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While technical communication consultants and researchers agree that content strategy requires attention to both customer needs and business goals, we found no evidence that technical communication educators promote an accurate understanding of business goals among their content strategy students. Through industry-academia collaboration, we integrate two existing models, using content tactics within organizational characteristics that define the maturity level of an organization's content operations. Analyzing the current state of maturity for each characteristic highlights gaps that can define a content strategy with prioritized tactics and, ultimately, encourages the growth of technical communicator leadership and the empowerment of our profession.

Abstract Well-differentiated liposarcoma (WDLS) displays amplification of genes on chromosome 12 (Chr12) in supernumerary ring or giant marker chromosomes. These structures have been suggested to develop through chromothripsis, followed by circularization and breakage-fusion-bridge (BFB) cycles. To test this hypothesis, we compared WDLSs with Chr12 amplification in rod-shaped chromosomes with WDLSs with rings. Both types of amplicons share the same spectrum of structural variants (SVs), show higher SV frequencies in Chr12 than in co-amplified segments, have SVs that fuse the telomeric ends of co-amplified chromosomes, and lack interspersed deletions. Combined with the finding of cells with transient rod-shaped structures in tumors with ring chromosomes, this suggests a stepwise process starting with the gain of Chr12 material that, after remodeling which does not fit with classical chromothripsis, forms a dicentric structure with other chromosomes. Depending on if and when telomeres from other chromosomes are captured, circularized or linear gain of 12q sequences will predominate.

Sverige blev medlem i Europeiska unionen (EU) i januari 1995. Medlemskapet har förändrat förutsättningarna för den svenska demokratin i flera hänseenden. Den här artikeln behandlar medlemskapets effekter på svenska konstitutionella förhållanden, inklusive relationen mellan de centrala statsorganen. Därefter diskuteras de svenska partierna och den allmänna opinionens förhållningssätt till EU. Den allmänna opinionen har över tid utvecklats i en betydligt mer EU-positiv riktning. Det gäller dock inte frågor om ytterligare fördjupning av EU eller svensk anslutning till euron. Frågan om hur Sverige samarbetar med andra medlemsstater lyfts fram. Sveriges samarbete med länder i den geografiska närheten är omfattande. Bland de sakfrågor som Sverige har prioriterat som EU-medlem finns konkurrenskraft och den inre marknaden, klimat- och miljöpolitik, de grundläggande värderingarna samt EU:s utvidgning och utrikespolitik. Sverige har varit mindre entusiastiskt över ökade medel till EU:s budget, starkare gemensam social- och arbetsmarknadspolitik, ökad överstatlighet och stärkt försvarssamarbete. De breda framtidsfrågorna, inklusive frågor om institutionell reform, har sällan mötts av större intresse i Sverige. I ljuset av den nu pågående diskussionen om utvidgning och reform av EU vore det rimligt om dessa frågor fick större plats i den svenska debatten.

In this study, we characterized a Klebsiella pneumoniae strain in a patient with shrapnel hip injury, which resulted in multiple phenotypic changes, including the formation of a small colony variant (SCV) phenotype. Although already described since the 1960s, there is little knowledge about SCV phenotypes in Enterobacteriaceae. The formation of SCVs has been recognized as a bacterial strategy to evade host immune responses and compromise the efficacy of antimicrobial therapies, leading to persistent and recurrent courses of infections. In this case, 14 isolates with different resisto- and morpho-types were distinguished from the patient’s urine and tissue samples. Whole genome sequencing revealed that all isolates were clonally identical belonging to the K. pneumoniae high-risk sequence type 147. Subculturing the SCV colonies consistently resulted in the reappearance of the initial SCV phenotype and three stable normal-sized phenotypes with distinct morphological characteristics. Additionally, an increase in resistance was observed over time in isolates that shared the same colony appearance. Our findings highlight the complexity of bacterial behavior by revealing a case of phenotypic “hyper-splitting” in a K. pneumoniae SCV and its potential clinical significance.

BackgroundIndividuals with multiple sclerosis (MS) frequently report sexual dysfunction, a condition that may result in low sexual satisfaction and decreased quality of life. Although sexual dysfunction is usually treated pharmacologically, physical therapists, especially those trained in pelvic floor physical therapy (PT), are well-equipped to address a variety of impairments that contribute to poor sexual function. The current evidence for effectiveness of PT interventions in improving sexual dysfunction, sexual satisfaction, and the emotional well-being aspect of quality of life was analyzed.MethodsThe PubMed, CINAHL, and PEDro databases were searched through December 2019. Articles were included if participants had a clinical diagnosis of MS, reported sexual dysfunction or pain with intercourse, and had an intervention within the PT scope that addressed sexual dysfunction. Means and SDs were extracted from each study independently by two authors. Effect sizes (d) and 95% CIs were calculated within and across studies.ResultsEight studies met the inclusion criteria. Combined effects were significant and large across six studies for sexual function (d = 0.82, 95% CI, 0.57-1.06), moderate across seven studies for sexual satisfaction (d = 0.65, 95% CI, 0.43-0.87), and moderately large across two studies for emotional well-being (d = 0.78, 95% CI, 0.17-1.40). Between-group differences reached significance for sexual satisfaction (d = 0.29, 95% CI, 0.03-0.55).ConclusionsSexual function, sexual satisfaction, and emotional well-being can all be effectively addressed with various PT interventions. Highly effective interventions included pelvic floor muscle training and mindfulness. Future research should compare PT interventions with non-PT controls to determine best practice in this population.

Background Plant hormones influence phenology, development, and function of above and belowground plant structures. In seedlings, auxin influences the initiation and development of lateral roots and root systems. How auxin-related genes influence root initiation at early life stages has been investigated from numerous perspectives. There is a gap in our understanding of how these genes influence root size through the life cycle and in mature plants. Across development, the influence of a particular gene on plant phenotypes is partly regulated by the addition of a poly-A tail to mRNA transcripts via alternative polyadenylation (APA). Auxin related genes have documented variation in APA, with auxin itself contributing to APA site switches. Studies of the influence of exogenous auxin on natural plant accessions and mutants of auxin pathway gene families exhibiting variation in APA are required for a more complete understanding of genotype by development by hormone interactions in whole plant and fitness traits. Methods We studied Arabidopsis thaliana homozygous mutant lines with inserts in auxin-related genes previously identified to exhibit variation in number of APA sites. Our growth chamber experiment included wildtype Col-0 controls, mutant lines, and natural accession phytometers. We applied exogenous auxin through the life cycle. We quantified belowground and aboveground phenotypes in 14 day old, 21 day old seedlings and plants at reproductive maturity. We contrasted root, rosette and flowering phenotypes across wildtype, auxin mutant, and natural accession lines, APA groups, hormone treatments, and life stages using general linear models. Results The root systems and rosettes of mutant lines in auxin related genes varied in response to auxin applications across life stages and varied between genotypes within life stages. In seedlings, exposure to auxin decreased size, but increased lateral root density, whereas at reproductive maturity, plants displayed greater aboveground mass and total root length. These differences may in part be due to a shift which delayed the reproductive stage when plants were treated with auxin. Root traits of auxin related mutants depended on the number of APA sites of mutant genes and the plant’s developmental stage. Mutants with inserts in genes with many APA sites exhibited lower early seedling belowground biomass than those with few APA sites but only when exposed to exogenous auxin. As we observed different responses to exogenous auxin across the life cycle, we advocate for further studies of belowground traits and hormones at reproductive maturity. Studying phenotypic variation of genotypes across life stages and hormone environments will uncover additional shared patterns across traits, assisting efforts to potentially reach breeding targets and enhance our understanding of variation of genotypes in natural systems.

ABSTRACTThe growing need for biologics to be administered subcutaneously and ocularly, coupled with certain indications requiring high doses, has resulted in an increase in drug substance (DS) and drug product (DP) protein concentrations. With this increase, more emphasis must be placed on identifying critical physico-chemical liabilities during drug development, including protein aggregation, precipitation, opalescence, particle formation, and high viscosity. Depending on the molecule, liabilities, and administration route, different formulation strategies can be used to overcome these challenges. However, due to the high material requirements, identifying optimal conditions can be slow, costly, and often prevent therapeutics from moving rapidly into the clinic/market. In order to accelerate and derisk development, new experimental and in-silico methods have emerged that can predict high concentration liabilities. Here, we review the challenges in developing high concentration formulations, the advances that have been made in establishing low mass and high-throughput predictive analytics, and advances in in-silico tools and algorithms aimed at identifying risks and understanding high concentration protein behavior.

Abstract The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) pandemic has led to extensive virological monitoring by whole genome sequencing (WGS). Investigating the advantages and limitations of different protocols is key when conducting population-level WGS. SARS-CoV-2 positive samples with Ct values of 14–30 were run using three different protocols: the Twist Bioscience SARS‑CoV‑2 protocol with bait hybridization enrichment sequenced with Illumina, and two tiled amplicon enrichment protocols, ARTIC V3 and Midnight, sequenced with Illumina and Oxford Nanopore Technologies, respectively. Twist resulted in better coverage uniformity and coverage of the entire genome, but has several drawbacks: high human contamination, laborious workflow, high cost, and variation between batches. The ARTIC and Midnight protocol produced an even coverage across samples, and almost all reads were mapped to the SARS-CoV-2 reference. ARTIC and Midnight represent robust, cost-effective, and highly scalable methods that are appropriate in a clinical environment. Lineage designations were uniform across methods, representing the dominant lineages in Sweden during the period of collection. This study provides insights into methodological differences in SARS‑CoV‑2 sequencing and guidance in selecting suitable methods for various purposes.

Co-operation and group-serving behaviour of group members has increasingly been acknowledged as essential to theflourishing of groups in general and the success of teams in organizations or companies in particular. Studying this,however, presupposes dissociating individual-level and group-level effects (involving a Simpsons Paradox). We havestarted investigating settings where true individual- and group-level effects could be dissociated in a learning paradigmconcerned with individuals in changing teams. Our results show that participants often evaluated the overall most effectivegroup-serving team-player much more negatively than all less effective non-interacting workers. This suggested a potentialTragedy of Personnel Selection, when personnel managers, relying on number-based outcomes, tend to ignore even strongand crucial group-level effects of team-players. Here we briefly summarize some findings and present an experiment,where we tried to improve participants ability to dissociate individual- from group-level effects, by explicitly providingthem with hypotheses about a team player.

Abstract Background Klebsiella pneumoniae, which is frequently associated with hospital- and community-acquired infections, contains multidrug-resistant (MDR), hypervirulent (hv), non-MDR/non-hv as well as convergent representatives. It is known that mostly international high-risk clonal lineages including sequence types (ST) 11, 147, 258, and 307 drive their global spread. ST395, which was first reported in the context of a carbapenemase-associated outbreak in France in 2010, is a less well-characterized, yet emerging clonal lineage. Methods We computationally analyzed a large collection of K. pneumoniae ST395 genomes (n = 297) both sequenced in this study and reported previously. By applying multiple bioinformatics tools, we investigated the core-genome phylogeny and evolution of ST395 as well as distribution of accessory genome elements associated with antibiotic resistance and virulence features. Results Clustering of the core-SNP alignment revealed four major clades with eight smaller subclades. The subclades likely evolved through large chromosomal recombination, which involved different K. pneumoniae donors and affected, inter alia, capsule and lipopolysaccharide antigen biosynthesis regions. Most genomes contained acquired resistance genes to extended-spectrum cephalosporins, carbapenems, and other antibiotic classes carried by multiple plasmid types, and many were positive for hypervirulence markers, including the siderophore aerobactin. The detection of “hybrid” resistance and virulence plasmids suggests the occurrence of the convergent ST395 pathotype. Conclusions To the best of our knowledge, this is the first study that investigated a large international collection of K. pneumoniae ST395 genomes and elucidated phylogenetics and detailed genomic characteristics of this emerging high-risk clonal lineage.

Abstract Background This analysis addresses the characteristics of two emergency department (ED) patient populations defined by three model diseases (hip fractures, respiratory, and cardiac symptoms) making use of survey (primary) and routine (secondary) data from hospital information systems (HIS). Our aims were to identify potential systematic inconsistencies between both data samples and implications of their use for future ED-based health services research. Methods The research network EMANET prospectively collected primary data (n=1442) from 2017-2019 and routine data from 2016 (n=9329) of eight EDs in a major German city. Patient populations were characterized using socio-structural (age, gender) and health- and care-related variables (triage, transport to ED, case and discharge type, multi-morbidity). Statistical comparisons between descriptive results of primary and secondary data samples for each variable were conducted using binomial test, chi-square goodness-of-fit test, or one-sample t-test according to scale level. Results Differences in distributions of patient characteristics were found in nearly all variables in all three disease populations, especially with regard to transport to ED, discharge type and prevalence of multi-morbidity. Recruitment conditions (e.g., patient non-response), project-specific inclusion criteria (e.g., age and case type restrictions) as well as documentation routines and practices of data production (e.g., coding of diagnoses) affected the composition of primary patient samples. Time restrictions of recruitment procedures did not generate meaningful differences regarding the distribution of characteristics in primary and secondary data samples. Conclusions Primary and secondary data types maintain their advantages and shortcomings in the context of emergency medicine health services research. However, differences in the distribution of selected variables are rather small. The identification and classification of these effects for data interpretation as well as the establishment of monitoring systems in the data collection process are pivotal. Trial registration DRKS00011930 (EMACROSS), DRKS00014273 (EMAAGE), NCT03188861 (EMASPOT)

To prepare students for the workforce, instructors of business, technical, and professional communication must incorporate team projects in their curriculum. However, both instructors and students have negative perceptions of team projects due to a variety of factors including team dysfunctions like social loafing. No prior study has examined the relationship between leader rapport management (LRM) and social loafing. LRM refers to the use of linguistic strategies to manage relationships between leaders and members. Therefore, we built and tested a model that examines the relationship between LRM and social loafing that is mediated by leader-member exchange and communication quality.

Organophosphates are essential to facilitate information storage and energy transfer in living organisms, but their prebiotic origins remain unknown. Here, the authors report a liquid sulfur dioxide-mediated phosphorylation of nucleosides from phosphorous acid in a single reaction step at room temperature.

Since 2015 the need for evidence-based guidance in primary health care management of refugees, asylum seekers, and immigrants has dramatically increased. The aims of this study were to identify the challenges met by primary care physicians in Switzerland, by performing semi-structured interviews and to identify possible approaches and interventions. Between January 2019 and January 2020, 20 GPs in 3 Swiss cantons were interviewed. The interviews were transcribed, coded with MAXQDA 18, and analyzed using the framework methodology. Following relevant findings were highlighted; (i) problems relating to health insurance companies among (health-insured) asylum seekers and refugees were negligible; (ii) there is a high acceptance for vaccination by refugees, asylum seekers, and immigrants; (iii) limitations in time for consultations and adequate reimbursement for practitioners pose a serious challenge; (iv) the majority of consultations are complaint-oriented, preventive consultations are rare; and (v) the language barrier is a major challenge for psychosocial consultations, whereas this appears less relevant for somatic complaints. The following issues were identified as high priority needs by the study participants; (i) increased networking between GPs, that is, establishing bridging services with asylum centers, (ii) improved training opportunities for GPs in Migration Medicine with regular updates of current guidelines, and (iii) a standardisation of health documentation facilitating exchange of medical data, that is, digital/paper-based “health booklet” or “health pass.”

This article examines how international trade and policy shape the economic consequences of climate-induced changes in crop productivity, considering both adaptation and mitigation. International trade serves as a global risk-sharing mechanism with the potential of ameliorating the adverse impacts of climate-induced crop shortages by allowing regions with agricultural surpluses to provide for those facing shortages. However, the effectiveness of trade in adaptation depends on whether changes in productivity occur in the short- or the long-run, the structure of tariffs and subsidies, and whether a country is a net importer or exporter of affected products. The most recent evidence on long-term adaptation suggests that the changes in domestic crop portfolios and a diversified set of suppliers are the most effective ways for food-dependent countries to adapt to projected changes in climate toward the mid-century. In the short term, trade helps to buffer against seasonal price shocks, offering relief from sudden price spikes in food staples. Concerns about importing price volatility have little support in the historical record. Still, they may be justified as shifts in climate may result in more frequent extreme events affecting large producing regions of the world. Emerging international trade policies aimed at climate change mitigation, such as carbon border adjustments and laws banning trade in products associated with deforestation, are gaining traction. The adaptability of the international trade regime to these policies remains uncertain. Critical areas for further research include moving from impact assessment to analyzing how the current structure of farm programs worldwide interacts with adaptation and mitigation strategies, expanding the range of crops, and including livestock products in the analysis.

Social dilemmas conceptually suggest distinguishing directindividual and group-level effects (also involving indirecteffects on others). Furthermore, the success of organizationsappears to rely on identifying not only individual excellencebut positive impact on others as well. In ‘Two-LevelPersonnel Evaluation Tasks’ (T-PETs) participants as humanresource managers evaluate employees when individual andgroup contributions are dissociated. Von Sydow, Braus, &Hahn (2018) have suggested a potential ‘Tragedy ofPersonnel Evaluation’: A group-serving employee with thesmallest individual contribution but by far the greatest po-sitive effect on the group’s overall earnings was often ratedthe most negatively. Here we investigate, in two experimentswith conflicting information, whether emphasizing the groupcan avert the ‘tragic’ outcome. Our results suggest that thetragedy is not as complete as suggested, and that contextualinformation can mitigate the tragedy. Nonetheless, the resultsalso corroborate the stability of underestimating the impact ofteam players.

We start with the distinction of outcome- and belief-based Bayesian models of the sequential update of agents beliefs andsubjective reliability of sources (trust). We then focus on discussing the influential Bayesian model of belief-based trustupdate by Eric Olsson, which models dichotomic events and explicitly represents anti-reliability. After sketching somedisastrous recent results for this perhaps most promising model of belief update, we show new simulation results for thetemporal dynamics of learning belief with and without trust update and with and without communication. The resultsseem to shed at least a somewhat more positive light on the communicating-and-trust-updating agents. This may be a lightat the end of the tunnel of belief-based models of trust updating, but the interpretation of the clear findings is much lessclear.

Mit dem MVF-Fachkongress „Theorie wagen“ im Dezember 2021 und dem MVF-Theorie-Baukasten möchte „Monitor Versorgungsforschung“ die Aufmerksamkeit der Versorgungsforscher:innen auf das Thema fokussieren. Auch wenn es einen „Grundkonflikt zwischen Grundlagen- und Anwendungsforschung“ gibt, wie Prof. Dr. Holger Pfaff (Direktor des Instituts für Medizinsoziologie, Versorgungsforschung und Rehabilitationswissenschaft in Köln) zu Protokoll gibt, hält Prof. Dr. Jörg Sydow (Lehrstuhl für Unternehmenskooperation des Management-Departments der Freien Universität Berlin) im Grundsatzinterview mit „Monitor Versorgungsforschung“ entgegen, dass es sich immer lohnen würde, sich mit Theorien zu beschäftigen, weil diese „wie ein intelligentes Brennglas“ wirkten: „Man weiß genau, was man schärfer sieht.“

pracowanie poświęcone jest analizie decyzji strukturalnych dotyczących sądownictwa administracyjnego w Niemczech na tle innych krajów europejskich. Koncentruje się w szczególności na strukturze instytucjonalnej sądownictwa administracyjnego i związanych z nim funkcjach. Odmienne rozumienie zakresu sądownictwa administracyjnego przesądza o kształcie poszczególnych przepisów administracyjnego prawa procesowego, np. regulacji dotyczących dostępu do sądów i kompetencji orzeczniczej sądów administracyjnych. Dlatego niniejszy artykuł ma na celu ukazanie – z perspektywy prawnoporównawczej – procesów wzajemnego oddziaływania, czyli sposobu przyjęcia decyzji strukturalnych dotyczących sądownictwa administracyjnego oraz zwrócenie uwagi na różne tendencje rozwojowe charakterystyczne dla poszczególnych krajów.

Additive technologies are now widely used for the production of complex precise parts and have high potential for the production of forming dies. In this work, hot-forming dies optimized for additive manufacturing were developed and produced with wire arc direct energy deposition (WA-DED) and laser powder bed fusion (L-PBF) technologies. The concept of lightweight hot-forming dies with a 2D-lattice structure was developed, which reduced the weight of each die by 56%, from 14.2 kg to 6.1 kg, in production using L-PBF. Maraging/precipitation-hardened steel 17-4PH was used as an alternative to traditional hot-working steels with slightly lower mechanical properties and a much higher processability in the additive manufacturing process. The workability of the manufactured dies was confirmed by forging tests on an industrial screw press.

Due to their versatile advantages, the use of additively manufactured components is growing. In addition, new additive manufacturing processes are constantly being developed, so that a wide range of printing processes are now available for metal. Despite the same starting material, the microstructure and thus also the final mechanical properties differ greatly compared to conventional processes. In most cases, only direction-dependent characteristic values from the uniaxial tension are used to qualify a printing process before it is used. The literature, on the other hand, demonstrates that the results are not transferable to other loading conditions. In this work, several engineering tests were integrated into a single test specimen so that they can be determined on the same specimen. The test specimen can be used to test tooth root strength, bending strength, notched bar impact energy, and thread strength depending on the mounting direction, thus representing industrial loading cases. In this study, test specimens were fabricated by conventional manufacturing (machining), L-PBF (Laser Powder Bed Fusion), and WA-DED (Wire Arc Direct Energy Deposition), and the results were compared using statistical methods. Factors to capture manufacturing influence and buildup direction were statistically validated on 316L. The work shows a benchmark with a typical initial microstructure of rolled and milled material, L-PBF, and WA-DED parts on loads close to the application and thus simplifies an industry-oriented evaluation of a new manufacturing process.

Cupriavidus necator is a facultative chemolithotrophic organism that grows under both heterotrophic and autotrophic conditions. It is becoming increasingly important due to its ability to convert CO2 into industrially valuable chemicals. To translate the potential of C. necator into technical applications, it is necessary to optimize and scale up production processes. A previous proof-of-principle study showed that C. necator can be used for the de novo production of the terpene α-humulene from CO2 up to concentrations of 11 mg L−1 in septum flasks. However, an increase in final product titer and space–time yield will be necessary to establish an economically viable industrial process. To ensure optimized growth and production conditions, the application of an improved process design in a gas bioreactor with the control of pH, dissolved oxygen and temperature including a controlled gas supply was investigated. In the controlled gas bioreactor, the concentration of α-humulene was improved by a factor of 6.6 and the space–time yield was improved by a factor of 13.2. These results represent an important step toward the autotrophic production of high-value chemicals from CO2. In addition, the in situ product removal of α-humulene was investigated and important indications of the critical logP value were obtained, which was in the range of 3.0–4.2.

Low-temperature contact freezing refrigeration solutions available on the market typically contain refrigerants inside the plates, which may result in harmful emissions into the atmosphere and the contamination of food products in case of failure. However, a concept for a refrigeration plant with new coolant—a solution of potassium formate—is introduced in this paper. It comprises two systems: the primary one, where the compressor system is cooling down the coolant in the evaporator (as a heat and mass exchanger), and the secondary one, where the pump system is responsible for coolant circulation. As a coolant in the intermediate system, a 48% aqueous solution of potassium formate was utilized due to its numerous benefits. This liquid is neutral to the pump circuit installation materials and does not pose a threat to the food product in case of leakage, as it is also used as a food preservative additive. The use of liquid coolant ensures that any malfunction results in a visible leak, allowing for prompt intervention, unlike refrigerants that escape unnoticed into the atmosphere. Moreover, a refrigerant with a lower GWP than traditional solutions was chosen, making the system more eco-friendly.

Introduction. Parkinson’s disease (PD) is a complex multifactorial disease, involving genetic susceptibility, environmental risk factors, and gene-environmental interactions. The microbiota-gut-brain axis is hypothesized to play a role in the pathophysiology of PD, and peptidoglycan recognition proteins (PGLYRPs), which modulate the gut microbiota, are, therefore, relevant candidate genes for PD. Methods. Using quantitative real-time PCR, we genotyped three PGLYRP variants (rs892145, rs959117, and rs10888557) and performed an association analysis in 508 PD patients and 585 control individuals. We further conducted a meta-analysis of rs892145 and analyzed PGLYRP2 gene expression in lymphocytes from patients with PD and controls. Results. Although initial analysis of the three variants rs892145, rs959117, and rs10888557 and a meta-analysis of rs892145 did not reveal any association between the selected variants and PD, we found an interaction between sex and genotype for rs892145, with a marked difference in the allele distribution of rs892145 between male and female patients. As compared to controls, the T allele was less common in female patients (odds ratio = 0.76, P = 0.04) and more common in male patients (odds ratio = 1.29, P = 0.04). No difference was found in PGLYRP2 gene expression between PD patients and controls (P = 0.38), nor between sexes (P = 0.07). Discussion. Overall, this genetic screening in Swedish PD patients does not support previous results demonstrating associations of PGLYRP variants with the risk of PD. Meta-analysis of rs892145 revealed pronounced heterogeneity between previously published studies which is likely to have influenced the results. Taken together, the genetic and gene expression analyses suggest a possible link between genetic variants in PGLYRP2 and sex differences in PD. Because of the limited sample size in our study, these results need to be verified in independent cohorts before concluding.

This paper describes a new method of classification based on spectral analysis. The motivations behind developing the new model were the failures of the classical spectral cluster analysis based on combinatorial and normalized Laplacian for a set of real-world datasets of textual documents. Reasons of the failures are analysed. While the known methods are all based on usage of eigenvectors of graph Laplacians, a new classification method based on eigenvalues of graph Laplacians is proposed and studied.

With the advent of social media, the last decade has seen pro-found changes to the way people receive information. This hasfueled debate about the ways (if any) changes to the nature ofour information networks might be affecting voters’ beliefsabout the world, voting results, and, ultimately, democracy. Atthe same time, much discussion in the public arena in recentyears has concerned the notion that ill-informed voters havebeen voting against their own self-interest. The research report-ed here brings these two strands together: simulations involvingagent-based models, interpreted through the formal frameworkof Condorcet’s (1785) Jury Theorem, demonstrate how changesto information networks may make voter error more likely eventhough individual competence has largely remained unchanged .

Peptide bond formation is one of the key biochemical reactions needed for the formation of life, but is thermodynamically unfavoured in water. Here, the authors report on the possibility of complex oligomer formation in liquid sulphur dioxide which may have existed on early Earth at the emergence of life.

Introduction: The Brazilian scientific production in Dermatology in the international scenario was verified by scientometrics (Sociology segment on quantitative aspects of science). Objective: The insertion of Brazil in the international scientific production scenario can and should be conducted from a more strategic perspective, and it is necessary to observe the production of documents indexed in Scopus in the Dermatology area and related topics in a more detailed way. Methods: Through exploratory, inductive, quantitative, and qualitative research on the Scopus platform – a digital platform comprising more than 25 thousand scientific articles and analytical tools to extract results and trends in the field of research, it was possible to obtain quantitative data on Brazilian scientific production in General Dermatology and six prominent dermatoses. Results: It was possible to analyze and point out the most prominent dermatoses currently in the literature and the related authors, compare Brazilian data with those from other countries that stand out in the scientific literature in Dermatology, and elaborate and justify effective strategies for the international insertion of Brazilian Dermatology scientific production.

A new effective dipole moment model for the XY2 (C2v−symmetry) molecule in a doublet electronic state is derived that includes (as special cases) all currently known models of effective dipole moments for such types of molecules, and allows us to take into account the influence of spin–rotation interactions on the effective dipole moment operator that were not considered in the preceding studies. Necessary for the analysis of absolute line strengths, the matrix elements of this dipole moment operator are derived. A comparison with the previous analog models is made and discussed. The efficiency of the obtained results is illustrated, which have been applied to a set of the “forbidden” ΔKa=2 transitions of the ν3 band of the OClO free radical molecule.

The effective dipole moment model for molecules of axial C3v symmetry is derived on the basis of the symmetry properties of a molecule which, on the one hand, is of the same order of efficiency (but much simpler and clearer in applications) as the analogous models derived on the basis of the irreducible tensorial sets theory, and, on the other hand, mathematically more correct in comparison with concepts like the Herman–Walles function used in the models. As an application of the general results obtained, we discuss high-resolution infrared spectra of CH335Cl, recorded with the Zürich prototype ZP2001 (Bruker IFS125 HR) Fourier transform infrared spectrometer at a resolution of 0.001 cm−1 and analyzed in the region of 880–1190 cm−1 (ν6 bending fundamental centered at ν0 = 1018.070790 cm−1). Absolute strengths of more than 2800 transitions (2081 lines) were obtained from the fit of their shapes both with Voigt and Hartmann–Tran profiles, and parameters of the effective dipole moment of the ν6 band were determined by the computer code SYMTOMLIST (SYMmetric TOp Molecules: LIne STrengths), created on the basis of a derived theoretical model. As the first step of the analysis of the experimental data, assignments of the recorded lines were made. A total of 5124 transitions with Jmax = 68, Kmax = 21 were assigned to the ν6 band. The weighted fit of 2077 upper energy values obtained from the experimentally recorded transitions was made with a Hamiltonian which takes into account different types of ro–vibrational effects in doubly degenerate vibrational states of the C3v-symmetric molecule. As the result, a set of 25 fitted parameters was obtained which reproduces the initial 2077 upper “experimental” ro–vibrational energy values with a root mean square deviation drms=4.7×10−5 cm−1. At the second step of the analysis, the computer code SYMTOMLIST was used for determination of the parameters of the derived effective dipole moment model. Six effective dipole moment parameters were obtained from the weighted fit procedure which reproduces absolute experimental strengths of the 2804 initial experimental transitions with a relative drms=3.4%.