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31 results on '"Synnergren, Mats"'

2. High‐sensitive troponinT, interleukin‐8, and interleukin‐6 link with post‐surgery risk in infant heart surgery.

Author

Thorlacius, Elin M., Keski‐Nisula, Juho, Vistnes, Maria, Ojala, Tiina, Molin, Mattias, Synnergren, Mats, Romlin, Birgitta S., Ricksten, Sven‐Erik, Wåhlander, Håkan, and Castellheim, Albert Gyllencreutz

Subjects
SURGICAL complications, CARDIAC surgery, CARDIOPULMONARY bypass, INTERLEUKIN-8, CORONARY artery bypass, INTERLEUKIN-6
Abstract

Background: This study focuses on biomarkers in infants after open heart surgery, and examines the association of high‐sensitive troponin T (hs‐cTnT), interleukin‐6 (IL‐6), and interleukin‐8 (IL‐8) with postoperative acute kidney injury (AKI), ventilatory support time and need of vasoactive drugs. Methods: Secondary exploratory study from a double‐blinded clinical randomized trial (Mile‐1) on 70 infants undergoing open heart surgery with cardiopulmonary bypass (CPB). In this sub‐study, the entire study population was examined without considering the study drugs. The biomarkers' peak concentration (highest concentration at 2 or 6 h post‐CPB) were used for statistical analyses. Results: Peak IL‐8, hs‐cTnT, and IL‐6 occurred at 2 h post‐CPB for 96%, 79%, and 63% of the patients, respectively. The odds ratio of developing AKI2‐3 for IL‐6 > 293 pg/mL was 23.4 (95% CI 5.3;104.0), for IL‐8 > 100 pg/mL it was 11.5 (3.0;44.2), and for hs‐cTnT >5597 pg/mL it was 6.1 (1.5; 24.5). In more than two third of the patients with the highest peak concentrations of IL‐8, IL‐6, and hs‐cTnT, there was a need for ventilatory support for >24 h and use of vasoactive drugs at 24 h post‐CPB, while in less than one third of the patients with the lowest peak concentrations of IL‐8 and hs‐cTnT such requirements were observed. Conclusions: The peak biomarker concentrations and CPB‐time strongly predicted AKI2‐3, with IL‐6 and IL‐8 emerging as strongest predictors. Furthermore, our findings suggest that measuring hs‐cTnT and IL‐8 just 2 h post‐CPB‐weaning may assist in identifying infants suitable for early extubation and highlight those at risk of prolonged ventilation. [ABSTRACT FROM AUTHOR]

Published
2024
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4. 4D Flow in Fontan Circulation - Relation to MR Relaxometry, MR and US Liver Stiffness/ Viscosity and Lymphatic Stasis

Author

Lange, Charlotte de, primary, Hebelka, Hanna, additional, Joelsson, Britt Mari Ekman, additional, Sunnegårdh, Jan, additional, Gustafsson, Staffan, additional, Synnergren, Mats Johansson, additional, Wåhlander, Håkan, additional, Svensson, Pär Arne, additional, Lagerstrand, Kerstin, additional, and Dangardt, Frida, additional

Published
2024
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9. Impact of Left Ventricular Morphology on Adverse Outcomes Following Stage 1 Palliation for Hypoplastic Left Heart Syndrome : 20 Years of National Data From Sweden

Author

Fricke, Katrin, Mellander, Mats, Hanséus, Katarina, Tran, Phan-Kiet, Synnergren, Mats, Ramgren, Jens Johansson, Rydberg, Annika, Sunnegårdh, Jan, Dalén, Magnus, Sjöberg, Gunnar, Weismann, Constance G., Liuba, Petru, Fricke, Katrin, Mellander, Mats, Hanséus, Katarina, Tran, Phan-Kiet, Synnergren, Mats, Ramgren, Jens Johansson, Rydberg, Annika, Sunnegårdh, Jan, Dalén, Magnus, Sjöberg, Gunnar, Weismann, Constance G., and Liuba, Petru

Abstract

BACKGROUND: Hypoplastic left heart syndrome is associated with significant morbidity and mortality. We aimed to assess the influence of left ventricular morphology and choice of shunt on adverse outcome in patients with hypoplastic left heart syndrome and stage 1 palliation. METHODS AND RESULTS: This was a retrospective analysis of patients with hypoplastic left heart syndrome with stage 1 palliation between 1999 and 2018 in Sweden. Patients (n=167) were grouped based on the anatomic subtypes aortic-mitral atresia, aortic atresia-mitral stenosis (AA-MS), and aortic-mitral stenosis. The left ventricular phenotypes including globular left ventricle (Glob-LV), miniaturized and slit-like left ventricle (LV), and the incidence of major adverse events (MAEs) including mortality were assessed. The overall mortality and MAEs were 31% and 41%, respectively. AA-MS (35%) was associated with both mortality (all other subtypes versus AA-MS: interstage-I: hazard ratio [HR], 2.7; P=0.006; overall: HR, 2.2; P=0.005) and MAEs (HR, 2.4; P=0.0009). Glob-LV (57%), noticed in all patients with AA-MS, 61% of patients with aortic stenosis-mitral stenosis, and 19% of patients with aortic atresia-mitral atresia, was associated with both mortality (all other left ventricular phenotypes versus Glob-LV: interstage-I: HR, 4.5; P=0.004; overall: HR, 3.4; P=0.0007) and MAEs (HR, 2.7; P=0.0007). There was no difference in mortality and MAEs between patients with AA-MS and without AA-MS with Glob-LV (P>0.15). Patients with AA-MS (35%) or Glob-LV (38%) palliated with a Blalock-Taussig shunt had higher overall mortality compared with those palliated with Sano shunts, irrespective of the stage 1 palliation year (AA-MS: HR, 2.6; P=0.04; Glob-LV: HR, 2.1; P=0.03). CONCLUSIONS: Glob-LV and AA-MS are independent morphological risk factors for adverse short-and long-term outcome, especially if a Blalock-Taussig shunt is used as part of stage 1 palliation. These findings are important for the clinical ma

Published
2022
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10. Early and late outcomes after surgical repair of congenital supravalvular aortic stenosis: a European Congenital Heart Surgeons Association multicentric study†

Author

Padalino, Massimo A., Frigo, Anna Chiara, Comisso, Marina, Kostolny, Martin, Omeje, Ikenna, Schreiber, Christian, von Ohain, Jelena Pabst, Cleuziou, Julie, Barron, David J., Meyns, Bart, Hraska, Viktor, Maruszewski, Bohdan, Kozlowski, Michal, Vricella, Luca A., Hibino, Narutoshi, Collica, Sarah, Berggren, Hakan, Synnergren, Mats, Lazarov, Stojan, Kalfa, David, Bacha, Emile, Pizarro, Christian, Hazekamp, Mark, Sojak, Vlado, Jacobs, Jeffrey P., Nosal, Matej, Fragata, Jose, Cicek, Sertac, Sarris, George E., Zografos, Panayotis, Vida, Vladimiro L., and Stellin, Giovanni

Published
2017
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11. Impact of Left Ventricular Morphology on Adverse Outcomes Following Stage 1 Palliation for Hypoplastic Left Heart Syndrome: 20 Years of National Data From Sweden

Author

Fricke, Katrin, primary, Mellander, Mats, additional, Hanséus, Katarina, additional, Tran, Phan‐Kiet, additional, Synnergren, Mats, additional, Johansson Ramgren, Jens, additional, Rydberg, Annika, additional, Sunnegårdh, Jan, additional, Dalén, Magnus, additional, Sjöberg, Gunnar, additional, Weismann, Constance G., additional, and Liuba,, Petru, additional

Published
2022
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15. Outcome and survival after open heart surgery for adults with congenital heart disease ��� a single center experience

Author

Fazlinovi��, Sanin, Wallinder, Andreas, Dellborg, Mikael, Furen��s, Eva, Eriksson, Peter, Synnergren, Mats, and Lid��n, Hans

Abstract

Introduction. Congenital heart disease (CHD) is the most common type of birth defect today. The adult congenital heart disease (ACHD) population is constantly growing and becoming older and more patients require cardiac surgery. The objective of this study was to review the surgical outcome of the open heart procedures performed on ACHD patients in the last 10 years at Sahlgrenska University Hospital (SUH) through a retrospective descriptive cohort study. Methods. A retrospective data collection was performed for 421 patients who underwent a total of 439 surgical procedures between 2009 and 2018 at the Cardiothoracic department in SUH. The primary outcomes were early (Results. 30-day mortality was 1.9%. Long-term survival after 3, 5 and 10 years were 96% �� 1, 94.3% �� 1.3 and 92.4% �� 1.8. 82 major complications occurred after 46 procedures (11.6%). The most common major complication was re-exploration due to hemorrhage. Risk factors for major complications were acute surgery and prolonged extracorporeal circulation time. 173 minor complications occurred after 90 procedures (22.5%). The most common minor complication was prolonged intensive care unit stay (>48 h). Conclusion. This study presents satisfactory early and midterm survival. The survival and frequency of major postoperative complications are well in line with what other studies have presented. Patients undergoing resternotomies had no increased risk for mortality or postoperative complications.

Published
2021
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16. Levosimendan Versus Milrinone and Release of Myocardial Biomarkers After Pediatric Cardiac Surgery: Post Hoc Analysis of Clinical Trial Data

Author

Thorlacius, Elin M., primary, Vistnes, Maria, additional, Ojala, Tiina, additional, Keski-Nisula, Juho, additional, Molin, Mattias, additional, Romlin, Birgitta S., additional, Synnergren, Mats, additional, Ricksten, Sven-Erik, additional, Wåhlander, Håkan, additional, and Castellheim, Albert, additional

Published
2021
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