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289 results on '"Symms, M"'

2. Temporal lobe epilepsy and affective disorders: the role of the subgenual anterior cingulate cortex

Author

Stretton, J, Pope, RA, Winston, GP, Sidhu, MK, Symms, M, Duncan, JS, Koepp, M, Thompson, PJ, and Foong, J

Subjects
Behavioral and Social Science, Clinical Research, Brain Disorders, Epilepsy, Mental Health, Neurodegenerative, Neurosciences, Depression, 2.1 Biological and endogenous factors, Aetiology, Mental health, Adolescent, Adult, Anisotropy, Case-Control Studies, Cerebral Cortex, Diffusion Tensor Imaging, Epilepsy, Temporal Lobe, Female, Functional Neuroimaging, Gray Matter, Gyrus Cinguli, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Middle Aged, Mood Disorders, Neural Pathways, Psychiatric Status Rating Scales, Psychomotor Performance, Young Adult, EPILEPSY, FUNCTIONAL IMAGING, LIMBIC SYSTEM, MEMORY, PSYCHIATRY, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

ObjectiveReduced deactivation within the default mode network (DMN) is common in individuals with primary affective disorders relative to healthy volunteers (HVs). It is unknown whether similar network abnormalities are present in temporal lobe epilepsy (TLE) patients with a history of affective psychopathology.Methods17 TLE patients with a lifetime affective diagnosis, 31 TLE patients with no formal psychiatric history and 30 HVs were included. We used a visuo-spatial 'n-back' paradigm to compare working memory (WM) network activation between these groups. Post hoc analyses included voxel-based morphometry and diffusion tensor imaging. The Beck Depression Inventory-Fast Screen and Beck Anxiety Inventory were completed on the day of scanning.FindingsEach group activated the fronto-parietal WM networks and deactivated the typical DMN in response to increasing task demands. Group comparison revealed that TLE patients with lifetime affective morbidity showed significantly greater deactivation in subgenual anterior cingulate cortex (sACC) than either the TLE-only or the HVs (p

Published
2015

3. Factors affecting reorganisation of memory encoding networks in temporal lobe epilepsy

Author

Sidhu, MK, Stretton, J, Winston, GP, Symms, M, Thompson, PJ, Koepp, MJ, and Duncan, JS

Subjects
Neurodegenerative, Clinical Research, Brain Disorders, Neurosciences, Epilepsy, 2.1 Biological and endogenous factors, Aetiology, Neurological, Adult, Age of Onset, Epilepsy, Temporal Lobe, Face, Female, Functional Laterality, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Neural Pathways, Neuropsychological Tests, Pattern Recognition, Visual, Photic Stimulation, Reading, Sclerosis, Seizures, Time Factors, Young Adult, Temporal lobe epilepsy, Episodic memory, Functional MRI, Seizure frequency, Duration, Neurology & Neurosurgery
Abstract

AimsIn temporal lobe epilepsy (TLE) due to hippocampal sclerosis reorganisation in the memory encoding network has been consistently described. Distinct areas of reorganisation have been shown to be efficient when associated with successful subsequent memory formation or inefficient when not associated with successful subsequent memory. We investigated the effect of clinical parameters that modulate memory functions: age at onset of epilepsy, epilepsy duration and seizure frequency in a large cohort of patients.MethodsWe studied 53 patients with unilateral TLE and hippocampal sclerosis (29 left). All participants performed a functional magnetic resonance imaging memory encoding paradigm of faces and words. A continuous regression analysis was used to investigate the effects of age at onset of epilepsy, epilepsy duration and seizure frequency on the activation patterns in the memory encoding network.ResultsEarlier age at onset of epilepsy was associated with left posterior hippocampus activations that were involved in successful subsequent memory formation in left hippocampal sclerosis patients. No association of age at onset of epilepsy was seen with face encoding in right hippocampal sclerosis patients. In both left hippocampal sclerosis patients during word encoding and right hippocampal sclerosis patients during face encoding, shorter duration of epilepsy and lower seizure frequency were associated with medial temporal lobe activations that were involved in successful memory formation. Longer epilepsy duration and higher seizure frequency were associated with contralateral extra-temporal activations that were not associated with successful memory formation.ConclusionAge at onset of epilepsy influenced verbal memory encoding in patients with TLE due to hippocampal sclerosis in the speech-dominant hemisphere. Shorter duration of epilepsy and lower seizure frequency were associated with less disruption of the efficient memory encoding network whilst longer duration and higher seizure frequency were associated with greater, inefficient, extra-temporal reorganisation.

Published
2015

4. Clinical language fMRI with real-time monitoring in temporal lobe epilepsy: Online processing methods

Author

Williams, EJ, Stretton, J, Centeno, M, Bartlett, P, Burdett, J, Symms, M, Duncan, JS, and Micallef, C

Subjects
Neurodegenerative, Clinical Research, Brain Disorders, Neurosciences, Epilepsy, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Neurological, Adolescent, Adult, Brain Mapping, Brain Waves, Cerebral Cortex, Epilepsy, Temporal Lobe, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Language, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Online Systems, Verbal Behavior, Young Adult, Language fMRI, Language mapping, Epilepsy surgery, Real time, BrainWave, Online, Language lateralization, Clinical Sciences, Neurology & Neurosurgery
Abstract

The increasing demand for clinical fMRI data has resulted in a need to translate research methods to clinical use. Referrals for language lateralization prior to epilepsy surgery are becoming more common, but time constraints make this unachievable in many busy neuroimaging departments. This study examines whether a single covert verbal fluency paradigm with real-time monitoring and online processing (BrainWave) could replace conventional offline processing (SPM) for the purpose of establishing expressive language dominance prior to epilepsy surgery. We analyzed language fMRI results of 30 patients (17 female; 24 right-handed; median age: 30.5) with temporal lobe epilepsy. Concordance between visual assessment of SPM and BrainWave was 92.8%. Lateralization indices correlated closely with visual assessments of lateralization with a concordance of 85.7%. BrainWave provided a real-time, fast and accurate display of language lateralization easily applied in a clinical setting using only online image processing.

Published
2012

12. A review of structural magnetic resonance neuroimaging

Author

Symms, M., Jager, H.R., Schmierer, K., and Yousry, T.A.

Subjects
Medical laboratory technology -- Technology application, Medical technology -- Technology application, Magnetic resonance imaging -- Evaluation, Technology application, Health, Psychology and mental health
Published
2004

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