1. Healthcare‐associated blood stream infections in hematological patients in Finland during the years 2006‐2016.
- Author
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Åttman, Emilia, Syrjänen, Jaana, Lyytikäinen, Outi, Ollgren, Jukka, Sinisalo, Marjatta, Vuento, Risto, Mattila, Erja, and Huttunen, Reetta
- Subjects
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ACUTE myeloid leukemia , *NON-Hodgkin's lymphoma , *GRAM-negative bacteria , *GRAM-positive bacteria , *NOSOCOMIAL infections , *CANDIDEMIA - Abstract
Objectives: The aim was to identify the clinical characteristics, outcome, and antimicrobial susceptibility of healthcare‐associated bloodstream infections (BSIs) in hematological patients. Methods: This retrospectively collected laboratory‐based surveillance data include 3404 healthcare‐associated BSIs in 2296 patients with a hematological malignancy in hospitals participating in the Finnish Hospital Infection Program from January 1, 2006, to December 31, 2016. Results: The most common underlying diseases were acute myelogenous leukemia (35%) and non‐Hodgkin lymphoma (22%). Gram‐positive organisms accounted for 60%‐46% and gram‐negative organisms for 24%‐36% of BSIs in 2006‐2016. The most common causative organism was coagulase‐negative staphylococci (CoNS) (n = 731). The 7‐ and 28‐day case fatality rates were 5.2% and 11.4%, respectively, and was highest in BSIs caused by Candida species (10.8% and 30.8%). The median age of patients increased from 59 years in 2006‐2008 to 62 years in 2015‐2016 (P <.01). Five percent of S aureus isolates were resistant to methicillin and five percent of Pseudomonas aeruginosa isolates were multidrug‐resistant. Four percent of Klebsiella and seven percent of E coli isolates were resistant to ceftazidime. Conclusions: The proportion of gram‐positive bacteria decreased and gram‐negative bacteria increased over time. The case fatality rate was low and the median age of patients increased during the study. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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