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849 results on '"Swelum, Ayman A."'

5. Potential pharmaceutical applications and molecular docking study for green fabricated ZnO nanoparticles mediated Raphanus sativus: In vitro and in vivo study

Author

Kadhum Hussam H., Ibraheem Sumayah, Jawad Zainab Nizar, Jeddoa Zuhair Mohammed Ali, Rasool Khetam H., Jabir Majid S., Najm Mazin A., Jawad Sabrean F., Al-kuraishy Hayder M., Nayef Uday M., Abdula Ahmed Mutanabbi, Ghotekar Suresh, and Swelum Ayman A.

Subjects
zno nps, antimicrobial, apoptosis, autophagy, inflammasome, molecular docking, Technology, Chemical technology, TP1-1185, Physical and theoretical chemistry, QD450-801
Abstract

The use of plant extracts as potent reducing agents for the environmentally friendly production of nanoparticles (NPs) has recently attracted the interest of scientists. NPs have received high attention because of their novel properties. The aim of the present study is to biosynthesize zinc oxide nanoparticles (ZnO NPs) using Raphanus sativus and study their effect as antibacterial, anticancer, antiviral, and antidiabetic, agents, NLRP3 inflammasome inhibitors, and inducers of phagocytosis and autophagy. The antibacterial, anticancer, and antiviral activities of ZnO NPs were investigated using different assays: well diffusion assay, MTT assay, reverse transcription polymerase chain reaction, reactive oxygen species generation, and apoptosis assay. Meanwhile, immunofluorescent assay, enzyme-linked immunosorbent assay, and flow cytometry were used for detection of autophagy and phagocytosis. Docking was also achieved to study their binding mode as well as affinity within the target enzymes (glucosamine-6-phosphate synthase) (PDB:1MOQ) active site, estrogen receptor (PDB:3ERT) active site, and tubulin receptor (PDB:4O2B) active site. The results demonstrated that the ZnO NPs have an inhibitory role against bacteria and the proliferation of lung cancer cells (A549). IC50 was 22.78 µg/mL for A549 cells. For MCF-10, was 272.24 µg/mL, antiviral activity against influenza virus, and antidiabetic agent. Conversely, the results showed the ability of ZnO NPs to reduce inflammasome activity via induction of autophagy. The study’s findings show that R. sativus can be easily and effectively used to synthesize ZnO NPs, and they also highlight the ZnO NPs’ considerable potential as antibacterial, antiviral, anticancer, NLRP3 inflammasome inhibitor, antidiabetic agent, and phagocytosis and autophagy inducer. Based on our findings, the green synthesized ZnO NPs could be used as promising therapeutic agents for biomedical applications.

Published
2024
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48. Modification of MWCNTs with Bi2WO6 nanoparticles targeting IL-1β and NLRP3 inflammasome via augmented autophagy.

Author

Rahoomi, Zenaa R., Ahmed, Duha S., Jabir, Majid S., Samir, Haney, and Swelum, Ayman A.

Subjects
BAND gaps, HYDROTHERMAL synthesis, VISIBLE spectra, NLRP3 protein, X-ray diffraction
Abstract

This study reports the facile hydrothermal synthesis of pure Bi2WO6 and Bi2WO6\MWCNTs nanocomposite at specific molar ratio 1:2.5 of Bi2WO6:MWCNTs and elucidates their role in modulating the NLRP3 inflammasome pathway via autophagy induction. Comprehensive characterization techniques, including XRD, Raman, UV.Vis PL,FESEM,EDS and TEM, revealed the successful incorporation of MWCNTs into the Bi2WO6 structures, leading to enhanced crystattlinity, reduced band gap energy (2.4 eV) suppressed charge carrier recombination and mitigated nanoparticles aggregation. Notably, the reduced band gap facikitaed improved visible light harvesting, a crucial attribute for photocatalytic applications. Significantly, the nanocompsoite exhibited a remarkable capacity to augment autophagy in bone marrow-derived macrophages (BMDMs), consequently down-regulating the NLRP3 inflammasom activation and IL-1β secretion upon LPS and ATP stimulation. Immunofluorescence assays unveiled increased co-localization of LC3 and NLRP3, suggestion enhanced targeting of NLRP3 by autophagy. Inhibition of autophagy by 3-MA reversed these effects, confirming the pivotal role of autophagy induction. Furthermore, the nanocomposite attenuated caspase-1 activation and ASC oligomerzation, thereby impeding inflammasome assembly. Collectively, these findings underscore the potential of Bi2WO6\MWCNTs nanocompsite as a multifaceted therapeutic platform, levering its tailored optoelectronic properties and sbility to modulate the NLRP3 infalmmasome via autophagy augmentation. This work covers the way for the development of advanced nanomaterials with tunable functionalities for combating inflammatory disorders and antimicrobial applications. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Impacts of Various Lighting Programs on Chicken Production and Behavior – A Review.

Author

Nissa, Shaista S., Sheikh, Islam U., Altaie, Hayman A.A., Adil, Sheikh, Banday, Mohammad T., Kamal, Mahmoud, Alqhtani, Abdulmohsen H., Swelum, Ayman A., Khafaga, Asmaa F., Al-Shehri, Mohammed, and Abd El-Hack, Mohamed E.

Subjects
ANIMAL welfare, ANIMAL behavior, AGRICULTURAL egg production, CHICKENS, BIRD behavior
Abstract

Environmental changes have an impact on agriculture, especially the production of poultry. These changes have caused grave concerns that will negatively affect the health and productivity of chickens. We must consider illumination, density, and dietary aspects when determining the optimal environmental conditions for poultry rearing and output. Each of these variables influences the performance and behavior of birds uniquely. A crucial aspect of evaluating animal well-being is that it understands animal behavior. Artificial lighting has been widely investigated in poultry production over the last fifty years to enhance muscle gain and egg production while preserving an effective feed conversion ratio, bird health, and well-being. Yet, researchers and breeders still disagree over the ideal light quality and quantity, density, and feeding levels for poultry farming, particularly for chickens. This evaluation, therefore, covered the most up-to-date practical methods for enhancing illumination, density, and feeding-related aspects of poultry behavior, health, and production. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Molecular surveillance based on anaplasmosis in domestic small ruminants: First report on zoonotic Anaplasma capra and phylogenetic insights from Faisalabad, Pakistan.

Author

Razzaq, Muhammad A., Imran, Muhammad, Atif, Farhan Ahmad, Abbas, Rao Z., Alvi, Mughees A., Swelum, Ayman A., Sindhu, Zia-ud-Din, Khan, Muhammad K., Sabir Mughal, Muhammad A., Khan, Adil, and Wu, Wen-Feng

Subjects
AGRICULTURE, ANAPLASMOSIS, TICK control, TICK infestations, LOGISTIC regression analysis, PESTE des petits ruminants
Abstract

Anaplasma is an intracellular alphaproteobacteria that infects diverse blood cell types in animal hosts including small ruminants. Epidemiological and risk factors information on zoonotic anaplasmosis with respect to anaplasmosis in sheep and goats are scarce. Therefore, the objective of the current study was to estimate the prevalence, risk factors of anaplasmosis and phylogenetic investigation of A. capra in sheep and goats from Faisalabad district, Pakistan. Briefly, 384 blood samples were randomly collected from sheep and goats of Faisalabad district, Pakistan, during January to May 2022. The samples were processed for the detection of Anaplasma targeting 16S rRNA gene using PCR. The data regarding disease determinants were collected using a predesigned questionnaire. Out of 384 samples, 131 samples were found positive for Anaplasma spp. with a prevalence rate of 34.11%. The results indicated a significantly higher prevalence of anaplasmosis in goats (41.88%) compared to sheep (22.00%). In addition, the chi square indicated that housing type, tick infestation, gender, tick control practices, age, mix farming, and hygiene were significantly associated with the occurrence of disease. The analysis of multivariate logistic regression expressed gender as the significant risk factor (p = 0.0001, OR = 1.757, CI = 1.305–2.366). The acquired sequences revealed four novel isolates of A. capra (Genbank accession numbers ON834323, ON838209, ON838210, and ON838211). The phylogenetic analysis of the 16S rRNA gene of A. capra revealed three distinct clusters with 99–100% homology with other isolates from different countries. Our isolates showed higher similarity with isolates from China (KM206273, KP314237, MT799937), Pakistan (ON238129, ON238130, ON238131), Angola (MT898988), India (MZ558066), Iran (MW692362), and Turkey (MT632469) isolated from human, sheep, ticks, goats, cattle, Gaddi goat, Persian Onager (Equus hemionus onager), and Turkish goats, respectively. In conclusion, A. capra is endemic in Punjab, Pakistan, there is a need to conduct large scale surveillance studies to assess the status of this pathogen at human-animal interface as well as to develop effective preventive and control strategies to reduce the economic losses associated with anaplasmosis in small ruminants. [ABSTRACT FROM AUTHOR]

Published
2024
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