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Assistance in processing local food based on blood cockle (Anadara granosa) can support the anemia prevention program for young women towards a stunting-free Gorontalo. The number of participants included was 20, it's made up of two craft teachers and two school managers. The participants came from SMAN 1 Tilango, SMAN 1 Batudaa Pantai, SMAN 1 Biluhu, SMAN 1 Dungaliyo, and SMAN 1 Pulubala. It involves 5 students from Gorontalo State University who participated in the MBKM research program. The purpose of this activity is for teachers and school canteen operators to gain knowledge about the processing of blood cockle meatballs and use them as potential for the development of local food products to prevent anemia in young women. The importance of innovation in local food processing, such as introducing new technology and developing healthier and more sustainable products. Activities are carried out using five methods, namely lecture, question-and-answer, discussion, practice, and evaluation methods. The result of this service activity was that the participants received the training material and received a positive response. Most participants stated that this activity helped them to innovate and develop their businesses in terms of diversifying local food processing.

Objective: Bronchopulmonary dysplasia (BPD) is a serious yet common morbidity of preterm birth. Although prior work suggests a possible role for phthalate exposure in the development of BPD, no study has rigorously evaluated this. Our objective was to determine whether hospital-based phthalate exposure is associated with the development of BPD and to identify developmental windows sensitive to exposure.Study Design: This is a prospective multicenter cohort study of 360 preterm infants born at 23–33 weeks gestation participating in the Developmental Impact of NICU Exposures (DINE) cohort. 939 urine specimens collected during the NICU stay were analyzed for biomarkers of phthalate exposure by liquid chromatography with tandem mass spectrometry. The modified Shennan definition was used to diagnose bronchopulmonary dysplasia. Reverse distributed-lag modeling identified developmental windows sensitive to specific phthalate exposure, controlling for relevant covariates including sex and respiratory support. Results: Thirty-five percent of participants were diagnosed with BPD. Exposure to specific phthalate mixtures at susceptible points in preterm infant development are associated with later diagnosis of BPD in models adjusted for use of respiratory support. The weighted influence of specific phthalate metabolites in the mixtures varied by sex. Metabolites of di(2-ethylhexyl) phthalate, a phthalate previously linked to neonatal respiratory support equipment, drove this association, particularly among female infants, at 26- to 30-weeks post-menstrual age. Conclusions: This is the largest and only multi-site study of NICU-based phthalate exposure and clinical impact yet reported. In well-constructed models accounting for infant sex and respiratory support, we found a significant positive association between ultimate diagnosis of BPD and prior exposure to phthalate mixtures with DEHP predominance at 26- to 30-weeks PMA or 34–36-weeks PMA. This information is critically important as it identifies a previously unrecognized and modifiable contributing factor to BPD.

Penelitian ini bertujuan untuk mengetahui pengaruh infusa daun gulma siam (Chromolaena odorata) terhadap pertumbuhan bakteri Escherichia coli dan Staphylococcus aureus dan perbedaan yang signifikan antar perlakuan infusa daun gulma siam (Chromolaena odorata) terhadap pertumbuhan bakteri Escherichia coli dan Staphylococcus aureus. Penelitian ini menggunakan metode eksperimen dengan menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 6 perlakuan dan 4 kali ulangan. Hasil penelitian menunjukkan bahwa infusa daun gulma siam (Chromolaena odorata) pada konsentrasi 100% memiliki aktivitas tertinggi dalam menghambat pertumbuhan bakteri Escherichia coli yaitu sebesar 5,8 mm dan pada bakteri Staphylococcus aureus sebesar 7,48 mm. Dari hasil analisis statistik One Way Anova dengan statistik uji F dengan taraf kepercayaan 5% bahwa terdapat pengaruh infusa daun gulma siam (C. odorata) terhadap pertumbuhan bakteri E.coli dan S. aureus. Setelah dilakukan uji lanjut (Uji Duncan) didapatkan hasil bahwa terdapat perbedaan yang signifikan antar perlakuan pada masing-masing konsentrasi yang berbeda.

Abstract Background Data on pediatric asthma morbidity and effective environmental interventions in U.S. agricultural settings are few. We evaluated the effectiveness of HEPA air cleaners on asthma morbidity among a cohort of rural Latino children. Methods Seventy-five children with poorly controlled asthma and living in non-smoking homes were randomly assigned to asthma education alone or along with HEPA air cleaners placed in their sleeping area and home living room. The Asthma Control Test (ACT) score, asthma symptoms in prior 2 weeks, unplanned clinical utilization, creatinine-adjusted urinary leukotriene E4 (uLTE4 [ng/mg]), and additional secondary outcomes were evaluated at baseline, six, and 12 months. Group differences were assessed using multivariable-adjusted generalized estimating equations. Incident rate ratios of ever experiencing the metrics of poorer asthma health during follow-up (suboptimal asthma management) were estimated using Poisson regression models in secondary analysis. Results Mean child age was 9.2 and 8.6 years in intervention and control groups, respectively, and two-thirds of participants were male. Primary analysis of repeated measures of ACT score did not differ between groups (HEPA group mean change compared to controls 10% [95% CI: − 12-39%]). A suggestion of greater decrease in uLTE4 (ng/mg creatinine) was observed (− 10% [95% CI: − 20 -1%]). Secondary analysis showed children with HEPAs were less likely to have an ACT score meeting a clinically defined cutoff for poorly controlled asthma using repeated measures (IRR: 0.45 [95% CI: 0.21–0.97]). In Poisson models, intervention participants had reduced risk of ever meeting this cutoff (IRR: 0.43 [95% CI: 0.21–0.89]), ever having symptoms in the past 2 weeks (IRR: 0.71 [95% CI: 0.52–0.98]), and lower risk of any unplanned clinical utilization (IRR: 0.35 [95% CI: 0.13–0.94]) compared to control participants. Discussion The HAPI study showed generally improved outcomes among children in the HEPA air cleaner group. However, primary analyses did not meet statistical significance and many outcomes were subjective (self-report) in this unblinded study, so findings must be interpreted cautiously. HEPA air cleaners may provide additional benefit for child asthma health where traditional asthmagens (traffic, tobacco smoke) are not prominent factors, but larger studies with more statistical power and blinded designs are needed. Trial registration ClinicalTrials.gov Identifier: NCT04919915 . Date of retrospective registration: May 19, 2021.

Penelitian ini bertujuan untuk mengetahui pengaruh lama penyimpanan telur ayam ras pada suhu refrigerator terhadap jumlah bakteri. Metode yang digunakan dalam penelitian ini adalah metode rancangan acak lengkap dengan 5 (lima) perlakuan dan 5 (lima) ulangan. Perlakuan yang dimaksud adalah perlakuan tanpa penyimpanan pada suhu refrigerator, perlakuan dengan penyimpanan selama 7 hari, 14 hari, 21 hari dan 28 hari pada suhu refrigerator. Hasil penelitian juga menunjukkan bahwa terdapat perbedaan yang nyata jumlah bakteri pada telur ayam ras selama masa penyimpanan pada suhu refrigrator. Dari hasil perhitungan diperoleh nilai Fhitung sebesar 65,53. Harga ini lebih besar bila dibandingkan dengan Ftabel pada taraf signifikan  = 0,05 dengan derajat bebas pembilang (1) = 4 dan derajat luas penyebut (2) = 20 atau Fo = 0,05 (4,20) = 2,87. Dengan demikian hipotesis tentang terdapat pengaruh lama penyimpanan telur ayam ras pada suhu refrigerator terhadap jumlah bakteri diterima.

Kerusakan danau Limboto, Gorontalo, Indonesia telah mempengaruhi fungsi ekologis danau sebagai habitat ikan-ikan native sehingga perlu dilakukan kajian tentang potensi ikan native danau Limboto. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dari mucus ikan-ikan native danau Limboto. Pengujian aktivitas antibakteri dilakukan melalui metode diffsion test dengan mengukur diameter zona hambat yang terbentuk pada beberapa bakteri uji. Ekstraksi mucus dilakukan dengan menggunakan pelarut aquadest dan asam asetat sementara bakteri uji yang digunakan yakni Staphylococcus aureus dan Vibrio alginolyticus. Hasil penelitian menunjukkan bahwa aktivitas antibakteri mucus tertinggi terhadap bakteri S. aureus dengan pelarut aquadest adalah ikan Giuris cf. margaritacea (Hulu’u) sebesar 7.45 mm sedangkan dengan pelarut asam adalah ikan Stiphodon sp (Manggabai) sebesar 8.67 mm. Selanjutnya aktivitas antibakteri mucus tertinggi terhadap V. alginolyticus pada pelarut aquadest adalah ikan Stiphodon sp. sebesar 6.85 mm dan pada pelarut asam adalah ikan Giuris cf. margaritacea sebesar 8.32 mm. Aktivitas antibakteri dari mucus ikan Stiphodon sp (Manggabai) dan Giuris cf. margaritacea (Hulu’u) memiliki aktivitas antibakteri dengan kriteria sedang terhadap bakteri S. aureus dan V. alginolyticus.

Background: Human exposures to bisphenol A (BPA) are widespread. The current study addresses uncertainties regarding human pharmacokinetics of BPA following dermal exposure. Objective: To examine the absorption, distribution, metabolism and excretion of BPA in humans following dermal administration. Methods: We dermally administered deuterated BPA (d6-BPA) to 10 subjects (6 men and 4 women) at a dose of 100 µg/kg over a 12-hour period and conducted blood and urine analysis from the beginning of dosing through a three- or six-day period. We present time-course serum and urine concentrations of total and unconjugated (“free”) d6-BPA and used this information to calculate terminal half-life and area under the curve. Results and Conclusions: Detectable serum levels of total d6-BPA were observed at 1.4 h after the start of dosing, and a maximum serum concentration (Cmax) of 3.26 nM was observed. Free d6-BPA was detectable in serum 2.8 h after start of dermal administration, with Cmax of 0.272 nM. Beginning at approximately seven hours and continuing to 12 h (which corresponds to cessation of exposure), the concentration of free and total serum d6-BPA plateaued. The terminal half-lives of total d6-BPA and free d6-BPA in the body were 21.4 ± 9.81 h and 17.6 ± 7.69 h, respectively. Elimination from the body was rate-limited by kinetics in the dermal compartment. Free d6-BPA was a greater percentage of the area under the curve of total serum BPA (8.81%) compared to the 0.56% observed in our previously published oral study. Recovery of total d6-BPA in urine was

Purpose The Neonatal Intensive Care Unit Hospital Exposures and Long-Term Health (NICU-HEALTH) longitudinal preterm birth cohort studies the impact of the NICU exposome on early-life development. NICU-HEALTH collects multiple biospecimens, complex observational and survey data and comprehensive multisystem outcome assessments to allow measurement of the impact of modifiable environmental exposures during the preterm period on neurodevelopmental, pulmonary and growth outcomes.Participants Moderately preterm infants without genetic or congenital anomalies and their mothers are recruited from an urban academic medical centre level IV NICU in New York City, New York, USA. Recruitment began in 2011 and continues through multiple enrolment phases to the present with goal enrolment of 400 infants. Follow-up includes daily data collection throughout the NICU stay and six follow-up visits in the first 2 years. Study retention is 77% to date, with the oldest patients turning age 8 in 2019.Findings to date NICU-HEALTH has already contributed significantly to our understanding of phthalate exposure in the NICU. Phase I produced the first evidence of the clinical impact of phthalate exposure in the NICU population. Further study identified specific sources of exposure to clinically relevant phthalate mixtures in the NICU.Future plans Follow-up from age 3 to 12 is co-ordinated through integration with the Environmental Influences on Child Health Outcomes (ECHO) programme. The NICU-HEALTH cohort will generate a wealth of biomarker, clinical and outcome data from which future studies of the impact of early-life chemical and non-chemical environmental exposures can benefit. Findings from study of this cohort and other collaborating environmental health cohorts will likely translate into improvements in the hospital environment for infant development.Trial registration numbers This observational cohort is registered with ClinicalTrials.gov (NCT01420029 and NCT01963065).

Every year in the United States, more than 300,000 infants are admitted to neonatal intensive care units (NICU) where they are exposed to a chemical-intensive hospital environment during a developmentally vulnerable period. The neurodevelopmental impact of environmental exposure to phthalates during the NICU stay is unknown. As phthalate exposure during the third trimester developmental window has been implicated in neurobehavioral deficits in term-born children that are strikingly similar to a phenotype of neurobehavioral morbidity common among children born premature, the role of early-life phthalate exposure on the neurodevelopmental trajectory of premature infants may be clinically important. In this study, premature newborns with birth weight

We welcome the recent paper by Bil et al. on differential biologic activity of per- and polyfluoroalkyl substances (PFAS). (1) That paper, along with others that show disparate binding of [...]

Background Persistent dyspnoea and pulmonary function impairment are common after coronavirus disease 2019 (COVID-19). However, long-term outcomes beyond 2 years of infection are unknown. Methods In this single-center study, we observed the trend of self-reported dyspnoea and pulmonary functions among subjects attending a post-COVID clinic in India after 2 years of COVID-19 illness. Using logistic regression, we explored the clinico-demographic factors associated with persistent dyspnoea and impaired lung functions beyond 2 years. Results Among 231 included subjects (68.8% male) with a mean [standard deviation (SD)] age of 44.8 (13.2) years, 119 (51.5%) had recovered from moderate-to-severe COVID-19. The median [inter-quartile range (IQR)] time intervals from COVID-19 diagnosis (T0) to clinical enrolment (T1) and final follow-up (T2) were 3.3 (1.9–5.5) months and 29.5 (27.2–32.2) months, respectively. Between T1 and T2, the prevalence of self-reported dyspnoea remained stable in the whole cohort (39.4% vs. 36.4%, P = 0.26) but declined in the sub-group with moderate-to-severe COVID-19 (63% vs. 54.6%, P = 0.03). Persistent dyspnoea at T2 was associated with female sex (P = 0.007), moderate-to-severe COVID-19 (P < 0.001), and infection during the delta wave (P < 0.001). At T2, impairment in forced vital capacity (FVC) was seen in 48.1% subjects. Persistently impaired FVC was associated with older age (P value = 0.047), female sex (P value