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152 results on '"Swijnenburg, R.-J."'

6. Clinical Added Value of Gadoxetic Acid Enhanced Liver MRI in Patients Scheduled for Local Therapy of Colorectal Liver Metastases Based on CT Imaging (CAMINO)

Author

Görgec, B., primary, Hansen, I., additional, Hartgrink, H.H., additional, Grünhagen, D., additional, Kok, N., additional, Kuhlmann, K., additional, Swijnenburg, R.-J., additional, Fretland, A.A., additional, Verhoef, K., additional, Besselink, M.G., additional, and Stoker, J., additional

Published
2023
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9. First-line Systemic Treatment Strategies in Patients with Initially Unresectable Colorectal Liver Metastases: Phase III CAIRO5 Study of the Dutch Colorectal Cancer Group

Author

Bond, M.J., primary, Bolhuis, K., additional, Kazemier, G., additional, Klaase, J.M., additional, Liem, M.S., additional, Rijken, A.M., additional, Verhoef, C., additional, de Wilt, J.H., additional, Lopez-Yurda, M., additional, Punt, C.J., additional, and Swijnenburg, R.-J., additional

Published
2023
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10. Impact of merging two university hospitals on surgical outcome after esophagogastric and hepato-pancreato-biliary surgery: Results from a retrospective study

Author

Ingwersen, E. W., Stam, W. T., van Kesteren, L. J., Wissink, I. J. A., van Berge Henegouwen, M. I., Besselink, M. G., Busch, O. R., Erdmann, J. I., Eshuis, W. J., Gisbertz, S. S., Kazemier, G., van der Peet, D. L., Swijnenburg, R. J., Zonderhuis, B., Daams, F., Surgery, CCA - Cancer Treatment and quality of life, CCA - Cancer biology and immunology, AII - Cancer immunology, Amsterdam Gastroenterology Endocrinology Metabolism, AGEM - Re-generation and cancer of the digestive system, APH - Quality of Care, ACS - Microcirculation, Graduate School, Intensive Care Medicine, CCA - Cancer Treatment and Quality of Life, CCA - Imaging and biomarkers, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA -Cancer Center Amsterdam, and Cancer Center Amsterdam

Subjects
Hepato-biliary-pancreatic, Complications, Merge, Upper gastrointestinal, Quality of care, Surgery, University centers
Abstract

Background: Due to centralization and super-specialization in medicine, hospital mergers are increasingly common. Their effect on postoperative outcomes in highly specialized surgical departments is unclear. As quality metrics often worsen after major organizational changes, preservation of quality of care during an hospital merge is of the utmost importance. Objective: To evaluate the effect of a merger of two Dutch university hospitals on quality of surgical care, volume, and timeliness of care. Methods: The upper gastro-intestinal and hepato-biliary-pancreatic sections merged on the 27th of January 2020 and the 31th of May 2021 respectively. Outcomes of all adult surgical patients were compared six months before and six months after the merger. Short-term quality metrics, volume, and timeliness of care were assessed. Results: Overall, a cohort of 631 patients were included of whom 195 were upper gastro-intestinal (97 prior to the merger, 98 after the merger) and 436 (223 prior to the merger, 213 after) hepato-biliary-pancreatic patients. There were no differences in mortality, readmission, number and severity of complications, volume, and timeliness of care six months post-merger as compared to before merger. Conclusion: This study shows that a hospital merger of two university hospitals can be performed without jeopardizing patient safety and while benefitting from centralization of highly specialized care and enhancement of medical research. Key message: This study investigated the impact of a merger of two Dutch university hospitals on quality of care, timeliness of care, and volume. It showed no deterioration in the evaluated short-term quality metrics, volume or timeliness for upper GI and HPB surgery, suggesting that a hospital merger of two university hospitals can be performed safely, while benefitting from centralization of highly specialized care and enhancement of medical research.

Published
2023

11. Adjuvant hepatic arterial infusion pump chemotherapy and resection versus resection alone in patients with low-risk resectable colorectal liver metastases – the multicenter randomized controlled PUMP trial

Author

Buisman, F. E., Homs, M. Y. V., Grünhagen, D. J., Filipe, W. F., Bennink, R. J., Besselink, M. G. H., Borel Rinkes, I. H. M., Bruijnen, R. C. G., Cercek, A., D’Angelica, M. I., van Delden, O. M., Donswijk, M. L., van Doorn, L., Doornebosch, P. G., Emmering, J., Erdmann, J. I., IJzerman, N. S., Grootscholten, C., Hagendoorn, J., Kemeny, N. E., Kingham, T. P., Klompenhouwer, E. G., Kok, N. F. M., Koolen, S., Kuhlmann, K. F. D., Kuiper, M. C., Lam, M. G. E., Mathijssen, R. H. J., Moelker, A., Oomen-de Hoop, E., Punt, C. J. A., te Riele, W. W., Roodhart, J. M. L., Swijnenburg, R. J., Prevoo, W., Tanis, P. J., Vermaas, M., Versleijen, M. W. J., Veuger, F. P., Weterman, M. J., Verhoef, C., and Groot Koerkamp, B.

Published
2019
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13. LBA21 FOLFOX/FOLFIRI plus either bevacizumab or panitumumab in patients with initially unresectable colorectal liver metastases (CRLM) and left-sided and RAS/BRAFV600E wild-type tumour: Phase III CAIRO5 study of the Dutch Colorectal Cancer Group

Author

Bond, M.J.G., primary, Bolhuis, K., additional, Loosveld, O.J.L., additional, Droogendijk, H.J., additional, de Groot, J.W.B., additional, Hendriks, M.P., additional, De Valk, B., additional, Liem, M.S.L., additional, Rijken, A.M., additional, Verhoef, K., additional, de Wilt, J.H.W., additional, de Jong, K.P., additional, Kazemier, G., additional, van Amerongen, M.J., additional, Engelbrecht, M.R.W., additional, Klaase, J.M., additional, Komurcu, A., additional, Lopez-Yurda, M.I., additional, Swijnenburg, R-J., additional, and Punt, C.J.A., additional

Published
2022
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14. Impact of shifting from laparoscopic to robotic surgery during 600 minimally invasive pancreatic and liver resections

Author

Emmen, Anouk. M. L. H., Görgec, B., Zwart, M. J. W., Daams, F., Erdmann, J., Festen, S., Gouma, D. J., van Gulik, T. M., van Hilst, J., Kazemier, G., Lof, S., Sussenbach, S. I., Tanis, P. J., Zonderhuis, B. M., Busch, O. R., Swijnenburg, R. J., Besselink, M. G., Graduate School, Radiology and Nuclear Medicine, Surgery, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Cancer biology and immunology, and CCA - Imaging and biomarkers

Subjects
Pancreatoduodenectomy, Distal pancreatectomy, Minimally invasive, Liver surgery
Abstract

Background: Many centers worldwide are shifting from laparoscopic to robotic minimally invasive hepato-pancreato-biliary resections (MIS-HPB) but large single center series assessing this process are lacking. We hypothesized that the introduction of robot-assisted surgery was safe and feasible in a high-volume center. Methods: Single center, post-hoc assessment of prospectively collected data including all consecutive MIS-HPB resections (January 2010–February 2022). As of December 2018, all MIS pancreatoduodenectomy and liver resections were robot-assisted. All surgeons had participated in dedicated training programs for laparoscopic and robotic MIS-HPB. Primary outcomes were in-hospital/30-day mortality and Clavien-Dindo ≥ 3 complications. Results: Among 1875 pancreatic and liver resections, 600 (32%) were MIS-HPB resections. The overall rate of conversion was 4.3%, Clavien-Dindo ≥ 3 complications 25.7%, and in-hospital/30-day mortality 1.8% (n = 11). When comparing the period before and after the introduction of robotic MIS-HPB (Dec 2018), the overall use of MIS-HPB increased from 25.3 to 43.8% (P < 0.001) and blood loss decreased from 250 ml [IQR 100–500] to 150 ml [IQR 50–300] (P < 0.001). The 291 MIS pancreatic resections included 163 MIS pancreatoduodenectomies (52 laparoscopic, 111 robotic) with 4.3% conversion rate. The implementation of robotic pancreatoduodenectomy was associated with reduced operation time (450 vs 361 min; P < 0.001), reduced blood loss (350 vs 200 ml; P < 0.001), and a decreased rate of delayed gastric emptying (28.8% vs 9.9%; P = 0.009). The 309 MIS liver resections included 198 laparoscopic and 111 robotic procedures with a 3.6% conversion rate. The implementation of robotic liver resection was associated with less overall complications (24.7% vs 10.8%; P = 0.003) and shorter hospital stay (4 vs 3 days; P < 0.001). Conclusion: The introduction of robotic surgery was associated with greater implementation of MIS-HPB in up to nearly half of all pancreatic and liver resections. Although mortality and major morbidity were not affected, robotic surgery was associated with improvements in some selected outcomes. Ultimately, randomized studies and high-quality registries should determine its added value. Graphical Abstract: [Figure not available: see fulltext.]

Published
2022

16. Impact of Positive Lymph Nodes and Resection Margin Status on the Overall Survival of Resected Perihilar Cholangiocarcinoma, the ENS-CCA Registry

Author

Nooijen, L.E., primary, Bañales, J., additional, de Boer, M.T., additional, Braconi, C., additional, Folseraas, T., additional, Forner, A., additional, Holowko, W., additional, Hoogwater, F.J.H., additional, Klümpen, H.-J., additional, Groot-Koerkamp, B., additional, Lamarca, A., additional, Landa-Magdalena, A., additional, López-López, F., additional, Sánchez, L. Izquierdo, additional, Scheiter, A., additional, Utpatel, K., additional, Swijnenburg, R.-J., additional, and Erdmann, J.I., additional

Published
2022
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18. Interobserver Variability in Morphologic Tumor Response Assessment Following Systemic Therapy in Patients with Initially Unresectable Colorectal Liver Metastases

Author

Wesdorp, N.J., primary, Kemna, R., additional, Waesberghe, J.-H.T. van, additional, Nota, I.M., additional, Struik, F., additional, Abdennabi, I. Oulad, additional, Phoa, S.S., additional, van Dieren, S., additional, Swijnenburg, R.-J., additional, Punt, C.J., additional, Huiskens, J., additional, Stoker, J., additional, and Kazemier, G., additional

Published
2022
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20. Development and Validation of Auto-segmentation Deep Learning Models for Automatic Total Tumor Volume Assessment in Patients with Initially Unresectable Colorectal Liver Metastases

Author

Wesdorp, N.J., primary, Zeeuw, J.M., additional, Postma, S.C., additional, Roor, J., additional, Vadakkumpadan, F., additional, Ambrozic, C., additional, Waesberghe, J.-H.T. van, additional, Swijnenburg, R.-J., additional, Punt, C.J., additional, Huiskens, J., additional, and Kazemier, G., additional

Published
2022
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21. Clinical added value of MRI to CT in patients scheduled for local therapy of colorectal liver metastases (CAMINO)

Author

Görgec, B., Hansen, I., Kemmerich, G., Syversveen, T., Abu Hilal, M., Belt, E. J. T., Bisschops, R. H. C., Bollen, T. L., Bosscha, K., Burgmans, M. C., Cappendijk, V., de Boer, M. T., D’Hondt, M., Edwin, B., Gielkens, H., Grünhagen, D. J., Gillardin, P., Gobardhan, P. D., Hartgrink, H. H., Horsthuis, K., Kok, N. F. M., Kint, P. A. M., Kruimer, J. W. H., Leclercq, W. K. G., Lips, D. J., Lutin, B., Maas, M., Marsman, H. A., Morone, M., Pennings, J. P., Peringa, J., te Riele, W. W., Vermaas, M., Wicherts, D., Willemssen, F. E. J. A., Zonderhuis, B. M., Bossuyt, P. M. M., Swijnenburg, R. J., Fretland, A., Verhoef, C., Besselink, M. G., Stoker, J., Bnà, C., de Meyere, C., Draaisma, W. A., Gerhards, M. F., Imani, F., Kuhlmann, K. F. D., Liem, M. S. L., Meyer, Y., Surgery, Radiology & Nuclear Medicine, Graduate School, Radiology and Nuclear Medicine, AMS - Rehabilitation & Development, AMS - Sports, Amsterdam Gastroenterology Endocrinology Metabolism, Epidemiology and Data Science, APH - Methodology, APH - Personalized Medicine, CCA - Imaging and biomarkers, CCA - Cancer Treatment and Quality of Life, Radiology and nuclear medicine, Pathology, Obstetrics and gynaecology, CCA - Cancer Treatment and quality of life, AGEM - Re-generation and cancer of the digestive system, and VU University medical center

Subjects
Gadolinium DTPA, Cancer Research, Colorectal cancer, Gadoxetic acid, Contrast Media, Diagnostic accuracy, Multimodal Imaging, Liver MRI, Study Protocol, Liver metastases, Prospective Studies, FDG-PET, RC254-282, OUTCOMES, medicine.diagnostic_test, Minimal clinically important difference, Liver Neoplasms, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Magnetic Resonance Imaging, Oncology, SURVIVAL, Radiology, Colorectal Neoplasms, Life Sciences & Biomedicine, medicine.drug, Adult, medicine.medical_specialty, STRATEGIES, HEPATIC RESECTION, SDG 3 - Good Health and Well-being, Genetics, medicine, Humans, In patient, CANCER PATIENTS, RADIOFREQUENCY ABLATION, Liver surgery, RECURRENCE, Protocol (science), Science & Technology, business.industry, Abdominal CT scan, Magnetic resonance imaging, Diffusion weighted imaging, PERFORMANCE, medicine.disease, Thermal ablation, Colorectal liver metastases, CONTRAST-ENHANCED CT, Tomography, X-Ray Computed, business, Diffusion MRI
Abstract

Background Abdominal computed tomography (CT) is the standard imaging method for patients with suspected colorectal liver metastases (CRLM) in the diagnostic workup for surgery or thermal ablation. Diffusion-weighted and gadoxetic-acid-enhanced magnetic resonance imaging (MRI) of the liver is increasingly used to improve the detection rate and characterization of liver lesions. MRI is superior in detection and characterization of CRLM as compared to CT. However, it is unknown how MRI actually impacts patient management. The primary aim of the CAMINO study is to evaluate whether MRI has sufficient clinical added value to be routinely added to CT in the staging of CRLM. The secondary objective is to identify subgroups who benefit the most from additional MRI. Methods In this international multicentre prospective incremental diagnostic accuracy study, 298 patients with primary or recurrent CRLM scheduled for curative liver resection or thermal ablation based on CT staging will be enrolled from 17 centres across the Netherlands, Belgium, Norway, and Italy. All study participants will undergo CT and diffusion-weighted and gadoxetic-acid enhanced MRI prior to local therapy. The local multidisciplinary team will provide two local therapy plans: first, based on CT-staging and second, based on both CT and MRI. The primary outcome measure is the proportion of clinically significant CRLM (CS-CRLM) detected by MRI not visible on CT. CS-CRLM are defined as liver lesions leading to a change in local therapeutical management. If MRI detects new CRLM in segments which would have been resected in the original operative plan, these are not considered CS-CRLM. It is hypothesized that MRI will lead to the detection of CS-CRLM in ≥10% of patients which is considered the minimal clinically important difference. Furthermore, a prediction model will be developed using multivariable logistic regression modelling to evaluate the predictive value of patient, tumor and procedural variables on finding CS-CRLM on MRI. Discussion The CAMINO study will clarify the clinical added value of MRI to CT in patients with CRLM scheduled for local therapy. This study will provide the evidence required for the implementation of additional MRI in the routine work-up of patients with primary and recurrent CRLM for local therapy. Trial registration The CAMINO study was registered in the Netherlands National Trial Register under number NL8039 on September 20th 2019.

Published
2021

22. Comparing practice and outcome of laparoscopic liver resection between high-volume expert centres and nationwide low-to-medium volume centres

Author

Görgec, B, primary, Fichtinger, R S, additional, Ratti, F, additional, Aghayan, D, additional, Van der Poel, M J, additional, Al-Jarrah, R, additional, Armstrong, T, additional, Cipriani, F, additional, Fretland, Å A, additional, Suhool, A, additional, Bemelmans, M, additional, Bosscha, K, additional, Braat, A E, additional, De Boer, M T, additional, Dejong, C H C, additional, Doornebosch, P G, additional, Draaisma, W A, additional, Gerhards, M F, additional, Gobardhan, P D, additional, Hagendoorn, J, additional, Kazemier, G, additional, Klaase, J, additional, Leclercq, W K G, additional, Liem, M S, additional, Lips, D J, additional, Marsman, H A, additional, Mieog, J S D, additional, Molenaar, Q I, additional, Nieuwenhuijs, V B, additional, Nota, C L, additional, Patijn, G A, additional, Rijken, A M, additional, Slooter, G D, additional, Stommel, M W J, additional, Swijnenburg, R J, additional, Tanis, P J, additional, Te Riele, W W, additional, Terkivatan, T, additional, Van den Tol, P M P, additional, Van den Boezem, P B, additional, Van der Hoeven, J A, additional, Vermaas, M, additional, Edwin, B, additional, Aldrighetti, L A, additional, Van Dam, R M, additional, Abu Hilal, M, additional, and Besselink, M G, additional

Published
2021
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24. LBA27 First-line systemic treatment in patients with initially unresectable colorectal cancer liver metastases (CRLM): Overall survival of the phase III CAIRO5 study of the Dutch Colorectal Cancer Group

Author

Punt, C.J.A., Bond, M.J.G., Bolhuis, K., Loosveld, O.J.L., de Groot, J.W., Droogendijk, H., Helgason, H.H., Hendriks, M.P., Klaase, J.M., Kazemier, G., Liem, M.S.L., Rijken, A.M., Verhoef, C., de Wilt, J.H.W., de Jong, K.P., van Amerongen, M.J., De Valk, B., Kerver, E.D., Komurcu, A., and Swijnenburg, R-J.

Published
2023
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25. Additional file 1 of Clinical added value of MRI to CT in patients scheduled for local therapy of colorectal liver metastases (CAMINO): study protocol for an international multicentre prospective diagnostic accuracy study

Author

Görgec, B., Hansen, I., Kemmerich, G., Syversveen, T., Abu Hilal, M., Belt, E. J. T., Bisschops, R. H. C., Bollen, T. L., Bosscha, K., Burgmans, M. C., Cappendijk, V., De Boer, M. T., D’Hondt, M., Edwin, B., Gielkens, H., Grünhagen, D. J., Gillardin, P., Gobardhan, P. D., Hartgrink, H. H., Horsthuis, K., Kok, N. F. M., Kint, P. A. M., Kruimer, J. W. H., Leclercq, W. K. G., Lips, D. J., Lutin, B., Maas, M., Marsman, H. A., Morone, M., Pennings, J. P., Peringa, J., Te Riele, W. W., Vermaas, M., Wicherts, D., Willemssen, F. E. J. A., Zonderhuis, B. M., Bossuyt, P. M. M., Swijnenburg, R. J., Fretland, Å. A., Verhoef, C., Besselink, M. G., and Stoker, J.

Abstract

Additional file 1. SPIRIT checklist

Published
2021
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26. Additional file 2 of Clinical added value of MRI to CT in patients scheduled for local therapy of colorectal liver metastases (CAMINO): study protocol for an international multicentre prospective diagnostic accuracy study

Author

Görgec, B., Hansen, I., Kemmerich, G., Syversveen, T., Abu Hilal, M., Belt, E. J. T., Bisschops, R. H. C., Bollen, T. L., Bosscha, K., Burgmans, M. C., Cappendijk, V., De Boer, M. T., D’Hondt, M., Edwin, B., Gielkens, H., Grünhagen, D. J., Gillardin, P., Gobardhan, P. D., Hartgrink, H. H., Horsthuis, K., Kok, N. F. M., Kint, P. A. M., Kruimer, J. W. H., Leclercq, W. K. G., Lips, D. J., Lutin, B., Maas, M., Marsman, H. A., Morone, M., Pennings, J. P., Peringa, J., Te Riele, W. W., Vermaas, M., Wicherts, D., Willemssen, F. E. J. A., Zonderhuis, B. M., Bossuyt, P. M. M., Swijnenburg, R. J., Fretland, Å. A., Verhoef, C., Besselink, M. G., and Stoker, J.

Abstract

Additional file 2. Imaging Protocols of The Radiological Society of the Netherlands

Published
2021
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27. One-year Impact of Surgery for Perihilar Cholangiocarcinoma

Author

van Keulen, A.-M., primary, Büttner, S., additional, Besselink, M.G., additional, Busch, O.R., additional, van Gulik, T.M., additional, IJzermans, J.N., additional, de Jonge, J., additional, Polak, W.G., additional, Swijnenburg, R.-J., additional, Groot Koerkamp, B., additional, Erdmann, J.I., additional, and Olthof, P.B., additional

Published
2021
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32. Cluster-randomized crossover trial of chlorhexidine-alcohol iodine-alcohol for prevention of surgical-site infection (SKINFECT trial)

Author

Charehbili, A, Koek, M B G, de Mol van Otterloo, J C A, Bronkhorst, M W G A, van der Zwaal, P, Thomassen, B, Waasdorp, E J, Govaert, J A, Bosman, A, van den Bremer, J, Ploeg, A J, Putter, H, Meijs, A P, van de Velde, C J H, van Gijn, W, and Swijnenburg, R J

Abstract

La infección del sitio quirúrgico (surgical site infection, SSI) es una complicación quirúrgica grave que se puede prevenir mediante una desinfección cutánea preoperatoria. En los países de Europa occidental, la desinfección preoperatoria se realiza habitualmente usando clorhexidina o yodo en una solución a base de alcohol. Nuestro objetivo fue investigar si la clorhexidina alcohólica es superior al yodo con alcohol para prevenir la SSI.

Published
2019

35. Volume–outcome relationship of liver surgery: a nationwide analysis

Author

Olthof, P B, primary, Elfrink, A K E, additional, Marra, E, additional, Belt, E J T, additional, van den Boezem, P B, additional, Bosscha, K, additional, Consten, E C J, additional, den Dulk, M, additional, Gobardhan, P D, additional, Hagendoorn, J, additional, van Heek, T N T, additional, IJzermans, J N M, additional, Klaase, J M, additional, Kuhlmann, K F D, additional, Leclercq, W K G, additional, Liem, M S L, additional, Manusama, E R, additional, Marsman, H A, additional, Mieog, J S D, additional, Oosterling, S J, additional, Patijn, G A, additional, te Riele, W, additional, Swijnenburg, R-J, additional, Torrenga, H, additional, van Duijvendijk, P, additional, Vermaas, M, additional, Kok, N F M, additional, Grünhagen, D J, additional, Besselink, M G H, additional, de Boer, M T, additional, Buis, C I, additional, van Gulik, T M, additional, Hoogwater, F J H, additional, Molenaar, I Q, additional, Dejong, C H C, additional, and Verhoef, C, additional

Published
2020
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37. Cluster‐randomized crossover trial of chlorhexidine–alcohol versus iodine–alcohol for prevention of surgical‐site infection (SKINFECT trial)

Author

Charehbili, A., primary, Koek, M. B. G., additional, Mol van Otterloo, J. C. A., additional, Bronkhorst, M. W. G. A., additional, Zwaal, P., additional, Thomassen, B., additional, Waasdorp, E. J., additional, Govaert, J. A., additional, Bosman, A., additional, Bremer, J., additional, Ploeg, A. J., additional, Putter, H., additional, Meijs, A. P., additional, Velde, C. J. H., additional, Gijn, W., additional, and Swijnenburg, R. J., additional

Published
2019
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41. Staging laparoscopy with ultrasound and near-infrared fluorescence imaging to detect occult metastases of pancreatic and periampullary cancer

Author

Handgraaf, H. J. M., primary, Sibinga Mulder, B. G., additional, Shahbazi Feshtali, S., additional, Boogerd, L. S. F., additional, van der Valk, M. J. M., additional, Fariña Sarasqueta, A., additional, Swijnenburg, R. J., additional, Bonsing, B. A., additional, Vahrmeijer, A. L., additional, and Mieog, J. S. D., additional

Published
2018
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