1. The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids
- Author
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Harald Groeger, Karlheinz Drauz, Stefan Buchholz, Helge Werner, Sylvie Godfrin, Christiane Sacherer, and Harald Trauthwein
- Subjects
chemistry.chemical_classification ,Aminoacylase ,Molecular Structure ,Chemistry ,Stereochemistry ,Organic Chemistry ,Molecular Conformation ,Enantioselective synthesis ,Substrate (chemistry) ,Stereoisomerism ,General Medicine ,Biochemistry ,Catalysis ,Amidohydrolases ,Amino acid ,chemistry.chemical_compound ,Enzyme ,Organic chemistry ,Amino Acids ,Physical and Theoretical Chemistry ,Beta (finance) ,Acyl group - Abstract
The first aminoacylase-catalyzed enantioselective synthesis of aromatic beta-amino acids is reported. The presence of an N-chloroacetyl group as acyl group in the substrate as well as the use of porcine kidney acylase I as a suitable enzyme component are prerequisites for this resolution process whereby optically active beta-amino acids are formed with high enantioselectivities of >98% ee.
- Published
- 2004