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Synthetic N-methoxybenzyl ("NBOMe") phenylethylamine derivatives were developed as highly potent agonists for the research of 5-hydroxytryptamine receptors, however they have become available on the black market in the past few years. They are sought by recreational users as "legal LSD", in worse cases the replacement is unsuspected and these substances are a cause of serious intoxication with signs of serotonin toxicity. At this moment, there is very little data available, but their low price, easy access via the internet and legal status make these substances an interesting target for recreational users and a big challenge for scientists and for the lawmakers. 2CBFly-NBOMe belongs to this group. There is no information about its recreational use for now, but thiat is probably only a matter of time. The aim of this study is to determine acute effects of 2CBFly-NBOMe in Wistar rats. Active substance significantly reduced locomotor activity of the animals and caused higher anxiety, it also disrupted sensorimotor gating and lowered body temperature of animals. Pharmacokinetic profile was measured only in the blood serum, the highest concentrations of 2CBFly-NBOMe were detected 30-60 minutes after the administration of hallucinogen. This paper provides first information on the effect of 2CBFly-NBOMe on...

This thesis is focused on the new building of the nursery school, its construction solutions, specific land placement, and dispositional solutions regarding the cardinal directions. The dispositional building possibilities are further described in connection with various functional units such as barrier-free access, daylight lighting, acoustic, hygiene, and other respective input information. The information is further applied and described with use of specific nursery school solutions.

The thesis is focused on the modern timber construction, its design solution, location on specific land and material composition. It is further concentrated on production process of peripheral wall panels and, consequently, the analysis of construction and material variants, both from the general point of view and afterwards, from a specific choice of an individual panel system which would be put into detail in a particular example of a family house.

Opioid substances have been used by mankind for several millenia not only for their ability to abolish even very intensive states of pain, but also for their ability to stimulate the brain reward circuit. However, a strong addiction can be formed to opioids quickly. This thesis focuses on collecting knowledge about the most abundant polymorphisms of these genes, their physiological impact and potential influence on drug addiction. Key words: opioid receptors, drug addiction, genetic polymorphism