Search

Your search keyword '"Swartz, Melody A."' showing total 889 results
Start Over Author "Swartz, Melody A."
889 results on '"Swartz, Melody A."'

1. Membrane-localized neoantigens predict the efficacy of cancer immunotherapy.

Author

Goldberger, Zoe, Hauert, Sylvie, Chang, Kevin, Kurtanich, Trevin, Alpar, Aaron, Repond, Grégoire, Wang, Yue, Gomes, Suzana, Krishnakumar, Raga, Siddarth, Prabha, Swartz, Melody, Hubbell, Jeffrey, and Briquez, Priscilla

Subjects
biomarkers, cancer, cell membrane, immunotherapy, neoantigens, tumor mutational burden, Animals, Humans, Mice, Biomarkers, Tumor, Immunotherapy, Melanoma
Abstract

Immune checkpoint immunotherapy (ICI) can re-activate immune reactions against neoantigens, leading to remarkable remission in cancer patients. Nevertheless, only a minority of patients are responsive to ICI, and approaches for prediction of responsiveness are needed to improve the success of cancer treatments. While the tumor mutational burden (TMB) correlates positively with responsiveness and survival of patients undergoing ICI, the influence of the subcellular localizations of the neoantigens remains unclear. Here, we demonstrate in both a mouse melanoma model and human clinical datasets of 1,722 ICI-treated patients that a high proportion of membrane-localized neoantigens, particularly at the plasma membrane, correlate with responsiveness to ICI therapy and improved overall survival across multiple cancer types. We further show that combining membrane localization and TMB analyses can enhance the predictability of cancer patient response to ICI. Our results may have important implications for establishing future clinical guidelines to direct the choice of treatment toward ICI.

Published
2023

3. Lymphatic coagulation and neutrophil extracellular traps in lung-draining lymph nodes of COVID-19 decedents

Author

MacDonald, Margo E., Weathered, Rachel K., Stewart, Emma C., Magold, Alexandra I., Mukherjee, Anish, Gurbuxani, Sandeep, Smith, Heather, McMullen, Phillip, Mueller, Jeffrey, Husain, Aliya N., Salles, Calixto M., Briquez, Priscilla S., Rouhani, Sherin J., Yu, Jovian, Trujillo, Jonathan, Pyzer, Athalia R., Gajewski, Thomas F., Sperling, Anne I., Kilarski, Witold W., and Swartz, Melody A.

Published
2022
Full Text
View/download PDF

4. Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant

Author

Gray, Laura T., Raczy, Michal M., Briquez, Priscilla S., Marchell, Tiffany M., Alpar, Aaron T., Wallace, Rachel P., Volpatti, Lisa R., Sasso, Maria Stella, Cao, Shijie, Nguyen, Mindy, Mansurov, Aslan, Budina, Erica, Watkins, Elyse A., Solanki, Ani, Mitrousis, Nikolaos, Reda, Joseph W., Yu, Shann S., Tremain, Andrew C., Wang, Ruyi, Nicolaescu, Vlad, Furlong, Kevin, Dvorkin, Steve, Manicassamy, Balaji, Randall, Glenn, Wilson, D. Scott, Kwissa, Marcin, Swartz, Melody A., and Hubbell, Jeffrey A.

Published
2021
Full Text
View/download PDF

6. Perivascular Macrophages Limit Permeability

Author

He, Huanhuan, Mack, Julia J, Güç, Esra, Warren, Carmen M, Squadrito, Mario Leonardo, Kilarski, Witold W, Baer, Caroline, Freshman, Ryan D, McDonald, Austin I, Ziyad, Safiyyah, Swartz, Melody A, De Palma, Michele, and Iruela-Arispe, M Luisa

Subjects
Medical Physiology, Biomedical and Clinical Sciences, 2.1 Biological and endogenous factors, Aetiology, Cardiovascular, Animals, Antigens, CD, Cadherins, Capillaries, Capillary Permeability, Cell Communication, Cell Movement, Cells, Cultured, Coculture Techniques, Dextrans, Endothelial Cells, Fluorescein-5-isothiocyanate, Humans, Macrophages, Peritoneal, Mesentery, Mice, Inbred C57BL, Mice, Nude, Mice, Transgenic, Ovalbumin, Peritoneum, Phenotype, Phosphorylation, Rhodamines, Skin, Time Factors, Transfection, capillaries, capillary permeability, cell communication, endothelial cells, macrophages, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectivePerivascular cells, including pericytes, macrophages, smooth muscle cells, and other specialized cell types, like podocytes, participate in various aspects of vascular function. However, aside from the well-established roles of smooth muscle cells and pericytes, the contributions of other vascular-associated cells are poorly understood. Our goal was to ascertain the function of perivascular macrophages in adult tissues under nonpathological conditions.Approach and resultsWe combined confocal microscopy, in vivo cell depletion, and in vitro assays to investigate the contribution of perivascular macrophages to vascular function. We found that resident perivascular macrophages are associated with capillaries at a frequency similar to that of pericytes. Macrophage depletion using either clodronate liposomes or antibodies unexpectedly resulted in hyperpermeability. This effect could be rescued when M2-like macrophages, but not M1-like macrophages or dendritic cells, were reconstituted in vivo, suggesting subtype-specific roles for macrophages in the regulation of vascular permeability. Furthermore, we found that permeability-promoting agents elicit motility and eventual dissociation of macrophages from the vasculature. Finally, in vitro assays showed that M2-like macrophages attenuate the phosphorylation of VE-cadherin upon exposure to permeability-promoting agents.ConclusionsThis study points to a direct contribution of macrophages to vessel barrier integrity and provides evidence that heterotypic cell interactions with the endothelium, in addition to those of pericytes, control vascular permeability.

Published
2016

10. Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity

Author

Kang, Seounghun, primary, Mansurov, Aslan, additional, Kurtanich, Trevin, additional, Chun, Hye Rin, additional, Slezak, Anna J., additional, Volpatti, Lisa R., additional, Chang, Kevin, additional, Wang, Thomas, additional, Alpar, Aaron T., additional, Refvik, Kirsten C., additional, Hansen, O. Isabella, additional, Borjas, Gustavo J., additional, Shim, Ha-Na, additional, Hultgren, Kevin T., additional, Gomes, Suzana, additional, Solanki, Ani, additional, Ishihara, Jun, additional, Swartz, Melody A., additional, and Hubbell, Jeffrey A., additional

Published
2023
Full Text
View/download PDF

25. Supplementary Table 1 from MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions

Author

Gkountidi, Anastasia O., primary, Garnier, Laure, primary, Dubrot, Juan, primary, Angelillo, Julien, primary, Harlé, Guillaume, primary, Brighouse, Dale, primary, Wrobel, Ludovic J., primary, Pick, Robert, primary, Scheiermann, Christoph, primary, Swartz, Melody A., primary, and Hugues, Stéphanie, primary

Published
2023
Full Text
View/download PDF

27. Supplementary Figures 1-12 from MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions

Author

Gkountidi, Anastasia O., primary, Garnier, Laure, primary, Dubrot, Juan, primary, Angelillo, Julien, primary, Harlé, Guillaume, primary, Brighouse, Dale, primary, Wrobel, Ludovic J., primary, Pick, Robert, primary, Scheiermann, Christoph, primary, Swartz, Melody A., primary, and Hugues, Stéphanie, primary

Published
2023
Full Text
View/download PDF

28. Data from MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell–Suppressive Functions

Author

Gkountidi, Anastasia O., primary, Garnier, Laure, primary, Dubrot, Juan, primary, Angelillo, Julien, primary, Harlé, Guillaume, primary, Brighouse, Dale, primary, Wrobel, Ludovic J., primary, Pick, Robert, primary, Scheiermann, Christoph, primary, Swartz, Melody A., primary, and Hugues, Stéphanie, primary

Published
2023
Full Text
View/download PDF

41. Supplementary Figure S4 from T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors

Author

Manzo, Teresa, primary, Sturmheit, Tabea, primary, Basso, Veronica, primary, Petrozziello, Elisabetta, primary, Hess Michelini, Rodrigo, primary, Riba, Michela, primary, Freschi, Massimo, primary, Elia, Angela R., primary, Grioni, Matteo, primary, Curnis, Flavio, primary, Protti, Maria Pia, primary, Schumacher, Ton N., primary, Debets, Reno, primary, Swartz, Melody A., primary, Corti, Angelo, primary, Bellone, Matteo, primary, and Mondino, Anna, primary

Published
2023
Full Text
View/download PDF

42. Supplementary Table S1 from T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors

Author

Manzo, Teresa, primary, Sturmheit, Tabea, primary, Basso, Veronica, primary, Petrozziello, Elisabetta, primary, Hess Michelini, Rodrigo, primary, Riba, Michela, primary, Freschi, Massimo, primary, Elia, Angela R., primary, Grioni, Matteo, primary, Curnis, Flavio, primary, Protti, Maria Pia, primary, Schumacher, Ton N., primary, Debets, Reno, primary, Swartz, Melody A., primary, Corti, Angelo, primary, Bellone, Matteo, primary, and Mondino, Anna, primary

Published
2023
Full Text
View/download PDF

43. Supplementary Table and Figure Legends from T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors

Author

Manzo, Teresa, primary, Sturmheit, Tabea, primary, Basso, Veronica, primary, Petrozziello, Elisabetta, primary, Hess Michelini, Rodrigo, primary, Riba, Michela, primary, Freschi, Massimo, primary, Elia, Angela R., primary, Grioni, Matteo, primary, Curnis, Flavio, primary, Protti, Maria Pia, primary, Schumacher, Ton N., primary, Debets, Reno, primary, Swartz, Melody A., primary, Corti, Angelo, primary, Bellone, Matteo, primary, and Mondino, Anna, primary

Published
2023
Full Text
View/download PDF

44. Supplementary Methods and References. from T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors

Author

Manzo, Teresa, primary, Sturmheit, Tabea, primary, Basso, Veronica, primary, Petrozziello, Elisabetta, primary, Hess Michelini, Rodrigo, primary, Riba, Michela, primary, Freschi, Massimo, primary, Elia, Angela R., primary, Grioni, Matteo, primary, Curnis, Flavio, primary, Protti, Maria Pia, primary, Schumacher, Ton N., primary, Debets, Reno, primary, Swartz, Melody A., primary, Corti, Angelo, primary, Bellone, Matteo, primary, and Mondino, Anna, primary

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results