1,075 results on '"Swertz, Morris A."'
Search Results
2. Social inequalities in child mental health trajectories: a longitudinal study using birth cohort data 12 countries
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Cadman, Tim, Avraam, Demetris, Carson, Jennie, Elhakeem, Ahmed, Grote, Veit, Guerlich, Kathrin, Guxens, Mònica, Howe, Laura D., Huang, Rae-Chi, Harris, Jennifer R., Houweling, Tanja A. J., Hyde, Eleanor, Jaddoe, Vincent, Jansen, Pauline W., Julvez, Jordi, Koletzko, Berthold, Lin, Ashleigh, Margetaki, Katerina, Melchior, Maria, Nader, Johanna Thorbjornsrud, Pedersen, Marie, Pizzi, Costanza, Roumeliotaki, Theano, Swertz, Morris, Tafflet, Muriel, Taylor-Robinson, David, Wootton, Robyn E., and Strandberg-Larsen, Katrine
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- 2024
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3. Systematic reanalysis of genomic data by diagnostic laboratories: a scoping review of ethical, economic, legal and (psycho)social implications
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van der Geest, Marije A., Maeckelberghe, Els L. M., van Gijn, Marielle E., Lucassen, Anneke M., Swertz, Morris A., van Langen, Irene M., and Plantinga, Mirjam
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- 2024
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4. Phenotypic and Genetic Factors Associated with Absence of Cardiomyopathy Symptoms in PLN:c.40_42delAGA Carriers
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Lopera-Maya, Esteban A., Li, Shuang, de Brouwer, Remco, Nolte, Ilja M., van Breen, Justin, Jongbloed, Jan D. H., Swertz, Morris A., Snieder, Harold, Franke, Lude, Wijmenga, Cisca, de Boer, Rudolf A., Deelen, Patrick, van der Zwaag, Paul A., and Sanna, Serena
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- 2023
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5. Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure
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Evangelou, Evangelos, Warren, Helen R., Gao, He, Ntritsos, Georgios, Dimou, Niki, Esko, Tonu, Mägi, Reedik, Milani, Lili, Almgren, Peter, Boutin, Thibaud, Debette, Stéphanie, Ding, Jun, Giulianini, Franco, Holliday, Elizabeth G., Jackson, Anne U., Li -Gao, Ruifang, Lin, Wei -Yu, Luan, Jian'an, Mangino, Massimo, Oldmeadow, Christopher, Prins, Bram Peter, Qian, Yong, Sargurupremraj, Muralidharan, Shah, Nabi, Surendran, Praveen, Thériault, Sébastien, Verweij, Niek, Willems, Sara M., Zhao, Jing -Hua, Amouyel, Philippe, Connell, John, de Mutsert, Renée, Doney, Alex S.F., Farrall, Martin, Menni, Cristina, Morris, Andrew D., Noordam, Raymond, Paré, Guillaume, Poulter, Neil R., Shields, Denis C., Stanton, Alice, Thom, Simon, Abecasis, Gonçalo, Amin, Najaf, Arking, Dan E., Ayers, Kristin L., Barbieri, Caterina M., Batini, Chiara, Bis, Joshua C., Blake, Tineka, Bochud, Murielle, Boehnke, Michael, Boerwinkle, Eric, Boomsma, Dorret I., Bottinger, Erwin P., Braund, Peter S., Brumat, Marco, Campbell, Archie, Campbell, Harry, Chakravarti, Aravinda, Chambers, John C., Chauhan, Ganesh, Ciullo, Marina, Cocca, Massimiliano, Collins, Francis, Cordell, Heather J., Davies, Gail, de Borst, Martin H., de Geus, Eco J., Deary, Ian J., Deelen, Joris, Del Greco M, Fabiola, Demirkale, Cumhur Yusuf, Dörr, Marcus, Ehret, Georg B., Elosua, Roberto, Enroth, Stefan, Erzurumluoglu, A. Mesut, Ferreira, Teresa, Frånberg, Mattias, Franco, Oscar H., Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Goel, Anuj, Gow, Alan J., Gudnason, Vilmundur, Guo, Xiuqing, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B., Harris, Sarah E., Hartman, Catharina A., Havulinna, Aki S., Hicks, Andrew A., Hofer, Edith, Hofman, Albert, Hottenga, Jouke-Jan, Huffman, Jennifer E., Hwang, Shih-Jen, Ingelsson, Erik, James, Alan, Jansen, Rick, Jarvelin, Marjo -Riitta, Joehanes, Roby, Johansson, Åsa, Johnson, Andrew D., Joshi, Peter K., Jousilahti, Pekka, Jukema, J. Wouter, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Keavney, Bernard D., Khaw, Kay-Tee, Knekt, Paul, Knight, Joanne, Kolcic, Ivana, Kooner, Jaspal S., Koskinen, Seppo, Kristiansson, Kati, Kutalik, Zoltan, Laan, Maris, Larson, Marty, Launer, Lenore J., Lehne, Benjamin, Lehtimäki, Terho, Liewald, David C.M., Lin, Li, Lind, Lars, Lindgren, Cecilia M., Liu, YongMei, Loos, Ruth J.F., Lopez, Lorna M., Lu, Yingchang, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Mamasoula, Chrysovalanto, Marrugat, Jaume, Marten, Jonathan, Milaneschi, Yuri, Morgan, Anna, Morris, Andrew P., Morrison, Alanna C., Munson, Peter J., Nalls, Mike A., Nandakumar, Priyanka, Nelson, Christopher P., Niiranen, Teemu, Nolte, Ilja M., Nutile, Teresa, Oldehinkel, Albertine J., Oostra, Ben A., O'Reilly, Paul F., Org, Elin, Padmanabhan, Sandosh, Palmas, Walter, Palotie, Aarno, Pattie, Alison, Penninx, Brenda W.J.H., Perola, Markus, Peters, Annette, Polasek, Ozren, Pramstaller, Peter P., Nguyen, Quang Tri, Raitakari, Olli T., Rettig, Rainer, Rice, Kenneth, Ridker, Paul M., Ried, Janina S., Riese, Harriëtte, Ripatti, Samuli, Robino, Antonietta, Rose, Lynda M., Rotter, Jerome I., Rudan, Igor, Ruggiero, Daniela, Saba, Yasaman, Sala, Cinzia F., Salomaa, Veikko, Samani, Nilesh J., Sarin, Antti-Pekka, Schmidt, Reinhold, Schmidt, Helena, Shrine, Nick, Siscovick, David, Smith, Albert V., Snieder, Harold, Sõber, Siim, Sorice, Rossella, Starr, John M., Stott, David J., Strachan, David P., Strawbridge, Rona J., Sundström, Johan, Swertz, Morris A., Taylor, Kent D., Teumer, Alexander, Tobin, Martin D., Tomaszewski, Maciej, Toniolo, Daniela, Traglia, Michela, Trompet, Stella, Tuomilehto, Jaakko, Tzourio, Christophe, Uitterlinden, André G., Vaez, Ahmad, van der Most, Peter J., van Duijn, Cornelia M., Verwoert, Germaine C., Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Vuckovic, Dragana, Watkins, Hugh, Wild, Sarah H., Willemsen, Gonneke, Wilson, James F., Wright, Alan F., Yao, Jie, Zemunik, Tatijana, Zhang, Weihua, Attia, John R., Butterworth, Adam S., Chasman, Daniel I., Conen, David, Cucca, Francesco, Danesh, John, Hayward, Caroline, Howson, Joanna M.M., Laakso, Markku, Lakatta, Edward G., Langenberg, Claudia, Melander, Olle, Mook-Kanamori, Dennis O., Palmer, Colin N.A., Risch, Lorenz, Scott, Robert A., Scott, Rodney J., Sever, Peter, Spector, Tim D., van der Harst, Pim, Wareham, Nicholas J., Zeggini, Eleftheria, Levy, Daniel, Munroe, Patricia B., Newton-Cheh, Christopher, Brown, Morris J., Metspalu, Andres, Psaty, Bruce M., Wain, Louise V., Elliott, Paul, Caulfield, Mark J., Ganji-Arjenaki, Mahboube, Kamali, Zoha, Sardari, Soroush, and de Borst, Martin
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- 2024
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6. The phenotypic spectrum of terminal and subterminal 6p deletions based on a social media-derived cohort and literature review
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Rraku, Eleana, Kerstjens-Frederikse, Wilhelmina S., Swertz, Morris A., Dijkhuizen, Trijnie, van Ravenswaaij-Arts, Conny M. A., and Engwerda, Aafke
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- 2023
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7. Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data
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Li, Shuang, Schmid, Katharina T., de Vries, Dylan H., Korshevniuk, Maryna, Losert, Corinna, Oelen, Roy, van Blokland, Irene V., Groot, Hilde E., Swertz, Morris A., van der Harst, Pim, Westra, Harm-Jan, van der Wijst, Monique G.P., Heinig, Matthias, and Franke, Lude
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- 2023
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8. Parent-reported phenotype data on chromosome 6 aberrations collected via an online questionnaire: data consistency and data availability
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Engwerda, Aafke, Frentz, Barbara, Rraku, Eleana, de Souza, Nadia F. Simoes, Swertz, Morris A., Plantinga, Mirjam, Kerstjens-Frederikse, Wilhelmina S., Ranchor, Adelita V., and van Ravenswaaij-Arts, Conny M. A.
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- 2023
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9. Urban environment in pregnancy and postpartum depression: An individual participant data meta-analysis of 12 European birth cohorts
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Cadman, Tim, Strandberg-Larsen, Katrine, Calas, Lucinda, Christiansen, Malina, Culpin, Iryna, Dadvand, Payam, de Castro, Montserrat, Foraster, Maria, Fossati, Serena, Guxens, Mònica, Harris, Jennifer R., Hillegers, Manon, Jaddoe, Vincent, Lee, Yunsung, Lepeule, Johanna, el Marroun, Hanan, Maule, Milena, McEachen, Rosie, Moccia, Chiara, Nader, Johanna, Nieuwenhuijsen, Mark, Nybo Andersen, Anne-Marie, Pearson, Rebecca, Swertz, Morris, Vafeiadi, Marina, Vrijheid, Martine, Wright, John, Lawlor, Deborah A, and Pedersen, Marie
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- 2024
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10. Comprehensive evaluation of smoking exposures and their interactions on DNA methylation
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Heijmans, Bastiaan, ’t Hoen, Peter, van Meurs, Joyce, Jansen, Rick, Franke, Lude, Boomsma, Dorret, Pool, René, van Dongen, Jenny, Hottenga, Jouke, van Greevenbroek, Marleen, Stehouwer, Coen, van der Kallen, Carla, Schalkwijk, Casper, Wijmenga, Cisca, Zhernakova, Sasha, Tigchelaar, Ettje, Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, Van Heemst, Diana, Veldink, Jan, van den Berg, Leonard, van Duijn, Cornelia, Hofman, Bert, Isaacs, Aaron, Uitterlinden, André, Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka, Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha, van ‘t Hof, Peter, Deelen, Patrick, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Luijk, René, Bonder, Marc, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon, Swertz, Morris, van Zwet, Erik, Hoang, Thanh T., Lee, Yunsung, McCartney, Daniel L., Kersten, Elin T.G., Page, Christian M., Hulls, Paige M., Lee, Mikyeong, Walker, Rosie M., Breeze, Charles E., Bennett, Brian D., Burkholder, Adam B., Ward, James, Brantsæter, Anne Lise, Caspersen, Ida H., Motsinger-Reif, Alison A., Richards, Marie, White, Julie D., Zhao, Shanshan, Richmond, Rebecca C., Magnus, Maria C., Koppelman, Gerard H., Evans, Kathryn L., Marioni, Riccardo E., Håberg, Siri E., and London, Stephanie J.
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- 2024
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11. Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus
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Mathieson, Iain, Day, Felix R., Barban, Nicola, Tropf, Felix C., Brazel, David M., Vaez, Ahmad, van Zuydam, Natalie, Bitarello, Bárbara D., Gardner, Eugene J., Akimova, Evelina T., Azad, Ajuna, Bergmann, Sven, Bielak, Lawrence F., Boomsma, Dorret I., Bosak, Kristina, Brumat, Marco, Buring, Julie E., Cesarini, David, Chasman, Daniel I., Chavarro, Jorge E., Cocca, Massimiliano, Concas, Maria Pina, Davey Smith, George, Davies, Gail, Deary, Ian J., Esko, Tõnu, Faul, Jessica D., Franco, Oscar, Ganna, Andrea, Gaskins, Audrey J., Gelemanovic, Andrea, de Geus, Eco J. C., Gieger, Christian, Girotto, Giorgia, Gopinath, Bamini, Grabe, Hans Jörgen, Gunderson, Erica P., Hayward, Caroline, He, Chunyan, van Heemst, Diana, Hill, W. David, Hoffmann, Eva R., Homuth, Georg, Hottenga, Jouke Jan, Huang, Hongyang, Hyppӧnen, Elina, Ikram, M. Arfan, Jansen, Rick, Johannesson, Magnus, Kamali, Zoha, Kardia, Sharon L. R., Kavousi, Maryam, Kifley, Annette, Kiiskinen, Tuomo, Kraft, Peter, Kühnel, Brigitte, Langenberg, Claudia, Liew, Gerald, Lind, Penelope A., Luan, Jian’an, Mägi, Reedik, Magnusson, Patrik K. E., Mahajan, Anubha, Martin, Nicholas G., Mbarek, Hamdi, McCarthy, Mark I., McMahon, George, Medland, Sarah E., Meitinger, Thomas, Metspalu, Andres, Mihailov, Evelin, Milani, Lili, Missmer, Stacey A., Mitchell, Paul, Møllegaard, Stine, Mook-Kanamori, Dennis O., Morgan, Anna, van der Most, Peter J., de Mutsert, Renée, Nauck, Matthias, Nolte, Ilja M., Noordam, Raymond, Penninx, Brenda W. J. H., Peters, Annette, Peyser, Patricia A., Polašek, Ozren, Power, Chris, Pribisalic, Ajka, Redmond, Paul, Rich-Edwards, Janet W., Ridker, Paul M., Rietveld, Cornelius A., Ring, Susan M., Rose, Lynda M., Rueedi, Rico, Shukla, Vallari, Smith, Jennifer A., Stankovic, Stasa, Stefánsson, Kári, Stöckl, Doris, Strauch, Konstantin, Swertz, Morris A., Teumer, Alexander, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thurik, A. Roy, Timpson, Nicholas J., Turman, Constance, Uitterlinden, André G., Waldenberger, Melanie, Wareham, Nicholas J., Weir, David R., Willemsen, Gonneke, Zhao, Jing Hau, Zhao, Wei, Zhao, Yajie, Snieder, Harold, den Hoed, Marcel, Ong, Ken K., Mills, Melinda C., and Perry, John R. B.
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- 2023
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12. A Solve-RD ClinVar-based reanalysis of 1522 index cases from ERN-ITHACA reveals common pitfalls and misinterpretations in exome sequencing
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Abbott, Kristin M., Banka, Siddharth, de Boer, Elke, Ciolfi, Andrea, Clayton-Smith, Jill, Dallapiccola, Bruno, Denommé-Pichon, Anne-Sophie, Faivre, Laurence, Gilissen, Christian, Haack, Tobias B., Havlovicova, Marketa, Hoischen, Alexander, Jackson, Adam, Kerstjens, Mieke, Kleefstra, Tjitske, Martín, Estrella López, Macek, Milan, Jr., Matalonga, Leslie, Maystadt, Isabelle, Morleo, Manuela, Nigro, Vicenzo, Pinelli, Michele, Pizzi, Simone, Posada, Manuel, Radio, Francesca C., Renieri, Alessandra, Riess, Olaf, Rooryck, Caroline, Ryba, Lukas, Agathe, Jean-Madeleine de Sainte, Santen, Gijs W.E., Schwarz, Martin, Tartaglia, Marco, Thauvin, Christel, Torella, Annalaura, Trimouille, Aurélien, Verloes, Alain, Vissers, Lisenka, Vitobello, Antonio, Votypka, Pavel, Zguro, Kristina, Boer, Elke de, Cohen, Enzo, Danis, Daniel, Gao, Fei, Horvath, Rita, Johari, Mridul, Johanson, Lennart, Li, Shuang, Morsy, Heba, Nelson, Isabelle, Paramonov, Ida, te Paske, Iris B.A.W., Robinson, Peter, Savarese, Marco, Steyaert, Wouter, Töpf, Ana, van der Velde, Joeri K., Vandrovcova, Jana, Graessner, Holm, Zurek, Birte, Ellwanger, Kornelia, Ossowski, Stephan, Demidov, German, Sturm, Marc, Schulze-Hentrich, Julia M., Schüle, Rebecca, Xu, Jishu, Kessler, Christoph, Wayand, Melanie, Synofzik, Matthis, Wilke, Carlo, Traschütz, Andreas, Schöls, Ludger, Hengel, Holger, Lerche, Holger, Kegele, Josua, Heutink, Peter, Brunner, Han, Scheffer, Hans, Hoogerbrugge, Nicoline, ‘t Hoen, Peter A.C., Vissers, Lisenka E.L.M., Sablauskas, Karolis, de Voer, Richarda M., Kamsteeg, Erik-Jan, van de Warrenburg, Bart, van Os, Nienke, Paske, Iris te, Janssen, Erik, Steehouwer, Marloes, Yaldiz, Burcu, Brookes, Anthony J., Veal, Colin, Gibson, Spencer, Maddi, Vatsalya, Mehtarizadeh, Mehdi, Riaz, Umar, Warren, Greg, Dizjikan, Farid Yavari, Shorter, Thomas, Straub, Volker, Bettolo, Chiara Marini, Manera, Jordi Diaz, Hambleton, Sophie, Engelhardt, Karin, Alexander, Elizabeth, Duffourd, Yannis, Bruel, Ange-Line, Peyron, Christine, Pélissier, Aurore, Beltran, Sergi, Gut, Ivo Glynne, Laurie, Steven, Piscia, Davide, Papakonstantinou, Anastasios, Bullich, Gemma, Corvo, Alberto, Fernandez-Callejo, Marcos, Hernández, Carles, Picó, Daniel, Lochmüller, Hanns, Gumus, Gulcin, Bros-Facer, Virginie, Rath, Ana, Hanauer, Marc, Lagorce, David, Hongnat, Oscar, Chahdil, Maroua, Lebreton, Emeline, Stevanin, Giovanni, Durr, Alexandra, Davoine, Claire-Sophie, Guillot-Noel, Léna, Heinzmann, Anna, Coarelli, Giulia, Bonne, Gisèle, Evangelista, Teresinha, Allamand, Valérie, Ben Yaou, Rabah, Metay, Corinne, Eymard, Bruno, Atalaia, Antonio, Stojkovic, Tanya, Turnovec, Marek, Thomasová, Dana, Kremliková, Radka Pourová, Franková, Vera, Havlovicová, Markéta, Lišková, Petra, Doležalová, Pavla, Parkinson, Helen, Keane, Thomas, Freeberg, Mallory, Thomas, Coline, Spalding, Dylan, Robert, Glenn, Costa, Alessia, Patch, Christine, Hanna, Mike, Houlden, Henry, Reilly, Mary, Efthymiou, Stephanie, Cali, Elisa, Magrinelli, Francesca, Sisodiya, Sanjay M., Rohrer, Jonathan, Muntoni, Francesco, Zaharieva, Irina, Sarkozy, Anna, Timmerman, Vincent, Baets, Jonathan, de Vries, Geert, De Winter, Jonathan, Beijer, Danique, de Jonghe, Peter, Van de Vondel, Liedewei, De Ridder, Willem, Weckhuysen, Sarah, Nigro, Vincenzo, Mutarelli, Margherita, Varavallo, Alessandra, Banfi, Sandro, Musacchia, Francesco, Piluso, Giulio, Ferlini, Alessandra, Selvatici, Rita, Gualandi, Francesca, Bigoni, Stefania, Rossi, Rachele, Neri, Marcella, Aretz, Stefan, Spier, Isabel, Sommer, Anna Katharina, Peters, Sophia, Oliveira, Carla, Pelaez, Jose Garcia, Matos, Ana Rita, José, Celina São, Ferreira, Marta, Gullo, Irene, Fernandes, Susana, Garrido, Luzia, Ferreira, Pedro, Carneiro, Fátima, Swertz, Morris A., Johansson, Lennart, van der Vries, Gerben, Neerincx, Pieter B., Ruvolo, David, Kerstjens Frederikse, Wilhemina S., Zonneveld-Huijssoon, Eveline, Roelofs-Prins, Dieuwke, van Gijn, Marielle, Köhler, Sebastian, Metcalfe, Alison, Drunat, Séverine, Heron, Delphine, Mignot, Cyril, Keren, Boris, Lacombe, Didier, Trimouille, Aurelien, Capella, Gabriel, Valle, Laura, Holinski-Feder, Elke, Laner, Andreas, Steinke-Lange, Verena, Cilio, Maria-Roberta, Carpancea, Evelina, Depondt, Chantal, Lederer, Damien, Sznajer, Yves, Duerinckx, Sarah, Mary, Sandrine, Macaya, Alfons, Cazurro-Gutiérrez, Ana, Pérez-Dueñas, Belén, Munell, Francina, Jarava, Clara Franco, Masó, Laura Batlle, Marcé-Grau, Anna, Colobran, Roger, Hackman, Peter, Udd, Bjarne, Hemelsoet, Dimitri, Dermaut, Bart, Schuermans, Nika, Poppe, Bruce, Verdin, Hannah, Osorio, Andrés Nascimento, Depienne, Christel, Roos, Andreas, Cordts, Isabell, Deschauer, Marcus, Striano, Pasquale, Zara, Federico, Riva, Antonella, Iacomino, Michele, Uva, Paolo, Scala, Marcello, Scudieri, Paolo, Başak, Ayşe Nazlı, Claeys, Kristl, Boztug, Kaan, Haimel, Matthias, W.E, Gijs, Ruivenkamp, Claudia A.L., Natera de Benito, Daniel, Thompson, Rachel, Polavarapu, Kiran, Grimbacher, Bodo, Zaganas, Ioannis, Kokosali, Evgenia, Lambros, Mathioudakis, Evangeliou, Athanasios, Spilioti, Martha, Kapaki, Elisabeth, Bourbouli, Mara, Radio, Francesca Clementina, Balicza, Peter, Molnar, Maria Judit, De la Paz, Manuel Posada, Sánchez, Eva Bermejo, Delgado, Beatriz Martínez, Alonso García de la Rosa, F. Javier, Schröck, Evelin, Rump, Andreas, Mei, Davide, Vetro, Annalisa, Balestrini, Simona, Guerrini, Renzo, Chinnery, Patrick F., Ratnaike, Thiloka, Schon, Katherine, Maver, Ales, Peterlin, Borut, Münchau, Alexander, Lohmann, Katja, Herzog, Rebecca, Pauly, Martje, May, Patrick, Beeson, David, Cossins, Judith, Furini, Simone, Fallerini, Chiara, Benetti, Elisa, Afenjar, Alexandra, Goldenberg, Alice, Masurel, Alice, Phan, Alice, Dieux-Coeslier, Anne, Fargeot, Anne, Guerrot, Anne-Marie, Toutain, Annick, Molin, Arnaud, Sorlin, Arthur, Putoux, Audrey, Jouret, Béatrice, Laudier, Béatrice, Demeer, Bénédicte, Doray, Bérénice, Bonniaud, Bertille, Isidor, Bertrand, Gilbert-Dussardier, Brigitte, Leheup, Bruno, Reversade, Bruno, Paul, Carle, Vincent-Delorme, Catherine, Neiva, Cecilia, Poirsier, Céline, Quélin, Chloé, Chiaverini, Christine, Coubes, Christine, Francannet, Christine, Colson, Cindy, Desplantes, Claire, Wells, Constance, Goizet, Cyril, Sanlaville, Damien, Amram, Daniel, Lehalle, Daphné, Geneviève, David, Gaillard, Dominique, Zivi, Einat, Sarrazin, Elisabeth, Steichen, Elisabeth, Schaefer, Élise, Lacaze, Elodie, Jacquemin, Emmanuel, Bongers, Ernie, Kilic, Esra, Colin, Estelle, Giuliano, Fabienne, Prieur, Fabienne, Laffargue, Fanny, Morice-Picard, Fanny, Petit, Florence, Cartault, François, Feillet, François, Baujat, Geneviève, Morin, Gilles, Diene, Gwenaëlle, Journel, Hubert, Perthus, Isabelle, Lespinasse, James, Alessandri, Jean-Luc, Amiel, Jeanne, Martinovic, Jelena, Delanne, Julian, Albuisson, Juliette, Lambert, Laëtitia, Perrin, Laurence, Ousager, Lilian Bomme, Van Maldergem, Lionel, Pinson, Lucile, Ruaud, Lyse, Samimi, Mahtab, Bournez, Marie, Bonnet-Dupeyron, Marie Noëlle, Vincent, Marie, Jacquemont, Marie-Line, Cordier-Alex, Marie-Pierre, Gérard-Blanluet, Marion, Willems, Marjolaine, Spodenkiewicz, Marta, Doco-Fenzy, Martine, Rossi, Massimiliano, Renaud, Mathilde, Fradin, Mélanie, Mathieu, Michèle, Holder-Espinasse, Muriel H., Houcinat, Nada, Hanna, Nadine, Leperrier, Nathalie, Chassaing, Nicolas, Philip, Nicole, Boute, Odile, Van Kien, Philippe Khau, Parent, Philippe, Bitoun, Pierre, Sarda, Pierre, Vabres, Pierre, Jouk, Pierre-Simon, Touraine, Renaud, El Chehadeh, Salima, Whalen, Sandra, Marlin, Sandrine, Passemard, Sandrine, Grotto, Sarah, Bellanger, Séverine Audebert, Blesson, Sophie, Nambot, Sophie, Naudion, Sophie, Lyonnet, Stanislas, Odent, Sylvie, Attie-Bitach, Tania, Busa, Tiffany, Drouin-Garraud, Valérie, Layet, Valérie, Bizaoui, Varoona, Cusin, Véronica, Capri, Yline, Alembik, Yves, Jean-Marçais, Nolwenn, López-Martín, Estrella, Macek, Milan, Mencarelli, Maria Antonietta, Moutton, Sébastien, Pfundt, Rolph, Safraou, Hana, Thauvin-Robinet, Christel, Thevenon, Julien, Tran Mau-Them, Frédéric, de Vries, Bert B.A., Willemsen, Marjolein H., and Philippe, Christophe
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- 2023
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13. Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19
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Zhang, Bowen, Zhang, Zhenhua, Koeken, Valerie A.C.M., Kumar, Saumya, Aillaud, Michelle, Tsay, Hsin-Chieh, Liu, Zhaoli, Kraft, Anke R.M., Soon, Chai Fen, Odak, Ivan, Bošnjak, Berislav, Vlot, Anna, Swertz, Morris A., Ohler, Uwe, Geffers, Robert, Illig, Thomas, Huehn, Jochen, Saliba, Antoine-Emmanuel, Sander, Leif Erik, Förster, Reinhold, Xu, Cheng-Jian, Cornberg, Markus, Schulte, Leon N., and Li, Yang
- Published
- 2023
- Full Text
- View/download PDF
14. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.
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Noordam, Raymond, Bos, Maxime M, Wang, Heming, Winkler, Thomas W, Bentley, Amy R, Kilpeläinen, Tuomas O, de Vries, Paul S, Sung, Yun Ju, Schwander, Karen, Cade, Brian E, Manning, Alisa, Aschard, Hugues, Brown, Michael R, Chen, Han, Franceschini, Nora, Musani, Solomon K, Richard, Melissa, Vojinovic, Dina, Aslibekyan, Stella, Bartz, Traci M, de Las Fuentes, Lisa, Feitosa, Mary, Horimoto, Andrea R, Ilkov, Marjan, Kho, Minjung, Kraja, Aldi, Li, Changwei, Lim, Elise, Liu, Yongmei, Mook-Kanamori, Dennis O, Rankinen, Tuomo, Tajuddin, Salman M, van der Spek, Ashley, Wang, Zhe, Marten, Jonathan, Laville, Vincent, Alver, Maris, Evangelou, Evangelos, Graff, Maria E, He, Meian, Kühnel, Brigitte, Lyytikäinen, Leo-Pekka, Marques-Vidal, Pedro, Nolte, Ilja M, Palmer, Nicholette D, Rauramaa, Rainer, Shu, Xiao-Ou, Snieder, Harold, Weiss, Stefan, Wen, Wanqing, Yanek, Lisa R, Adolfo, Correa, Ballantyne, Christie, Bielak, Larry, Biermasz, Nienke R, Boerwinkle, Eric, Dimou, Niki, Eiriksdottir, Gudny, Gao, Chuan, Gharib, Sina A, Gottlieb, Daniel J, Haba-Rubio, José, Harris, Tamara B, Heikkinen, Sami, Heinzer, Raphaël, Hixson, James E, Homuth, Georg, Ikram, M Arfan, Komulainen, Pirjo, Krieger, Jose E, Lee, Jiwon, Liu, Jingmin, Lohman, Kurt K, Luik, Annemarie I, Mägi, Reedik, Martin, Lisa W, Meitinger, Thomas, Metspalu, Andres, Milaneschi, Yuri, Nalls, Mike A, O'Connell, Jeff, Peters, Annette, Peyser, Patricia, Raitakari, Olli T, Reiner, Alex P, Rensen, Patrick CN, Rice, Treva K, Rich, Stephen S, Roenneberg, Till, Rotter, Jerome I, Schreiner, Pamela J, Shikany, James, Sidney, Stephen S, Sims, Mario, Sitlani, Colleen M, Sofer, Tamar, Strauch, Konstantin, Swertz, Morris A, Taylor, Kent D, and Uitterlinden, André G
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Humans ,Lipids ,Chromosome Mapping ,Sleep ,Phylogeny ,Polymorphism ,Single Nucleotide ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Middle Aged ,Female ,Male ,Young Adult ,Genetic Loci ,Polymorphism ,Single Nucleotide ,and over - Abstract
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.
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- 2019
15. Semantic modelling of common data elements for rare disease registries, and a prototype workflow for their deployment over registry data
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Kaliyaperumal, Rajaram, Wilkinson, Mark D., Moreno, Pablo Alarcón, Benis, Nirupama, Cornet, Ronald, dos Santos Vieira, Bruna, Dumontier, Michel, Bernabé, César Henrique, Jacobsen, Annika, Le Cornec, Clémence M. A., Godoy, Mario Prieto, Queralt-Rosinach, Núria, Schultze Kool, Leo J., Swertz, Morris A., van Damme, Philip, van der Velde, K. Joeri, Lalout, Nawel, Zhang, Shuxin, and Roos, Marco
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- 2022
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16. FAIR Genomes metadata schema promoting Next Generation Sequencing data reuse in Dutch healthcare and research
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van der Velde, K. Joeri, Singh, Gurnoor, Kaliyaperumal, Rajaram, Liao, XiaoFeng, de Ridder, Sander, Rebers, Susanne, Kerstens, Hindrik H. D., de Andrade, Fernanda, van Reeuwijk, Jeroen, De Gruyter, Fini E., Hiltemann, Saskia, Ligtvoet, Maarten, Weiss, Marjan M., van Deutekom, Hanneke W. M., Jansen, Anne M. L., Stubbs, Andrew P., Vissers, Lisenka E. L. M., Laros, Jeroen F. J., van Enckevort, Esther, Stemkens, Daphne, ‘t Hoen, Peter A. C., Beliën, Jeroen A. M., van Gijn, Mariëlle E., and Swertz, Morris A.
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- 2022
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17. Towards FAIRification of sensitive and fragmented rare disease patient data: challenges and solutions in European reference network registries
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dos Santos Vieira, Bruna, Bernabé, César H., Zhang, Shuxin, Abaza, Haitham, Benis, Nirupama, Cámara, Alberto, Cornet, Ronald, Le Cornec, Clémence M. A., ’t Hoen, Peter A. C., Schaefer, Franz, van der Velde, K. Joeri, Swertz, Morris A., Wilkinson, Mark D., Jacobsen, Annika, and Roos, Marco
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- 2022
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18. Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
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Lopera-Maya, Esteban A., Kurilshikov, Alexander, van der Graaf, Adriaan, Hu, Shixian, Andreu-Sánchez, Sergio, Chen, Lianmin, Vila, Arnau Vich, Gacesa, Ranko, Sinha, Trishla, Collij, Valerie, Klaassen, Marjiolein A. Y., Bolte, Laura A., Gois, Milla F. Brandao, Neerincx, Pieter B. T., Swertz, Morris A., Harmsen, Hermie J. M., Wijmenga, Cisca, Fu, Jingyuan, Weersma, Rinse K., Zhernakova, Alexandra, and Sanna, Serena
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- 2022
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19. Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity
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Bakker, Mark K., Kanning, Jos P., Abraham, Gad, Martinsen, Amy E., Winsvold, Bendik S., Zwart, John-Anker, Bourcier, Romain, Sawada, Tomonobu, Koido, Masaru, Kamatani, Yoichiro, Morel, Sandrine, Amouyel, Philippe, Debette, Stéphanie, Bijlenga, Philippe, Berrandou, Takiy, Ganesh, Santhi K., Bouatia-Naji, Nabila, Jones, Gregory, Bown, Matthew, Rinkel, Gabriel J.E., Veldink, Jan H., Ruigrok, Ynte M., Hege Aamodt, Anne, Heidi Skogholt, Anne, Brumpton, Ben M, Willer, Cristen J, Sandset, Else C, Kristoffersen, Espen S, Ellekjær, Hanne, Heuch, Ingrid, Nielsen, Jonas B, Hagen, Knut, Hveem, Kristian, Fritsche, Lars G, Thomas, Laurent F, Pedersen, Linda M, Gabrielsen, Maiken E, Holmen, Oddgeir L, Børte, Sigrid, Zhou, Wei, Abboud, Shérine, Pandolfo, Massimo, Thijs, Vincent, Leys, Didier, Bodenant, Marie, Louillet, Fabien, Touzé, Emmanuel, Mas, Jean-Louis, Samson, Yves, Leder, Sara, Léger, Anne, Deltour, Sandrine, Crozier, Sophie, Méresse, Isabelle, Canaple, Sandrine, Godefroy, Olivier, Giroud, Maurice, Béjot, Yannick, Decavel, Pierre, Medeiros, Elizabeth, Montiel, Paola, Moulin, Thierry, Vuillier, Fabrice, Dallongeville, Jean, Metso, Antti J, Metso, Tiina, Tatlisumak, Turgut, Grond-Ginsbach, Caspar, Lichy, Christoph, Kloss, Manja, Werner, Inge, Arnold, Marie-Luise, Dos Santos, Michael, Grau, Armin, Dichgans, Martin, Thomas-Feles, Constanze, Weber, Ralf, Brandt, Tobias, Pezzini, Alessandro, De Giuli, Valeria, Caria, Filomena, Poli, Loris, Padovani, Alessandro, Bersano, Anna, Lanfranconi, Silvia, Beretta, Simone, Ferrarese, Carlo, Giacolone, Giacomo, Paolucci, Stefano, Lyrer, Philippe, Engelter, Stefan, Fluri, Felix, Hatz, Florian, Gisler, Dominique, Bonati, Leo, Gensicke, Henrik, Amort, Margareth, Markus, Hugh, Majersik, Jennifer, Worrall, Bradford, Southerland, Andrew, Cole, John, Kittner, Steven, Evangelou, Evangelos, Warren, Helen R, Gao, He, Ntritsos, Georgios, Dimou, Niki, Esko, Tonu, Mägi, Reedik, Milani, Lili, Almgren, Peter, Boutin, Thibaud, Ding, Jun, Giulianini, Franco, Holliday, Elizabeth G, Jackson, Anne U, Li-Gao, Ruifang, Lin, Wei-Yu, Luan, Jian’an, Mangino, Massimo, Oldmeadow, Christopher, Peter Prins, Bram, Qian, Yong, Sargurupremraj, Muralidharan, Shah, Nabi, Surendran, Praveen, Thériault, Sébastien, Verweij, Niek, Willems, Sara M, Zhao, Jing-Hua, Connell, John, de Mutsert, Renée, Doney, Alex SF, Farrall, Martin, Menni, Cristina, Morris, Andrew D, Noordam, Raymond, Paré, Guillaume, Poulter, Neil R, Shields, Denis C, Stanton, Alice, Thom, Simon, Abecasis, Gonçalo, Amin, Najaf, Arking, Dan E, Ayers, Kristin L, Barbieri, Caterina M, Batini, Chiara, Bis, Joshua C, Blake, Tineka, Bochud, Murielle, Boehnke, Michael, Boerwinkle, Eric, Boomsma, Dorret I, Bottinger, Erwin P, Braund, Peter S, Brumat, Marco, Campbell, Archie, Campbell, Harry, Chakravarti, Aravinda, Chambers, John C, Chauhan, Ganesh, Ciullo, Marina, Cocca, Massimiliano, Collins, Francis, Cordell, Heather J, Davies, Gail, de Borst, Martin H, de Geus, Eco J, Deary, Ian J, Deelen, Joris, Del Greco M, Fabiola, Yusuf Demirkale, Cumhur, Dörr, Marcus, Ehret, Georg B, Elosua, Roberto, Enroth, Stefan, Mesut Erzurumluoglu, A, Ferreira, Teresa, Frånberg, Mattias, Franco, Oscar H, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Goel, Anuj, Gow, Alan J, Gudnason, Vilmundur, Guo, Xiuqing, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B, Harris, Sarah E, Hartman, Catharina A, Havulinna, Aki S, Hicks, Andrew A, Hofer, Edith, Hofman, Albert, Hottenga, Jouke-Jan, Huffman, Jennifer E, Hwang, Shih-Jen, Ingelsson, Erik, James, Alan, Jansen, Rick, Jarvelin, Marjo-Riitta, Joehanes, Roby, Johansson, Åsa, Johnson, Andrew D, Joshi, Peter K, Jousilahti, Pekka, Wouter Jukema, J, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Keavney, Bernard D, Khaw, Kay-Tee, Knekt, Paul, Knight, Joanne, Kolcic, Ivana, Kooner, Jaspal S, Koskinen, Seppo, Kristiansson, Kati, Kutalik, Zoltan, Laan, Maris, Larson, Marty, Launer, Lenore J, Lehne, Benjamin, Lehtimäki, Terho, Liewald, David CM, Lin, Li, Lind, Lars, Lindgren, Cecilia M, Liu, YongMei, Loos, Ruth JF, Lopez, Lorna M, Lu, Yingchang, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Mamasoula, Chrysovalanto, Marrugat, Jaume, Marten, Jonathan, Milaneschi, Yuri, Morgan, Anna, Morris, Andrew P, Morrison, Alanna C, Munson, Peter J, Nalls, Mike A, Nandakumar, Priyanka, Nelson, Christopher P, Niiranen, Teemu, Nolte, Ilja M, Nutile, Teresa, Oldehinkel, Albertine J, Oostra, Ben A, O’Reilly, Paul F, Org, Elin, Padmanabhan, Sandosh, Palmas, Walter, Palotie, Aarno, Pattie, Alison, WJH Penninx, Brenda, Perola, Markus, Peters, Annette, Polasek, Ozren, Pramstaller, Peter P, Tri Nguyen, Quang, Raitakari, Olli T, Rettig, Rainer, Rice, Kenneth, Ridker, Paul M, Ried, Janina S, Riese, Harriëtte, Ripatti, Samuli, Robino, Antonietta, Rose, Lynda M, Rotter, Jerome I, Rudan, Igor, Ruggiero, Daniela, Saba, Yasaman, Sala, Cinzia F, Salomaa, Veikko, Samani, Nilesh J, Sarin, Antti-Pekka, Schmidt, Reinhold, Schmidt, Helena, Shrine, Nick, Siscovick, David, Smith, Albert V, Snieder, Harold, Sõber, Siim, Sorice, Rossella, Starr, John M, Stott, David J, Strachan, David P, Strawbridge, Rona J, Sundström, Johan, Swertz, Morris A, Taylor, Kent D, Teumer, Alexander, Tobin, Martin D, Tomaszewski, Maciej, Toniolo, Daniela, Traglia, Michela, Trompet, Stella, Tuomilehto, Jaakko, Tzourio, Christophe, Uitterlinden, André G, Vaez, Ahmad, van der Most, Peter J, van Duijn, Cornelia M, Verwoert, Germaine C, Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Vuckovic, Dragana, Watkins, Hugh, Wild, Sarah H, Willemsen, Gonneke, Wilson, James F, Wright, Alan F, Yao, Jie, Zemunik, Tatijana, Zhang, Weihua, Attia, John R, Butterworth, Adam S, Chasman, Daniel I, Conen, David, Cucca, Francesco, Danesh, John, Hayward, Caroline, Howson, Joanna MM, Laakso, Markku, Lakatta, Edward G, Langenberg, Claudia, Melander, Olle, Mook-Kanamori, Dennis O, Palmer, Colin NA, Risch, Lorenz, Scott, Robert A, Scott, Rodney J, Sever, Peter, Spector, Tim D, van der Harst, Pim, Wareham, Nicholas J, Zeggini, Eleftheria, Levy, Daniel, Munroe, Patricia B, Newton-Cheh, Christopher, Brown, Morris J, Metspalu, Andres, Psaty, Bruce M., Wain, Louise V, Elliott, Paul, Caulfield, Mark J, Gormley, Padhraig, Anttila, Verneri, Palta, Priit, Esko, Tonu, Pers, Tune H, Farh, Kai-How, Cuenca-Leon, Ester, Muona, Mikko, Furlotte, Nicholas A, Kurth, Tobias, Ingason, Andres, McMahon, George, Ligthart, Lannie, Terwindt, Gisela M, Kallela, Mikko, Freilinger, Tobias M, Ran, Caroline, Gordon, Scott G, Stam, Anine H, Steinberg, Stacy, Borck, Guntram, Koiranen, Markku, Quaye, Lydia, Adams, Hieab H H, Lehtimäki, Terho, Sarin, Antti-Pekka, Wedenoja, Juho, Hinds, David A, Buring, Julie E, Schürks, Markus, Ridker, Paul M, Gudlaug Hrafnsdottir, Maria, Stefansson, Hreinn, Ring, Susan M, Hottenga, Jouke-Jan, Penninx, Brenda W J H, Färkkilä, Markus, Artto, Ville, Kaunisto, Mari, Vepsäläinen, Salli, Malik, Rainer, Heath, Andrew C, Madden, Pamela A F, Martin, Nicholas G, Montgomery, Grant W, Kurki, Mitja I, Kals, Mart, Mägi, Reedik, Pärn, Kalle, Hämäläinen, Eija, Huang, Hailiang, Byrnes, Andrea E, Franke, Lude, Huang, Jie, Stergiakouli, Evie, Lee, Phil H, Sandor, Cynthia, Webber, Caleb, Cader, Zameel, Muller-Myhsok, Bertram, Schreiber, Stefan, Meitinger, Thomas, Eriksson, Johan G, Salomaa, Veikko, Heikkilä, Kauko, Loehrer, Elizabeth, Uitterlinden, Andre G, Hofman, Albert, van Duijn, Cornelia M, Cherkas, Lynn, Pedersen, Linda M, Stubhaug, Audun, Nielsen, Christopher S, Männikkö, Minna, Mihailov, Evelin, Milani, Lili, Göbel, Hartmut, Esserlind, Ann-Louise, Francke Christensen, Anne, Folkmann Hansen, Thomas, Werge, Thomas, Kaprio, Jaakko, Aromaa, Arpo J, Raitakari, Olli, Arfan Ikram, M, Spector, Tim, Järvelin, Marjo-Riitta, Metspalu, Andres, Kubisch, Christian, Strachan, David P, Ferrari, Michel D, Belin, Andrea C, Dichgans, Martin, Wessman, Maija, van den Maagdenberg, Arn M J M, Boomsma, Dorret I, Davey Smith, George, Stefansson, Kari, Eriksson, Nicholas, Daly, Mark J, Neale, Benjamin M, Olesen, Jes, Chasman, Daniel I, Nyholt, Dale R, Palotie, Aarno, Akiyama, Masato, Alg, Varinder S., Børte, Sigrid, Broderick, Joseph P., Brumpton, Ben M., Dauvillier, Jérôme, Desal, Hubert, Dina, Christian, Friedrich, Christoph M., Gaál-Paavola, Emília I., Gentric, Jean-Christophe, Hirsch, Sven, Hostettler, Isabel C., Houlden, Henry, Hveem, Kristian, Jääskeläinen, Juha E., Johnsen, Marianne Bakke, Li, Liming, Lin, Kuang, Lindgren, Antti, Martin, Olivier, Matsuda, Koichi, Millwood, Iona Y., Naggara, Olivier, Niemelä, Mika, Pera, Joanna, Redon, Richard, Rouleau, Guy A., Sandvei, Marie Søfteland, Schilling, Sabine, Shotar, Eimad, Slowik, Agnieszka, Terao, Chikashi, Verschuren, W. M. Monique, Walters, Robin G., Werring, David J., Willer, Cristen J., Woo, Daniel, Worrall, Bradford B., and Zhou, Sirui
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- 2023
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20. DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation
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Richard, Melissa A, Huan, Tianxiao, Ligthart, Symen, Gondalia, Rahul, Jhun, Min A, Brody, Jennifer A, Irvin, Marguerite R, Marioni, Riccardo, Shen, Jincheng, Tsai, Pei-Chien, Montasser, May E, Jia, Yucheng, Syme, Catriona, Salfati, Elias L, Boerwinkle, Eric, Guan, Weihua, Mosley, Thomas H, Bressler, Jan, Morrison, Alanna C, Liu, Chunyu, Mendelson, Michael M, Uitterlinden, André G, van Meurs, Joyce B, Consortium, BIOS, Heijmans, Bastiaan T, Hoen, Peter AC ’t, van Meurs, Joyce, Isaacs, Aaron, Jansen, Rick, Franke, Lude, Boomsma, Dorret I, Pool, René, van Dongen, Jenny, Hottenga, Jouke J, van Greevenbroek, Marleen MJ, Stehouwer, Coen DA, van der Kallen, Carla JH, Schalkwijk, Casper G, Wijmenga, Cisca, Zhernakova, Alexandra, Tigchelaar, Ettje F, Slagboom, P Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, Veldink, Jan H, van den Berg, Leonard H, van Duijn, Cornelia M, Hofman, Albert, Jhamai, P Mila, Verbiest, Michael, Suchiman, H Eka D, Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, van ’t Hof, Peter, Deelen, Patrick, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Zhernakova, Dasha V, Luijk, René, Bonder, Marc Jan, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon M, Swertz, Morris A, van Zwet, Erik W, Franco, Oscar H, Zhang, Guosheng, Li, Yun, Stewart, James D, Bis, Joshua C, Psaty, Bruce M, Chen, Yii-Der Ida, Kardia, Sharon LR, Zhao, Wei, Turner, Stephen T, Absher, Devin, Aslibekyan, Stella, Starr, John M, McRae, Allan F, Hou, Lifang, Just, Allan C, Schwartz, Joel D, Vokonas, Pantel S, Menni, Cristina, Spector, Tim D, Shuldiner, Alan, Damcott, Coleen M, Rotter, Jerome I, Palmas, Walter, Liu, Yongmei, and Paus, Tomáš
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Epidemiology ,Biological Sciences ,Health Sciences ,Genetics ,Human Genome ,Biotechnology ,Aetiology ,2.1 Biological and endogenous factors ,Aged ,Blood Pressure ,CpG Islands ,Cross-Sectional Studies ,DNA Methylation ,Epigenesis ,Genetic ,Genetic Variation ,Genome-Wide Association Study ,Humans ,Mendelian Randomization Analysis ,Middle Aged ,Nerve Tissue Proteins ,Quantitative Trait Loci ,Tetraspanins ,BIOS Consortium ,DNA methylation ,Mendelian randomization ,blood pressure ,epigenome-wide association study ,gene expression ,sequence variation ,Medical and Health Sciences ,Genetics & Heredity ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
Genome-wide association studies have identified hundreds of genetic variants associated with blood pressure (BP), but sequence variation accounts for a small fraction of the phenotypic variance. Epigenetic changes may alter the expression of genes involved in BP regulation and explain part of the missing heritability. We therefore conducted a two-stage meta-analysis of the cross-sectional associations of systolic and diastolic BP with blood-derived genome-wide DNA methylation measured on the Infinium HumanMethylation450 BeadChip in 17,010 individuals of European, African American, and Hispanic ancestry. Of 31 discovery-stage cytosine-phosphate-guanine (CpG) dinucleotides, 13 replicated after Bonferroni correction (discovery: N = 9,828, p < 1.0 × 10-7; replication: N = 7,182, p 30%) and independent of known BP genetic variants, explaining an additional 1.4% and 2.0% of the interindividual variation in systolic and diastolic BP, respectively. Bidirectional Mendelian randomization among up to 4,513 individuals of European ancestry from 4 cohorts suggested that methylation at cg08035323 (TAF1B-YWHAQ) influences BP, while BP influences methylation at cg00533891 (ZMIZ1), cg00574958 (CPT1A), and cg02711608 (SLC1A5). Gene expression analyses further identified six genes (TSPAN2, SLC7A11, UNC93B1, CPT1A, PTMS, and LPCAT3) with evidence of triangular associations between methylation, gene expression, and BP. Additional integrative Mendelian randomization analyses of gene expression and DNA methylation suggested that the expression of TSPAN2 is a putative mediator of association between DNA methylation at cg23999170 and BP. These findings suggest that heritable DNA methylation plays a role in regulating BP independently of previously known genetic variants.
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- 2017
21. MOLGENIS VIP: an open-source and modular pipeline for high-throughput and integrated DNA variant analysis
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Maassen, Willem T.K., primary, Johansson, Lennart F., additional, Charbon, Bart, additional, Hendriksen, Dennis, additional, van den Hoek, Sander, additional, Slofstra, Mariska K., additional, Mulder, Rene, additional, Meems-Veldhuis, Martine T., additional, Sietsma, Robert, additional, Lemmink, Henny H., additional, van Diemen, Cleo C., additional, van Gijn, Marielle E., additional, Swertz, Morris A., additional, and van der Velde, Kasper J., additional
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- 2024
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22. Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure
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Ganji-Arjenaki, Mahboube, primary, Kamali, Zoha, additional, Evangelou, Evangelos, additional, Warren, Helen R., additional, Gao, He, additional, Ntritsos, Georgios, additional, Dimou, Niki, additional, Esko, Tonu, additional, Mägi, Reedik, additional, Milani, Lili, additional, Almgren, Peter, additional, Boutin, Thibaud, additional, Debette, Stéphanie, additional, Ding, Jun, additional, Giulianini, Franco, additional, Holliday, Elizabeth G., additional, Jackson, Anne U., additional, Li -Gao, Ruifang, additional, Lin, Wei -Yu, additional, Luan, Jian'an, additional, Mangino, Massimo, additional, Oldmeadow, Christopher, additional, Prins, Bram Peter, additional, Qian, Yong, additional, Sargurupremraj, Muralidharan, additional, Shah, Nabi, additional, Surendran, Praveen, additional, Thériault, Sébastien, additional, Verweij, Niek, additional, Willems, Sara M., additional, Zhao, Jing -Hua, additional, Amouyel, Philippe, additional, Connell, John, additional, de Mutsert, Renée, additional, Doney, Alex S.F., additional, Farrall, Martin, additional, Menni, Cristina, additional, Morris, Andrew D., additional, Noordam, Raymond, additional, Paré, Guillaume, additional, Poulter, Neil R., additional, Shields, Denis C., additional, Stanton, Alice, additional, Thom, Simon, additional, Abecasis, Gonçalo, additional, Amin, Najaf, additional, Arking, Dan E., additional, Ayers, Kristin L., additional, Barbieri, Caterina M., additional, Batini, Chiara, additional, Bis, Joshua C., additional, Blake, Tineka, additional, Bochud, Murielle, additional, Boehnke, Michael, additional, Boerwinkle, Eric, additional, Boomsma, Dorret I., additional, Bottinger, Erwin P., additional, Braund, Peter S., additional, Brumat, Marco, additional, Campbell, Archie, additional, Campbell, Harry, additional, Chakravarti, Aravinda, additional, Chambers, John C., additional, Chauhan, Ganesh, additional, Ciullo, Marina, additional, Cocca, Massimiliano, additional, Collins, Francis, additional, Cordell, Heather J., additional, Davies, Gail, additional, de Borst, Martin H., additional, de Geus, Eco J., additional, Deary, Ian J., additional, Deelen, Joris, additional, Del Greco M, Fabiola, additional, Demirkale, Cumhur Yusuf, additional, Dörr, Marcus, additional, Ehret, Georg B., additional, Elosua, Roberto, additional, Enroth, Stefan, additional, Erzurumluoglu, A. Mesut, additional, Ferreira, Teresa, additional, Frånberg, Mattias, additional, Franco, Oscar H., additional, Gandin, Ilaria, additional, Gasparini, Paolo, additional, Giedraitis, Vilmantas, additional, Gieger, Christian, additional, Girotto, Giorgia, additional, Goel, Anuj, additional, Gow, Alan J., additional, Gudnason, Vilmundur, additional, Guo, Xiuqing, additional, Gyllensten, Ulf, additional, Hamsten, Anders, additional, Harris, Tamara B., additional, Harris, Sarah E., additional, Hartman, Catharina A., additional, Havulinna, Aki S., additional, Hicks, Andrew A., additional, Hofer, Edith, additional, Hofman, Albert, additional, Hottenga, Jouke-Jan, additional, Huffman, Jennifer E., additional, Hwang, Shih-Jen, additional, Ingelsson, Erik, additional, James, Alan, additional, Jansen, Rick, additional, Jarvelin, Marjo -Riitta, additional, Joehanes, Roby, additional, Johansson, Åsa, additional, Johnson, Andrew D., additional, Joshi, Peter K., additional, Jousilahti, Pekka, additional, Jukema, J. Wouter, additional, Jula, Antti, additional, Kähönen, Mika, additional, Kathiresan, Sekar, additional, Keavney, Bernard D., additional, Khaw, Kay-Tee, additional, Knekt, Paul, additional, Knight, Joanne, additional, Kolcic, Ivana, additional, Kooner, Jaspal S., additional, Koskinen, Seppo, additional, Kristiansson, Kati, additional, Kutalik, Zoltan, additional, Laan, Maris, additional, Larson, Marty, additional, Launer, Lenore J., additional, Lehne, Benjamin, additional, Lehtimäki, Terho, additional, Liewald, David C.M., additional, Lin, Li, additional, Lind, Lars, additional, Lindgren, Cecilia M., additional, Liu, YongMei, additional, Loos, Ruth J.F., additional, Lopez, Lorna M., additional, Lu, Yingchang, additional, Lyytikäinen, Leo-Pekka, additional, Mahajan, Anubha, additional, Mamasoula, Chrysovalanto, additional, Marrugat, Jaume, additional, Marten, Jonathan, additional, Milaneschi, Yuri, additional, Morgan, Anna, additional, Morris, Andrew P., additional, Morrison, Alanna C., additional, Munson, Peter J., additional, Nalls, Mike A., additional, Nandakumar, Priyanka, additional, Nelson, Christopher P., additional, Niiranen, Teemu, additional, Nolte, Ilja M., additional, Nutile, Teresa, additional, Oldehinkel, Albertine J., additional, Oostra, Ben A., additional, O'Reilly, Paul F., additional, Org, Elin, additional, Padmanabhan, Sandosh, additional, Palmas, Walter, additional, Palotie, Aarno, additional, Pattie, Alison, additional, Penninx, Brenda W.J.H., additional, Perola, Markus, additional, Peters, Annette, additional, Polasek, Ozren, additional, Pramstaller, Peter P., additional, Nguyen, Quang Tri, additional, Raitakari, Olli T., additional, Rettig, Rainer, additional, Rice, Kenneth, additional, Ridker, Paul M., additional, Ried, Janina S., additional, Riese, Harriëtte, additional, Ripatti, Samuli, additional, Robino, Antonietta, additional, Rose, Lynda M., additional, Rotter, Jerome I., additional, Rudan, Igor, additional, Ruggiero, Daniela, additional, Saba, Yasaman, additional, Sala, Cinzia F., additional, Salomaa, Veikko, additional, Samani, Nilesh J., additional, Sarin, Antti-Pekka, additional, Schmidt, Reinhold, additional, Schmidt, Helena, additional, Shrine, Nick, additional, Siscovick, David, additional, Smith, Albert V., additional, Snieder, Harold, additional, Sõber, Siim, additional, Sorice, Rossella, additional, Starr, John M., additional, Stott, David J., additional, Strachan, David P., additional, Strawbridge, Rona J., additional, Sundström, Johan, additional, Swertz, Morris A., additional, Taylor, Kent D., additional, Teumer, Alexander, additional, Tobin, Martin D., additional, Tomaszewski, Maciej, additional, Toniolo, Daniela, additional, Traglia, Michela, additional, Trompet, Stella, additional, Tuomilehto, Jaakko, additional, Tzourio, Christophe, additional, Uitterlinden, André G., additional, Vaez, Ahmad, additional, van der Most, Peter J., additional, van Duijn, Cornelia M., additional, Verwoert, Germaine C., additional, Vitart, Veronique, additional, Völker, Uwe, additional, Vollenweider, Peter, additional, Vuckovic, Dragana, additional, Watkins, Hugh, additional, Wild, Sarah H., additional, Willemsen, Gonneke, additional, Wilson, James F., additional, Wright, Alan F., additional, Yao, Jie, additional, Zemunik, Tatijana, additional, Zhang, Weihua, additional, Attia, John R., additional, Butterworth, Adam S., additional, Chasman, Daniel I., additional, Conen, David, additional, Cucca, Francesco, additional, Danesh, John, additional, Hayward, Caroline, additional, Howson, Joanna M.M., additional, Laakso, Markku, additional, Lakatta, Edward G., additional, Langenberg, Claudia, additional, Melander, Olle, additional, Mook-Kanamori, Dennis O., additional, Palmer, Colin N.A., additional, Risch, Lorenz, additional, Scott, Robert A., additional, Scott, Rodney J., additional, Sever, Peter, additional, Spector, Tim D., additional, van der Harst, Pim, additional, Wareham, Nicholas J., additional, Zeggini, Eleftheria, additional, Levy, Daniel, additional, Munroe, Patricia B., additional, Newton-Cheh, Christopher, additional, Brown, Morris J., additional, Metspalu, Andres, additional, Psaty, Bruce M., additional, Wain, Louise V., additional, Elliott, Paul, additional, Caulfield, Mark J., additional, Sardari, Soroush, additional, and de Borst, Martin, additional
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- 2024
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23. The Data Use Ontology to streamline responsible access to human biomedical datasets
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Lawson, Jonathan, Cabili, Moran N., Kerry, Giselle, Boughtwood, Tiffany, Thorogood, Adrian, Alper, Pinar, Bowers, Sarion R., Boyles, Rebecca R., Brookes, Anthony J., Brush, Matthew, Burdett, Tony, Clissold, Hayley, Donnelly, Stacey, Dyke, Stephanie O.M., Freeberg, Mallory A., Haendel, Melissa A., Hata, Chihiro, Holub, Petr, Jeanson, Francis, Jene, Aina, Kawashima, Minae, Kawashima, Shuichi, Konopko, Melissa, Kyomugisha, Irene, Li, Haoyuan, Linden, Mikael, Rodriguez, Laura Lyman, Morita, Mizuki, Mulder, Nicola, Muller, Jean, Nagaie, Satoshi, Nasir, Jamal, Ogishima, Soichi, Ota Wang, Vivian, Paglione, Laura D., Pandya, Ravi N., Parkinson, Helen, Philippakis, Anthony A., Prasser, Fabian, Rambla, Jordi, Reinold, Kathy, Rushton, Gregory A., Saltzman, Andrea, Saunders, Gary, Sofia, Heidi J., Spalding, John D., Swertz, Morris A., Tulchinsky, Ilia, van Enckevort, Esther J., Varma, Susheel, Voisin, Craig, Yamamoto, Natsuko, Yamasaki, Chisato, Zass, Lyndon, Guidry Auvil, Jaime M., Nyrönen, Tommi H., and Courtot, Mélanie
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- 2021
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24. The LifeCycle Project-EU Child Cohort Network : a federated analysis infrastructure and harmonized data of more than 250,000 children and parents
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LifeCycle Project Group, Jaddoe, Vincent W. V., Felix, Janine F., Andersen, Anne-Marie Nybo, Charles, Marie-Aline, Chatzi, Leda, Corpeleijn, Eva, Donner, Nina, Elhakeem, Ahmed, Eriksson, Johan G., Foong, Rachel, Grote, Veit, Haakma, Sido, Hanson, Mark, Harris, Jennifer R., Heude, Barbara, Huang, Rae-Chi, Inskip, Hazel, Järvelin, Marjo-Riitta, Koletzko, Berthold, Lawlor, Deborah A., Lindeboom, Maarten, McEachan, Rosemary R. C., Mikkola, Tuija M., Nader, Johanna L. T., de Moira, Angela Pinot, Pizzi, Costanza, Richiardi, Lorenzo, Sebert, Sylvain, Schwalber, Ameli, Sunyer, Jordi, Swertz, Morris A., Vafeiadi, Marina, Vrijheid, Martine, Wright, John, and Duijts, Liesbeth
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- 2020
25. Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
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Alizadeh, Behrooz Z., Boezen, H. Marike, Franke, Lude, van der Harst, Pim, Navis, Gerjan, Rots, Marianne, Snieder, Harold, Swertz, Morris, Wolffenbuttel, Bruce H.R., Wijmenga, Cisca, Abecasis, Goncalo, Baras, Aris, Cantor, Michael, Coppola, Giovanni, Economides, Aris, Lotta, Luca A., Overton, John D., Reid, Jeffrey G., Shuldiner, Alan, Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Lopez, Alexander, Schleicher, Thomas D., Padilla, Maria Sotiropoulos, Toledo, Karina, Widom, Louis, Wolf, Sarah E., Pradhan, Manasi, Manoochehri, Kia, Ulloa, Ricardo H., Bai, Xiaodong, Balasubramanian, Suganthi, Barnard, Leland, Blumenfeld, Andrew, Eom, Gisu, Habegger, Lukas, Hawes, Alicia, Khalid, Shareef, Maxwell, Evan K., Salerno, William, Staples, Jeffrey C., Jones, Marcus B., Mitnaul, Lyndon J., Gorski, Mathias, Jung, Bettina, Li, Yong, Matias-Garcia, Pamela R., Wuttke, Matthias, Coassin, Stefan, Thio, Chris H.L., Kleber, Marcus E., Winkler, Thomas W., Wanner, Veronika, Chai, Jin-Fang, Chu, Audrey Y., Cocca, Massimiliano, Feitosa, Mary F., Ghasemi, Sahar, Hoppmann, Anselm, Horn, Katrin, Li, Man, Nutile, Teresa, Scholz, Markus, Sieber, Karsten B., Teumer, Alexander, Tin, Adrienne, Wang, Judy, Tayo, Bamidele O., Ahluwalia, Tarunveer S., Almgren, Peter, Bakker, Stephan J.L., Banas, Bernhard, Bansal, Nisha, Biggs, Mary L., Boerwinkle, Eric, Bottinger, Erwin P., Brenner, Hermann, Carroll, Robert J., Chalmers, John, Chee, Miao-Li, Chee, Miao-Ling, Cheng, Ching-Yu, Coresh, Josef, de Borst, Martin H., Degenhardt, Frauke, Eckardt, Kai-Uwe, Endlich, Karlhans, Franke, Andre, Freitag-Wolf, Sandra, Gampawar, Piyush, Gansevoort, Ron T., Ghanbari, Mohsen, Gieger, Christian, Hamet, Pavel, Ho, Kevin, Hofer, Edith, Holleczek, Bernd, Xian Foo, Valencia Hui, Hutri-Kähönen, Nina, Hwang, Shih-Jen, Ikram, M. Arfan, Josyula, Navya Shilpa, Kähönen, Mika, Khor, Chiea-Chuen, Koenig, Wolfgang, Kramer, Holly, Krämer, Bernhard K., Kühnel, Brigitte, Lange, Leslie A., Lehtimäki, Terho, Lieb, Wolfgang, Loos, Ruth J.F., Lukas, Mary Ann, Lyytikäinen, Leo-Pekka, Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Milaneschi, Yuri, Mishra, Pashupati P., Mononen, Nina, Mychaleckyj, Josyf C., Nadkarni, Girish N., Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M., O’Donoghue, Michelle L., Orho-Melander, Marju, Pendergrass, Sarah A., Penninx, Brenda W.J.H., Preuss, Michael H., Psaty, Bruce M., Raffield, Laura M., Raitakari, Olli T., Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M., Rosenkranz, Alexander R., Rossing, Peter, Rotter, Jerome I., Sabanayagam, Charumathi, Schmidt, Helena, Schmidt, Reinhold, Schöttker, Ben, Schulz, Christina-Alexandra, Sedaghat, Sanaz, Shaffer, Christian M., Strauch, Konstantin, Szymczak, Silke, Taylor, Kent D., Tremblay, Johanne, Chaker, Layal, van der Most, Peter J., Verweij, Niek, Völker, Uwe, Waldenberger, Melanie, Wallentin, Lars, Waterworth, Dawn M., White, Harvey D., Wilson, James G., Wong, Tien-Yin, Woodward, Mark, Yang, Qiong, Yasuda, Masayuki, Yerges-Armstrong, Laura M., Zhang, Yan, Wanner, Christoph, Böger, Carsten A., Köttgen, Anna, Kronenberg, Florian, Pattaro, Cristian, and Heid, Iris M.
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- 2021
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26. Metadata for Data dIscoverability aNd Study rEplicability in obseRVAtional Studies (MINERVA): Development and Pilot of a Metadata List and Catalogue in Europe
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Infection & Immunity, Child Health, Data Science & Biostatistiek, Pajouheshnia, Romin, Gini, Rosa, Gutierrez, Lia, Swertz, Morris A, Hyde, Eleanor, Sturkenboom, Miriam, Arana, Alejandro, Franzoni, Carla, Ehrenstein, Vera, Roberto, Giuseppe, Gil, Miguel, Maciá, Miguel Angel, Schäfer, Wiebke, Haug, Ulrike, Thurin, Nicolas H, Lassalle, Régis, Droz-Perroteau, Cécile, Zaccagnino, Silvia, Busto, Maria Paula, Middelkoop, Bas, Gembert, Karin, Sanchez-Saez, Francisco, Rodriguez-Bernal, Clara, Sanfélix-Gimeno, Gabriel, Hurtado, Isabel, Acosta, Manuel Barreiro de, Poblador-Plou, Beatriz, Carmona-Pírez, Jonás, Gimeno-Miguel, Antonio, Prados-Torres, Alexandra, Schultze, Anna, Jansen, Ella, Herings, Ron, Kuiper, Josine, Locatelli, Igor, Jazbar, Janja, Žerovnik, Špela, Kos, Mitja, Smit, Steven, Lind, Sirje, Metspalu, Andres, Simou, Stefania, Hedenmalm, Karin, Cochino, Ana, Alcini, Paolo, Kurz, Xavier, Perez-Gutthann, Susana, Infection & Immunity, Child Health, Data Science & Biostatistiek, Pajouheshnia, Romin, Gini, Rosa, Gutierrez, Lia, Swertz, Morris A, Hyde, Eleanor, Sturkenboom, Miriam, Arana, Alejandro, Franzoni, Carla, Ehrenstein, Vera, Roberto, Giuseppe, Gil, Miguel, Maciá, Miguel Angel, Schäfer, Wiebke, Haug, Ulrike, Thurin, Nicolas H, Lassalle, Régis, Droz-Perroteau, Cécile, Zaccagnino, Silvia, Busto, Maria Paula, Middelkoop, Bas, Gembert, Karin, Sanchez-Saez, Francisco, Rodriguez-Bernal, Clara, Sanfélix-Gimeno, Gabriel, Hurtado, Isabel, Acosta, Manuel Barreiro de, Poblador-Plou, Beatriz, Carmona-Pírez, Jonás, Gimeno-Miguel, Antonio, Prados-Torres, Alexandra, Schultze, Anna, Jansen, Ella, Herings, Ron, Kuiper, Josine, Locatelli, Igor, Jazbar, Janja, Žerovnik, Špela, Kos, Mitja, Smit, Steven, Lind, Sirje, Metspalu, Andres, Simou, Stefania, Hedenmalm, Karin, Cochino, Ana, Alcini, Paolo, Kurz, Xavier, and Perez-Gutthann, Susana
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- 2024
27. Metadata for Data dIscoverability aNd Study rEplicability in obseRVAtional Studies (MINERVA): Lessons Learnt From the MINERVA Project in Europe
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Data Science & Biostatistiek, Child Health, Infection & Immunity, Gini, Rosa, Pajouheshnia, Romin, Gutierrez, Lia, Swertz, Morris A, Hyde, Eleanor, Sturkenboom, Miriam, Arana, Alejandro, Franzoni, Carla, Ehrenstein, Vera, Roberto, Giuseppe, Gil, Miguel, Maciá, Miguel Angel, Schäfer, Wiebke, Haug, Ulrike, Thurin, Nicolas H, Lassalle, Régis, Droz-Perroteau, Cécile, Zaccagnino, Silvia, Busto, Maria Paula, Middelkoop, Bas, Gembert, Karin, Sanchez-Saez, Francisco, Rodriguez-Bernal, Clara, Sanfélix-Gimeno, Gabriel, Hurtado, Isabel, Acosta, Manuel Barreiro de, Poblador-Plou, Beatriz, Carmona-Pírez, Jonás, Gimeno-Miguel, Antonio, Prados-Torres, Alexandra, Schultze, Anna, Jansen, Ella, Herings, Ron, Kuiper, Josine, Locatelli, Igor, Jazbar, Janja, Žerovnik, Špela, Kos, Mitja, Smit, Steven, Lind, Sirje, Metspalu, Andres, Simou, Stefania, Hedenmalm, Karin, Cochino, Ana, Alcini, Paolo, Kurz, Xavier, Perez-Gutthann, Susana, Data Science & Biostatistiek, Child Health, Infection & Immunity, Gini, Rosa, Pajouheshnia, Romin, Gutierrez, Lia, Swertz, Morris A, Hyde, Eleanor, Sturkenboom, Miriam, Arana, Alejandro, Franzoni, Carla, Ehrenstein, Vera, Roberto, Giuseppe, Gil, Miguel, Maciá, Miguel Angel, Schäfer, Wiebke, Haug, Ulrike, Thurin, Nicolas H, Lassalle, Régis, Droz-Perroteau, Cécile, Zaccagnino, Silvia, Busto, Maria Paula, Middelkoop, Bas, Gembert, Karin, Sanchez-Saez, Francisco, Rodriguez-Bernal, Clara, Sanfélix-Gimeno, Gabriel, Hurtado, Isabel, Acosta, Manuel Barreiro de, Poblador-Plou, Beatriz, Carmona-Pírez, Jonás, Gimeno-Miguel, Antonio, Prados-Torres, Alexandra, Schultze, Anna, Jansen, Ella, Herings, Ron, Kuiper, Josine, Locatelli, Igor, Jazbar, Janja, Žerovnik, Špela, Kos, Mitja, Smit, Steven, Lind, Sirje, Metspalu, Andres, Simou, Stefania, Hedenmalm, Karin, Cochino, Ana, Alcini, Paolo, Kurz, Xavier, and Perez-Gutthann, Susana
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- 2024
28. Comparing Sequence-Based and Literature-Based Pathogenicity Scoring Methods for Human Variants
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Mottin, Luc, Naderi, Nona, Mottaz, Anaïs, Michel, Pierre André, Been, Gerieke, Johansson, Lennart, Swertz, Morris, Stubbs, Andrew, Pasche, Emilie, Gobeill, Julien, Ruch, Patrick, Mottin, Luc, Naderi, Nona, Mottaz, Anaïs, Michel, Pierre André, Been, Gerieke, Johansson, Lennart, Swertz, Morris, Stubbs, Andrew, Pasche, Emilie, Gobeill, Julien, and Ruch, Patrick
- Abstract
Assessing the pathogenicity of genetic variants is a critical aspect of genomic medicine and precision healthcare. Over the last decades, the identification of genetic variants and their characterization has become simpler (advent of high-throughput sequencing technologies, analysis, and visualization support tools, etc.). However, the quality of assessments to distinguish benign from pathogenic variants is critical to inform clinical decision-making and improve patient outcomes. In this article, we investigate the relationships using correlation tests between the characterization of genetic variants in the literature and their pathogenicity scores computed by two state-of-the-art assessment tools (SIFT and PolyPhen-2).
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- 2024
29. Urban environment in pregnancy and postpartum depression:An individual participant data meta-analysis of 12 European birth cohorts
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Cadman, Tim, Strandberg-Larsen, Katrine, Calas, Lucinda, Christiansen, Malina, Culpin, Iryna, Dadvand, Payam, de Castro, Montserrat, Foraster, Maria, Fossati, Serena, Guxens, Mònica, Harris, Jennifer R., Hillegers, Manon, Jaddoe, Vincent, Lee, Yunsung, Lepeule, Johanna, el Marroun, Hanan, Maule, Milena, McEachen, Rosie, Moccia, Chiara, Nader, Johanna, Nieuwenhuijsen, Mark, Nybo Andersen, Anne Marie, Pearson, Rebecca, Swertz, Morris, Vafeiadi, Marina, Vrijheid, Martine, Wright, John, Lawlor, Deborah A., Pedersen, Marie, Cadman, Tim, Strandberg-Larsen, Katrine, Calas, Lucinda, Christiansen, Malina, Culpin, Iryna, Dadvand, Payam, de Castro, Montserrat, Foraster, Maria, Fossati, Serena, Guxens, Mònica, Harris, Jennifer R., Hillegers, Manon, Jaddoe, Vincent, Lee, Yunsung, Lepeule, Johanna, el Marroun, Hanan, Maule, Milena, McEachen, Rosie, Moccia, Chiara, Nader, Johanna, Nieuwenhuijsen, Mark, Nybo Andersen, Anne Marie, Pearson, Rebecca, Swertz, Morris, Vafeiadi, Marina, Vrijheid, Martine, Wright, John, Lawlor, Deborah A., and Pedersen, Marie
- Abstract
Background: Urban environmental exposures associate with adult depression, but it is unclear whether they are associated to postpartum depression (PPD). Objectives: We investigated associations between urban environment exposures during pregnancy and PPD. Methods: We included women with singleton deliveries to liveborn children from 12 European birth cohorts (N with minimum one exposure = 30,772, analysis N range 17,686–30,716 depending on exposure; representing 26–46 % of the 66,825 eligible women). We estimated maternal exposure during pregnancy to ambient air pollution with nitrogen dioxide (NO2) and particulate matter (PM2.5 and PM10), road traffic noise (Lden), natural spaces (Normalised Difference Vegetation Index; NDVI, proximity to major green or blue spaces) and built environment (population density, facility richness and walkability). Maternal PPD was assessed 3–18 months after birth using self-completed questionnaires. We used adjusted logistic regression models to estimate cohort-specific associations between each exposure and PPD and combined results via meta-analysis using DataSHIELD. Results: Of the 30,772 women included, 3,078 (10 %) reported having PPD. Exposure to PM10 was associated with slightly increased odds of PPD (adjusted odd ratios (OR) of 1.08 [95 % Confidence Intervals (CI): 0.99, 1.17] per inter quartile range increment of PM10) whilst associations for exposure to NO2 and PM2.5 were close to null. Exposure to high levels of road traffic noise (≥65 dB vs. < 65 dB) was associated with an OR of 1.12 [CI: 0.95, 1.32]. Associations between green spaces and PPD were close to null; whilst proximity to major blue spaces was associated with increased risk of PPD (OR 1.12, 95 %CI: 1.00, 1.26). All associations between built environment and PPD were close to null. Multiple exposure models showed similar results. Discussion: The study findings suggest that
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- 2024
30. Position paper on management of personal data in environment and health research in Europe
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Govarts Eva, Gilles Liese, Bopp Stephanie, Holub Petr, Matalonga Leslie, Vermeulen Roel, Vrijheid Martine, Beltran Sergi, Hartlev Mette, Jones Sarah, Rodriguez Martin Laura, Standaert Arnout, Swertz Morris A., Theunis Jan, Trier Xenia, Vogel Nina, Van Espen Koert, Remy Sylvie, and Schoeters Greet
- Subjects
Data protection ,Biomonitoring data ,Health data ,FAIR principles ,GDPR ,Environmental sciences ,GE1-350 - Abstract
Management of datasets that include health information and other sensitive personal information of European study participants has to be compliant with the General Data Protection Regulation (GDPR, Regulation (EU) 2016/679). Within scientific research, the widely subscribed’FAIR’ data principles should apply, meaning that research data should be findable, accessible, interoperable and re-usable. Balancing the aim of open science driven FAIR data management with GDPR compliant personal data protection safeguards is now a common challenge for many research projects dealing with (sensitive) personal data.In December 2020 a workshop was held with representatives of several large EU research consortia and of the European Commission to reflect on how to apply the FAIR data principles for environment and health research (E&H). Several recent data intensive EU funded E&H research projects face this challenge and work intensively towards developing solutions to access, exchange, store, handle, share, process and use such sensitive personal data, with the aim to support European and transnational collaborations. As a result, several recommendations, opportunities and current limitations were formulated.New technical developments such as federated data management and analysis systems, machine learning together with advanced search software, harmonized ontologies and data quality standards should in principle facilitate the FAIRification of data. To address ethical, legal, political and financial obstacles to the wider re-use of data for research purposes, both specific expertise and underpinning infrastructure are needed. There is a need for the E&H research data to find their place in the European Open Science Cloud. Communities using health and population data, environmental data and other publicly available data have to interconnect and synergize. To maximize the use and re-use of environment and health data, a dedicated supporting European infrastructure effort, such as the EIRENE research infrastructure within the ESFRI roadmap 2021, is needed that would interact with existing infrastructures.
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- 2022
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31. LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases
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Ronkainen, Justiina, Nedelec, Rozenn, Atehortua, Angelica, Balkhiyarova, Zhanna, Cascarano, Anna, Ngoc Dang, Vien, Elhakeem, Ahmed, van Enckevort, Esther, Goncalves Soares, Ana, Haakma, Sido, Halonen, Miia, Heil, Katharina F., Heiskala, Anni, Hyde, Eleanor, Jacquemin, Bénédicte, Keikkala, Elina, Kerckhoffs, Jules, Klåvus, Anton, Kopinska, Joanna A., Lepeule, Johanna, Marazzi, Francesca, Motoc, Irina, Näätänen, Mari, Ribbenstedt, Anton, Rundblad, Amanda, Savolainen, Otto, Simonetti, Valentina, de Toro Eadie, Nina, Tzala, Evangelia, Ulrich, Anna, Wright, Thomas, Zarei, Iman, d’Amico, Enrico, Belotti, Federico, Brunius, Carl, Castleton, Christopher, Charles, Marie-Aline, Gaillard, Romy, Hanhineva, Kati, Hoek, Gerard, Holven, Kirsten B., Jaddoe, Vincent W. V., Kaakinen, Marika A., Kajantie, Eero, Kavousi, Maryam, Lakka, Timo, Matthews, Jason, Piano Mortari, Andrea, Vääräsmäki, Marja, Voortman, Trudy, Webster, Claire, Zins, Marie, Atella, Vincenzo, Bulgheroni, Maria, Chadeau-Hyam, Marc, Conti, Gabriella, Evans, Jayne, Felix, Janine F., Heude, Barbara, Järvelin, Marjo-Riitta, Kolehmainen, Marjukka, Landberg, Rikard, Lekadir, Karim, Parusso, Stefano, Prokopenko, Inga, de Rooij, Susanne R., Roseboom, Tessa, Swertz, Morris, Timpson, Nicholas, Ulven, Stine M., Vermeulen, Roel, Juola, Teija, Sebert, Sylvain, Sebert, Sylvain, Juola, Teija, Nedelec, Rozenn, Ronkainen, Justiina, Heiskala, Anni, Halonen, Miia, He, Yiyan, Miettunen, Jouko, Karhunen, Ville, Kajantie, Eero, Vääräsmäki, Marja, Keikkala, Elina, Nyberg, Pia, Serpi, Raisa, Felix, Janine, Jaddoe, Vincent, Marques, Irene, Moreira da Silva Santos, Susana, Kavousi, Maryam, Voortman, Trudy, Ginos, Bigina, Chadeau-Hyam, Marc, Järvelin, Marjo-Riitta, Tzala, Evangelia, De Toro, Nina, Wright, Thomas, Bodinier, Barbara, Dagnino, Sonia, Evans, Jayne, Webster, Claire, Kolehmainen, Marjukka, Hanhineva, Kati, Lakka, Timo, Savolainen, Otto, Zarei, Iman, Näätänen, Mari, Klåvus, Anton, Eloranta, Aino-Maija, Väistö, Juuso, Kårlund, Anna, Mikkonen, Santtu, Atalay, Merja, Atalay, Mustafa, Landberg, Rikard, Brunius, Carl, Ribbenstedt, Anton, Swertz, Morris, Hyde, Eleanor, Haakma, Sido, van Enckevort, Esther, Heude, Barbara, Charles, Marie-Aline, Zins, Marie, Lepeule, Johanna, Jacquemin, Bénédicte, Calas, Lucinda, Lequy-Flahault, Emeline, Lun Yuan, Wen, Seyve, Emie, Conti, Gabriella, Vermeulen, Roel, Hoek, Gerard, Kerckhoffs, Jules, Prokopenko, Inga, Kaakinen, Marika, Balkhiyarova, Zhanna, Ulrich, Anna, Roseboom, Tessa, De Rooij, Susanne, Motoc, Irina, Marie Ulven, Stine, Holven, Kirsten B., Matthews, Jason, Rundblad, Amanda, Das, Siddhartha, Timpson, Nicholas, Elhakeem, Ahmed, Luiza Goncalves Soares, Ana, Lekadir, Karim, Maria Cascarano, Anna, Maria Atehortua Labrador, Angélica, Ngoc Dang, Vien, Heil, Katharina F., Gallin, Catherine, Díaz, Oliver, Bulgheroni, Maria, Simonetti, Valentina, D’Amico, Enrico, Giani, Laura, Manzino, Fabrizio, Parusso, Stefano, Castleton, Christopher, Moimas, Diego, Atella, Vincenzo, Piano Mortari, Andrea, Kopinska, Joanna, Marazzi, Francesca, Giaccherini, Matilde, and Belotti, Federico
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- 2022
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32. Metadata for Data dIscoverability aNd Study rEplicability in obseRVAtional Studies (MINERVA): Lessons Learnt From the MINERVA Project in Europe.
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Gini, Rosa, Pajouheshnia, Romin, Gutierrez, Lia, Swertz, Morris A., Hyde, Eleanor, Sturkenboom, Miriam, Arana, Alejandro, Franzoni, Carla, Ehrenstein, Vera, Roberto, Giuseppe, Gil, Miguel, Maciá, Miguel Angel, Schäfer, Wiebke, Haug, Ulrike, Thurin, Nicolas H., Lassalle, Régis, Droz‐Perroteau, Cécile, Zaccagnino, Silvia, Busto, Maria Paula, and Middelkoop, Bas
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- 2024
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33. Metadata for Data dIscoverability aNd Study rEplicability in obseRVAtional Studies (MINERVA): Development and Pilot of a Metadata List and Catalogue in Europe.
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Pajouheshnia, Romin, Gini, Rosa, Gutierrez, Lia, Swertz, Morris A., Hyde, Eleanor, Sturkenboom, Miriam, Arana, Alejandro, Franzoni, Carla, Ehrenstein, Vera, Roberto, Giuseppe, Gil, Miguel, Maciá, Miguel Angel, Schäfer, Wiebke, Haug, Ulrike, Thurin, Nicolas H., Lassalle, Régis, Droz‐Perroteau, Cécile, Zaccagnino, Silvia, Busto, Maria Paula, and Middelkoop, Bas
- Abstract
Purpose: Metadata for data dIscoverability aNd study rEplicability in obseRVAtional studies (MINERVA), a European Medicines Agency–funded project (EUPAS39322), defined a set of metadata to describe real‐world data sources (RWDSs) and piloted metadata collection in a prototype catalogue to assist investigators from data source discoverability through study conduct. Methods: A list of metadata was created from a review of existing metadata catalogues and recommendations, structured interviews, a stakeholder survey, and a technical workshop. The prototype was designed to comply with the FAIR principles (findable, accessible, interoperable, reusable), using MOLGENIS software. Metadata collection was piloted by 15 data access partners (DAPs) from across Europe. Results: A total of 442 metadata variables were defined in six domains: institutions (organizations connected to a data source); data banks (data collections sustained by an organization); data sources (collections of linkable data banks covering a common underlying population); studies; networks (of institutions); and common data models (CDMs). A total of 26 institutions were recorded in the prototype. Each DAP populated the metadata of one data source and its selected data banks. The number of data banks varied by data source; the most common data banks were hospital administrative records and pharmacy dispensation records (10 data sources each). Quantitative metadata were successfully extracted from three data sources conforming to different CDMs and entered into the prototype. Conclusions: A metadata list was finalized, a prototype was successfully populated, and a good practice guide was developed. Setting up and maintaining a metadata catalogue on RWDSs will require substantial effort to support discoverability of data sources and reproducibility of studies in Europe. [ABSTRACT FROM AUTHOR]
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- 2024
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34. Comprehensive evaluation of smoking exposures and their interactions on DNA methylation
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Hoang, Thanh T., primary, Lee, Yunsung, additional, McCartney, Daniel L., additional, Kersten, Elin T.G., additional, Page, Christian M., additional, Hulls, Paige M., additional, Lee, Mikyeong, additional, Walker, Rosie M., additional, Breeze, Charles E., additional, Bennett, Brian D., additional, Burkholder, Adam B., additional, Ward, James, additional, Brantsæter, Anne Lise, additional, Caspersen, Ida H., additional, Motsinger-Reif, Alison A., additional, Richards, Marie, additional, White, Julie D., additional, Zhao, Shanshan, additional, Richmond, Rebecca C., additional, Magnus, Maria C., additional, Koppelman, Gerard H., additional, Evans, Kathryn L., additional, Marioni, Riccardo E., additional, Håberg, Siri E., additional, London, Stephanie J., additional, Heijmans, Bastiaan, additional, ’t Hoen, Peter, additional, van Meurs, Joyce, additional, Jansen, Rick, additional, Franke, Lude, additional, Boomsma, Dorret, additional, Pool, René, additional, van Dongen, Jenny, additional, Hottenga, Jouke, additional, van Greevenbroek, Marleen, additional, Stehouwer, Coen, additional, van der Kallen, Carla, additional, Schalkwijk, Casper, additional, Wijmenga, Cisca, additional, Zhernakova, Sasha, additional, Tigchelaar, Ettje, additional, Slagboom, P. Eline, additional, Beekman, Marian, additional, Deelen, Joris, additional, Van Heemst, Diana, additional, Veldink, Jan, additional, van den Berg, Leonard, additional, van Duijn, Cornelia, additional, Hofman, Bert, additional, Isaacs, Aaron, additional, Uitterlinden, André, additional, Jhamai, P. Mila, additional, Verbiest, Michael, additional, Suchiman, H. Eka, additional, Verkerk, Marijn, additional, van der Breggen, Ruud, additional, van Rooij, Jeroen, additional, Lakenberg, Nico, additional, Mei, Hailiang, additional, van Iterson, Maarten, additional, van Galen, Michiel, additional, Bot, Jan, additional, Zhernakova, Dasha, additional, van ‘t Hof, Peter, additional, Deelen, Patrick, additional, Nooren, Irene, additional, Moed, Matthijs, additional, Vermaat, Martijn, additional, Luijk, René, additional, Bonder, Marc, additional, van Dijk, Freerk, additional, Arindrarto, Wibowo, additional, Kielbasa, Szymon, additional, Swertz, Morris, additional, and van Zwet, Erik, additional
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- 2024
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35. Habitual dietary intake of IBD patients differs from population controls: a case–control study
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Peters, Vera, Tigchelaar-Feenstra, Ettje F., Imhann, Floris, Dekens, Jackie A. M., Swertz, Morris A., Franke, Lude H., Wijmenga, Cisca, Weersma, Rinse K., Alizadeh, Behrooz Z., Dijkstra, Gerard, and Campmans-Kuijpers, Marjo J. E.
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- 2021
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36. A high-quality human reference panel reveals the complexity and distribution of genomic structural variants.
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Hehir-Kwa, Jayne Y, Marschall, Tobias, Kloosterman, Wigard P, Francioli, Laurent C, Baaijens, Jasmijn A, Dijkstra, Louis J, Abdellaoui, Abdel, Koval, Vyacheslav, Thung, Djie Tjwan, Wardenaar, René, Renkens, Ivo, Coe, Bradley P, Deelen, Patrick, de Ligt, Joep, Lameijer, Eric-Wubbo, van Dijk, Freerk, Hormozdiari, Fereydoun, Genome of the Netherlands Consortium, Uitterlinden, André G, van Duijn, Cornelia M, Eichler, Evan E, de Bakker, Paul IW, Swertz, Morris A, Wijmenga, Cisca, van Ommen, Gert-Jan B, Slagboom, P Eline, Boomsma, Dorret I, Schönhuth, Alexander, Ye, Kai, and Guryev, Victor
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Genome of the Netherlands Consortium ,Chromosomes ,Humans ,RNA ,Polymerase Chain Reaction ,Sequence Analysis ,DNA ,Sequence Analysis ,RNA ,Computational Biology ,Genomics ,Gene Deletion ,Genotype ,Haplotypes ,Linkage Disequilibrium ,Polymorphism ,Single Nucleotide ,Genome ,Human ,Algorithms ,Software ,Netherlands ,INDEL Mutation ,Genomic Structural Variation ,Sequence Analysis ,DNA ,Polymorphism ,Single Nucleotide ,Genome ,Human - Abstract
Structural variation (SV) represents a major source of differences between individual human genomes and has been linked to disease phenotypes. However, the majority of studies provide neither a global view of the full spectrum of these variants nor integrate them into reference panels of genetic variation. Here, we analyse whole genome sequencing data of 769 individuals from 250 Dutch families, and provide a haplotype-resolved map of 1.9 million genome variants across 9 different variant classes, including novel forms of complex indels, and retrotransposition-mediated insertions of mobile elements and processed RNAs. A large proportion are previously under reported variants sized between 21 and 100 bp. We detect 4 megabases of novel sequence, encoding 11 new transcripts. Finally, we show 191 known, trait-associated SNPs to be in strong linkage disequilibrium with SVs and demonstrate that our panel facilitates accurate imputation of SVs in unrelated individuals.
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- 2016
37. Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels
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van Leeuwen, Elisabeth M, Sabo, Aniko, Bis, Joshua C, Huffman, Jennifer E, Manichaikul, Ani, Smith, Albert V, Feitosa, Mary F, Demissie, Serkalem, Joshi, Peter K, Duan, Qing, Marten, Jonathan, van Klinken, Jan B, Surakka, Ida, Nolte, Ilja M, Zhang, Weihua, Mbarek, Hamdi, Li-Gao, Ruifang, Trompet, Stella, Verweij, Niek, Evangelou, Evangelos, Lyytikäinen, Leo-Pekka, Tayo, Bamidele O, Deelen, Joris, van der Most, Peter J, van der Laan, Sander W, Arking, Dan E, Morrison, Alanna, Dehghan, Abbas, Franco, Oscar H, Hofman, Albert, Rivadeneira, Fernando, Sijbrands, Eric J, Uitterlinden, Andre G, Mychaleckyj, Josyf C, Campbell, Archie, Hocking, Lynne J, Padmanabhan, Sandosh, Brody, Jennifer A, Rice, Kenneth M, White, Charles C, Harris, Tamara, Isaacs, Aaron, Campbell, Harry, Lange, Leslie A, Rudan, Igor, Kolcic, Ivana, Navarro, Pau, Zemunik, Tatijana, Salomaa, Veikko, Study, The LifeLines Cohort, Kooner, Angad S, Kooner, Jaspal S, Lehne, Benjamin, Scott, William R, Tan, Sian-Tsung, de Geus, Eco J, Milaneschi, Yuri, Penninx, Brenda WJH, Willemsen, Gonneke, de Mutsert, Renée, Ford, Ian, Gansevoort, Ron T, Segura-Lepe, Marcelo P, Raitakari, Olli T, Viikari, Jorma S, Nikus, Kjell, Forrester, Terrence, McKenzie, Colin A, de Craen, Anton JM, de Ruijter, Hester M, Group, CHARGE Lipids Working, Pasterkamp, Gerard, Snieder, Harold, Oldehinkel, Albertine J, Slagboom, P Eline, Cooper, Richard S, Kähönen, Mika, Lehtimäki, Terho, Elliott, Paul, van der Harst, Pim, Jukema, J Wouter, Mook-Kanamori, Dennis O, Boomsma, Dorret I, Chambers, John C, Swertz, Morris, Ripatti, Samuli, van Dijk, Ko Willems, Vitart, Veronique, Polasek, Ozren, Hayward, Caroline, Wilson, James G, Wilson, James F, Gudnason, Vilmundur, Rich, Stephen S, Psaty, Bruce M, Borecki, Ingrid B, Boerwinkle, Eric, Rotter, Jerome I, Cupples, L Adrienne, and van Duijn, Cornelia M
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Biological Sciences ,Genetics ,Biotechnology ,Human Genome ,Aetiology ,2.1 Biological and endogenous factors ,Angiopoietin-Like Protein 4 ,Angiopoietins ,Exons ,Fasting ,Female ,Genome ,Human ,Genome-Wide Association Study ,Genotype ,Humans ,Male ,Middle Aged ,Polymorphism ,Single Nucleotide ,LifeLines Cohort Study ,CHARGE Lipids Working Group ,Complex traits ,Epidemiology ,Genome-wide ,circulating lipid levels ,Medical and Health Sciences ,Genetics & Heredity ,Clinical sciences - Abstract
BackgroundSo far, more than 170 loci have been associated with circulating lipid levels through genome-wide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels.MethodsWe used the 1000 Genomes Project as a reference panel for the imputations of GWAS data from ∼60 000 individuals in the discovery stage and ∼90 000 samples in the replication stage.ResultsOur study resulted in the identification of five new associations with circulating lipid levels at four loci. All four loci are within genes that can be linked biologically to lipid metabolism. One of the variants, rs116843064, is a damaging missense variant within the ANGPTL4 gene.ConclusionsThis study illustrates that GWAS with high-scale imputation may still help us unravel the biological mechanism behind circulating lipid levels.
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- 2016
38. The FAIR Guiding Principles for scientific data management and stewardship.
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Wilkinson, Mark D, Dumontier, Michel, Aalbersberg, I Jsbrand Jan, Appleton, Gabrielle, Axton, Myles, Baak, Arie, Blomberg, Niklas, Boiten, Jan-Willem, da Silva Santos, Luiz Bonino, Bourne, Philip E, Bouwman, Jildau, Brookes, Anthony J, Clark, Tim, Crosas, Mercè, Dillo, Ingrid, Dumon, Olivier, Edmunds, Scott, Evelo, Chris T, Finkers, Richard, Gonzalez-Beltran, Alejandra, Gray, Alasdair JG, Groth, Paul, Goble, Carole, Grethe, Jeffrey S, Heringa, Jaap, 't Hoen, Peter AC, Hooft, Rob, Kuhn, Tobias, Kok, Ruben, Kok, Joost, Lusher, Scott J, Martone, Maryann E, Mons, Albert, Packer, Abel L, Persson, Bengt, Rocca-Serra, Philippe, Roos, Marco, van Schaik, Rene, Sansone, Susanna-Assunta, Schultes, Erik, Sengstag, Thierry, Slater, Ted, Strawn, George, Swertz, Morris A, Thompson, Mark, van der Lei, Johan, van Mulligen, Erik, Velterop, Jan, Waagmeester, Andra, Wittenburg, Peter, Wolstencroft, Katherine, Zhao, Jun, and Mons, Barend
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Data Collection ,Reproducibility of Results ,Research Design ,Database Management Systems ,Guidelines as Topic ,Data Curation - Abstract
There is an urgent need to improve the infrastructure supporting the reuse of scholarly data. A diverse set of stakeholders-representing academia, industry, funding agencies, and scholarly publishers-have come together to design and jointly endorse a concise and measureable set of principles that we refer to as the FAIR Data Principles. The intent is that these may act as a guideline for those wishing to enhance the reusability of their data holdings. Distinct from peer initiatives that focus on the human scholar, the FAIR Principles put specific emphasis on enhancing the ability of machines to automatically find and use the data, in addition to supporting its reuse by individuals. This Comment is the first formal publication of the FAIR Principles, and includes the rationale behind them, and some exemplar implementations in the community.
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- 2016
39. IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis
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Zhang, Zhenhua, Trypsteen, Wim, Blaauw, Marc, Chu, Xiaojing, Rutsaert, Sofie, Vandekerckhove, Linos, van der Heijden, Wouter, dos Santos, Jéssica Cristina, Xu, Cheng-Jian, Swertz, Morris A., van der Ven, Andre, and Li, Yang
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- 2021
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40. Feasibility of predicting allele specific expression from DNA sequencing using machine learning
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Zhang, Zhenhua, van Dijk, Freerk, de Klein, Niek, van Gijn, Mariëlle E, Franke, Lude H, Sinke, Richard J, Swertz, Morris A, and van der Velde, K Joeri
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- 2021
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41. Author Correction: Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project
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Lopera-Maya, Esteban A., Kurilshikov, Alexander, van der Graaf, Adriaan, Hu, Shixian, Andreu-Sánchez, Sergio, Chen, Lianmin, Vila, Arnau Vich, Gacesa, Ranko, Sinha, Trishla, Collij, Valerie, Klaassen, Marjiolein A. Y., Bolte, Laura A., Gois, Milla F. Brandao, Neerincx, Pieter B. T., Swertz, Morris A., Harmsen, Hermie J. M., Wijmenga, Cisca, Fu, Jingyuan, Weersma, Rinse K., Zhernakova, Alexandra, and Sanna, Serena
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- 2022
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42. A Resource for Guiding Data Stewards to Make European Rare Disease Patient Registries FAIR
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European Commission, van Damme, Philip [0000-0002-7124-8949], Alarcón-Moreno, Pablo [0000-0001-5974-589X], Bernabé, César Henrique [0000-0003-1795-5930], Cámara, Alberto [0000-0001-5613-9704], Dos Santos Vieira, Bruna [0000-0001-7893-0505], van der Velde, K. Joeri [0000-0002-0934-8375], Zhang, Shuxin [0000-0003-4715-9070], Carta, Claudio [0000-0003-3545-198X], Cornet, Ronald [0000-0002-1704-5980], t Hoen, Peter A.C.[0000-0003-4450-3112], Jacobsen, Annika [0000-0003-4818-2360], Swertz, Morris A. [0000-0002-0979-3401], Roos, Marco [0000-0002-8691-772X], Benis, Nirupama [0000-0002-2101-6154], van Damme, Philip, Alarcón-Moreno, Pablo, Bernabé, César Henrique, Cámara, Alberto, Le Cornec, Clémence M. A., Dos Santos Vieira, Bruna, Van der Velde, K. Joeri, Zhang, Shuxin, Carta, Claudio, Cornet, Ronald, t Hoen, Peter A.C., Jacobsen, Annika, Swertz, Morris A., Roos, Marco, Benis, Nirupama, European Commission, van Damme, Philip [0000-0002-7124-8949], Alarcón-Moreno, Pablo [0000-0001-5974-589X], Bernabé, César Henrique [0000-0003-1795-5930], Cámara, Alberto [0000-0001-5613-9704], Dos Santos Vieira, Bruna [0000-0001-7893-0505], van der Velde, K. Joeri [0000-0002-0934-8375], Zhang, Shuxin [0000-0003-4715-9070], Carta, Claudio [0000-0003-3545-198X], Cornet, Ronald [0000-0002-1704-5980], t Hoen, Peter A.C.[0000-0003-4450-3112], Jacobsen, Annika [0000-0003-4818-2360], Swertz, Morris A. [0000-0002-0979-3401], Roos, Marco [0000-0002-8691-772X], Benis, Nirupama [0000-0002-2101-6154], van Damme, Philip, Alarcón-Moreno, Pablo, Bernabé, César Henrique, Cámara, Alberto, Le Cornec, Clémence M. A., Dos Santos Vieira, Bruna, Van der Velde, K. Joeri, Zhang, Shuxin, Carta, Claudio, Cornet, Ronald, t Hoen, Peter A.C., Jacobsen, Annika, Swertz, Morris A., Roos, Marco, and Benis, Nirupama
- Abstract
Objective: This paper reports on the development of a dynamic data management planning questionnaire to guide data stewards of the European Reference Network (ERN) rare disease patient registries to make their data findable, accessible, interoperable, and reusable (FAIR). As part of this work, the questionnaire was validated through expert review and aligned with existing resources on rare diseases and FAIR data management. Materials and Methods: The questionnaire was developed for the Data Stewardship Wizard, a tool for data management planning. Knowledge sources on FAIR data, ERN patient registries, and data management were used to compose questions. Ten domain experts validated the questionnaire. The topics in the questionnaire were aligned with existing knowledge bases. Results: A total of 57 questions were included in the questionnaire. Twenty-three references to the FAIR Cookbook and Research Data Management toolkit for Life Sciences were added. Expert validation provided a total of 166 comments on content, structure, and software-related issues. A public instance of the Data Stewardship Wizard was deployed for use by data stewards of ERN patient registries. Discussion: The questionnaire addresses issues that ERNs encounter when making their registries FAIR and follows the implementation choices made by the European rare disease community. A challenging task for future research is to extend the questionnaire to other types of registries and to validate with users. Conclusion: This smart questionnaire is the first model created for the Data Stewardship Wizard that helps ERN patient registries with making their data FAIR. It will assist data stewards in aligning their efforts and providing guidance on FAIR data.
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- 2023
43. Surveyed common data access policies preferences amongst European Reference Networks
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European Commission, Cámara, Alberto [0000-0001-5613-9704], Benis, Nirupama [0000-0002-2101-6154], Vieira, Bruna Dos Santos [0000-0001-7893-0505], Ramírez Valiente, José Alberto [0000-0002-5951-2938], Van der Velde, K. Joeri [0000-0002-0934-8375], Zhang, Shuxin [0000-0003-4715-9070], Cornet, Ronald [0000-0002-1704-5980], Jacobsen, Annika [0000-0003-4818-2360], Roos, Marco [0000-0002-8691-772X], Swertz, Morris A. [0000-0002-0979-3401], Wilkinson, Mark D. [0000-0001-6960-357X], Cámara, Alberto, Benis, Nirupama, Bernabé, César Henrique, Coelho, Inés D., Le Cornec, Clémence M. A., Demir, Aylin, Vieira, Bruna Dos Santos, Ramírez Valiente, José Alberto, Van der Velde, K. Joeri, Zhang, Shuxin, Cornet, Ronald, Jacobsen, Annika, Roos, Marco, Schaefer, Franz, Swertz, Morris A., Wilkinson, Mark D., European Commission, Cámara, Alberto [0000-0001-5613-9704], Benis, Nirupama [0000-0002-2101-6154], Vieira, Bruna Dos Santos [0000-0001-7893-0505], Ramírez Valiente, José Alberto [0000-0002-5951-2938], Van der Velde, K. Joeri [0000-0002-0934-8375], Zhang, Shuxin [0000-0003-4715-9070], Cornet, Ronald [0000-0002-1704-5980], Jacobsen, Annika [0000-0003-4818-2360], Roos, Marco [0000-0002-8691-772X], Swertz, Morris A. [0000-0002-0979-3401], Wilkinson, Mark D. [0000-0001-6960-357X], Cámara, Alberto, Benis, Nirupama, Bernabé, César Henrique, Coelho, Inés D., Le Cornec, Clémence M. A., Demir, Aylin, Vieira, Bruna Dos Santos, Ramírez Valiente, José Alberto, Van der Velde, K. Joeri, Zhang, Shuxin, Cornet, Ronald, Jacobsen, Annika, Roos, Marco, Schaefer, Franz, Swertz, Morris A., and Wilkinson, Mark D.
- Abstract
Background: Data sharing amongst existing Rare Disease (RD) registries, even though being a process that presents multiple barriers, would enrich and ease research, as well as facilitate interoperability between the registries themselves. Methods: To understand their preferences on sharing data, we surveyed 24 European Reference Networks (ERNs) from the RD Domain. Results: The answers show that most ERNs are willing to share a set of Common Data Elements for free with authenticated users at an aggregated or pseudonymized level the moment the data is collected. The one exception is the industry sector, to which ERNs prefer to ask for a fee. Objective: Our aim is to create a reference for how most RD registries are willing to share their data, improving the ability of other stakeholders to make informed decisions to make their data interoperable.
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- 2023
44. Characteristics of de novo structural changes in the human genome
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Kloosterman, Wigard P, Francioli, Laurent C, Hormozdiari, Fereydoun, Marschall, Tobias, Hehir-Kwa, Jayne Y, Abdellaoui, Abdel, Lameijer, Eric-Wubbo, Moed, Matthijs H, Koval, Vyacheslav, Renkens, Ivo, van Roosmalen, Markus J, Arp, Pascal, Karssen, Lennart C, Coe, Bradley P, Handsaker, Robert E, Suchiman, Eka D, Cuppen, Edwin, Thung, Djie Tjwan, McVey, Mitch, Wendl, Michael C, Consortium, Genome of the Netherlands, Uitterlinden, André, van Duijn, Cornelia M, Swertz, Morris A, Wijmenga, Cisca, van Ommen, GertJan B, Slagboom, P Eline, Boomsma, Dorret I, Schönhuth, Alexander, Eichler, Evan E, de Bakker, Paul IW, Ye, Kai, and Guryev, Victor
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Genetics ,Human Genome ,Alleles ,Amino Acid Sequence ,Female ,Genetic Variation ,Genome ,Human ,Genomics ,Haplotypes ,Humans ,INDEL Mutation ,Male ,Molecular Sequence Data ,Mutation Rate ,Polymorphism ,Single Nucleotide ,Retroelements ,Sequence Alignment ,Sequence Analysis ,DNA ,Genome of Netherlands Consortium ,Biological Sciences ,Medical and Health Sciences ,Bioinformatics - Abstract
Small insertions and deletions (indels) and large structural variations (SVs) are major contributors to human genetic diversity and disease. However, mutation rates and characteristics of de novo indels and SVs in the general population have remained largely unexplored. We report 332 validated de novo structural changes identified in whole genomes of 250 families, including complex indels, retrotransposon insertions, and interchromosomal events. These data indicate a mutation rate of 2.94 indels (1-20 bp) and 0.16 SVs (>20 bp) per generation. De novo structural changes affect on average 4.1 kbp of genomic sequence and 29 coding bases per generation, which is 91 and 52 times more nucleotides than de novo substitutions, respectively. This contrasts with the equal genomic footprint of inherited SVs and substitutions. An excess of structural changes originated on paternal haplotypes. Additionally, we observed a nonuniform distribution of de novo SVs across offspring. These results reveal the importance of different mutational mechanisms to changes in human genome structure across generations.
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- 2015
45. Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels.
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van Leeuwen, Elisabeth M, Karssen, Lennart C, Deelen, Joris, Isaacs, Aaron, Medina-Gomez, Carolina, Mbarek, Hamdi, Kanterakis, Alexandros, Trompet, Stella, Postmus, Iris, Verweij, Niek, van Enckevort, David J, Huffman, Jennifer E, White, Charles C, Feitosa, Mary F, Bartz, Traci M, Manichaikul, Ani, Joshi, Peter K, Peloso, Gina M, Deelen, Patrick, van Dijk, Freerk, Willemsen, Gonneke, de Geus, Eco J, Milaneschi, Yuri, Penninx, Brenda WJH, Francioli, Laurent C, Menelaou, Androniki, Pulit, Sara L, Rivadeneira, Fernando, Hofman, Albert, Oostra, Ben A, Franco, Oscar H, Mateo Leach, Irene, Beekman, Marian, de Craen, Anton JM, Uh, Hae-Won, Trochet, Holly, Hocking, Lynne J, Porteous, David J, Sattar, Naveed, Packard, Chris J, Buckley, Brendan M, Brody, Jennifer A, Bis, Joshua C, Rotter, Jerome I, Mychaleckyj, Josyf C, Campbell, Harry, Duan, Qing, Lange, Leslie A, Wilson, James F, Hayward, Caroline, Polasek, Ozren, Vitart, Veronique, Rudan, Igor, Wright, Alan F, Rich, Stephen S, Psaty, Bruce M, Borecki, Ingrid B, Kearney, Patricia M, Stott, David J, Adrienne Cupples, L, Genome of The Netherlands Consortium, Jukema, J Wouter, van der Harst, Pim, Sijbrands, Eric J, Hottenga, Jouke-Jan, Uitterlinden, Andre G, Swertz, Morris A, van Ommen, Gert-Jan B, de Bakker, Paul IW, Eline Slagboom, P, Boomsma, Dorret I, Wijmenga, Cisca, and van Duijn, Cornelia M
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Genome of The Netherlands Consortium ,Humans ,Cholesterol ,ATP-Binding Cassette Transporters ,Gene Frequency ,Mutation ,Missense ,Netherlands ,Genetic Association Studies ,Mutation ,Missense - Abstract
Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. Here we impute nine large Dutch biobanks (~35,000 samples) with the population-specific reference panel created by the Genome of The Netherlands Project and perform association testing with blood lipid levels. We report the discovery of five novel associations at four loci (P value
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- 2015
46. Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C
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van Leeuwen, Elisabeth M, Huffman, Jennifer E, Bis, Joshua C, Isaacs, Aaron, Mulder, Monique, Sabo, Aniko, Smith, Albert V, Demissie, Serkalem, Manichaikul, Ani, Brody, Jennifer A, Feitosa, Mary F, Duan, Qing, Schraut, Katharina E, Navarro, Pau, van Vliet-Ostaptchouk, Jana V, Zhu, Gu, Mbarek, Hamdi, Trompet, Stella, Verweij, Niek, Lyytikäinen, Leo-Pekka, Deelen, Joris, Nolte, Ilja M, van der Laan, Sander W, Davies, Gail, Vermeij-Verdoold, Andrea JM, van Oosterhout, Andy ALJ, Vergeer-Drop, Jeannette M, Arking, Dan E, Trochet, Holly, Medina-Gomez, Carolina, Rivadeneira, Fernando, Uitterlinden, Andre G, Dehghan, Abbas, Franco, Oscar H, Sijbrands, Eric J, Hofman, Albert, White, Charles C, Mychaleckyj, Josyf C, Peloso, Gina M, Swertz, Morris A, Willemsen, Gonneke, de Geus, Eco J, Milaneschi, Yuri, Penninx, Brenda WJH, Ford, Ian, Buckley, Brendan M, de Craen, Anton JM, Starr, John M, Deary, Ian J, Pasterkamp, Gerard, Oldehinkel, Albertine J, Snieder, Harold, Slagboom, P Eline, Nikus, Kjell, Kähönen, Mika, Lehtimäki, Terho, Viikari, Jorma S, Raitakari, Olli T, van der Harst, Pim, Jukema, J Wouter, Hottenga, Jouke-Jan, Boomsma, Dorret I, Whitfield, John B, Montgomery, Grant, Martin, Nicholas G, Polasek, Ozren, Vitart, Veronique, Hayward, Caroline, Kolcic, Ivana, Wright, Alan F, Rudan, Igor, Joshi, Peter K, Wilson, James F, Lange, Leslie A, Wilson, James G, Gudnason, Vilmundur, Harris, Tamar B, Morrison, Alanna C, Borecki, Ingrid B, Rich, Stephen S, Padmanabhan, Sandosh, Psaty, Bruce M, Rotter, Jerome I, Smith, Blair H, Boerwinkle, Eric, Cupples, L Adrienne, and van Duijn, Cornelia
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Biological Sciences ,Genetics ,Aetiology ,2.1 Biological and endogenous factors ,Generation Scotland ,LifeLines Cohort Study ,CHARGE Lipids Working Group ,Biochemistry and Cell Biology ,Medical Biotechnology ,Clinical Sciences ,Biochemistry and cell biology - Abstract
BackgroundIndividuals with exceptional longevity and their offspring have significantly larger high-density lipoprotein concentrations (HDL-C) particle sizes due to the increased homozygosity for the I405V variant in the cholesteryl ester transfer protein (CETP) gene. In this study, we investigate the association of CETP and HDL-C further to identify novel, independent CETP variants associated with HDL-C in humans.MethodsWe performed a meta-analysis of HDL-C within the CETP region using 59,432 individuals imputed with 1000 Genomes data. We performed replication in an independent sample of 47,866 individuals and validation was done by Sanger sequencing.ResultsThe meta-analysis of HDL-C within the CETP region identified five independent variants, including an exonic variant and a common intronic insertion. We replicated these 5 variants significantly in an independent sample of 47,866 individuals. Sanger sequencing of the insertion within a single family confirmed segregation of this variant. The strongest reported association between HDL-C and CETP variants, was rs3764261; however, after conditioning on the five novel variants we identified the support for rs3764261 was highly reduced (βunadjusted=3.179 mg/dl (P value=5.25×10-509), βadjusted=0.859 mg/dl (P value=9.51×10-25)), and this finding suggests that these five novel variants may partly explain the association of CETP with HDL-C. Indeed, three of the five novel variants (rs34065661, rs5817082, rs7499892) are independent of rs3764261.ConclusionsThe causal variants in CETP that account for the association with HDL-C remain unknown. We used studies imputed to the 1000 Genomes reference panel for fine mapping of the CETP region. We identified and validated five variants within this region that may partly account for the association of the known variant (rs3764261), as well as other sources of genetic contribution to HDL-C.
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- 2015
47. Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm.
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Farlow, Janice L, Lin, Hai, Sauerbeck, Laura, Lai, Dongbing, Koller, Daniel L, Pugh, Elizabeth, Hetrick, Kurt, Ling, Hua, Kleinloog, Rachel, van der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A, Verweij, Bon H, Regli, Luca, Rinkel, Gabriel JE, Ruigrok, Ynte M, Doheny, Kimberly, Liu, Yunlong, Broderick, Joseph, Foroud, Tatiana, and FIA Study Investigators
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FIA Study Investigators ,Humans ,Intracranial Aneurysm ,Genetic Predisposition to Disease ,Membrane Proteins ,Cohort Studies ,Chromosome Mapping ,Pedigree ,Sequence Analysis ,DNA ,Computational Biology ,Base Sequence ,Phenotype ,Molecular Sequence Data ,Genetic Variation ,Exome ,Sequence Analysis ,DNA ,General Science & Technology - Abstract
Genetic risk factors for intracranial aneurysm (IA) are not yet fully understood. Genomewide association studies have been successful at identifying common variants; however, the role of rare variation in IA susceptibility has not been fully explored. In this study, we report the use of whole exome sequencing (WES) in seven densely-affected families (45 individuals) recruited as part of the Familial Intracranial Aneurysm study. WES variants were prioritized by functional prediction, frequency, predicted pathogenicity, and segregation within families. Using these criteria, 68 variants in 68 genes were prioritized across the seven families. Of the genes that were expressed in IA tissue, one gene (TMEM132B) was differentially expressed in aneurysmal samples (n=44) as compared to control samples (n=16) (false discovery rate adjusted p-value=0.023). We demonstrate that sequencing of densely affected families permits exploration of the role of rare variants in a relatively common disease such as IA, although there are important study design considerations for applying sequencing to complex disorders. In this study, we explore methods of WES variant prioritization, including the incorporation of unaffected individuals, multipoint linkage analysis, biological pathway information, and transcriptome profiling. Further studies are needed to validate and characterize the set of variants and genes identified in this study.
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- 2015
48. Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults
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Heijmans, Bastiaan T., ’t Hoen, Peter A.C., van Meurs, Joyce, Isaacs, Aaron, Jansen, Rick, Franke, Lude, Boomsma, Dorret I., Pool, René, van Dongen, Jenny, Hottenga, Jouke J., van Greevenbroek, Marleen M.J., Stehouwer, Coen D.A., van der Kallen, Carla J.H., Schalkwijk, Casper G., Wijmenga, Cisca, Zhernakova, Sasha, Tigchelaar, Ettje F., Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, Veldink, Jan H., van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Uitterlinden, André G., Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha V., Hof, Peter van ’t, Deelen, Patrick, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Luijk, René, Bonder, Marc Jan, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik. W., Hoen, Peter-Bram ’t, Zilhão, Nuno R., Sugden, Karen, Hannon, Eilis J., Mill, Jonathan, Caspi, Avshalom, Agnew-Blais, Jessica, Arseneault, Louise, Corcoran, David L., Moffitt, Terrie E., Poulton, Richie, and Franke, Barbara
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- 2019
- Full Text
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49. Advancing tools for human early lifecourse exposome research and translation (ATHLETE): Project overview
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Vrijheid, Martine, Basagaña, Xavier, Gonzalez, Juan R., Jaddoe, Vincent W. V., Jensen, Genon, Keun, Hector C., McEachan, Rosemary R. C., Porcel, Joana, Siroux, Valerie, Swertz, Morris A., Thomsen, Cathrine, Aasvang, Gunn Marit, Andrušaitytė, Sandra, Angeli, Karine, Avraam, Demetris, Ballester, Ferran, Burton, Paul, Bustamante, Mariona, Casas, Maribel, Chatzi, Leda, Chevrier, Cécile, Cingotti, Natacha, Conti, David, Crépet, Amélie, Dadvand, Payam, Duijts, Liesbeth, van Enckevort, Esther, Esplugues, Ana, Fossati, Serena, Garlantezec, Ronan, Gómez Roig, María Dolores, Grazuleviciene, Regina, Gützkow, Kristine B., Guxens, Mònica, Haakma, Sido, Hessel, Ellen V. S., Hoyles, Lesley, Hyde, Eleanor, Klanova, Jana, van Klaveren, Jacob D., Kortenkamp, Andreas, Le Brusquet, Laurent, Leenen, Ivonne, Lertxundi, Aitana, Lertxundi, Nerea, Lionis, Christos, Llop, Sabrina, Lopez-Espinosa, Maria-Jose, Lyon-Caen, Sarah, Maitre, Lea, Mason, Dan, Mathy, Sandrine, Mazarico, Edurne, Nawrot, Tim, Nieuwenhuijsen, Mark, Ortiz, Rodney, Pedersen, Marie, Perelló, Josep, Pérez-Cruz, Míriam, Philippat, Claire, Piler, Pavel, Pizzi, Costanza, Quentin, Joane, Richiardi, Lorenzo, Rodriguez, Adrian, Roumeliotaki, Theano, Sabin Capote, José Manuel, Santiago, Leonardo, Santos, Susana, Siskos, Alexandros P., Strandberg-Larsen, Katrine, Stratakis, Nikos, Sunyer, Jordi, Tenenhaus, Arthur, Vafeiadi, Marina, Wilson, Rebecca C., Wright, John, Yang, Tiffany, and Slama, Remy
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- 2021
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50. Ten quick tips for building FAIR workflows
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de Visser, Casper, primary, Johansson, Lennart F., additional, Kulkarni, Purva, additional, Mei, Hailiang, additional, Neerincx, Pieter, additional, Joeri van der Velde, K., additional, Horvatovich, Péter, additional, van Gool, Alain J., additional, Swertz, Morris A., additional, Hoen, Peter A. C. ‘t, additional, and Niehues, Anna, additional
- Published
- 2023
- Full Text
- View/download PDF
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