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7. Editorial: Protein post-translational modifications in the nervous system: from development to disease and ageing.

Author

Alvarez, Beatriz, Symmank, Judit, Zimmer-Bensch, Geraldine, Diaz-Hernandez, Miguel, and Franzka, Patricia

Subjects
MOLECULAR biology, DEUBIQUITINATING enzymes, STEM cell niches, HUMAN genetics, NEUROLOGICAL disorders, POST-translational modification, DEVELOPMENTAL neurobiology
Abstract

The editorial in Frontiers in Molecular Neuroscience discusses protein post-translational modifications (PTMs) in the nervous system, emphasizing their role in development, disease, and aging. PTMs increase the functional diversity of proteins, contributing to the complexity of the proteome beyond the genome's coding capacity. The research topic explores PTMs in neurodegenerative diseases like Alzheimer's and Parkinson's, as well as their impact on aging, highlighting the critical role of PTMs in nervous system and muscle function. [Extracted from the article]

Published
2024
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8. Immunometabolic capacities of nutritional fatty acids in regulation of inflammatory bone cell interaction and systemic impact of periodontal infection

Author

Döding, Annika, primary, Zimmermann, Svenja, additional, Maghames, Ahmed, additional, Reimann, Michael, additional, Symmank, Judit, additional, Thürmer, Maria, additional, Gräler, Markus H., additional, Wolf, Michael, additional, Jacobs, Collin, additional, Koeberle, Andreas, additional, Sigusch, Bernd, additional, and Schulze-Späte, Ulrike, additional

Published
2023
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9. Influence of the orthodontic bonding procedure on biofilm formation

Author

Blochberger, Bijan Levent, primary, Symmank, Judit, additional, Nitzsche, Ánn, additional, Nietzsche, Sandor, additional, Steiniger, Frank, additional, Guellmar, André, additional, Reise, Markus, additional, Sigusch, Bernd, additional, Jacobs, Collin, additional, and Hennig, Christoph‐Ludwig, additional

Published
2023
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11. Influence of the orthodontic bonding procedure on biofilm formation.

Author

Blochberger, Bijan Levent, Symmank, Judit, Nitzsche, Ánn, Nietzsche, Sandor, Steiniger, Frank, Guellmar, André, Reise, Markus, Sigusch, Bernd, Jacobs, Collin, and Hennig, Christoph‐Ludwig

Subjects
CORRECTIVE orthodontics, SCANNING electron microscopes, TOOTH demineralization, BIOFILMS, BACTERIAL growth, DENTAL bonding, SURFACE roughness
Abstract

Introduction: In orthodontics, white spot lesions are a persistent and widespread problem caused by the demineralization of buccal tooth surfaces around bonded brackets. The remaining adhesive around the brackets leads to surface roughness, which might contribute to demineralization. The present in vitro study aimed to compare a conventional and a modern adhesive system (APC Flash‐Free technology) for orthodontic brackets with regard to the adhesion of Streptococcus sobrinus, a leading caries pathogen. Methods: This in vitro study included 20 premolar teeth and compared 10 APC Flash‐Free adhesive‐coated ceramic brackets (FF)with 10 conventionally bonded (CB) ceramic clarity brackets. Specimens were incubated in an S. sobrinus suspension for 3 h. To evaluate the bacterial formation, samples were analysed with a scanning electron microscope (SEM). Imaging software was used to quantify and statistically compare percentage values of colonization (PVC) in both groups' adhesion and transition areas. Results: We found a significant difference in biofilm formation between the groups for the adhesive and transition areas. PVC in the adhesive area was approximately 10.3‐fold greater for the CB group compared with the FF group (median: 3.2 vs 0.31; P < 0.0001). For the transition area, median PVC was approximately 2.4‐fold greater for the CB group compared with the FF group (median: 53.17 vs 22.11; P < 0.01). Conclusions: There was a significantly lower level of S. sobrinus formation around the FF bracket system than there was surrounding the conventionally bonded group. This study suggests that the FF adhesive bracket system can help reduce the occurrence of bacterial growth around orthodontic brackets. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Mediterranean diet component oleic acid increases protective lipid mediators and improves trabecular bone in a Porphyromonas gingivalis inoculation model

Author

Döding, Annika, primary, Hüfner, Mira, additional, Nachtsheim, Franziska, additional, Iffarth, Viktoria, additional, Bölter, Anna, additional, Bastian, Asisa, additional, Symmank, Judit, additional, Andreas, Nico, additional, Schädel, Patrick, additional, Thürmer, Maria, additional, Becker, Kathrin, additional, Wolf, Michael, additional, Jacobs, Collin, additional, Kamradt, Thomas, additional, Koeberle, Andreas, additional, Werz, Oliver, additional, Sigusch, Bernd, additional, and Schulze‐Späte, Ulrike, additional

Published
2022
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17. GDF15 Promotes the Osteogenic Cell Fate of Periodontal Ligament Fibroblasts, thus Affecting Their Mechanobiological Response.

Author

Lösch, Lukas, Stemmler, Albert, Fischer, Adrian, Steinmetz, Julia, Schuldt, Lisa, Hennig, Christoph-Ludwig, Symmank, Judit, and Jacobs, Collin

Subjects
PERIODONTAL ligament, GROWTH differentiation factors, BONE mechanics, CORRECTIVE orthodontics, FIBROBLASTS, BONE remodeling
Abstract

Periodontal ligament fibroblasts (PdLFs) exert important functions in oral tissue and bone remodeling following mechanical forces, which are specifically applied during orthodontic tooth movement (OTM). Located between the teeth and the alveolar bone, mechanical stress activates the mechanomodulatory functions of PdLFs including regulating local inflammation and activating further bone-remodeling cells. Previous studies suggested growth differentiation factor 15 (GDF15) as an important pro-inflammatory regulator during the PdLF mechanoresponse. GDF15 exerts its effects through both intracrine signaling and receptor binding, possibly even in an autocrine manner. The extent to which PdLFs are susceptible to extracellular GDF15 has not yet been investigated. Thus, our study aims to examine the influence of GDF15 exposure on the cellular properties of PdLFs and their mechanoresponse, which seems particularly relevant regarding disease- and aging-associated elevated GDF15 serum levels. Therefore, in addition to investigating potential GDF15 receptors, we analyzed its impact on the proliferation, survival, senescence, and differentiation of human PdLFs, demonstrating a pro-osteogenic effect upon long-term stimulation. Furthermore, we observed altered force-related inflammation and impaired osteoclast differentiation. Overall, our data suggest a major impact of extracellular GDF15 on PdLF differentiation and their mechanoresponse. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Mediterranean diet component oleic acid increases protective lipid mediators and improves trabecular bone in a Porphyromonas gingivalis inoculation model.

Author

Döding, Annika, Hüfner, Mira, Nachtsheim, Franziska, Iffarth, Viktoria, Bölter, Anna, Bastian, Asisa, Symmank, Judit, Andreas, Nico, Schädel, Patrick, Thürmer, Maria, Becker, Kathrin, Wolf, Michael, Jacobs, Collin, Kamradt, Thomas, Koeberle, Andreas, Werz, Oliver, Sigusch, Bernd, and Schulze‐Späte, Ulrike

Subjects
MEDITERRANEAN diet, WESTERN diet, BIOLOGICAL models, LIPOPOLYSACCHARIDES, IN vitro studies, MONOUNSATURATED fatty acids, BODY weight, FIBROBLASTS, INFLAMMATION, FOOD consumption, ANIMAL experimentation, NUTRITION, GRAM-negative anaerobic bacteria, PERIODONTAL disease, ALVEOLAR process, PLACEBOS, TREATMENT effectiveness, LINOLEIC acid, GINGIVAL hyperplasia, DESCRIPTIVE statistics, TUMOR necrosis factors, RESEARCH funding, LIPIDS, CANCELLOUS bone, MICE
Abstract

Aim: Therapeutic modulation of bacterial‐induced inflammatory host response is being investigated in gingival inflammation and periodontal disease pathology. Therefore, dietary intake of the monounsaturated fatty acid (FA) oleic acid (OA (C18:1)), which is the main component of Mediterranean‐style diets, and saturated FA palmitic acid (PA (C16:0)), which is a component of Western‐style diets, was investigated for their modifying potential in an oral inoculation model of Porphyromonas gingivalis. Materials and Methods: Normal‐weight C57BL/6‐mice received OA‐ or PA‐enriched diets (PA‐ED, OA‐ED, PA/OA‐ED) or normal standard diet for 16 weeks and were inoculated with P. gingivalis/placebo (n = 12/group). Gingival inflammation, alveolar bone structure, circulating lipid mediators, and in vitro cellular response were determined. Results: FA treatment of P. gingivalis‐lipopolysaccharide‐incubated gingival fibroblasts (GFbs) modified inflammatory activation, which only PA exacerbated with concomitant TNF‐α stimulation. Mice exhibited no signs of acute inflammation in gingiva or serum and no inoculation‐ or nutrition‐associated changes of the crestal alveolar bone. However, following P. gingivalis inoculation, OA‐ED improved oral trabecular bone micro‐architecture and enhanced circulating pro‐resolving mediators resolvin D4 (RvD4) and 4‐hydroxydocosahexaenoic acid (4‐HDHA), whereas PA‐ED did not. In vitro experiments demonstrated significantly improved differentiation in RvD4‐ and 4‐HDHA‐treated primary osteoblast cultures and reduced the expression of osteoclastogenic factors in GF. Further, P. gingivalis infection of OA‐ED animals led to a serum composition that suppressed osteoclastic differentiation in vitro. Conclusions: Our results underline the preventive impact of Mediterranean‐style OA‐EDs by indicating their pro‐resolving nature beyond anti‐inflammatory properties. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Hyperlipidemic Conditions Impact Force-Induced Inflammatory Response of Human Periodontal Ligament Fibroblasts Concomitantly Challenged with P. gingivalis-LPS

Author

Symmank, Judit, primary, Appel, Sophie, additional, Bastian, Jana Asisa, additional, Knaup, Isabel, additional, Marciniak, Jana, additional, Hennig, Christoph-Ludwig, additional, Döding, Annika, additional, Schulze-Späte, Ulrike, additional, Jacobs, Collin, additional, and Wolf, Michael, additional

Published
2021
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25. Hyperlipidemic Conditions Impact Force-Induced Inflammatory Response of Human Periodontal Ligament Fibroblasts Concomitantly Challenged with P. gingivalis-LPS

Author

Symmank, Judit, Appel, Sophie, Bastian, Jana Asisa, Knaup, Isabel, Marciniak, Jana, Hennig, Christoph-Ludwig, Döding, Annika, Schulze-Späte, Ulrike, Jacobs, Collin, and Wolf, Michael

Subjects
Lipopolysaccharides, obesity, Compressive Strength, Periodontal Ligament, QH301-705.5, periodontal ligament fibroblasts, Hyperlipidemias, Fibroblasts, Article, orthodontic tooth movement, Chemistry, inflammation, Pressure, Cytokines, Humans, Stress, Mechanical, Biology (General), Porphyromonas gingivalis, periodontitis, QD1-999
Abstract

International journal of molecular sciences 22(11), 6069 (2021). doi:10.3390/ijms22116069 special issue: "Special Issue "Molecular Links between Periodontitis and Systemic Diseases" / Special Issue Editor: Prof. Dr. Kenichi Imai, Guest Editor", Published by Molecular Diversity Preservation International, Basel

Published
2021
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28. DNA Methylation-Mediated Modulation of Endocytosis as Potential Mechanism for Synaptic Function Regulation in Murine Inhibitory Cortical Interneurons

Author

Pensold, Daniel, primary, Reichard, Julia, primary, Van Loo, Karen M J, primary, Ciganok, Natalja, primary, Hahn, Anne, primary, Bayer, Cathrin, primary, Liebmann, Lutz, primary, Groß, Jonas, primary, Tittelmeier, Jessica, primary, Lingner, Thomas, primary, Salinas-Riester, Gabriela, primary, Symmank, Judit, primary, Halfmann, Claas, primary, González-Bermúdez, Lourdes, primary, Urbach, Anja, primary, Gehrmann, Julia, primary, Costa, Ivan, primary, Pieler, Tomas, primary, Hübner, Christian A, primary, Vatter, Hartmut, primary, Kampa, Björn, primary, Becker, Albert J, primary, and Zimmer-Bensch, Geraldine, primary

Published
2020
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29. LHX1-a multifunctional regulator in preoptic area-derived interneuron development

Author

Symmank, Judit and Zimmer-Bensch, Geraldine

Subjects
Preoptic area, medicine.anatomical_structure, Developmental Neuroscience, Interneuron, Perspective, medicine, Regulator, ddc:610, Biology, Neuroscience, lcsh:Neurology. Diseases of the nervous system, lcsh:RC346-429
Abstract

Neural regeneration research : NRR 14(7), 1213-1214 (2019). doi:10.4103/1673-5374.251303, Published by Wolters Kluwer Health Medknow, Mumbai

Published
2019
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35. Neuronal Lhx1expression is regulated by DNMT1-dependent modulation of histone marks

Author

Symmank, Judit, Bayer, Cathrin, Reichard, Julia, Pensold, Daniel, and Zimmer-Bensch, Geraldine

Abstract

ABSTRACTApart from the conventional view of repressive promoter methylation, the DNA methyltransferase 1 (DNMT1) was recently described to modulate gene expression through a variety of interactions with diverse epigenetic key players. We here investigated the DNMT1-dependent transcriptional control of the homeobox transcription factor LHX1, which we previously identified as an important regulator in cortical interneuron development. We found that LHX1 expression in embryonic interneurons originating in the embryonic pre-optic area (POA) is regulated by non-canonic DNMT1 function. Analysis of histone methylation and acetylation revealed that both epigenetic modifications seem to be implicated in the control of Lhx1gene activity and that DNMT1 contributes to their proper establishment. This study sheds further light on the regulatory network of cortical interneuron development including the complex interplay of epigenetic mechanisms.

Published
2020
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36. Festsitzende Retainer - Wirkung und Nebenwirkung.

Author

Hennig, Christoph-Ludwig, Symmank, Judit, Schmidt, Nina Maria, and Jacobs, Collin

Abstract

Copyright of Quintessenz Zahnmedizin is the property of Quintessenz Verlags GmbH and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020

38. Regulation of neuronal survival by DNA methyltransferases

Author

Symmank, Judit and Zimmer, Geraldine

Subjects
0301 basic medicine, Histone-modifying enzymes, Methyltransferase, Context (language use), lcsh:RC346-429, cortical interneurons, 03 medical and health sciences, Developmental Neuroscience, Gene expression, Gene silencing, Epigenetics, lcsh:Neurology. Diseases of the nervous system, Invited Review, neurodevelopment, biology, DNA methyltransferase 1, neuronal death, neuronal aging, Cell biology, PAK6, neuropsychiatric diseases, 030104 developmental biology, Histone, DNA methylation, biology.protein
Abstract

The limited regenerative capacity of neuronal cells requires tight orchestration of cell death and survival regulation in the context of longevity, age-associated diseases as well as during the development of the nervous system. Subordinate to genetic networks epigenetic mechanisms like DNA methylation and histone modifications are involved in the regulation of neuronal development, function and aging. DNA methylation by DNA methyltransferases (DNMTs), mostly correlated with gene silencing, is a dynamic and reversible process. In addition to their canonical actions performing cytosine methylation, DNMTs influence gene expression by interactions with histone modifying enzymes or complexes increasing the complexity of epigenetic transcriptional networks. DNMTs are expressed in neuronal progenitors, post-mitotic as well as adult neurons. In this review, we discuss the role and mode of actions of DNMTs including downstream networks in the regulation of neuronal survival in the developing and aging nervous system and its relevance for associated disorders.

Published
2017

39. The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics of Migrating POA-Derived Interneurons Fated for the Murine Cerebral Cortex

Author

Pensold, Daniel, primary, Symmank, Judit, additional, Hahn, Anne, additional, Lingner, Thomas, additional, Salinas-Riester, Gabriela, additional, Downie, Bryan R, additional, Ludewig, Fabian, additional, Rotzsch, Anne, additional, Haag, Natja, additional, Andreas, Nico, additional, Schubert, Katrin, additional, Hübner, Christian A, additional, Pieler, Tomas, additional, and Zimmer, Geraldine, additional

Published
2016
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42. DNMT1 modulates interneuron morphology by regulating Pak6expression through crosstalk with histone modifications

Author

Symmank, Judit, Bayer, Cathrin, Schmidt, Christiane, Hahn, Anne, Pensold, Daniel, and Zimmer-Bensch, Geraldine

Abstract

ABSTRACTEpigenetic mechanisms of gene regulation, including DNA methylation and histone modifications, call increasing attention in the context of development and human health. Thereby, interactions between DNA methylating enzymes and histone modifications tremendously multiply the spectrum of potential regulatory functions. Epigenetic networks are critically involved in the establishment and functionality of neuronal circuits that are composed of gamma-aminobutyric acid (GABA)-positive inhibitory interneurons and excitatory principal neurons in the cerebral cortex. We recently reported a crucial role of the DNA methyltransferase 1 (DNMT1) during the migration of immature POA-derived cortical interneurons by promoting the migratory morphology through repression of Pak6. However, the DNMT1-dependent regulation of Pak6expression appeared to occur independently of direct DNA methylation. Here, we show that in addition to its DNA methylating activity, DNMT1 can act on gene transcription by modulating permissive H3K4 and repressive H3K27 trimethylation in developing inhibitory interneurons, similar to what was found in other cell types. In particular, the transcriptional control of Pak6, interactions of DNMT1 with the Polycomb-repressor complex 2 (PCR2) core enzyme EZH2, mediating repressive H3K27 trimethylations at regulatory regions of the Pak6gene locus. Similar to what was observed upon Dnmt1depletion, inhibition of EZH2 caused elevated Pak6expression levels accompanied by increased morphological complexity, which was rescued by siRNA-mediated downregulation of Pak6expression. Together, our data emphasise the relevance of DNMT1-dependent crosstalk with histone tail methylation for transcriptional control of genes like Pak6required for proper cortical interneuron migration.

Published
2018
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43. A Hereditary Spastic Paraplegia Mouse Model Supports a Role of ZFYVE26/SPASTIZIN for the Endolysosomal System

Author

Khundadze, Mukhran, primary, Kollmann, Katrin, additional, Koch, Nicole, additional, Biskup, Christoph, additional, Nietzsche, Sandor, additional, Zimmer, Geraldine, additional, Hennings, J. Christopher, additional, Huebner, Antje K., additional, Symmank, Judit, additional, Jahic, Amir, additional, Ilina, Elena I., additional, Karle, Kathrin, additional, Schöls, Ludger, additional, Kessels, Michael, additional, Braulke, Thomas, additional, Qualmann, Britta, additional, Kurth, Ingo, additional, Beetz, Christian, additional, and Hübner, Christian A., additional

Published
2013
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