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6 results on '"Syniugin, Anatolii R."'

2. Identification of dual-targeted Mycobacterium tuberculosis aminoacyl-tRNA synthetase inhibitors using machine learning

Author

Volynets, Galyna P, primary, Usenko, Mariia O, additional, Gudzera, Olga I, additional, Starosyla, Segiy A, additional, Balanda, Anatoliy O, additional, Syniugin, Anatolii R, additional, Gorbatiuk, Oksana B, additional, Prykhod'ko, Andrii O, additional, Bdzhola, Volodymyr G, additional, Yarmoluk, Sergiy M, additional, and Tukalo, Michael A, additional

Published
2022
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6. Efficient Preparation of Imidazo[1,5-α]pyridine-1-carboxylic Acids.

Author

Tverdiy, Dmytro O., Chekanov, Maksym O., Savitskiy, Pavlo V., Syniugin, Anatolii R., Yarmoliuk, Sergiy M., and Fokin, Andrey A.

Subjects
CARBOXYLIC acids, CHLORIDES, ACYL chlorides, TRIFLUOROACETIC acid, AMIDES, CHEMICAL synthesis
Abstract

We report a novel and efficient approach to the synthesis of imidazo[1,5-α]pyridine-1-carboxylic acids. By using the reaction of 2- (aminomethyl)pyridine with acyl chlorides followed by one-pot treatment with trifluoroacetic anhydride, 2,2,2-trifluoro-1-imidazo[1,5-α]pyridin-1-ylethanones were obtained, which were then converted into imidazo[1,5-α]pyridine-1-carboxylic acids in high preparative yields through haloform cleavage. [ABSTRACT FROM AUTHOR]

Published
2016
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