1.1 and 5.5 years, respectively. Ten patients were recurrence-free. Ten patients who underwent surgery within 60 days after the diagnosis demonstrated a better prognosis regarding OS (p CONCLUSIONS: Early surgical resection for high-grade neuroendocrine carcinoma stage I may lead to a better prgonosis.
- Published
- 2016
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