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22 results on '"Swartz, Jina"'

2. Understanding the health needs of internally displaced persons: A scoping review

Author

Cantor, David, Swartz, Jina, Roberts, Bayard, Abbara, Aula, Ager, Alastair, Bhutta, Zulfiqar A., Blanchet, Karl, Madoro Bunte, Derebe, Chukwuorji, JohnBosco Chika, Daoud, Nihaya, Ekezie, Winifred, Jimenez-Damary, Cecilia, Jobanputra, Kiran, Makhashvili, Nino, Rayes, Diana, Restrepo-Espinosa, Maria Helena, Rodriguez-Morales, Alfonso J., Salami, Bukola, and Smith, James

Published
2021
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4. Tackling gaps in developing life-changing treatments for dementia

Author

Mauricio, Rui, Benn, Caroline, Davis, John, Dawson, Gerry, Dawson, Lee A., Evans, Alison, Fox, Nick, Gallacher, John, Hutton, Mike, Isaac, John, Jones, Declan N.C., Jones, Lesley, Lalli, Giovanna, Libri, Vincenzo, Lovestone, Simon, Moody, Catherine, Noble, Wendy, Perry, Hugh, Pickett, James, Reynolds, David, Ritchie, Craig, Rohrer, Jonathan D., Routledge, Carol, Rowe, James, Snyder, Heather, Spires-Jones, Tara, Swartz, Jina, Truyen, Luc, and Whiting, Paul

Published
2019
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9. Candidate Single-Nucleotide Polymorphisms From a Genomewide Association Study of Alzheimer Disease

Author

Li, Hao, Wetten, Sally, Li, Li, St. Jean, Pamela L., Upmanyu, Ruchi, Surh, Linda, Hosford, David, Barnes, Michael R., Briley, James David, Borrie, Michael, Coletta, Natalie, Delisle, Richard, Dhalla, Daniella, Ehm, Margaret G., Feldman, Howard H., Fornazzari, Luis, Gauthier, Serge, Goodgame, Neil, Guzman, Danilo, Hammond, Sandra, Hollingworth, Paul, Hsiung, Ging-Yuek, Johnson, Joan, Kelly, Devon D., Keren, Ron, Kertesz, Andrew, King, Karen S., Lovestone, Simon, Loy-English, Inge, Matthews, Paul M., Owen, Michael J., Plumpton, Mary, Pryse-Phillips, William, Prinjha, Rab K., Richardson, Jill C., Saunders, Ann, Slater, Andrew J., St. George-Hyslop, Peter H., Stinnett, Sandra W., Swartz, Jina E., Taylor, Rachel L., Wherrett, John, Williams, Julie, Yarnall, David P., Gibson, Rachel A., Irizarry, Michael C., Middleton, Lefkos T., and Roses, Allen D.

Published
2008

10. Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinsonʼs disease families

Author

Ishihara, Lianna, Gibson, Rachel A., Warren, Liling, Amouri, Rim, Lyons, Kelly, Wielinski, Catherine, Hunter, Christine, Swartz, Jina E., Elango, Ramu, Akkari, Anthony P., Leppert, David, Surh, Linda, Reeves, Kevin H., Thomas, Siwan, Ragone, Leigh, Hattori, Nobutaka, Pahwa, Rajesh, Jankovic, Joseph, Nance, Martha, Freeman, Alan, Gouider-Khouja, Neziha, Kefi, Mounir, Zouari, Mourad, Ben Sassi, Samia, Ben Yahmed, Samia, El Euch-Fayeche, Ghada, Middleton, Lefkos, Burn, David J., Watts, Ray L., and Hentati, Faycal

Published
2007
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13. Researching health and internal displacement: Introduction to the special series

Author

Swartz, Jina, Roberts, Bayard, and Cantor, David

Abstract

This special series on ‘health and internal displacement’ is concerned primarily with the health needs of internally displaced persons (IDPs) in conflict contexts. Curated by editors from the recently established Health and Internal Displacement Network (HIDN), the series brings together a selection of thirteen new research articles from among many submitted in response to an open call for papers by HIDN and the Journal of Migration and Health. The aims of this series are to increase engagement with the health needs of IDPs and to support research, policy and programming in this relatively neglected area. The series focuses on IDP health but is not prescriptive in terms of health conditions, age groups, geographic region, or camp or urban setting, and reflects the diversity of IDP populations, contexts and needs.

Published
2024
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14. Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

Author

Wyttenbach, Andreas, Carmichael, Jenny, Swartz, Jina, Furlong, Robert A., Narain, Yolanda, Rankin, Julia, and Rubinsztein, David C.

Subjects
Huntington's chorea -- Research, Cell research -- Analysis, Polygonaceae -- Research, Mammals -- Research, Science and technology
Abstract

Huntington's disease (HD), spinocerebellar ataxias types 1 and 3 (SCA1, SCA3), and spinobulbar muscular atrophy (SBMA) are caused by CAG/polyglutamine expansion mutations. A feature of these diseases is ubiquitinated intraneuronal inclusions derived from the mutant proteins, which colocalize with heat shock proteins (HSPs) in SCA1 and SBMA and proteasomal components in SCA1, SCA3, and SBMA. Previous studies suggested that HSPs might protect against inclusion formation, because overexpression of HDJ-2/HSDJ (a human HSP40 homologue) reduced ataxin-1 (SCA1) and androgen receptor (SBMA) aggregate formation in HeLa cells. We investigated these phenomena by transiently transfecting part of huntingtin exon 1 in COS-7, PC12, and SH-SY5Y cells. Inclusion formation was not seen with constructs expressing 23 glutamines but was repeat length and time dependent for mutant constructs with 43-74 repeats. HSP70, HSP40, the 20S proteasome and ubiquitin colocalized with inclusions. Treatment with heat shock and lactacystin, a proteasome inhibitor, increased the proportion of mutant huntingtin exon 1-expressing cells with inclusions. Thus, inclusion formation may be enhanced in polyglutamine diseases, if the pathological process results in proteasome inhibition or a heat-shock response. Overexpression of HDJ-2/HSDJ did not modify inclusion formation in PC12 and SH-SY5Y cells but increased inclusion formation in COS-7 cells. To our knowledge, this is the first report of an HSP increasing aggregation of an abnormally folded protein in mammalian cells and expands the current understanding of the roles of HDJ-2/HSDJ in protein folding.

Published
2000

16. State hospitals, academic medicine and the decline of health care in South Africa: A cry of support from those who have left for those who stay.

Author

Don-Wauchope, Andrew C, primary, Karas, Andreas, additional, Chetty, Vasudhevan T, additional, Davidson, Howard K, additional, Gottschalk, Raymond, additional, Rabiner, Eugenii A, additional, Sam, Flora, additional, Sommerville, Garth P, additional, Swartz, Jina, additional, and Viljoen, Adie, additional

Published
2010
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19. Efficacy and Safety of Donepezil in the Treatment of Parkinson's Disease Patients With Dementia

Author

Dubois, Bruno, primary, Tolosa, Eduardo, additional, Kulisevsky, Jaime, additional, Reichmann, Heinz, additional, Jones, Roy W., additional, Burn, David J., additional, Harre, Mark, additional, Thomas, Gail, additional, Harris, Ray, additional, Moline, Margaret, additional, Silver, Gabrielle, additional, Swartz, Jina E., additional, Schindler, Rachel, additional, and Gray, Julian, additional

Published
2007
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21. Tackling gaps in developing life-changing treatments for dementia

Author

Mauricio, Rui, Benn, Caroline, Davis, John, Dawson, Gerry, Dawson, Lee A, Evans, Alison, Fox, Nick, Gallacher, John, Hutton, Mike, Isaac, John, Jones, Declan NC, Jones, Lesley, Lalli, Giovanna, Libri, Vincenzo, Lovestone, Simon, Moody, Catherine, Noble, Wendy, Perry, Hugh, Pickett, James, Reynolds, David, Ritchie, Craig, Rohrer, Jonathan D, Routledge, Carol, Rowe, James, Snyder, Heather, Spires-Jones, Tara, Swartz, Jina, Truyen, Luc, Whiting, Paul, and Therapeutics For Dementia Consortium

Subjects
Clinical trials, Diagnosis, Dementia, Disease-modifying treatment, Earlier detection, Genetic risk factors, Alzheimer's disease, Neurodegeneration, 3. Good health, Target validation
Abstract

Since the G8 dementia summit in 2013, a number of initiatives have been established with the aim of facilitating the discovery of a disease-modifying treatment for dementia by 2025. This report is a summary of the findings and recommendations of a meeting titled "Tackling gaps in developing life-changing treatments for dementia", hosted by Alzheimer's Research UK in May 2018. The aim of the meeting was to identify, review, and highlight the areas in dementia research that are not currently being addressed by existing initiatives. It reflects the views of leading experts in the field of neurodegeneration research challenged with developing a strategic action plan to address these gaps and make recommendations on how to achieve the G8 dementia summit goals. The plan calls for significant advances in (1) translating newly identified genetic risk factors into a better understanding of the impacted biological processes; (2) enhanced understanding of selective neuronal resilience to inform novel drug targets; (3) facilitating robust and reproducible drug-target validation; (4) appropriate and evidence-based selection of appropriate subjects for proof-of-concept clinical trials; (5) improving approaches to assess drug-target engagement in humans; and (6) innovative approaches in conducting clinical trials if we are able to detect disease 10-15 years earlier than we currently do today.

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