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252 results on '"Sweeney, Deborah F."'

2. Contributors

Author

Anand, Vijay, primary, Atkinson, Kerry, additional, Bennett, Edward S., additional, Bergmanson, Jan P.G., additional, Bowden, Tim, additional, Cagnolati, Wolfgang, additional, Carnt, Nicole, additional, Caroline, Patrick J., additional, Cho, Pauline, additional, Clamp, John H., additional, Craig, Jennifer P., additional, Curtis, Michael, additional, Diec, Jennie, additional, Downie, Laura E., additional, Dumbleton, Kathy, additional, Eperjesi, Frank, additional, Fonn, Desmond, additional, Gilmartin, Bernard, additional, Hough, Tony, additional, Hoy, Lachlan, additional, Hui, Alex, additional, Jalbert, Isabelle, additional, Jones, Lyndon, additional, Lamb, Jaqueline, additional, Lindsay, Richard G., additional, Logan, Nicola S., additional, Mann, Aisling M., additional, McMahon, Jennifer, additional, McMonnies, Charles W., additional, Mihailidis, Michael, additional, Morris, Judith, additional, Mountford, John, additional, Newman, Stephen D., additional, Papas, Eric B., additional, Phillips, Anthony J., additional, Pullum, Kenneth W., additional, Rabbetts, Ronald, additional, Speedwell, Lynne, additional, Stapleton, Fiona, additional, Swarbrick, Helen A., additional, Sweeney, Deborah F., additional, Terry, Robert, additional, Tighe, Brian J., additional, Tromans, Cindy, additional, Vojlay, Richard, additional, Walker, Maria K., additional, Watters, Grant, additional, Williams, Lewis, additional, Wolffsohn, James S., additional, and Young, Graeme, additional

Published
2019
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3. Interaction between, the Contact Lens and the Ocular Surface

Author

O’Hare, Nicole, Stapleton, Fiona, Naduvilath, Thomas, Jalbert, Isabelle, Sweeney, Deborah F., Holden, Brien A., Sullivan, David A., editor, Stern, Michael E., editor, Tsubota, Kazuo, editor, Dartt, Darlene A., editor, Sullivan, Rose M., editor, and Bromberg, B. Britt, editor

Published
2002
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14. BRIEN ANTHONY HOLDEN OAM, PHD, DSC -- HIS SIGNIFICANCE AND ROLE IN THE DEVELOPMENT OF CONTACT LENSES, THE INSTITUTIONS AND GLOBAL VISION CARE.

Author

Fonn, Desmond, Sweeney, Deborah F., Rao, Gullapalli N., Naidoo, Kovin, and Erickson, Paul

Subjects
*SOFT contact lenses, *CONTACT lenses, *REFRACTIVE errors, *VISION disorders
Abstract

The purpose of this paper is to describe Brien Holden's enormous contributions to the science and development of soft contact lenses, the creation of associations and centers for research and how he was responsible for making Australia and, in particular Sydney, the epicenter of the contact lens research world for the better part of 40 years. His ingenuity with support of his co-workers generated hundreds of millions of dollars in royalties from co-development of contact lenses, which were ploughed back into research and funding of his humanitarian programs to provide eyecare services and spectacles for millions of underprivileged visually impaired people. His memorable achievements and awards are unsurpassed in our era but arguably the most significant is his research and fostering of education on contact lenses that contributed to the growth of contact lenses throughout the world. [ABSTRACT FROM AUTHOR]

Published
2021
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17. The role of MMPS and TIMPS in the feline ocular surface system during corneal epithelial wound healing

Author

Sweeney, Deborah F, University of Western Sydney, Evans, Margaret DM, CSIRO, Garrett, Qian, Brien Holden Vision Institute, Petznick, Andrea, Optometry & Vision Science, Faculty of Science, UNSW, Sweeney, Deborah F, University of Western Sydney, Evans, Margaret DM, CSIRO, Garrett, Qian, Brien Holden Vision Institute, and Petznick, Andrea, Optometry & Vision Science, Faculty of Science, UNSW

Abstract

The ocular surface system is a complex microenvironment including the cornea, conjunctiva, lacrimal gland, meibomian glands and tear film. Matrix metalloproteinases (MMPs), a family of zinc- and calcium-dependent proteinases involved in maintaining and remodelling extracellular matrix and inflammation, have been found in ocular tissues and tears. The analysis of tears has been used to identify potential biomarkers for eye diseases. Contributions of individual ocular surface components to tear proteins are not fully understood. This study investigated the expression of MMPs and tissue inhibitors of MMPs (TIMPs) (particularly MMP-9 and -2) in tears and ocular tissues following corneal epithelial wounding (debridement) at predetermined time points using a feline model. Preliminary work validated the use of eye-flush tears (collected after instillation of saline) and procedural control eyes (same treatment as wounded eyes) as controls for the tear collection study. Gelatin zymography and immunohistochemistry were used to detect MMPs and TIMPs in tears and ocular surface tissues, and data was then analysed using statistical methods. During corneal healing, expression of MMP-9 was detected in all ocular surface components with significant increase in tears, the corneal and limbal epithelium, keratocytes and conjunctival epithelium. In contrast, MMP-2 was found significantly increased only in tears and the corneal and conjunctival epithelium. Analysis of tears from wounded and procedural control eyes suggested a minimal contribution of the healing corneal epithelium to tear-derived MMP-9 and -2. Other possible contributors to increased tear MMP-9 levels included the lacrimal gland, inflammatory cells in conjunctival tissue including conjunctival-associated lymphoid tissue (CALT). Expression of MMP-1, TIMP-1 and -2 in ocular tissues in response to wounding were also investigated. MMP-1 was increased in the healing corneal epithelium, keratocytes and limbal epithelium. TIMP

Published
2010

21. Microbial keratitis and vision loss with contact lenses

Author

Holden, Brien A., Sweeney, Deborah F., Sankaridurg, Padmaja, Carnt, Nicola, Edwards, Katie P., Stretton, Serina, Stapleton, Fiona, Holden, Brien A., Sweeney, Deborah F., Sankaridurg, Padmaja, Carnt, Nicola, Edwards, Katie P., Stretton, Serina, and Stapleton, Fiona

Abstract

PURPOSE: Microbial keratitis is the only sight-threatening adverse event that occurs with contact lens wear. This article gives a preliminary estimation of the incidence of microbial keratitis and vision loss with continuous-wear contact lenses made from highly oxygen permeable (Dk) materials. METHODS: The most up-to-date data available on microbial keratitis and vision loss are collected from a range of sources including industry, private practice, and publications and is reviewed. RESULTS: There have been 16 cases of microbial keratitis with high-Dk silicone hydrogel lenses. Of the 13 where data are available, none have lost two or more lines of best-corrected visual acuity (BCVA). CONCLUSION: First approximation indicates that the incidence of microbial keratitis with high-Dk silicone hydrogel lenses may be lower than the incidence with low-Dk soft lenses during extended wear. The rate of loss of more than two lines of BCVA is low in patients that develop microbial keratitis with low- and high-Dk soft lenses.

Published
2003

23. Synthetic corneal inlays

Author

Sweeney, Deborah F, primary, Vannas, Antti, additional, Hughes, Timothy C, additional, Evans, Margaret Dm, additional, Mclean, Keith M, additional, Xie, Ruo Zhong, additional, Pravin, Vk, additional, and Prakasam, Ruby Kala, additional

Published
2008
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31. Letters to the Editor

Author

Sweeney, Deborah F, primary, Jalbert, Isabelle, additional, Covey, Michael, additional, Sankaridurg, Padmaja R, additional, Vajdic, Claire, additional, Holden, Brien A, additional, Sharma, Savitri, additional, Ramachandran, Lakshmi, additional, Willcox, Mark D.P, additional, and Rao, Gullapalli N, additional

Published
2004
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