219 results on '"Sylvain Brochard"'
Search Results
2. Quantitative gait analysis and prediction using artificial intelligence for patients with gait disorders
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Nawel Ben Chaabane, Pierre-Henri Conze, Mathieu Lempereur, Gwenolé Quellec, Olivier Rémy-Néris, Sylvain Brochard, Béatrice Cochener, and Mathieu Lamard
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Medicine ,Science - Abstract
Abstract Quantitative Gait Analysis (QGA) is considered as an objective measure of gait performance. In this study, we aim at designing an artificial intelligence that can efficiently predict the progression of gait quality using kinematic data obtained from QGA. For this purpose, a gait database collected from 734 patients with gait disorders is used. As the patient walks, kinematic data is collected during the gait session. This data is processed to generate the Gait Profile Score (GPS) for each gait cycle. Tracking potential GPS variations enables detecting changes in gait quality. In this regard, our work is driven by predicting such future variations. Two approaches were considered: signal-based and image-based. The signal-based one uses raw gait cycles, while the image-based one employs a two-dimensional Fast Fourier Transform (2D FFT) representation of gait cycles. Several architectures were developed, and the obtained Area Under the Curve (AUC) was above 0.72 for both approaches. To the best of our knowledge, our study is the first to apply neural networks for gait prediction tasks.
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- 2023
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3. Bimanual movements in children with cerebral palsy: a systematic review of instrumented assessments
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Marine Cacioppo, Anthéa Loos, Mathieu Lempereur, and Sylvain Brochard
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Children ,Cerebral palsy ,Bimanual ,Upper limb ,Motion analysis ,Instrumented measures ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Background Assessment of bimanual movements, which are frequently impaired in children with cerebral palsy, is highly challenging in clinical practice. Instrumented measures have been developed to evaluate and help to understand impaired upper limb movement during bimanual tasks in these children. The aim of this review was to report instrumented measurement tools (3D motion analysis, sensors, etc.) used for bimanual task movement analysis, and the metrological properties of the measures in children with cerebral palsy. Methods A systematic review was conducted (Prospero CRD42022308517). PubMed, Web of Science, Cochrane and Scopus databases were searched with relevant keywords and inclusion/exclusion criteria. Article quality and biomechanical methods were evaluated with a customized scale and metrological properties with the COSMIN checklist. Results In total, 452 children, mostly with unilateral cerebral palsy, mean age 10.9 (SD 3.2) years, underwent quantitative bimanual assessments in the 31 included studies (mean quality score 22/32 points [SD 4.7]). The tools used were 3D motion analysis (n = 26), accelerometers (n = 2), and other instruments (cube, digitizer, etc.) (n = 3). Children performed 1–5 bimanual tasks in laboratory settings, mostly activities of daily living or game scenarios. Analyses focused mostly on spatiotemporal variables, 6 of which were specifically developed for bilateral measures (task completion time, goal synchronization, movement overlap time, interlimb coupling, continuous relative phase and asynchrony). These instrumented measurements had moderate to good discriminant and convergent validity, but reliability and responsiveness assessments were lacking. Conclusions A large number of quantitative bimanual assessments involving different tools, bimanual tasks and specific variables developed to evaluate bimanual function were found. Development of other relevant variables and validation of these tools are needed to further determine their usefulness, both as research outcomes and to guide therapies in clinical practice. Future research, involving younger children and real-life assessments, will improve our understanding of bimanual function in children with cerebral palsy.
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- 2023
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4. Bone Deformities through the Prism of the International Classification of Functioning, Disability and Health in Ambulant Children with Cerebral Palsy: A Systematic Review
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Rodolphe Bailly, Christelle Pons, Anne-Charlotte Haes, Lisa Nguyen, Matthias Thepaut, Laëtitia Houx, Mathieu Lempereur, and Sylvain Brochard
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bone deformity ,ICF ,gait ,cerebral palsy ,children ,Pediatrics ,RJ1-570 - Abstract
(1) Aim: The aim of this study was to determine the relationship between lower limb bone deformities and body functions, activity, and participation in ambulant children with CP and whether changing bone morphology affects outcomes in these domains. (2) Methods: A systematic literature search (PROSPERO CRD42020208416) of studies reporting correlations between measures of lower limb bone deformities and measures of body function, activity or participation, or post-surgical outcomes in these domains was conducted from 1990 to 2023 in Medline, Scopus, and Cochrane Library. We assessed study quality with the Checklist for Case Series (CCS) and a quality assessment developed by Quebec University Hospital. Meta-analysis was not possible; therefore, descriptive synthesis was performed. (3) Results: A total of 12 of 3373 screened articles were included. No studies evaluated the relationships between bone deformities and activity or participation, or the effect of isolated bone surgery on these domains. Correlations between bone deformities and body functions were poor-to-moderate. Internal hip rotation during gait improved after femoral derotation osteotomy. (4) Conclusions: A shift in paradigm is urgently required for the research and management of bone deformities in children with CP to include the activity and participation domains of the ICF, as well as consider more psychological aspects such as self-image.
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- 2024
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5. Digital technologies for motor rehabilitation in children: protocol for a cross-sectional European survey
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Christelle Pons, Sylvain Brochard, Javier de la Cruz, Anca Grigoriu, Christopher J Newman, Elegast Monbaliu, Johanne Mensah-Gourmel, Delphine Gaudin-Drouelle, Anis Toumi, and Marco Konings
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Medicine - Abstract
Introduction Digital technologies can be used as part of paediatric motor rehabilitation to remediate impairment, promote recovery and improve function. However, the uptake of digital technologies in this clinical field may be limited.The aim of this study is to describe and explain digital technology use for paediatric motor rehabilitation. The specific objectives will be: (1) to describe the access to, acceptance of and use of digital technologies as a function of individual factors related to professionals practicing motor rehabilitation with children, and of environmental factors related to paediatric rehabilitation practice and (2) to explain digital technology use with a causal model based on the ‘unified theory of acceptance and use of technology’.Methods and analysis RehaTech4child (Rehabilitation Technologies For children) is a cross-sectional study involving an online survey, that is sponsored by the European Academy of Childhood Disability (EACD). The survey protocol follows the Strengthening the Reporting of Observational Studies in Epidemiology and CHERRIES (Checklist for Reporting Results of Internet E-Surveys) guidelines. The survey includes 43 questions about (1) respondents’ individual and environmental characteristics; (2) the ease of access to digital technologies, and the frequency, type and purpose of use of those technologies and (3) acceptance of technologies and barriers to their use. The survey is intended for professionals involved in paediatric motor rehabilitation. It is disseminated across Europe by the EACD network in 20 languages. Participation is anonymous and voluntary. We aim to include 500 respondents to ensure sufficient precision for the description of study outcomes and to perform stratified analyses by the main determinants.Ethics and dissemination Ethics approval was waived by the Brest CHRU Institutional Review Board. The study is conducted according to current French legislation (loi Jardé (n°2012-300)) and the survey is GDPR compliant. Study findings will be presented at national and international meetings and submitted for publication in a peer-reviewed journal.Trial registration number NCT05176522.
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- 2023
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6. Comprehensive personalized ankle joint shape analysis of children with cerebral palsy from pediatric MRI
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Yue Cheng, Rodolphe Bailly, Claire Scavinner-Dorval, Benjamin Fouquet, Bhushan Borotikar, Douraied Ben Salem, Sylvain Brochard, and François Rousseau
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shape analysis ,ankle joint ,MRI ,cerebral palsy ,morphometry ,Biotechnology ,TP248.13-248.65 - Abstract
Cerebral palsy, a common physical disability in childhood, often causes abnormal patterns of movement and posture. To better understand the pathology and improve rehabilitation of patients, a comprehensive bone shape analysis approach is proposed in this article. First, a group analysis is performed on a clinical MRI dataset using two state-of-the-art shape analysis methods: ShapeWorks and a voxel-based method relying on Advanced Normalization Tools (ANTs) registration. Second, an analysis of three bones of the ankle is done to provide a complete view of the ankle joint. Third, a bone shape analysis is carried out at subject level to highlight variability patterns for personnalized understanding of deformities.
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- 2022
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7. Detecting Movement Changes in Children with Hemiparesis after Upper Limb Therapies: A Responsiveness Analysis of a 3D Bimanual Protocol
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Marine Cacioppo, Mathieu Lempereur, Laetitia Houx, Sandra Bouvier, Rodolphe Bailly, and Sylvain Brochard
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children ,cerebral palsy ,motion analysis ,upper limb ,bimanual ,kinematics ,Chemical technology ,TP1-1185 - Abstract
The “Be an Airplane Pilot” (BE API) protocol was developed to evaluate upper limb (UL) kinematics in children with unilateral cerebral palsy (uCP) during bimanual tasks. The aim of this study was to investigate the responsiveness of this protocol to changes in kinematics and movement quality after UL therapies, using individual and group analyses, and to analyse the relationships between kinematic and functional changes in these children. Twenty children with uCP (5–15 years old) either participated in bimanual intensive therapy or received UL botulinum toxin injections. All the children performed the BE API protocol and functional assessments (Assisting Hand Assessment [AHA]) before and after the interventions. The individual analyses found kinematic changes in 100% of the children after therapy. The group analysis found significantly higher trunk and shoulder deviations after the intensive therapy. No significant changes were found for smoothness or trajectory straightness. The changes in the kinematic deviations were moderately correlated with the changes in the AHA scores. This study confirmed the responsiveness of the BE API protocol to change after therapy; therefore, the protocol is now fully validated and can be implemented in clinical practice. Its use should help in the accurate identification of impairments so that individualized treatments can be proposed.
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- 2023
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8. The Use and Outcomes of Motor Rehabilitation Services Among People With Cerebral Palsy Change Across the Lifespan
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Gwenaël Cornec, Sylvain Brochard, Gaelle Drewnowski, Isabelle Desguerre, Philippe Toullet, Audrey Fontaine, Yann Le Lay, Julia Boivin, Eric Bérard, Maria Bodoria, Vincent Gautheron, and Javier De la Cruz
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disability ,cerebral palsy ,rehabilitation ,healthcare service ,transition to adult care ,adult neurology ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background and AimsThe provision of coordinated and multidisciplinary rehabilitation programs that adapt to the individual with cerebral palsy (CP) evolving rehabilitation needs throughout the different phases of life is highly challenging for healthcare systems. The aim of this study was to report the changes in motor rehabilitation (MR) environmental factors, service use and patient outcomes between children and adults with cerebral palsy and to identify if changes took place earlier or later than the standard division between pediatric and adult healthcare systems at 18 years.MethodsWe used data from the French ESPaCe survey to select a set of indicators for MR environmental factors, service use and patient outcomes, highlighted by patients and families in previous studies. We then compared the distribution of the indicator data between children and adults, as well as between four transition age groups: children under 12, adolescents up to 17 years, young adults, and adults over 25 years of age. We estimated odds ratios adjusted for motor involvement, associated impairments and informant type.ResultsA total of 997 respondents over 2 years of age were included in this study (484 children and 513 adults). Finding an available physiotherapist was very difficult for almost half of the children, and a greater proportion of adolescents and adults. Physiotherapy was provided in a private outpatient practice for twice as many adults over 25 years as children and adolescents. The weekly amount of physical therapy decreased as outpatient practice increased. Multidisciplinary rehabilitation decreased sharply from adolescence and was halved at adulthood. Satisfaction with the MR program decreased from childhood into adolescence and adulthood. Perceived impact of physiotherapy on people with CP and their main carers were less positive in adolescents.ConclusionsHealthcare policies should focus on accessibility issues at all ages, consider adolescents as a specific population, consider a wide transition phase (12–25 yo) and maintain a multidisciplinary approach at adulthood. There is a strong need for national rehabilitation strategies for individuals with CP.
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- 2022
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9. Protocol of changes induced by early Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (e-HABIT-ILE) in pre-school children with bilateral cerebral palsy: a multisite randomized controlled trial
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Rodrigo Araneda, Stephane V. Sizonenko, Christopher J. Newman, Mickael Dinomais, Gregoire Le Gal, Daniela Ebner-Karestinos, Julie Paradis, Anne Klöcker, Geoffroy Saussez, Josselin Demas, Rodolphe Bailly, Sandra Bouvier, Emmanuel Nowak, Andrea Guzzetta, Inmaculada Riquelme, Sylvain Brochard, and Yannick Bleyenheuft
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Cerebral palsy ,Intensive training ,Bilateral ,Randomized controlled trials ,Neuroplasticity ,Biomechanical changes ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background Cerebral palsy (CP), which is the leading cause of motor disability during childhood, can produce sensory and cognitive impairments at different degrees. Most recent therapeutic interventions for these patients have solely focused on upper extremities (UE), although more than 60% of these patients present lower extremities (LE) deficits. Recently, a new therapeutic concept, Hand-arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE), has been proposed, involving the constant stimulation of UE and LE. Based on motor skill learning principles, HABIT-ILE is delivered in a day-camp setting, promoting voluntary movements for several hours per day during 10 consecutive week days. Interestingly, the effects of this intervention in a large scale of youngsters are yet to be observed. This is of interest due to the lack of knowledge on functional, neuroplastic and biomechanical changes in infants with bilateral CP. The aim of this randomized controlled study is to assess the effects of HABIT-ILE adapted for pre-school children with bilateral CP regarding functional, neuroplastic and biomechanical factors. Methods This international, multicentric study will include 50 pre-school children with CP from 12 to 60 months of age, comparing the effect of 50 h (2 weeks) of HABIT-ILE versus regular motor activity and/or customary rehabilitation. HABIT-ILE presents structured activities and functional tasks with continuous increase in difficulty while the child evolves. Assessments will be performed at 3 period times: baseline, two weeks later and 3 months later. The primary outcome will be the Gross Motor Function Measure 66. Secondary outcomes will include Both Hands Assessment, Melbourne Assessment-2, Semmes-Weinstein Monofilament Test, algometry assessments, executive function tests, ACTIVLIM-CP questionnaire, Pediatric Evaluation of Disability Inventory (computer adaptative test), Young Children’s Participation and Environment Measure, Measure of the Process of Care, Canadian Occupational Performance Measure, neuroimaging and kinematics. Discussion The results of this study should highlight the impact of a motor, intensive, goal-directed therapy (HABIT-ILE) in pre-school children at a functional, neuroplastic and biomechanical level. In addition, this changes could demonstrated the impact of this intervention in the developmental curve of each child, improving functional ability, activity and participation in short-, mid- and long-term. Name of the registry Evaluation of Functional, Neuroplastic and Biomechanical Changes Induced by an Intensive, Playful Early-morning Treatment Including Lower Limbs (EARLY-HABIT-ILE) in Preschool Children With Uni and Bilateral Cerebral Palsy (HABIT-ILE). Trial registration NCT04017871 Registration date July 12, 2019.
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- 2020
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10. Dynamic MRI for articulating joint evaluation on 1.5 T and 3.0 T scanners: setup, protocols, and real-time sequences
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Marc Garetier, Bhushan Borotikar, Karim Makki, Sylvain Brochard, François Rousseau, and Douraïed Ben Salem
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Joints ,Motion ,Musculoskeletal system ,Magnetic resonance imaging ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Dynamic magnetic resonance imaging (MRI) is a non-invasive method that can be used to increase the understanding of the pathomechanics of joints. Various types of real-time gradient echo sequences used for dynamic MRI acquisition of joints include balanced steady-state free precession sequence, radiofrequency-spoiled sequence, and ultra-fast gradient echo sequence. Due to their short repetition time and echo time, these sequences provide high temporal resolution, a good signal-to-noise ratio and spatial resolution, and soft tissue contrast. The prerequisites of the evaluation of joints with dynamic MRI include suitable patient installation and optimal positioning of the joint in the coil to allow joint movement, sometimes with dedicated coil support. There are currently few recommendations in the literature regarding appropriate protocol, sequence standardizations, and diagnostic criteria for the use of real-time dynamic MRI to evaluate joints. This article summarizes the technical parameters of these sequences from various manufacturers on 1.5 T and 3.0 T MRI scanners. We have reviewed pertinent details of the patient and coil positioning for dynamic MRI of various joints. The indications and limitations of dynamic MRI of joints are discussed.
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- 2020
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11. Improvement in Gait and Participation in a Child with Angelman Syndrome after Translingual Neurostimulation Associated with Goal-Oriented Therapy: A Case Report
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Delphine Gaudin-Drouelle, Laetitia Houx, Mathieu Lempereur, Sylvain Brochard, and Christelle Pons
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Angelman ,translingual neurostimulation ,gait analysis ,rehabilitation ,case report ,Pediatrics ,RJ1-570 - Abstract
Angelman syndrome is a genetic neurobehavioral syndrome characterized by motor and cognitive developmental delay, with a severe reduction in activity and participation. Treatments are limited and the effects of rehabilitation have not been studied. We report on the progress made by a 7-year-old boy with Angelman syndrome following an innovative synergic intervention involving translingual neurostimulation (TLNS) and goal-oriented rehabilitation to improve gait. The parents were interviewed regarding the child’s abilities and participation level and three-dimensional gait analysis was performed before and after the 4-week intervention (five days per week, 4 h per day) and 6 months later. Spatiotemporal and kinematic gait variables improved considerably at 4 weeks, with a reduction in lower limb agonist-antagonist co-contractions, and a large increase in walking distance (from 500 m to 2 km). The child’s engagement and ability to perform activities of daily living improved, as well as several functions not targeted by the intervention. Six months after cessation of the intervention, improvements were partially sustained. The rapid and considerable improvement in motor ability was likely due to potentiation of the rehabilitation by the TLNS. Further studies are required to understand the mechanisms underlying this effect and to determine if it is generalizable to other children with similar disorders.
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- 2022
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12. Improvement in activities and participation in an adolescent following secondary foot amputation
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Marion Prigent, Sylvain Brochard, Matthias Thepaut, Thierry Cornic, M.T. Cariou, Catherine Le Rouzic, Philippe Le Moine, Christelle Pons, and Laetitia Houx
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Amputation ,Children ,Rehabilitation ,Quality of life ,Participation ,Pediatrics ,RJ1-570 ,Surgery ,RD1-811 - Abstract
Background: When severe limb trauma occurs in a child, all efforts are made to preserve the limb as far as possible. In rare cases, however, secondary amputation may be necessary to improve functional outcome and participation. Case report: In this paper, we report on a young adolescent male with a severe loss of function following foot trauma, who underwent secondary trans-tibial amputation 17 months post injury. This paper describes how a structured multidisciplinary approach around the child and his family led to a successful outcome. Clinical rehabilitation impact: It is hoped that this case report may help other health professionals with decision-making in cases of secondary amputations, and to implement appropriate follow-up for such patients.
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- 2020
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13. Quantifying skeletal muscle volume and shape in humans using MRI: A systematic review of validity and reliability.
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Christelle Pons, Bhushan Borotikar, Marc Garetier, Valérie Burdin, Douraied Ben Salem, Mathieu Lempereur, and Sylvain Brochard
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Medicine ,Science - Abstract
AimsThe aim of this study was to report the metrological qualities of techniques currently used to quantify skeletal muscle volume and 3D shape in healthy and pathological muscles.MethodsA systematic review was conducted (Prospero CRD42018082708). PubMed, Web of Science, Cochrane and Scopus databases were searched using relevant keywords and inclusion/exclusion criteria. The quality of the articles was evaluated using a customized scale.ResultsThirty articles were included, 6 of which included pathological muscles. Most evaluated lower limb muscles. Partially or completely automatic and manual techniques were assessed in 10 and 24 articles, respectively. Manual slice-by-slice segmentation reliability was good-to-excellent (n = 8 articles) and validity against dissection was moderate to good(n = 1). Manual slice-by-slice segmentation was used as a gold-standard method in the other articles. Reduction of the number of manually segmented slices (n = 6) provided good to excellent validity if a sufficient number of appropriate slices was chosen. Segmentation on one slice (n = 11) increased volume errors. The Deformation of a Parametric Specific Object (DPSO) method (n = 5) decreased the number of manually-segmented slices required for any chosen level of error. Other automatic techniques combined with different statistical shape or atlas/images-based methods (n = 4) had good validity. Some particularities were highlighted for specific muscles. Except for manual slice by slice segmentation, reliability has rarely been reported.ConclusionsThe results of this systematic review help the choice of appropriate segmentation techniques, according to the purpose of the measurement. In healthy populations, techniques that greatly simplified the process of manual segmentation yielded greater errors in volume and shape estimations. Reduction of the number of manually segmented slices was possible with appropriately chosen segmented slices or with DPSO. Other automatic techniques showed promise, but data were insufficient for their validation. More data on the metrological quality of techniques used in the cases of muscle pathology are required.
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- 2018
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14. Dynamic MRI to quantify musculoskeletal motion: A systematic review of concurrent validity and reliability, and perspectives for evaluation of musculoskeletal disorders.
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Bhushan Borotikar, Mathieu Lempereur, Mathieu Lelievre, Valérie Burdin, Douraied Ben Salem, and Sylvain Brochard
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Medicine ,Science - Abstract
To report evidence for the concurrent validity and reliability of dynamic MRI techniques to evaluate in vivo joint and muscle mechanics, and to propose recommendations for their use in the assessment of normal and impaired musculoskeletal function.The search was conducted on articles published in Web of science, PubMed, Scopus, Academic search Premier, and Cochrane Library between 1990 and August 2017. Studies that reported the concurrent validity and/or reliability of dynamic MRI techniques for in vivo evaluation of joint or muscle mechanics were included after assessment by two independent reviewers. Selected articles were assessed using an adapted quality assessment tool and a data extraction process. Results for concurrent validity and reliability were categorized as poor, moderate, or excellent.Twenty articles fulfilled the inclusion criteria with a mean quality assessment score of 66% (±10.4%). Concurrent validity and/or reliability of eight dynamic MRI techniques were reported, with the knee being the most evaluated joint (seven studies). Moderate to excellent concurrent validity and reliability were reported for seven out of eight dynamic MRI techniques. Cine phase contrast and real-time MRI appeared to be the most valid and reliable techniques to evaluate joint motion, and spin tag for muscle motion.Dynamic MRI techniques are promising for the in vivo evaluation of musculoskeletal mechanics; however results should be evaluated with caution since validity and reliability have not been determined for all joints and muscles, nor for many pathological conditions.
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- 2017
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15. Muscle Activation during Gait in Children with Duchenne Muscular Dystrophy.
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Juliette Ropars, Mathieu Lempereur, Carole Vuillerot, Vincent Tiffreau, Sylviane Peudenier, Jean-Marie Cuisset, Yann Pereon, Fabien Leboeuf, Ludovic Delporte, Yannick Delpierre, Raphaël Gross, and Sylvain Brochard
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Medicine ,Science - Abstract
The aim of this prospective study was to investigate changes in muscle activity during gait in children with Duchenne muscular Dystrophy (DMD). Dynamic surface electromyography recordings (EMGs) of 16 children with DMD and pathological gait were compared with those of 15 control children. The activity of the rectus femoris (RF), vastus lateralis (VL), medial hamstrings (HS), tibialis anterior (TA) and gastrocnemius soleus (GAS) muscles was recorded and analysed quantitatively and qualitatively. The overall muscle activity in the children with DMD was significantly different from that of the control group. Percentage activation amplitudes of RF, HS and TA were greater throughout the gait cycle in the children with DMD and the timing of GAS activity differed from the control children. Significantly greater muscle coactivation was found in the children with DMD. There were no significant differences between sides. Since the motor command is normal in DMD, the hyper-activity and co-contractions likely compensate for gait instability and muscle weakness, however may have negative consequences on the muscles and may increase the energy cost of gait. Simple rehabilitative strategies such as targeted physical therapies may improve stability and thus the pattern of muscle activity.
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- 2016
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16. Towards a diagnostic tool for neurological gait disorders in childhood combining 3D gait kinematics and deep learning.
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Zhengyang Lan, Mathieu Lempereur, Gwenael Gueret, Laetitia Houx, Marine Cacioppo, Christelle Pons, Johanne Mensah, Olivier Rémy-Néris, Abdeldjalil Aïssa-El-Bey, François Rousseau 0002, and Sylvain Brochard
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- 2024
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17. Morphological analysis of ankle shorts bones of children with cerebral palsy: a comparative study.
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Yue Cheng, Rodolphe Bailly, Bhushan Borotikar, Claire Scavinner-Dorval, Benjamin Fouquet, Douraied Ben Salem, Sylvain Brochard, and François Rousseau 0002
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- 2023
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18. Semi-automatic muscle segmentation in MR images using deep registration-based label propagation.
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Nathan Decaux, Pierre-Henri Conze, Juliette Ropars, Xinyan He, Frances T. Sheehan, Christelle Pons, Douraied Ben Salem, Sylvain Brochard, and François Rousseau 0002
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- 2023
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19. Deep convolutional encoder-decoders for deltoid segmentation using healthy versus pathological learning transferability.
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Pierre-Henri Conze, Christelle Pons, Valérie Burdin, Frances T. Sheehan, and Sylvain Brochard
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- 2019
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20. 4D in vivo quantification of ankle joint space width using dynamic MRI.
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Karim Makki, Bhushan Borotikar, Marc Garetier, Oscar Acosta, Sylvain Brochard, Douraied Ben Salem, and François Rousseau 0002
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- 2019
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21. Temporal resolution enhancement of dynamic MRI sequences within a motion-based framework.
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Karim Makki, Bhushan Borotikar, Marc Garetier, Sylvain Brochard, Douraied Ben Salem, and François Rousseau 0002
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- 2019
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22. Independent sequences and freeness criteria
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Sylvain Brochard
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13C10 (primary), 13C40, 13D02, 11F80 (secondary) ,Algebra and Number Theory ,Mathematics - Number Theory ,FOS: Mathematics ,Number Theory (math.NT) ,Commutative Algebra (math.AC) ,Mathematics - Commutative Algebra - Abstract
Let $M$ be a module over a Noetherian local ring $A$. We study $M$-independent sequences of elements of $\mathfrak{m}_A$ in the sense of Lech and Hanes. The main tool is a new characterization of the $M$-independence of a sequence in terms of the associated Koszul complex. As applications, we give a result in linkage theory, a freeness criterion for $M$ in terms of the existence of a strongly $M$-independent sequence of length $edim(A)$, and another freeness criterion inspired from the patching method of Calegari and Geraghty for balanced modules in their 2018 paper., 17 pages
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- 2023
23. High-resolution temporal reconstruction of ankle joint from dynamic MRI.
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Karim Makki, Bhushan Borotikar, Marc Garetier, Sylvain Brochard, Douraied Ben Salem, and François Rousseau 0002
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- 2018
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24. Chirurgie du muscle droit fémoral dans le traitement de la marche en genou raide : revue systématique et méta-analyse
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Matthias Thepaut, Hassene Affes, Sylvain Brochard, Christelle Pons, Julie Chan-Waï-Nam, Camille Printemps, and Antoine Josse
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Orthopedics and Sports Medicine ,Surgery - Abstract
Resume Introduction Le transfert du muscle droit femoral (DF) a longtemps ete la reference dans le traitement de la marche en genou raide ou stiff knee gait (SKG). Son efficacite a ete remise en cause au profit de la tenotomie distale du DF. Notre objectif etait d’etudier l’efficacite de 2 techniques chirurgicales. Notre hypothese etait que ces 2 techniques amelioraient significativement 4 parametres cinematiques du genou a 1 an postoperatoire. Patients et methode Cette meta-analyse a ete realisee selon les criteres PRISMA. Les bases de donnees suivantes ont ete utilisees : Medline, Science Direct, Cochrane Registry, Scopus et Pascal. La recherche a ete effectuee jusqu’au 01/03/2020 par 2 auteurs (A.J & M.T). L’index MINORS evaluait la qualite methodologique des etudes. Les etudes devaient comprendre des patients avec SKG, operes d’un transfert ou d’une tenotomie distale du DF. La meta-analyse des effets de la chirurgie a ete realisee sur 4 parametres : Peak Knee Flexion during swing (PKFSW) ; Knee Range of Motion (KROM) ; time to Peak Knee Flexion (t-PKFGC) ; Maximum Knee Extension in Stance Phase (MKEST). Le Standard Mean Deviation (SMD) evaluait la taille d’effet de l’intervention. Resultats Nous avons identifie 695 etudes, 16 ont ete incluses. Parmi elles, 14 etudiaient le transfert et 5 la tenotomie. Nous avons analyse les donnees de 768 patients soit 1079 membres. Seul le transfert du DF ameliore le PKFSW (SMD = 0,29) avec un effet faible. Les trois autres parametres sont ameliores avec un effet modere par les deux techniques. Discussion Nos resultats objectivent une amelioration de la cinematique du genou apres transfert mais seulement avec un effet faible ou modere de la chirurgie. L’effet de la tenotomie sur le PKF ne peut etre evalue dans cette meta-analyse en raison d’un biais de publication. La forte heterogeneite et le faible niveau de preuve des etudes incluses doivent faire interpreter nos resultats avec precautions. Niveau de preuve III.
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- 2023
25. Recommandations françaises de bonne pratique pour la paralysie cérébrale : Un long chemin, et maintenant ?
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Gaëlle Drewnowski, Sylvain Brochard, Julia Boivin, Danièle Langloys, Jacky Vagnoni, Philippe Toullet, and Alain Chatelin
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Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation - Published
- 2023
26. Subject-specific shoulder muscle attachment region prediction using statistical shape models: A validity study.
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Asma Salhi, Valérie Burdin, Tinashe E. M. Mutsvangwa, Sudesh Sivarasu, Sylvain Brochard, and Bhushan Borotikar
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- 2017
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27. A fast and memory-efficient algorithm for smooth interpolation of polyrigid transformations: application to human joint tracking.
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Karim Makki, Bhushan Borotikar, Marc Garetier, Sylvain Brochard, Douraied Ben Salem, and François Rousseau 0002
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- 2020
28. Participation in physical activity of adolescents with congenital heart disease
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Pauline Lavenant, Marine Cacioppo, Hélène Ansquer, Sophie Guillaumont, Laetitia Houx, Sylvain Brochard, Pascal Amedro, and Christelle Pons
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Pediatrics, Perinatology and Child Health ,Public Health, Environmental and Occupational Health ,Developmental and Educational Psychology - Abstract
Participation in physical activity improves health in individuals with congenital heart disease. However, most do not sufficiently engage in physical activity. The aim of this study was to collect information regarding the experiences of adolescents with congenital heart disease who practiced physical activities.French adolescents aged 13-18 years, diagnosed with congenital heart disease, class I or II dyspnoea on the NYHA scale and authorized physical activity were interviewed individually about their physical activity experiences using a semi-structured format. The qualitative interview transcript data were analysed using a phenomenological approach; data analysis was performed independently by three researchers and merged at each step until saturation.Eleven adolescents with congenital heart disease participated. Three main themes emerged: 'own representation', 'physical activity (PA) set-up' and 'environment'. Adolescents had a generally positive view of physical activity, which was associated with positive experiences. However, they reported that their physical condition limited PA, and they wished for adapted activities. The results revealed the importance of environmental factors, for example, within the social and school environments. The participants indicated that they appreciated the social interactions that PA afforded, but that integration into a group could be difficult, especially in school, with some participants describing feelings such as anxiety, frustration or guilt when they could not participate fully. PA facilitators included familial support. However, participants noted a lack of clear medical guidance to help them choose suitable activities based on their circumstances and personal preferences. They wished for the public to be better informed about congenital heart disease to reduce stigmatism.This study provides valuable information for clinicians, physical educators and policy makers to help them promote physical activity and support adolescents and their families in understanding their own condition, maximizing their potential and in their choice of activities.
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- 2022
29. Développement d’un nouvel outil de communication « enfant-thérapeute » pour améliorer la motivation en rééducation : KID’EM
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Fanny Breton, Laetitia Houx, Sylvain Brochard, and Rodolphe Bailly
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Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation - Published
- 2022
30. Incidence and risk factors for care-related pain in children with physical disabilities
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Amandine DUBOIS, Caroline HALL, Emmanuelle COURTOIS-COMMUNIER, Arnaud BRASSEUR, Marine CACIOPPO, and Sylvain BROCHARD
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Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation - Published
- 2023
31. Healthy versus pathological learning transferability in shoulder muscle MRI segmentation using deep convolutional encoder-decoders.
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Pierre-Henri Conze, Sylvain Brochard, Valérie Burdin, Frances T. Sheehan, and Christelle Pons
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- 2019
32. Assistive Products and Technology to Facilitate Activities and Participation for Children with Disabilities
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Johanne Mensah-Gourmel, Margot Thépot, Jan Willem Gorter, Maxime Bourgain, Christèle Kandalaft, Alain Chatelin, Guy Letellier, Sylvain Brochard, and Christelle Pons
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children ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,participation ,survey ,daily life ,assistive products and technology ,needs - Abstract
We aimed to identify activity limitations and participation restrictions encountered by children and youth with disabilities for which assistive products and technology could be helpful. We used a convergent, parallel, mixed-methods design involving a nationwide, French survey composed of closed questions (quantitative) and open questions (qualitative) that enlightened the quantitative data. A total of 1055 responses were received, and 962 included: 92 from children and youth with disabilities, 493 from relatives and 377 from professionals. Difficulties frequently checked and described in detail were participation in recreational activities, leaving the house and traveling, participating in a group, and getting ready. Transversal explanations for difficulties were spontaneously provided (e.g., lack of accessibility and mobility). Solutions proposed included personal assistive devices to facilitate home life, high-tech devices, devices to compensate for impaired body functions, and adaptation of the familiar environment and daily activities. Few public solutions were proposed. The necessity of human assistance was emphasized. The mixed-methods design and involvement of different stakeholders identified common, macroscopic trends in difficulties encountered and desired solutions. Products and technology are required in the following domains: the familiar environment, accessibility and mobility, sports and leisure, high-technology, and family support. We provide suggestions to facilitate the development of innovative solutions.
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- 2023
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33. Assessing spino-cortical proprioceptive processing in childhood unilateral cerebral palsy with corticokinematic coherence
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Josselin Démas, Mathieu Bourguignon, Xavier De Tiège, Vincent Wens, Nicolas Coquelet, Antonin Rovai, Sandra Bouvier, Rodolphe Bailly, Sylvain Brochard, Mickael Dinomais, and Patrick Van Bogaert
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Neurology ,Cerebral Palsy ,Child, Preschool ,Movement ,Physiology (medical) ,Humans ,Infant ,Magnetoencephalography ,Neurology (clinical) ,General Medicine ,Child ,Hand ,Proprioception - Abstract
To develop an electrophysiological marker of proprioceptive spino-cortical tracts integrity based on corticokinematic coherence (CKC) in young children with unilateral cerebral palsy (UCP), in whom behavioral measures are not applicable.Electroencephalography (EEG) signals from 12 children with UCP aged 19 to 57 months were recorded using 128-channel EEG caps while their fingers were moved at 2 Hz by an experimenter, in separate sessions for the affected and non-affected hands. The coherence between movement kinematics and EEG signals (i.e., CKC) was computed at the sensor and source (using a realistic head model) levels. Peaks of CKC obtained for the affected and non-affected hands were compared for location and strength. The relation between CKC strength on the lesion-side, the lesion-type (cortico-subcortical vs. subcortical) and the level of manual ability were studied with 2-way repeated-measures ANOVA.At the individual level, a significant CKC peak at the central area contralateral to the moved hand was found in all young children with their non-affected hand and in 8 out of 12 children with their affected hand. At the group level, CKC to the affected hand movements was weaker than CKC to the non-affected hand movements. This difference was influenced by the type of lesion, the effect being predominant in the subgroup (n = 5) with cortico-subcortical lesions.CKC is measurable with EEG in young children with UCP and provides electrophysiological evidence for altered proprioceptive spino-cortical tracts on the lesioned brain hemisphere, particularly in children with cortico-subcortical lesions.
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- 2022
34. Healthy versus pathological learning transferability in shoulder muscle MRI segmentation using deep convolutional encoder-decoders.
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Pierre-Henri Conze, Sylvain Brochard, Valérie Burdin, Frances T. Sheehan, and Christelle Pons
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- 2020
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35. A FREENESS CRITERION WITHOUT PATCHING FOR MODULES OVER LOCAL RINGS
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Sylvain Brochard, Srikanth B. Iyengar, and Chandrashekhar B. Khare
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Mathematics - Number Theory ,General Mathematics ,FOS: Mathematics ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,13C10 (primary), 13D02, 11F80 (secondary) ,Number Theory (math.NT) ,Commutative Algebra (math.AC) ,Mathematics - Commutative Algebra - Abstract
It is proved that if $\varphi\colon A\to B$ is a local homomorphism of commutative noetherian local rings, a nonzero finitely generated $B$-module $N$ whose flat dimension over $A$ is at most $\mathrm{edim}\, A - \mathrm{edim}\, B$, is free over $B$, and $\varphi$ is a special type of complete intersection. This result is motivated by a "patching method" developed by Taylor and Wiles, and a conjecture of de Smit, proved by the first author, dealing with the special case when $N$ is flat over $A$., Comment: 11 page; minor changes in version 2. To appear in J. Inst. Math. Jussieu
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- 2021
36. Implementation of Motor Function Measure score percentile curves - Predicting motor function loss in Duchenne muscular dystrophy
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Patricia Hafner, Simone Schmidt, Sabine Schädelin, Pascal Rippert, Dalil Hamroun, Solenn Fabien, Bettina Henzi, Niveditha Putananickal, Daniela Rubino-Nacht, Carole Vuillerot, Dirk Fischer, Stéphanie Fontaine-Carbonnel, Camille De Montferrand, Sylvie Ragot-Mandry, Stéphane Chabrier, Manuella Fournier Mehouas, Hélène Rauscent, Claude Cances, François Rivier, Jon Andoni Urtizberea, Sylviane Peudenier, Sylvain Brochard, Emmanuelle Lagrue, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), University of Basel (Unibas), Hospices Civils de Lyon (HCL), Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), MFM registry Study Group: Stéphanie Fontaine-Carbonnel, Camille De Montferrand, Sylvie Ragot-Mandry, Stéphane Chabrier, Manuella Fournier Mehouas, Hélène Rauscent, Claude Cances, François Rivier, Jon Andoni Urtizberea, Sylviane Peudenier, Sylvain Brochard, Emmanuelle Lagrue, and MORNET, Dominique
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Disease progression ,Adolescent ,[SDV]Life Sciences [q-bio] ,General Medicine ,Duchenne ,Muscular dystrophy ,Reference values ,[SDV] Life Sciences [q-bio] ,Muscular Dystrophy, Duchenne ,Neuromuscular diseases ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Pediatrics, Perinatology and Child Health ,Humans ,Neurology (clinical) ,Motor skills disorder ,Child ,Glucocorticoids ,030217 neurology & neurosurgery ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience; The Motor Function Measure is a standardized scoring system to evaluate motor function and monitor disease progression in neuromuscular diseases such as Duchenne muscular dystrophy. There are no available reference percentile curves for this measure. The aim of this analysis was to generate Motor Function Measure percentile curves for ambulant and non-ambulant patients affected by Duchenne Muscular Dystrophy, providing the opportunity to better evaluate the status and progression of an individual patient compared to other patients in the same age group. Data of patients aged between 6 and 15 years (819 measurements) was obtained from the international Motor Function Measure database. Age-dependent percentile curves were estimated using a "Generalized additive model for location, scale and shape" as suggested by the World Health Organisation Multicentre Growth Reference Study Group. Percentile curves for the Motor Function Measure total score and its sub-scores for patients with and without treatment with glucocorticoids are presented. Mean scores decline with age. Patients treated with glucocorticoids have higher mean values compared to glucocorticoid-naïve patients at the same age. The percentile curves with the online tool extend the clinical utility of the Motor Function Measure by facilitating the interpretation of individual standing and disease progression.
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- 2022
37. Starting from the needs: what are the appropriate sources to co-create innovative solutions for persons with disabilities?
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Johanne Mensah-Gourmel, Maxime Bourgain, Christèle Kandalaft, Alain Chatelin, Odile Tissier, Guy Letellier, Jan Willem Gorter, Sylvain Brochard, Christelle Pons, Asma Benyahia, Inès Bréchoire, Pauline Julia, Tuong-Xuân Nguyen-Luong, Pierre Mirlesse, Tomas Studenik, Sebastien Loriot, Brian Tesar, Nolwenn Le Menn, Thomas Gayon, Amelie Genot, Juliette Ropars, Christopher J Newman, Julie Paradis, Laetitia Houx, Rodolphe Bailly, and Martine Venineaux
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Speech and Hearing ,Rehabilitation ,Biomedical Engineering ,Orthopedics and Sports Medicine ,Physical Therapy, Sports Therapy and Rehabilitation - Abstract
Technical solutions could facilitate activities and participation in individuals with disabilities. For the development of solutions, hackathons are a method of interdisciplinary collaboration. For hackathon, the definition of pain points that require solutions is crucial. We aimed to determine engineers' preferences and expectations regarding pain point qualities.We used a collaborative approach involving individuals with disability, families, and healthcare professionals to determine pain points for use by engineering students during a disability Hackathon. A pain point bank was built using 3 upstream sources: a survey (350 responses, 20 pain points selected), interviews (8 children, 13 pain points), and a multidisciplinary workshop based on design thinking methods (45 people, 32 pain points). A fourth source was 20 adults with disabilities present during the Hackathon. Engineering students rated pain point qualities from each source in a questionnaire that included closed questions relating to predefined criteria: achievability, specificity, relevance and attractiveness and open questions to collect non-predefined quality criteria.Pain points from the workshop were most frequently used (48%); followed by on-site discussions with mentors (43%), the survey (38%), and interviews (31%). On-site discussions received the highest quality ratings followed by the workshop, survey, and interviews. Three quality criteria emerged from the responses to open questions: "representative", "empathy", and "real-need".To be actionable by engineers, pain points must relate to real needs, be achievable, specific, relevant and attractive but also representative and arouse empathy. We devised a checklist of qualities along with a toolbox of methods to achieve each.Implications For RehabilitationThe first step of the development of technical solutions for children and individuals with disabilities is the identification of their needs and their adequate formulation to be submitted to technical solutions providers.Daily life needs of individuals with disability were gathered for an engineering hackathon and proposed as pain points to 400 engineering students.To facilitate the development of solutions by engineers, pain points must relate to real needs, be specific, relevant, achievable and attractive; be representative and arouse empathy; a toolbox of needs collection methods is proposed to achieve each of those qualities.Discussions with individuals with disability and health professionals should be provided.
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- 2022
38. Rectus femoris surgery for the correction of stiff knee gait in cerebral palsy: A systematic review and meta-analysis
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Julie Chan-Waï-Nam, Sylvain Brochard, Christelle Pons, Camille Printemps, Matthias Thepaut, Antoine Josse, and Hassene Affes
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medicine.medical_specialty ,business.industry ,Study methodology ,Publication bias ,Knee extension ,medicine.disease ,Surgery ,Cerebral palsy ,Meta-analysis ,medicine ,Time to peak ,Orthopedics and Sports Medicine ,business ,Range of motion ,Stiff knee gait - Abstract
Introduction Rectus femoris (RF) transfer was long the gold-standard treatment for stiff knee gait (SKG), but efficacy now seems less than that of distal RF release. The aim of the present study was to compare efficacy between the two. The study hypothesis was that both significantly improve 4 knee kinematic parameters at 1 year. Patients and Method A meta-analysis was performed, using PRISMA criteria, on the Medline, Science Direct, Cochrane Registry, Scopus and Pascal databases. Search was conducted up to March 1, 2020 by two authors (A.J & M.T). Study methodology was assessed on MINORS index. Inclusion criteria comprised patients with SKG, treated by RF transfer or distal release. Endpoints comprised: Peak Knee Flexion in swing phase (PKFSW), Knee Range of Motion (KROM), time to Peak Knee Flexion (t-PKFGC), and Maximum Knee Extension in stance phase (MKEST). Effect size was assessed on Standard Mean Deviation (SMD). Results A total of 695 studies were identified, 16 of which were included: 14 transfer, 5 release. Data were analyzed for 1,079 limbs in 768 patients. Only transfer improved PKFSW, with small effect size (SMD = 0.29). The other three parameters were improved by both techniques, with moderate effect size. Discussion Results showed improved knee kinematics after RF transfer, but with small or moderate effect size. The effect of distal release on PKF could not be assessed, due to publication bias. The heterogeneity of studies and low levels of evidence call for caution in interpreting the present results. Level of evidence III.
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- 2023
39. Neuropsychological Profile of Intellectually Gifted Children: A Systematic Review
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Justine Allard, Aurélie Bucaille, S. Peudenier, Arnaud Roy, Sylvain Brochard, and Christophe Jarry
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Intelligence ,Population ,Neuropsychological Tests ,Executive Function ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Child ,education ,Problem Solving ,education.field_of_study ,Intelligence quotient ,Working memory ,Child, Gifted ,General Neuroscience ,05 social sciences ,050301 education ,Cognition ,Executive functions ,Social problem-solving ,Psychiatry and Mental health ,Clinical Psychology ,Memory, Short-Term ,Systematic review ,Learning disability ,Neurology (clinical) ,medicine.symptom ,0503 education ,030217 neurology & neurosurgery ,Cognitive psychology - Abstract
Objective:The term intellectually gifted (IG) refers to children of high intelligence, which is classically measured by the intelligence quotient (IQ). Some researchers assume that the cognitive profiles of these children are characterized by both strengths and weaknesses, compared with those of their typically developing (TD) peers of average IQ. The aim of the present systematic review was to verify this assumption, by compiling data from empirical studies of cognitive functions (language, motor skills, visuospatial processing, memory, attention and executive functions, social and emotional cognition) and academic performances.Method:The literature search yielded 658 articles, 15 of which met the selection criteria taken from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses model. We undertook a qualitative summary, to highlight any discrepancies between cognitive functions.Results:IG children exhibited better skills than TD children in a number of domains, including attention, language, mathematics, verbal working memory, shifting, and social problem solving. However, the two groups had comparable skills in visuospatial processing, memory, planning, inhibition, and visual working memory, or facial recognition.Conclusion:Although IG children may have some strengths, many studies have failed to find differences between this population and their TD peers on many other cognitive measures. Just like any other children, they can display learning disabilities, which can be responsible for academic underachievement. Further studies are needed to better understand this heterogeneity. The present review provides pointers for overcoming methodological problems and opens up new avenues for giftedness research.
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- 2021
40. Parent satisfaction with medical and rehabilitation services for children with physical disabilities during lockdown
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Marine Cacioppo, Clémence Lucas, Shenhao Dai, Rodolphe Bailly, Dominic Pérennou, Roxane Varengue, Laetitia Houx, Mathieu Lempereur, Christèle Kandalaft, Alain Chatelin, Jacky Vagnoni, Carole Vuillerot, Vincent Gautheron, Mickael Dinomais, Elea Dheilly, Sandra Bouvier, Sylvain Brochard, Christelle Pons, Emmanuelle Filly, Johanne Mensah-Gourmel, Amélie Génot, Juliette Ropars, Philippe Toullet, Capucine De Lattre, Evelyne Klinger, Isabelle Laffont, Clara Sitruk, Patrick Van Boagert, and Chantal Tessiot
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Rehabilitation ,Orthopedics and Sports Medicine - Published
- 2022
41. Assessment and comparison of image quality between two real-time sequences for dynamic MRI of distal joints at 3.0 Tesla
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Marc Garetier, Jean Rousset, Karim Makki, Sylvain Brochard, François Rousseau, Douraïed Ben Salem, and Bhushan Borotikar
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Radiological and Ultrasound Technology ,Radiology, Nuclear Medicine and imaging ,General Medicine - Abstract
Background Real-time sequences allow functional evaluation of various joint structures during a continuous motion and help understand the pathomechanics of underlying musculoskeletal diseases. Purpose To assess and compare the image quality of the two most frequently used real-time sequences for joint dynamic magnetic resonance imaging (MRI), acquired during finger and ankle joint motion. Material and Methods A real-time dynamic acquisition protocol, including radiofrequency (RF)-spoiled and balanced steady-state free precession (bSSFP) sequences, optimized for temporal resolution with similar spatial resolution, was performed using a 3.0-T MRI scanner on 10 fingers and 12 ankles from healthy individuals during active motion. Image quality criteria were evaluated on each time frame and compared between these two sequences. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were determined and compared from regions of interest placed on cortical bone, tendon, fat, and muscle. Visualization of anatomical structures and overall image quality appreciation were rated by two radiologists using a 0–10 grading scale. Results Mean CNR was significantly higher with bSSFP sequence compared to RF-spoiled sequence. The grading score was in the range of 5–9.3 and was significantly higher with RF-spoiled sequence for bone and joint evaluation and overall image appreciation on the two joints. The standard deviation for SNR, CNR, and grading score during motion was smaller with RF-spoiled sequence for both the joints. The inter-reader reliability was excellent (>0.75) for evaluating anatomical structures in both sequences. Conclusion A RF-spoiled real-time sequence is recommended for the in vivo clinical evaluation of distal joints on a 3.0-T MRI scanner.
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- 2022
42. HABIT-ILE chez les enfants d’âge préscolaire atteints de paralysie cérébrale unilatérale : un essai contrôlé randomisé multisite
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Rodrigo Araneda, Daniela Ebner-Karestinos, Julie Paradis, Rodolphe Bailly, Sandra Bouvier, Anne Klöcker, Geoffroy Saussez, Josselin Demas, Stéphane Sizonenko, Christopher Newman, Mickael Dinomais, Grégoire Legal, Emmanuel Nowak, Andrea Guzzetta, Sylvain Brochard, and Yannick Bleyenheuft
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Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation - Published
- 2023
43. Using merged kinematic and anatomical data to evaluate humeral motion estimation: a pilot study.
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Cédric Schwartz, Fabien Leboeuf, Olivier Rémy-Néris, Sylvain Brochard, Mathieu Lempereur, and Valérie Burdin
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- 2013
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44. Evidence-Based, Implementable Motor Rehabilitation Guidelines for Individuals With Cerebral Palsy
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Anthony Demont, Michel Gedda, Céline Lager, Capucine de Lattre, Yann Gary, Elisabeth Keroulle, Brigitte Feuillerat, Hervé Caudan, Zoé Sancelme, Arnaud Isapof, Elke Viehweger, Matthieu Chatelin, Marianne Hochard, Julia Boivin, Pascale Vurpillat, Nathalie Genès, Xavier de Boissezon, Audrey Fontaine, and Sylvain Brochard
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Adolescent ,Cerebral Palsy ,Muscles ,Humans ,Neurology (clinical) ,Child ,Gait Disorders, Neurologic ,Physical Therapy Modalities ,Exercise Therapy - Abstract
BackgroundCerebral palsy is a life-long condition that causes heterogeneous motor disorders. Motor rehabilitation interventions must be adapted to the topography of the symptoms, ambulatory capacity, and age of the individual. Current guidelines do not differentiate between the different profiles of individuals with cerebral palsy, which limits their implementation.ObjectivesTo develop evidence-based, implementable guidelines for motor rehabilitation interventions for individuals with cerebral palsy according to the age, topography of the cerebral palsy, and ambulatory capacity of the individual and to determine a level of priority for each intervention.MethodsWe used a mixed methods design that combined a systematic review of the literature on available motor rehabilitation interventions with expert opinions. Based on the French National Authority for Health methodology, recommendations were graded as strong, conditional, or weak. Interventions were then prioritized by the experts according to both the evidence and their own opinions on relevance and implementability to provide a guide for clinicians. All recommendations were approved by experts who were independent from the working group.ResultsStrong recommendations as first-line treatments were made for gait training, physical activities, and hand-arm bimanual intensive therapy for all children and adolescents with cerebral palsy. Moderate recommendations were made against passive joint mobilizations, muscle stretching, prolonged stretching with the limb fixed, and neurodevelopmental therapies for all children and adolescents with cerebral palsy. Strong recommendations as first-line treatments were made for gait training for all adults with cerebral palsy and moderate recommendations as moderate importance interventions for strengthening exercises and ankle-foot orthoses for motor impairment of the feet and the ankles.DiscussionThese guidelines, which combine research evidence and expert opinions, could help individuals with cerebral palsy and their families to codetermine rehabilitation goals with health professionals, according to their preferences.
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- 2022
45. Motor patterns of the impaired upper limb in children with unilateral cerebral palsy performing bimanual tasks
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Marine Cacioppo, Mathieu Lempereur, Antoine Marin, Hélène Rauscent, Armel Crétual, Sylvain Brochard, Isabelle Bonan, Optimisation Continue des Actions Thérapeutiques par l'Intégration d'Informations Multimodales, Université de Brest (UBO)-Télécom Bretagne-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Fondation ILDYS (ILDYS), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Laboratoire Mouvement Sport Santé (M2S), Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Neuroimagerie: méthodes et applications (EMPENN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAL, IMAGE ET LANGAGE (IRISA-D6), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), This work was supported by the IPSEN Company. They provided financial support for the conduct of the research. They were not involved in study design, in the collection, analysis and interpretation of data, in the writing of the report, and and in the decision to submit the article for publication.
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Bimanual ,Motor pattern ,[SDV]Life Sciences [q-bio] ,Biophysics ,Torso ,Hand ,Biomechanical Phenomena ,Upper Extremity ,Motion analysis ,Humans ,Cerebral palsy ,Orthopedics and Sports Medicine ,Child ,Upper limb ,Children - Abstract
International audience; Background: Upper limb movement patterns have not yet been identified in bimanual conditions despite the difficulties children with unilateral cerebral palsy have performing bimanual activities. The aim was to identify specific motor patterns from kinematic deviations during bimanual tasks in this population. Methods: Twenty children with unilateral cerebral palsy and 20 age-matched, typically developing children performed the five tasks of a 3D bimanual protocol. To evaluate upper limb kinematic deviations, 10 Arm Variable Scores were calculated for the affected /non-dominant upper limb of each participant for each task. Sparse K-means cluster analysis was applied to the 50 Arm Variable Scores of all the children to identify motor patterns and determining variables. Clinical tests of impairment (muscle strength, selectivity, spasticity) and function (Assisting hand assessment, Abilhand-Kids) were compared between the clusters obtained. Findings: Three different motor patterns were identified using the data from all the children: mild, proximal-distal and proximal-distal with trunk. The most important cluster determinants were the Arm Variable Scores for pronation-supination and wrist extension. In the cerebral palsy group, scores of impairments (p < .01) and function (Assisting Hand Assessment [p < .0011 and Abilhand-Kids [p = .0041) differed for each motor pattern. Supination and wrist extension deviations differed significantly between the groups (p < .001). Interpretation: During performance of bimanual tasks, children with unilateral cerebral palsy used distinct motor patterns that each corresponded to a specific clinical profile. Elbow-wrist deviations were the largest and most decisive and were specific to the cerebral palsy group: they should be the target of interventions to enhance bimanual function. ClinicalTrials.gov identifier: NCT03888443
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- 2022
46. Duality for Commutative Group Stacks
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Sylvain Brochard
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Pure mathematics ,Functor ,General Mathematics ,010102 general mathematics ,Algebraic number field ,01 natural sciences ,Mathematics - Algebraic Geometry ,14K30, 14A20 ,Mathematics::Algebraic Geometry ,Section (category theory) ,Morphism ,Mathematics::Category Theory ,0103 physical sciences ,FOS: Mathematics ,Torsor ,Universal property ,010307 mathematical physics ,0101 mathematics ,Abelian group ,Algebraic Geometry (math.AG) ,Stack (mathematics) ,Mathematics - Abstract
We study in this article the dual of a (strictly) commutative group stack $G$ and give some applications. Using the Picard functor and the Picard stack of $G$, we first give some sufficient conditions for $G$ to be dualizable. Then, for an algebraic stack $X$ with suitable assumptions, we define an Albanese morphism $a_X : X\to A^1(X)$ where $A^1(X)$ is a torsor under the dual commutative group stack $A^0(X)$ of $Pic_{X/S}$. We prove that $a_X$ satisfies a natural universal property. We give two applications of our Albanese morphism. On the one hand, we give a geometric description of the elementary obstruction and of universal torsors (standard tools in the study of rational varieties over number fields). On the other hand we give some examples of algebraic stacks that satisfy Grothendieck's section conjecture., 40 pages. Final version, including the comments of the referees. To appear in IMRN
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- 2019
47. Detection of pronator muscle overactivity in children with unilateral spastic cerebral palsy: Development of a semi-automatic method using EMG data
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Aurélie Sarcher, Guy Letellier, Maxime Raison, Fabien Leboeuf, Raphaël Gross, Brigitte Perrouin-Verbe, and Sylvain Brochard
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Male ,030506 rehabilitation ,medicine.medical_specialty ,Adolescent ,Elbow ,Physical examination ,Electromyography ,Supination ,Cerebral palsy ,03 medical and health sciences ,0302 clinical medicine ,Spastic cerebral palsy ,Physical medicine and rehabilitation ,Predictive Value of Tests ,Positive predicative value ,medicine ,Humans ,Supinator muscle ,Pronation ,Orthopedics and Sports Medicine ,Child ,Paresis ,medicine.diagnostic_test ,business.industry ,Cerebral Palsy ,Rehabilitation ,Reproducibility of Results ,medicine.disease ,Biomechanical Phenomena ,medicine.anatomical_structure ,Muscle Spasticity ,Case-Control Studies ,Female ,medicine.symptom ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
Background The pronator teres and pronator quadratus muscles are frequently injected with neuromuscular blocking agents to improve supination in children with spastic cerebral palsy and limited active elbow supination. However, determining by simple clinical examination whether these muscles are overactive during active movement is difficult. Objective This study aimed to develop a semi-automatic method to detect pronator muscle overactivity by using surface electromyography (EMG) during active supination movements in children with cerebral palsy. Methods In total, 25 children with unilateral spastic cerebral palsy (10 males; mean [SD] age 10.6 [3.0] years) and 12 typically developing children (7 males; mean age 11.0 [3.0] years) performed pronation–supination movements at 0.50 Hz. Kinematic parameters and surface EMG signals were recorded for both pronator muscles. Three experts visually assessed muscle overactivity in the EMG signals of the children with cerebral palsy, in comparison with the reference group. The reliability and discrimination ability of the visual assessments were analysed. Overactivity detection thresholds for the semi-automatic method were adjusted by using the visual assessment by the EMG experts. The positive and negative predictive values of the semi-automatic detection method were calculated. Results Intra-rater reliability of visual assessment by EMG experts was excellent and inter-rater reliability was moderate. For the 25 children with unilateral spastic cerebral palsy, EMG experts could discriminate different profiles of pronator overactivity during active supination: no pronator overactivity, one overactive pronator, or overactivity of both pronators. The positive and negative predictive values were 96% and 91%, respectively, for this semi-automatic detection method. Conclusions Detection of pronator overactivity by using surface EMG provides an important complement to the clinical examination. This method can be used clinically, with the condition that clinicians be aware of surface EMG limitations. We believe use of this method can increase the accuracy of treatment for muscle overactivity, resulting in improved motor function and no worsening of paresis.
- Published
- 2019
48. Perceived impact of lockdown on daily life in children with physical disabilities and their families during the COVID-19 pandemic
- Author
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Roxane Varengue, Sylvain Brochard, Sandra Bouvier, Rodolphe Bailly, Laetitia Houx, Mathieu Lempereur, Christèle Kandalaft, Alain Chatelin, Jacky Vagnoni, Carole Vuillerot, Vincent Gautheron, Elea Dheilly, Christelle Pons, Mickael Dinomais, and Marine Cacioppo
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Male ,Parents ,Caregivers ,Pediatrics, Perinatology and Child Health ,Communicable Disease Control ,Public Health, Environmental and Occupational Health ,Developmental and Educational Psychology ,COVID-19 ,Humans ,Female ,Child ,Pandemics - Abstract
The first lockdown during COVID-19 pandemic in France led to an abrupt change in children's daily lives. For children with physical disabilities and their families, activities were limited, access to healthcare and therapy was disrupted, and family organization was altered. The objective was to report the impact of the lockdown on daily life activities and well-being of children with physical disabilities as perceived by caregivers.Two online national surveys were addressed to the parents of children with physical disabilities (ECHO survey: 6 April to 11 May 2020) and without disabilities (E-COPAIN survey: 24 April to 11 May 2020), confined at home during the lockdown. A lockdown impact score was calculated from difficulties related to children's well-being (morale, behaviour and social interaction) and daily life activities (schooling and physical activity) and compared between groups. Data on family environment, parental stress and concerns were collected.One thousand three hundred seventy-six children (9.45 ± 4.78 years, 54% girls) in ECHO survey and 367 children (7.3 ± 4.4 years, 48% girls) in E-COPAIN survey were included. A negative impact of lockdown was found on 81% of children with physical disabilities. Behavioural problems were significantly more frequent (59.5% vs. 47.4%, P .005) and parental stress was higher (6.1 ± 3.33 vs. 5.3 ± 3.01, P = .005) in the ECHO group. Associated impairments (odds ratio [OR] = 1.45 [1.30-1.62], P .001), parental stress (OR = 1.09 [1.06-1.12], P .001) and continuation of rehabilitation (OR = 0.80 [0.72-0.89], P .001) were determinants of the level of difficulty experienced.The lockdown had a considerable, negative impact on the daily life of children with disabilities and their families. Guiding policymakers with the essential daily life activities and the services to provide for children with physical disabilities would offer valuable insights to manage such a sanitary crisis and allow to identify the most vulnerable population.
- Published
- 2021
49. Wiles defect for modules and criteria for freeness
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Sylvain Brochard, Srikanth B Iyengar, and Chandrashekhar B Khare
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Mathematics::Commutative Algebra ,Mathematics - Number Theory ,General Mathematics ,Mathematics::Number Theory ,FOS: Mathematics ,11F80 (primary), 13C99, 13F99 (secondary) ,Number Theory (math.NT) ,Commutative Algebra (math.AC) ,Mathematics - Commutative Algebra - Abstract
F. Diamond proved a numerical criterion for modules over local rings to be free modules over complete intersection rings. We formulate a refinement of these results using the notion of Wiles defect. A key step in the proof is a formula that expresses the Wiles defect of a module in terms of the Wiles defect of the underlying ring., 15 pages; minor revision. To appear in the Int. Math. Res. Notices
- Published
- 2021
50. Emerging health challenges for children with physical disabilities and their parents during the COVID-19 pandemic: The ECHO French survey
- Author
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V. Gautheron, Marine Cacioppo, Carole Vuillerot, Sandra Bouvier, Sylvain Brochard, Mickael Dinomais, Rodolphe Bailly, Johanne Mensah-Gourmel, Alain Chatelin, Mathieu Lempereur, Laetitia Houx, Christèle Kandalaft, Roxane Varengue, Elea Dheilly, Jacky Vagnoni, and Christelle Pons
- Subjects
Occupational therapy ,Male ,030506 rehabilitation ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Adolescent ,Cross-sectional study ,medicine.medical_treatment ,Health benefits ,Article ,Cerebral palsy ,Children with physical disabilities ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Health care ,Pandemic ,Lockdown ,medicine ,Humans ,Orthopedics and Sports Medicine ,Child ,Pandemics ,Health Services Needs and Demand ,Rehabilitation ,business.industry ,Cerebral Palsy ,COVID-19 ,Infant ,Continuity of Patient Care ,medicine.disease ,Disabled Children ,Health risks ,Cross-Sectional Studies ,Family medicine ,Child, Preschool ,Female ,France ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
Background The daily lives of children with physical disabilities and their families have been significantly affected by the COVID-19 pandemic. The children face health risks, especially mental, behavioral, social and physical risks. Objective This study aimed to identify potential healthcare issues relating to the wellbeing of disabled children, continuity of rehabilitation and medical care, and parental concerns during the COVID-19 lockdown. Methods The Enfant Confinement Handicap besOins (ECHO [child lockdown disability needs]) national survey was developed by a multidisciplinary group and disseminated in France from April 6, 2020 via email and social networks. This online survey was addressed to the parents of children with physical disabilities aged 0 to 18 years. It explored the experiences of children and their families during the lockdown. Information regarding children's wellbeing, rehabilitation and family organization was collected. The first 1000 eligible surveys were analyzed. Results The children (mean [SD] age 9.5 [4.8] years) mostly had cerebral palsy (42%) or neuromuscular diseases (11%). The lockdown had negative effects on morale (44% of children), behaviour (55% of children) and social interactions (55% no contact with other children). Overall, 44% of children stopped physical activities; 76% were educated at home; 22% maintained medical follow-up, and 48% and 27% continued physiotherapy and occupational therapy respectively. For more than 60% of children, parents performed the therapy. The main parental concern was rehabilitation (72%) and their main difficulty was the mental load (50%); parents complained of lack of help and support (60%). Conclusions This study highlighted substantial effects on the health of children with physical disabilities and loss of opportunity, with a massive interruption of medical follow-up and rehabilitation, during the lockdown. Regular assessment of the health benefit/risk is essential to support families and ensure continuity of care during a pandemic.
- Published
- 2021
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