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Graphical abstract, Highlights • Evaluating the pharmacokinetics of nicotine absorption from electronic cigarettes. • Nicotine absorption into the blood is influenced by several factors. • These include e-liquid composition, user behavior and device characteristics. • Any regulation of nicotine levels in e-liquids should reflect this heterogeneity., Several regulatory initiatives around the world restrict the amount of nicotine permitted in electronic cigarette liquids in an attempt to reproduce the nicotine delivery of combusted tobacco products, such as cigarettes, and or reduce the risk of consumers absorbing too much nicotine into their body at one time. Such an approach, however, assumes that (i) there is a strong correlation between the levels of nicotine in electronic cigarette liquids and nicotine intake into the body and (ii) that this correlation holds true across the various different types of electronic cigarette devices currently available on the market. In order to test these hypotheses, this study examines the available scientific literature on nicotine intake from electronic cigarettes, as measured by levels in the blood. Analysis of the published data reveals that nicotine absorption into the body is influenced by a combination of many factors, including electronic cigarette liquid composition, user behavior and device characteristics. Notably, it was observed that open-tank (refillable) electronic cigarettes, which often enable users to vary device power, can deliver high nicotine levels to consumers, sometimes at greater doses than a conventional tobacco cigarette, even at the lower nicotine liquid concentrations typically available. For electronic cigarettes to be viable alternative choices to smoking, they should provide consumers with an equally satisfying experience, including in terms of nicotine absorption into the body. Therefore, any regulation seeking to restrict the amount of nicotine in electronic cigarette liquids should take all the factors influencing nicotine intake into account.

International audience; Strong-field light-matter interactions initiate a wide range of phenomena in which the quantumpaths of electronic wavepackets can be manipulated by tailoring the laser field. Among the electronsreleased by a strong laser pulse from atomic and molecular targets, some are subsequently drivenback to the vicinity of the ionic core by the oscillating laser field. The trajectories of these returningelectrons are bent towards the core by the ionic potential, an effect known as Coulomb focusing.This process, studied over the past two decades, has been associated with the long range influenceof the Coulomb potential. Here we explore the structural properties of the Coulomb focusingphenomenon. Specifically, we numerically study the sensitivity of the returning electron dynamicsto the anisotropy of the ionic potential. We employ orthogonally polarized two-color strong fieldsand chiral molecules, whose asymmetric features lead to unambiguous fingerprints of the potentialon the freed electrons. The Coulomb-focused electrons show an enhanced sensitivity to chirality,related to an asymmetric attoclock-like angular streaking stemming from field-assisted scatteringof the electrons onto the chiral ionic potential. Anisotropic features of the ionic potential thusmonitor the motion of Coulomb-focused electrons throughout their returning paths, shedding lighton the structural properties of the interaction.

Background Accurately monitoring adherence to treatment with recombinant human growth hormone (r-hGH) enables appropriate intervention in cases of poor adherence. The electronic r-hGH auto-injector, easypod™, automatically records the patient's adherence to treatment. This study evaluated adherence to treatment of children who started using the auto-injector and assessed opinions about the device. Methods A multicentre, multinational, observational 3-month survey in which children received r-hGH as part of their normal care. Physicians reviewed the recorded dose history and children (with or without parental assistance) completed a questionnaire-based survey. Children missing ≤2 injections per month (92% of injections given) were considered adherent to treatment. Adherence was compared between GH treatment-naïve and treatment-experienced children. Results Of 834 recruited participants, 824 were evaluated. The median (range) age was 11 (1-18) years. From the recorded dose history, 87.5% of children were adherent to treatment over the 3-month period. Recorded adherence was higher in treatment-naïve (89.7%, n = 445/496) than in treatment-experienced children (81.7%, n = 152/186) [Fisher's exact test FI(X) = 7.577; p = 0.0062]. According to self-reported data, 90.2% (607/673) of children were adherent over 3 months; 51.5% (421/817) missed ≥1 injection over this period (mainly due to forgetfulness). Concordance between reported and recorded adherence was 84.3%, with a trend towards self-reported adherence being higher than recorded adherence. Most children liked the auto-injector: over 80% gave the top two responses from five options for ease of use (720/779), speed (684/805) and comfort (716/804). Although 38.5% (300/780) of children reported pain on injection, over half of children (210/363) considered the pain to be less or much less than expected. Given the choice, 91.8% (732/797) of children/parents would continue using the device. Conclusions easypod™ provides an accurate method of monitoring adherence to treatment with r-hGH. In children who received treatment with r-hGH using easypod™, short-term adherence is good, and significantly higher in treatment-naïve children compared with experienced children. Children/parents rate the device highly. The high level of acceptability of the device is reflected by a desire to continue using it by over 90% of the children in the survey.