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1,084 results on '"Syrjänen, Kari"'

18. Accuracy of Prediction Models in Diagnosis of Acute Diverticulitis.

Author

ESKELINEN, MAARET, PULKKINEN, JUKKA, SELANDER, TUOMAS, SYRJÄNEN, KARI, and ESKELINEN, MATTI

Subjects
DIVERTICULITIS, EMERGENCY medical services, ABDOMINAL pain, RECEIVER operating characteristic curves, DATA analysis, ACCURACY
Abstract

Background/Aim: The diagnostic score models (DMs) for patients with acute diverticulitis (AcDi) have been rarely evaluated. Therefore, we tried to develop diagnostic models (DMs) to enhance the diagnostic accuracy (DA) of AcDi. Patients and Methods: In this AAP (acute abdominal pain) cohort, 30 AcDi patients were compared to 1,303 non- AcDi patients, with regard to their i) clinical symptoms (n=22), ii) signs and tests (n=14) as well as iii) laboratory analyses (n=3). The triage was performed at patient arrival to the emergency department (ED) (triage I) and at follow-up (triage II) before final decision. The triage included a suggested diagnosis of the AAP patient. Bivariate random effects metaanalysis was performed separately for 1) the pooled symptoms (n=22), 2) signs & tests (n=17) as well as 3) pooled DMs (IV) with different cut-offs (with or without triage) to assess the diagnostic accuracy (DA) in detection of AcDi by HSROC (hierarchical summary receiver operating characteristic) curves. Results: In the conventional receiver operating characteristic (ROC) analysis (for test optimization and finding optimal cut-off points), the area under curve (AUC) reached the following values for AcDi: i) DM without triage, AUC=0.843, ii) DM with triage I, AUC=0.866 and iii) DM with triage I and II, AUC=0.926. In the HSROC analysis, the AUC values for detection of AcDi were as follows; i) pooled clinical symptoms, AUC=0.540, ii) pooled clinical signs & tests, AUC=0.556 and iii) pooled DMs globally, AUC=0.853. In roccomp analysis for differences in AUC values: i) and iii) p<0.0001; between ii) and iii) p<0.0001. Conclusion: As confirmed by ROC and HSROC analysis, the new DMs with triage mode proved to be far superior in their DA for AcDi as compared to both symptoms and signs & tests. In the lack of earlier studies, these data report the first evidence that the DM including triage at an ED could improve the detection of AcDi. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Additional file 2 of Somatic targeted mutation profiling of colorectal cancer precursor lesions

Author

dos Santos, Wellington, dos Reis, Mariana Bisarro, Porto, Jun, de Carvalho, Ana Carolina, Matsushita, Marcus, Oliveira, Gabriela, Syrjänen, Kari, Reis, Rui Manuel, and Guimarães, Denise Peixoto

Abstract

Additional file 2: Figure S2. Lollipop plots showing the distribution of mutations in 16 genes identified altered in colorectal cancer precursor lesions. The Y-axis represents the number of mutations at each residue. Truncating mutations are represented by black circles and green circles indicated a missense mutation. Plot from cBioPortal ( http://www.cBioPortal ).

Published
2022
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35. Additional file 3 of Somatic targeted mutation profiling of colorectal cancer precursor lesions

Author

dos Santos, Wellington, dos Reis, Mariana Bisarro, Porto, Jun, de Carvalho, Ana Carolina, Matsushita, Marcus, Oliveira, Gabriela, Syrjänen, Kari, Reis, Rui Manuel, and Guimarães, Denise Peixoto

Abstract

Additional file 3: Figure S3. Number of driver mutations detected in the sequencing differs between the four classes of precursor lesions (Kruskal-Wallis test p < 0.001). The boxplot shows the median number of mutations observed across the early adenomas, advanced adenomas, hyperplastic polyps and sessile serrated lesion. Mann-Whitney test was used to determine the statistical significance with Bonferroni multiple comparisons correction: *p < 0.05; **p < 0.001.

Published
2022
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36. Additional file 1 of Somatic targeted mutation profiling of colorectal cancer precursor lesions

Author

dos Santos, Wellington, dos Reis, Mariana Bisarro, Porto, Jun, de Carvalho, Ana Carolina, Matsushita, Marcus, Oliveira, Gabriela, Syrjänen, Kari, Reis, Rui Manuel, and Guimarães, Denise Peixoto

Abstract

Additional file 1: Figure S1. Boxplots reporting the median coverage of the 207 amplicons sequenced across the 50 genes for all precursor lesion samples. The average depth of all amplicons was 1631.5x per sample (ranging from 0x to 13823x).

Published
2022
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39. Increased Risk of Oncogenic Human Papillomavirus Infections and Incident High-Grade Cervical Intraepithelial Neoplasia Among Smokers: Experience From the Latin American Screening Study

Author

Sarian, Luis Otavio, Hammes, Luciano Serpa, Longatto-Filho, Adhemar, Guarisi, Renata, Derchain, Sophie F. M., Roteli-Martins, Cecília, Naud, Paulo, Eržen, Mojca, Branca, Margherita, Tatti, Sílvio, de Matos, Jean Carlos, Gontijo, Renata, Maeda, Marina Y. S., Lima, Temístocles, Costa, Silvano, Syrjänen, Stina, and Syrjänen, Kari

Published
2009

44. Smoking is an independent risk factor for oncogenic human papillomavirus (HPV) infections but not for high-grade CIN

Author

Syrjänen, Kari, Shabalova, Irena, Petrovichev, Nicolay, Kozachenko, Vladimir, Zakharova, Tatjana, Pajanidi, Julia, Podistov, Jurij, Chemeris, Galina, Sozaeva, Larisa, Lipova, Elena, Tsidaeva, Irena, Ivanchenko, Olga, Pshepurko, Alla, Zakharenko, Sergej, Nerovjna, Raisa, Kljukina, Ludmila, Erokhina, Oksana, Branovskaja, Marina, Nikitina, Maritta, Grunberga, Valerija, Grunberg, Alexandr, Juschenko, Anna, Santopietro, Rosa, Cintorino, Marcella, Tosi, Piero, and Syrjänen, Stina

Published
2007

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