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2. Recognising Potential Ambiguities in Measurements of Oxygen in Tissues

Author

Swartz, Harold M., Vaupel, Peter, Flood, Ann Barry, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Rosenhouse-Dantsker, Avia, Series Editor, Gerlai, Robert, Series Editor, Sakatani, Kaoru, editor, Masamoto, Kazuto, editor, Yamada, Yukio, editor, Scholkmann, Felix, editor, and LaManna, Joseph C., editor

Published
2024
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4. A Radiation Biological Analysis of the Oxygen Effect as a Possible Mechanism in FLASH

Author

Swartz, Harold M., Hoopes, P. Jack, Gladstone, David J., Demidov, Valentin, Vaupel, Peter, Flood, Ann Barry, Williams, Benjamin B., Zhang, Rongxiao, Pogue, Brian W., Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Scholkmann, Felix, editor, LaManna, Joseph, editor, and Wolf, Ursula, editor

Published
2022
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5. Measurement of Tissue Oxygen as a Novel Approach to Optimizing Red Blood Cell Quality Assessment

Author

Buehler, Paul W., Flood, Ann Barry, Swartz, Harold M., Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Nemoto, Edwin M., editor, Harrison, Eileen M., editor, Pias, Sally C., editor, Bragin, Denis E., editor, Harrison, David K., editor, and LaManna, Joseph C., editor

Published
2021
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6. What Is the Meaning of an Oxygen Measurement? : Analysis of Methods Purporting to Measure Oxygen in Targeted Tissues

Author

Swartz, Harold M., Flood, Ann Barry, Williams, Benjamin B., Pogue, Brian W., Schaner, Philip E., Vaupel, Peter, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Nemoto, Edwin M., editor, Harrison, Eileen M., editor, Pias, Sally C., editor, Bragin, Denis E., editor, Harrison, David K., editor, and LaManna, Joseph C., editor

Published
2021
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16. Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016

Author

Vostal, Jaroslav G, Buehler, Paul W, Gelderman, Monique P, Alayash, Abdu I, Doctor, Alan, Zimring, James C, Glynn, Simone A, Hess, John R, Klein, Harvey, Acker, Jason P, Spinella, Philip C, D'Alessandro, Angelo, Palsson, Bernhard, Raife, Thomas J, Busch, Michael P, McMahon, Timothy J, Intaglietta, Marcos, Swartz, Harold M, Dubick, Michael A, Cardin, Sylvain, Patel, Rakesh P, Natanson, Charles, Weisel, John W, Muszynski, Jennifer A, Norris, Philip J, and Ness, Paul M

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Immunology, Good Health and Well Being, Adult, Animals, Biological Products, Blood Preservation, Blood Safety, Child, Erythrocyte Transfusion, Erythrocytes, Humans, Models, Animal, Randomized Controlled Trials as Topic, Transfusion Reaction, United States, United States Food and Drug Administration, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

The US Food and Drug Administration (FDA) held a workshop on red blood cell (RBC) product regulatory science on October 6 and 7, 2016, at the Natcher Conference Center on the National Institutes of Health (NIH) Campus in Bethesda, Maryland. The workshop was supported by the National Heart, Lung, and Blood Institute, NIH; the Department of Defense; the Office of the Assistant Secretary for Health, Department of Health and Human Services; and the Center for Biologics Evaluation and Research, FDA. The workshop reviewed the status and scientific basis of the current regulatory framework and the available scientific tools to expand it to evaluate innovative and future RBC transfusion products. A full record of the proceedings is available on the FDA website (http://www.fda.gov/BiologicsBloodVaccines/NewsEvents/WorkshopsMeetingsConferences/ucm507890.htm). The contents of the summary are the authors' opinions and do not represent agency policy.

Published
2018

26. Guidance to Transfer ‘Bench-Ready’ Medical Technology into Usual Clinical Practice: Case Study – Sensors and Spectrometer Used in EPR Oximetry

Author

Flood, Ann Barry, Wood, Victoria A., Schreiber, Wilson, Williams, Benjamin B., Gallez, Bernard, Swartz, Harold M., COHEN, IRUN R., Editorial Board Member, LAJTHA, ABEL, Editorial Board Member, LAMBRIS, JOHN D., Editorial Board Member, PAOLETTI, RODOLFO, Editorial Board Member, REZAEI, NIMA, Editorial Board Member, Thews, Oliver, editor, LaManna, Joseph C., editor, and Harrison, David K., editor

Published
2018
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31. The role of oxygen during fracture healing

Author

Lu, Chuanyong, Saless, Neema, Wang, Xiaodong, Sinha, Arjun, Decker, Sebastian, Kazakia, Galateia, Hou, Huagang, Williams, Benjamin, Swartz, Harold M, Hunt, Thomas K, Miclau, Theodore, and Marcucio, Ralph S

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Stem Cell Research, Regenerative Medicine, Stem Cell Research - Nonembryonic - Non-Human, Physical Injury - Accidents and Adverse Effects, Musculoskeletal, Animals, Cell Differentiation, Enzyme-Linked Immunosorbent Assay, Fracture Healing, Mice, Oxygen, Stem Cells, Vascular Endothelial Growth Factor A, Fracture, Hypoxia, Hyperoxia, Angiogenesis, Biological Sciences, Engineering, Medical and Health Sciences, Endocrinology & Metabolism, Clinical sciences
Abstract

Oxygen affects the activity of multiple skeletogenic cells and is involved in many processes that are important for fracture healing. However, the role of oxygen in fracture healing has not been fully studied. Here we systematically examine the effects of oxygen tension on fracture healing and test the ability of hyperoxia to rescue healing defects in a mouse model of ischemic fracture healing. Mice with tibia fracture were housed in custom-built gas chambers and groups breathed a constant atmosphere of 13% oxygen (hypoxia), 21% oxygen (normoxia), or 50% oxygen (hyperoxia). The influx of inflammatory cells to the fracture site, stem cell differentiation, tissue vascularization, and fracture healing were analyzed. In addition, the efficacy of hyperoxia (50% oxygen) as a treatment regimen for fracture nonunion was tested. Hypoxic animals had decreased tissue vascularity, decreased bone formation, and delayed callus remodeling. Hyperoxia increased tissue vascularization, altered fracture healing in un-complicated fractures, and improved bone repair in ischemia-induced delayed fracture union. However, neither hypoxia nor hyperoxia significantly altered chondrogenesis or osteogenesis during early stages of fracture healing, and infiltration of macrophages and neutrophils was not affected by environmental oxygen after bone injury. In conclusion, our results indicate that environmental oxygen levels affect tissue vascularization and fracture healing, and that providing oxygen when fractures are accompanied by ischemia may be beneficial.

Published
2013

37. Comparison of Tumor Control and Skin Damage in a Mouse Model after Ultra-High Dose Rate Irradiation and Conventional Irradiation

Author

Duval, Kayla E. A., primary, Aulwes, Ethan, additional, Zhang, Rongxiao, additional, Rahman, Mahbubur, additional, Ashraf, M. Ramish, additional, Sloop, Austin, additional, Sunnerberg, Jacob, additional, Williams, Benjamin B., additional, Cao, Xu, additional, Bruza, Petr, additional, Kheirollah, Alireza, additional, Tavakkoli, Armin, additional, Jarvis, Lesley A., additional, Schaner, Philip E., additional, Swartz, Harold M., additional, Gladstone, David J., additional, Pogue, Brian W., additional, and Hoopes, P. Jack, additional

Published
2023
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40. Recurrent Low-Dose Chemotherapy to Inhibit and Oxygenate Head and Neck Tumors

Author

Khan, Nadeem, Hou, Huagang, Hodge, Sassan, Kuppusamy, Muthulakshmi, Chen, Eunice Y., Eastman, Alan, Kuppusamy, Periannan, Swartz, Harold M., Cohen, Irun R., Series Editor, Lajtha, Abel, Series Editor, Paoletti, Rodolfo, Series Editor, Lambris, John D., Series Editor, Swartz, Harold M., editor, Harrison, David K., editor, and Bruley, Duane F., editor

Published
2014
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41. Real-Time, In Vivo Determination of Dynamic Changes in Lung and Heart Tissue Oxygenation Using EPR Oximetry

Author

Rivera, Brian K., Naidu, Shan K., Subramanian, Kamal, Joseph, Matthew, Hou, Huagang, Khan, Nadeem, Swartz, Harold M., Kuppusamy, Periannan, Cohen, Irun R., Series Editor, Lajtha, Abel, Series Editor, Paoletti, Rodolfo, Series Editor, Lambris, John D., Series Editor, Swartz, Harold M., editor, Harrison, David K., editor, and Bruley, Duane F., editor

Published
2014
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42. Skeletal Muscle and Glioma Oxygenation by Carbogen Inhalation in Rats: A Longitudinal Study by EPR Oximetry Using Single-Probe Implantable Oxygen Sensors

Author

Hou, Huagang, Khan, Nadeem, Lariviere, Jean, Hodge, Sassan, Chen, Eunice Y., Jarvis, Lesley A., Eastman, Alan, Williams, Benjamin B., Kuppusamy, Periannan, Swartz, Harold M., Cohen, Irun R., Series Editor, Lajtha, Abel, Series Editor, Paoletti, Rodolfo, Series Editor, Lambris, John D., Series Editor, Swartz, Harold M., editor, Harrison, David K., editor, and Bruley, Duane F., editor

Published
2014
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43. Advances in Probes and Methods for Clinical EPR Oximetry

Author

Swartz, Harold M., Hou, Huagang, Khan, Nadeem, Jarvis, Lesley A., Chen, Eunice Y., Williams, Benjamin B., Kuppusamy, Periannan, Cohen, Irun R., Series Editor, Lajtha, Abel, Series Editor, Paoletti, Rodolfo, Series Editor, Lambris, John D., Series Editor, Swartz, Harold M., editor, Harrison, David K., editor, and Bruley, Duane F., editor

Published
2014
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44. Direct and Repeated Clinical Measurements of pO2 for Enhancing Cancer Therapy and Other Applications

Author

Swartz, Harold M., Williams, Benjamin B., Hou, Huagang, Khan, Nadeem, Jarvis, Lesley A., Chen, Eunice Y., Schaner, Philip E., Ali, Arif, Gallez, Bernard, Kuppusamy, Periannan, Flood, Ann B., COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, Luo, Qingming, editor, Li, Lin Z., editor, Harrison, David K., editor, Shi, Hua, editor, and Bruley, Duane F., editor

Published
2016
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50. Applications of Magnetic Resonance in Model Systems: Cancer Therapeutics

Author

Evelhoch, Jeffrey L, Gillies, Robert J, Karczmar, Gregory S, Koutcher, Jason A, Maxwell, Ross J, Nalcioglu, Orhan, Raghunand, Natarajan, Ronen, Sabrina M, Ross, Brian D, and Swartz, Harold M

Subjects
nuclear magnetic resonance, neoplasms, pathophysiology, metabolism, therapy, nuclear magnetic resonance, neoplasms, pathophysiology, metabolism, therapyweighted h-1-nmr spectroscopy, carbogen-induced changes, cells in-vitro, thymidine kinase, human breast, tumor-cells, murine tumor, brain-tumor, p-31 nmr, capillary-permeability
Abstract

AbstractThe lack of information regarding the metabolism and pathophysiology of individual tumors limits, in part, both the development of new anti-cancer therapies and the optimal implementation of currently available treatments. Magnetic resonance [MR, including magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and electron paramagnetic resonance (EPR)] provides a powerful tool to assess many aspects of tumor metabolism and pathophysiology. Moreover, since this information can be obtained non-destructively, pre-clinical results from cellular or animal models are often easily translated into the clinic. This review presents selected examples of how MR has been used to identify metabolic changes associated with apoptosis, detect therapeutic response prior to a change in tumor volume, optimize the combination of metabolic inhibitors with chemotherapy and/or radiation, characterize and exploit the influence of tumor pH on the effectiveness of chemotherapy, characterize tumor reoxygenation and the effects of modifiers of tumor oxygenation in individual tumors, image transgene expression and assess the efficacy of gene therapy. These examples provide an overview of several of the areas in which cellular and animal model studies using MR have contributed to our understanding of the effects of treatment on tumor metabolism and pathophysiology and the importance of tumor metabolism and pathophysiology as determinants of therapeutic response.

Published
2000

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