208 results on '"Swart, Karin M. A."'
Search Results
2. A meta-analysis of previous falls and subsequent fracture risk in cohort studies
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Vandenput, Liesbeth, Johansson, Helena, McCloskey, Eugene V., Liu, Enwu, Schini, Marian, Åkesson, Kristina E., Anderson, Fred A., Azagra, Rafael, Bager, Cecilie L., Beaudart, Charlotte, Bischoff-Ferrari, Heike A., Biver, Emmanuel, Bruyère, Olivier, Cauley, Jane A., Center, Jacqueline R., Chapurlat, Roland, Christiansen, Claus, Cooper, Cyrus, Crandall, Carolyn J., Cummings, Steven R., da Silva, José A. P., Dawson-Hughes, Bess, Diez-Perez, Adolfo, Dufour, Alyssa B., Eisman, John A., Elders, Petra J. M., Ferrari, Serge, Fujita, Yuki, Fujiwara, Saeko, Glüer, Claus-Christian, Goldshtein, Inbal, Goltzman, David, Gudnason, Vilmundur, Hall, Jill, Hans, Didier, Hoff, Mari, Hollick, Rosemary J., Huisman, Martijn, Iki, Masayuki, Ish-Shalom, Sophia, Jones, Graeme, Karlsson, Magnus K., Khosla, Sundeep, Kiel, Douglas P., Koh, Woon-Puay, Koromani, Fjorda, Kotowicz, Mark A., Kröger, Heikki, Kwok, Timothy, Lamy, Olivier, Langhammer, Arnulf, Larijani, Bagher, Lippuner, Kurt, McGuigan, Fiona E. A., Mellström, Dan, Merlijn, Thomas, Nguyen, Tuan V., Nordström, Anna, Nordström, Peter, O’Neill, Terence W., Obermayer-Pietsch, Barbara, Ohlsson, Claes, Orwoll, Eric S., Pasco, Julie A., Rivadeneira, Fernando, Schott, Anne-Marie, Shiroma, Eric J., Siggeirsdottir, Kristin, Simonsick, Eleanor M., Sornay-Rendu, Elisabeth, Sund, Reijo, Swart, Karin M. A., Szulc, Pawel, Tamaki, Junko, Torgerson, David J., van Schoor, Natasja M., van Staa, Tjeerd P., Vila, Joan, Wareham, Nicholas J., Wright, Nicole C., Yoshimura, Noriko, Zillikens, MCarola, Zwart, Marta, Harvey, Nicholas C., Lorentzon, Mattias, Leslie, William D., and Kanis, John A.
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- 2024
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3. Risk of cardiovascular events after an exacerbation of chronic obstructive pulmonary disease: results from the EXACOS-CV cohort study using the PHARMO Data Network in the Netherlands
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Swart, Karin M. A., Baak, Brenda N., Lemmens, Louise, Penning-van Beest, Fernie J. A., Bengtsson, Camilla, Lobier, Muriel, Hoti, Fabian, Vojinovic, Dina, van Burk, Lindy, Rhodes, Kirsty, Garbe, Edeltraut, Herings, Ron M. C., Nordon, Clementine, and Simons, Sami O.
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- 2023
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4. Impact of 2018 EU Risk Minimisation Measures and Revised Pregnancy Prevention Programme on Utilisation and Prescribing Trends of Medicinal Products Containing Valproate: An Interrupted Time Series Study
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Abtahi, Shahab, Pajouheshnia, Romin, Durán, Carlos E., Riera-Arnau, Judit, Gamba, Magdalena, Alsina, Ema, Hoxhaj, Vjola, Andersen, Morten, Bartolini, Claudia, Kristiansen, Sarah Brøgger, Brown, Jeremy, Hallgreen, Christine Erikstrup, Garcia-Poza, Patricia, Gardarsdottir, Helga, Gini, Rosa, Girardi, Anna, Holthuis, Emily, Huerta, Consuelo, Ibánez, Luisa, Limoncella, Giorgio, Martín-Pérez, Mar, Paoletti, Olga, Roberto, Giuseppe, Souverein, Patrick, Swart, Karin M. A., Wing, Kevin, Sturkenboom, Miriam, and Klungel, Olaf
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- 2023
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5. Time Trends in Patient Characteristics of New Rivaroxaban Users with Atrial Fibrillation in Germany and the Netherlands
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Voss, Annemarie, Smits, Elisabeth, Swart, Karin M. A., Balabanova, Yanina, Brobert, Gunnar, Suzart-Woischnik, Kiliana, Herings, Ron M. C., Schink, Tania, and Haug, Ulrike
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- 2023
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6. The association between hyperkyphosis and fall incidence among community-dwelling older adults
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Koelé, Marije C., Willems, Hanna C., Swart, Karin M. A., van Dijk, Suzanne C., Lips, Paul, de Groot, Lisette C. P. G. M., van der Cammen, Tischa J. M., Zillikens, M. Carola, van Schoor, Natasja M., and van der Velde, Nathalie
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- 2022
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7. Challenges and lessons learned from a long-term postauthorisation safety study programme of rivaroxaban in Europe
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Brobert, Gunnar, primary, Ruigomez, Ana, additional, Schink, Tania, additional, Voss, Annemarie, additional, Herings, Ron, additional, Smits, Elisabeth, additional, Swart, Karin M A, additional, Friberg, Leif, additional, Balabanova, Yanina, additional, Tarenz, Christine, additional, Suzart-Woischnik, Kiliana, additional, Soriano-Gabarró, Montse, additional, Vora, Pareen, additional, Homering, Martin, additional, Dyszynski, Tomasz, additional, Nagel, Gerd, additional, Amaya, Pablo, additional, and García Rodríguez, Luis Alberto, additional
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- 2024
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8. The Impact of the COVID-19 Pandemic in The Netherlands on Primary Healthcare Use and Clinical Outcomes in Persons with Type 2 Diabetes
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van den Berg, Jesse M., primary, Blom, Marieke T., additional, Swart, Karin M. A., additional, Overbeek, Jetty A., additional, Remmelzwaal, S., additional, Elders, Petra J. M., additional, and Herings, Ron M. C., additional
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- 2023
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9. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
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Justice, Anne E., Karaderi, Tugce, Highland, Heather M., Young, Kristin L., Graff, Mariaelisa, Lu, Yingchang, Turcot, Valérie, Auer, Paul L., Fine, Rebecca S., Guo, Xiuqing, Schurmann, Claudia, Lempradl, Adelheid, Marouli, Eirini, Mahajan, Anubha, Winkler, Thomas W., Locke, Adam E., Medina-Gomez, Carolina, Esko, Tõnu, Vedantam, Sailaja, Giri, Ayush, Lo, Ken Sin, Alfred, Tamuno, Mudgal, Poorva, Ng, Maggie C. Y., Heard-Costa, Nancy L., Feitosa, Mary F., Manning, Alisa K., Willems, Sara M., Sivapalaratnam, Suthesh, Abecasis, Goncalo, Alam, Dewan S., Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Broer, Linda, Burt, Amber A., Butterworth, Adam S., Caulfield, Mark J., Cesana, Giancarlo, Chambers, John C., Chasman, Daniel I., Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Collins, Francis S., Cook, James P., Cox, Amanda J., Crosslin, David S., Danesh, John, de Bakker, Paul I. W., Denus, Simon de, Mutsert, Renée de, Dedoussis, George, Demerath, Ellen W., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Dörr, Marcus, Drenos, Fotios, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Fornage, Myriam, Fox, Caroline S., Franks, Paul W., Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Girotto, Giorgia, Gorski, Mathias, Grallert, Harald, Grarup, Niels, Grove, Megan L., Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T., Hayward, Caroline, Heid, Iris M., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Hung, Yi-Jen, Hveem, Kristian, Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jarvik, Gail P., Jia, Yucheng, Jørgensen, Torben, Jousilahti, Pekka, Justesen, Johanne M., Kahali, Bratati, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kee, Frank, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kovacs, Peter, Krämer, Bernhard K., Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lee, Wen-Jane, Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Luan, Jian’an, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mägi, Reedik, Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Masca, Nicholas G. D., McCarthy, Mark I., Meidtner, Karina, Mihailov, Evelin, Moilanen, Leena, Moitry, Marie, Mook-Kanamori, Dennis O., Morgan, Anna, Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Ntalla, Ioanna, O’Connell, Jeffrey R., Owen, Katharine R., Pedersen, Oluf, Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Ewing, Ailith, Polasek, Ozren, Raitakari, Olli T., Rasheed, Asif, Raulerson, Chelsea K., Rauramaa, Rainer, Reilly, Dermot F., Reiner, Alex P., Ridker, Paul M., Rivas, Manuel A., Robertson, Neil R., Robino, Antonietta, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo, Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Blair H., Smith, Jennifer A., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swart, Karin M. A., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Torres, Mina, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van Duijn, Cornelia M., Vanhala, Mauno, Varma, Rohit, Vermeulen, Sita H., Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Zillikens, M. Carola, Rivadeneira, Fernando, Borecki, Ingrid B., Pospisilik, J. Andrew, Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, Mohlke, Karen L., Rotter, Jerome I., Kutalik, Zoltán, Hirschhorn, Joel N., Cupples, L. Adrienne, Loos, Ruth J. F., North, Kari E., and Lindgren, Cecilia M.
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- 2019
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10. Safety and effectiveness of rivaroxaban for prevention of stroke in patients with nonvalvular atrial fibrillation: analysis of routine clinical data from four countries
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García Rodríguez, Luis Alberto, primary, Ruigómez, Ana, additional, Schink, Tania, additional, Voss, Annemarie, additional, Smits, Elisabeth, additional, Swart, Karin M. A., additional, Balabanova, Yanina, additional, Suzart-Woischnik, Kiliana, additional, Brobert, Gunnar, additional, and Herings, Ron M. C., additional
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- 2023
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11. Impact of 2018 EU Risk Minimisation Measures and Revised Pregnancy Prevention Programme on Utilisation and Prescribing Trends of Medicinal Products Containing Valproate: An Interrupted Time Series Study
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Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, PECP - Centre for Pharmacoepidemiology, Abtahi, Shahab, Pajouheshnia, Romin, Durán, Carlos E, Riera-Arnau, Judit, Gamba, Magdalena, Alsina, Ema, Hoxhaj, Vjola, Andersen, Morten, Bartolini, Claudia, Kristiansen, Sarah Brøgger, Brown, Jeremy, Hallgreen, Christine Erikstrup, Garcia-Poza, Patricia, Gardarsdottir, Helga, Gini, Rosa, Girardi, Anna, Holthuis, Emily, Huerta, Consuelo, Ibánez, Luisa, Limoncella, Giorgio, Martín-Pérez, Mar, Paoletti, Olga, Roberto, Giuseppe, Souverein, Patrick, Swart, Karin M A, Wing, Kevin, Sturkenboom, Miriam, Klungel, Olaf, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, PECP - Centre for Pharmacoepidemiology, Abtahi, Shahab, Pajouheshnia, Romin, Durán, Carlos E, Riera-Arnau, Judit, Gamba, Magdalena, Alsina, Ema, Hoxhaj, Vjola, Andersen, Morten, Bartolini, Claudia, Kristiansen, Sarah Brøgger, Brown, Jeremy, Hallgreen, Christine Erikstrup, Garcia-Poza, Patricia, Gardarsdottir, Helga, Gini, Rosa, Girardi, Anna, Holthuis, Emily, Huerta, Consuelo, Ibánez, Luisa, Limoncella, Giorgio, Martín-Pérez, Mar, Paoletti, Olga, Roberto, Giuseppe, Souverein, Patrick, Swart, Karin M A, Wing, Kevin, Sturkenboom, Miriam, and Klungel, Olaf
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- 2023
12. Impact of 2018 EU Risk Minimisation Measures and Revised Pregnancy Prevention Programme on Utilisation and Prescribing Trends of Medicinal Products Containing Valproate: An Interrupted Time Series Study
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RWE/Causal inference, Epi Infectieziekten Team 2, Apotheek O&O&O, Child Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Data Science & Biostatistiek, Abtahi, Shahab, Pajouheshnia, Romin, Durán, Carlos E, Riera-Arnau, Judit, Gamba, Magdalena, Alsina, Ema, Hoxhaj, Vjola, Andersen, Morten, Bartolini, Claudia, Kristiansen, Sarah Brøgger, Brown, Jeremy, Hallgreen, Christine Erikstrup, Garcia-Poza, Patricia, Gardarsdottir, Helga, Gini, Rosa, Girardi, Anna, Holthuis, Emily, Huerta, Consuelo, Ibánez, Luisa, Limoncella, Giorgio, Martín-Pérez, Mar, Paoletti, Olga, Roberto, Giuseppe, Souverein, Patrick, Swart, Karin M A, Wing, Kevin, Sturkenboom, Miriam, Klungel, Olaf, RWE/Causal inference, Epi Infectieziekten Team 2, Apotheek O&O&O, Child Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Data Science & Biostatistiek, Abtahi, Shahab, Pajouheshnia, Romin, Durán, Carlos E, Riera-Arnau, Judit, Gamba, Magdalena, Alsina, Ema, Hoxhaj, Vjola, Andersen, Morten, Bartolini, Claudia, Kristiansen, Sarah Brøgger, Brown, Jeremy, Hallgreen, Christine Erikstrup, Garcia-Poza, Patricia, Gardarsdottir, Helga, Gini, Rosa, Girardi, Anna, Holthuis, Emily, Huerta, Consuelo, Ibánez, Luisa, Limoncella, Giorgio, Martín-Pérez, Mar, Paoletti, Olga, Roberto, Giuseppe, Souverein, Patrick, Swart, Karin M A, Wing, Kevin, Sturkenboom, Miriam, and Klungel, Olaf
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- 2023
13. Vitamin D deficiency in Europe: pandemic?
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Cashman, Kevin D, Dowling, Kirsten G, Škrabáková, Zuzana, Gonzalez-Gross, Marcela, Valtueña, Jara, De Henauw, Stefaan, Moreno, Luis, Damsgaard, Camilla T, Michaelsen, Kim F, Mølgaard, Christian, Jorde, Rolf, Grimnes, Guri, Moschonis, George, Mavrogianni, Christina, Manios, Yannis, Thamm, Michael, Mensink, Gert BM, Rabenberg, Martina, Busch, Markus A, Cox, Lorna, Meadows, Sarah, Goldberg, Gail, Prentice, Ann, Dekker, Jacqueline M, Nijpels, Giel, Pilz, Stefan, Swart, Karin M, van Schoor, Natasja M, Lips, Paul, Eiriksdottir, Gudny, Gudnason, Vilmundur, Cotch, Mary Frances, Koskinen, Seppo, Lamberg-Allardt, Christel, Durazo-Arvizu, Ramon A, Sempos, Christopher T, and Kiely, Mairead
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- 2016
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14. Effectiveness of COVID-19 Vaccines in Adults with Diabetes Mellitus: A Systematic Review
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van den Berg, Jesse M., primary, Remmelzwaal, Sharon, additional, Blom, Marieke T., additional, van Hoek, Beryl A. C. E., additional, Swart, Karin M. A., additional, Overbeek, Jetty A., additional, Burchell, George L., additional, Herings, Ron M. C., additional, and Elders, Petra J. M., additional
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- 2022
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15. Myocarditis and pericarditis associated with SARS-CoV-2 vaccines: A population-based descriptive cohort and a nested self-controlled risk interval study using electronic health care data from four European countries
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Bots, Sophie H., primary, Riera-Arnau, Judit, additional, Belitser, Svetlana V., additional, Messina, Davide, additional, Aragón, Maria, additional, Alsina, Ema, additional, Douglas, Ian J., additional, Durán, Carlos E., additional, García-Poza, Patricia, additional, Gini, Rosa, additional, Herings, Ron M. C., additional, Huerta, Consuelo, additional, Sisay, Malede Mequanent, additional, Martín-Pérez, Mar, additional, Martin, Ivonne, additional, Overbeek, Jetty A., additional, Paoletti, Olga, additional, Pallejà-Millán, Meritxell, additional, Schultze, Anna, additional, Souverein, Patrick, additional, Swart, Karin M. A., additional, Villalobos, Felipe, additional, Klungel, Olaf H., additional, and Sturkenboom, Miriam C. J. M., additional
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- 2022
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16. Impact of 2018 EU Risk Minimisation Measures and Revised Pregnancy Prevention Programme on Utilisation and Prescribing Trends of Medicinal Products Containing Valproate:An Interrupted Time Series Study
- Author
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Abtahi, Shahab, Pajouheshnia, Romin, Durán, Carlos E, Riera-Arnau, Judit, Gamba, Magdalena, Alsina, Ema, Hoxhaj, Vjola, Andersen, Morten, Bartolini, Claudia, Kristiansen, Sarah Brøgger, Brown, Jeremy, Hallgreen, Christine Erikstrup, Garcia-Poza, Patricia, Gardarsdottir, Helga, Gini, Rosa, Girardi, Anna, Holthuis, Emily, Huerta, Consuelo, Ibánez, Luisa, Limoncella, Giorgio, Martín-Pérez, Mar, Paoletti, Olga, Roberto, Giuseppe, Souverein, Patrick, Swart, Karin M A, Wing, Kevin, Sturkenboom, Miriam, Klungel, Olaf, Pharmacoepidemiology and Clinical Pharmacology, and Afd Pharmacoepi & Clinical Pharmacology
- Subjects
Italy/epidemiology ,Valproic Acid/adverse effects ,Pharmacology ,Contraception ,Pregnancy ,Humans ,Female ,Interrupted Time Series Analysis ,Pharmacology (medical) ,Toxicology ,Europe/epidemiology - Abstract
Introduction: Due to established teratogenicity of valproates, the EU risk minimisation measures (RMMs) with a pregnancy prevention programme (PPP) for valproate were updated in March 2018. Objectives: To investigate the effectiveness of the 2018 EU RMMs on valproate utilisation in five European countries/regions. Methods: A multi-database, times series study of females of childbearing potential (12–55 years) was conducted using electronic medical records from five countries/regions (01.01.2010–31.12.2020): Denmark, Tuscany (Italy), Spain, the Netherlands, and the UK. Clinical and demographic information from each database was transformed to the ConcePTION Common Data Model, quality checks were conducted and a distributed analysis was performed using common scripts. Incident and prevalent use of valproate, proportion of discontinuers and switchers to alternative medicine, frequency of contraception coverage during valproate use, and occurrence of pregnancies during valproate exposure were estimated per month. Interrupted time series analyses were conducted to estimate the level or trend change in the outcome measures. Results: We included 69,533 valproate users from 9,699,371 females of childbearing potential from the five participating centres. A significant decline in prevalent use of valproates was observed in Tuscany, Italy (mean difference post-intervention −7.7%), Spain (−11.3%), and UK (−5.9%) and a non-significant decline in the Netherlands (−3.3%), but no decline in incident use after the 2018 RMMs compared to the period before. The monthly proportion of compliant valproate prescriptions/dispensings with a contraceptive coverage was low (
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- 2023
17. Factors related to intentional non-initiation of bisphosphonate treatment in patients with a high fracture risk in primary care: a qualitative study
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Swart, Karin M. A., van Vilsteren, Myrthe, van Hout, Wesley, Draak, Esther, van der Zwaard, Babette C., van der Horst, Henriette E., Hugtenburg, Jacqueline G., and Elders, Petra J. M.
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- 2018
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18. A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study
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Swart, Karin M. A., Ham, Annelies C., van Wijngaarden, Janneke P., Enneman, Anke W., van Dijk, Suzanne C., Sohl, Evelien, Brouwer-Brolsma, Elske M., van der Zwaluw, Nikita L., Carola Zillikens, M., Dhonukshe-Rutten, Rosalie A. M., van der Velde, Nathalie, Brug, Johannes, Uitterlinden, André G., de Groot, Lisette C. P. G. M., Lips, Paul, and van Schoor, Natasja M.
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- 2016
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19. The Association Between the Kyphosis Angle and Physical Performance in Community-Dwelling Older Adults
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Koelé, Marije C, primary, Willems, Hanna C, additional, Harmsen, Iris M, additional, Swart, Karin M A, additional, van Dijk, Suzanne C, additional, Lips, Paul, additional, de Groot, Lisette C P G M, additional, van der Cammen, Tischa J M, additional, Zillikens, M Carola, additional, van Schoor, Natasja M, additional, and van der Velde, Nathalie, additional
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- 2022
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20. Myocarditis and pericarditis associated with SARS-CoV-2 vaccines: A population-based descriptive cohort and a nested self-controlled risk interval study using electronic health care data from four European countries
- Author
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Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Bots, Sophie H, Riera-Arnau, Judit, Belitser, Svetlana V, Messina, Davide, Aragón, Maria, Alsina, Ema, Douglas, Ian J, Durán, Carlos E, García-Poza, Patricia, Gini, Rosa, Herings, Ron M C, Huerta, Consuelo, Sisay, Malede Mequanent, Martín-Pérez, Mar, Martin, Ivonne, Overbeek, Jetty A, Paoletti, Olga, Pallejà-Millán, Meritxell, Schultze, Anna, Souverein, Patrick, Swart, Karin M A, Villalobos, Felipe, Klungel, Olaf H, Sturkenboom, Miriam C J M, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Bots, Sophie H, Riera-Arnau, Judit, Belitser, Svetlana V, Messina, Davide, Aragón, Maria, Alsina, Ema, Douglas, Ian J, Durán, Carlos E, García-Poza, Patricia, Gini, Rosa, Herings, Ron M C, Huerta, Consuelo, Sisay, Malede Mequanent, Martín-Pérez, Mar, Martin, Ivonne, Overbeek, Jetty A, Paoletti, Olga, Pallejà-Millán, Meritxell, Schultze, Anna, Souverein, Patrick, Swart, Karin M A, Villalobos, Felipe, Klungel, Olaf H, and Sturkenboom, Miriam C J M
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- 2022
21. Beta‐blocker use and fall risk in older individuals: Original results from two studies with meta‐analysis
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Ham, Annelies C., van Dijk, Suzanne C., Swart, Karin M. A., Enneman, Anke W., van der Zwaluw, Nikita L., Brouwer‐Brolsma, Elske M., van Schoor, Natasja M., Zillikens, M. Carola, Lips, Paul, de Groot, Lisette C. P. G. M., Hofman, Albert, Witkamp, Renger F., Uitterlinden, André G., Stricker, Bruno H., and van der Velde, Nathalie
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- 2017
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22. Effect of Vitamin B12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial
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Enneman, Anke W., Swart, Karin M. A., van Wijngaarden, Janneke P., van Dijk, Suzanne C., Ham, Annelies C., Brouwer-Brolsma, Elske M., van der Zwaluw, Nikita L., Dhonukshe-Rutten, Rosalie A. M., van der Cammen, Tischa J. M., de Groot, Lisette C. P. G. M., van Meurs, Joyce, Lips, Paul, Uitterlinden, André G., Zillikens, M. Carola, van Schoor, Natasja M., and van der Velde, Nathalie
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- 2015
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23. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
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Zillikens, M. Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M., Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltán, Luan, Jian’an, Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J., Barroso, Inês, Bennett, David A., Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B., Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A., Cawthon, Peggy M., Cederberg, Henna, Chen, Zhao, Cho, Nam H., Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R., De Jager, Philip L., Demuth, Ilja, Dhonukshe-Rutten, Rosalie A. M., Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W., Erdos, Mike, Eriksson, Johan G., Eriksson, Joel, Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L., Hayward, Caroline, Hofman, Albert, Hoffman, Eric P., Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J., Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S. L., Koistinen, Heikki A., Kraus, William E., Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Launer, Lenore J., Lee, Jong-Young, Lerch, Markus M., Lewis, Joshua R., Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N., Maixner, William, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, Nielson, Carrie M., O’Connell, Jeffrey R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Parker, Stephen C. J., Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L., Räikkönen, Katri, Ralston, Stuart H., Ripatti, Samuli, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E., Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M. A., Tan, Sian-Tsung, Tarnopolsky, Mark A., Thompson, Patricia, Thomson, Cynthia A., Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N., Welch, Ryan, Wichmann, H.-Erich, Widen, Elisabeth, Williams, Frances M. K., Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C., Döring, Angela, van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Kooner, Jaspal S., Psaty, Bruce M., Spector, Timothy D., Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G., Wareham, Nicholas J., Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J. F., Karasik, David, Harris, Tamara B., Ohlsson, Claes, and Kiel, Douglas P.
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- 2017
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24. Development and validation of an algorithm to estimate the risk of severe complications of COVID-19: a retrospective cohort study in primary care in the Netherlands
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Herings, Ron M C, primary, Swart, Karin M A, additional, van der Zeijst, Bernard A M, additional, van der Heijden, Amber A, additional, van der Velden, Koos, additional, Hiddink, Eric G, additional, Heymans, Martijn W, additional, Herings, Reinier A R, additional, van Hout, Hein P J, additional, Beulens, Joline W J, additional, Nijpels, Giel, additional, and Elders, Petra J M, additional
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- 2021
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25. Associations Between Medication Use and Homocysteine Levels in an Older Population, and Potential Mediation by Vitamin B12 and Folate: Data from the B-PROOF Study
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Ham, Annelies C., Enneman, Anke W., van Dijk, Suzanne C., Oliai Araghi, Sadaf, Swart, Karin M. A., Sohl, Evelien, van Wijngaarden, Janneke P., van der Zwaluw, Nikita L., Brouwer-Brolsma, Elske M., Dhonukshe-Rutten, Rosalie A. M., van Schoor, Natasja M., van der Cammen, Tischa J. M., Zillikens, M. Carola, de Jonge, Robert, Lips, Paul, de Groot, Lisette C. P. G. M., van Meurs, Joyce B. J., Uitterlinden, André G., Witkamp, Renger F., Stricker, Bruno H. C., and van der Velde, Nathalie
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- 2014
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26. Effectiveness of COVID-19 Vaccines in Adults with Diabetes Mellitus: A Systematic Review.
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van den Berg, Jesse M., Remmelzwaal, Sharon, Blom, Marieke T., van Hoek, Beryl A. C. E., Swart, Karin M. A., Overbeek, Jetty A., Burchell, George L., Herings, Ron M. C., and Elders, Petra J. M.
- Subjects
VACCINE effectiveness ,COVID-19 vaccines ,DIABETES ,BREAKTHROUGH infections ,COVID-19 - Abstract
Persons with diabetes mellitus may have an increased risk of severe illness or death from COVID-19 compared to persons without diabetes. Prior studies indicate that immune response and thus vaccine effectiveness might be lower in persons with diabetes. We aimed to systematically review the effectiveness of COVID-19 vaccines in adults with diabetes. Pubmed, Embase, Web of Science and Cochrane Library were searched for studies that evaluated the effectiveness of COVID-19 vaccines in adults with diabetes, published before 4 March 2022. Risk of bias in the included studies was evaluated using the ROBINS-I tool. At least two reviewers conducted the study selection, data extraction, and risk of bias assessment independently. After screening of 2196 studies, a total of 17 articles were included. Six different COVID-19 vaccines (Ad5-nCoV-S, AZD1222, BNT162b2, CoronaVac, JNJ-78436735, and mRNA-1273) were included in the synthesis. Vaccine effectiveness was reported for SARS-CoV-2 infection, symptomatic COVID-19, hospitalization, and death, and ranged from 24 to 96% in persons with diabetes, and from 33 to 97% in total study populations; effectiveness was generally lower for persons with diabetes. Odds ratios for breakthrough infection or severe COVID-19 ranged from 1.03 to 2.41 in vaccinated persons with diabetes compared to persons without diabetes. Even though the included studies were very heterogeneous, results from the synthesis indicate that effectiveness of COVID-19 vaccines might be lower in persons with diabetes. More research is needed on the comparison of vaccine effectiveness between persons with and without diabetes, and the effectiveness of repeat COVID-19 vaccinations. [ABSTRACT FROM AUTHOR]
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- 2023
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27. The association between hyperkyphosis and fall incidence among community-dwelling older adults
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Koelé, Marije C., primary, Willems, Hanna C., additional, Swart, Karin M. A., additional, van Dijk, Suzanne C., additional, Lips, Paul, additional, de Groot, Lisette C. P. G. M., additional, van der Cammen, Tischa J. M., additional, Zillikens, M. Carola, additional, van Schoor, Natasja M., additional, and van der Velde, Nathalie, additional
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- 2021
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28. Predicting hospital admissions from individual patient data (IPD): an applied example to explore key elements driving external validity
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Meid, Andreas Daniel, primary, Gonzalez-Gonzalez, Ana Isabel, additional, Dinh, Truc Sophia, additional, Blom, Jeanet, additional, van den Akker, Marjan, additional, Elders, Petra, additional, Thiem, Ulrich, additional, Küllenberg de Gaudry, Daniela, additional, Swart, Karin M A, additional, Rudolf, Henrik, additional, Bosch-Lenders, Donna, additional, Trampisch, Hans J, additional, Meerpohl, Joerg J, additional, Gerlach, Ferdinand M, additional, Flaig, Benno, additional, Kom, Ghainsom, additional, Snell, Kym I E, additional, Perera, Rafael, additional, Haefeli, Walter Emil, additional, Glasziou, Paul, additional, and Muth, Christiane, additional
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- 2021
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29. Non-linear associations between serum 25-OH vitamin D and indices of arterial stiffness and arteriosclerosis in an older population
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van Dijk, Suzanne C., Sohl, Evelien, Oudshoorn, Christian, Enneman, Anke W., Ham, Annelies C., Swart, Karin M. A., van Wijngaarden, Janneke P., Brouwer-Brolsma, Elske M., van der Zwaluw, Nikita L., Uitterlinden, Andre G., de Groot, Lisette C. P. G. M., Dhonukshe-Rutten, Rosalie A. M., Lips, Paul, van Schoor, Natasja M., Blom, Henk J., Geleijnse, Johanna M., Feskens, Edith J., Smulders, Yvo M., Zillikens, M. Carola, de Jongh, Renate T., van den Meiracker, Anton H., Mattace Raso, Francesco U. S., and van der Velde, Nathalie
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- 2015
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30. Medication-Related Fall Incidents in an Older, Ambulant Population: The B-PROOF Study
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Ham, Annelies C., Swart, Karin M. A., Enneman, Anke W., van Dijk, Suzanne C., Araghi, Sadaf Oliai, van Wijngaarden, Janneke P., van der Zwaluw, Nikita L., Brouwer-Brolsma, Elske M., Dhonukshe-Rutten, Rosalie A. M., van Schoor, Natasja M., van der Cammen, Tischa J. M., Lips, Paul, de Groot, Lisette C. P. G. M., Uitterlinden, André G., Witkamp, Renger F., Stricker, Bruno H., and van der Velde, Nathalie
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- 2014
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31. Vitamin B12, Folic Acid, and Bone
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Swart, Karin M. A., van Schoor, Natasja M., and Lips, Paul
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- 2013
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32. Predicting hospital admissions from individual patient data (IPD): an applied example to explore key elements driving external validity
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Meid, Andreas, González-González, Ana I., Dinh, Truc Sophia, Blom, Jeanette Wilhelmina, Akker, Marjan van den, Elders, Petra, Thiem, Ulrich, Küllenberg de Gaudry, Daniela, Swart, Karin M. A., Rudolf, Henrik, Bosch-Lenders, Donna, Trampisch, Hans Joachim, Meerpohl, Jörg J., Gerlach, Ferdinand M., Flaig, Benno, Kom, Ghainsom D., Snell, Kym I. E., Perera, Rafael, Haefeli, Walter E., Glasziou, Paul, Muth, Christiane, Meid, Andreas, González-González, Ana I., Dinh, Truc Sophia, Blom, Jeanette Wilhelmina, Akker, Marjan van den, Elders, Petra, Thiem, Ulrich, Küllenberg de Gaudry, Daniela, Swart, Karin M. A., Rudolf, Henrik, Bosch-Lenders, Donna, Trampisch, Hans Joachim, Meerpohl, Jörg J., Gerlach, Ferdinand M., Flaig, Benno, Kom, Ghainsom D., Snell, Kym I. E., Perera, Rafael, Haefeli, Walter E., Glasziou, Paul, and Muth, Christiane
- Abstract
Objective To explore factors that potentially impact external validation performance while developing and validating a prognostic model for hospital admissions (HAs) in complex older general practice patients. Study design and setting Using individual participant data from four cluster-randomised trials conducted in the Netherlands and Germany, we used logistic regression to develop a prognostic model to predict all-cause HAs within a 6-month follow-up period. A stratified intercept was used to account for heterogeneity in baseline risk between the studies. The model was validated both internally and by using internal-external cross-validation (IECV). Results Prior HAs, physical components of the health-related quality of life comorbidity index, and medication-related variables were used in the final model. While achieving moderate discriminatory performance, internal bootstrap validation revealed a pronounced risk of overfitting. The results of the IECV, in which calibration was highly variable even after accounting for between-study heterogeneity, agreed with this finding. Heterogeneity was equally reflected in differing baseline risk, predictor effects and absolute risk predictions. Conclusions Predictor effect heterogeneity and differing baseline risk can explain the limited external performance of HA prediction models. With such drivers known, model adjustments in external validation settings (eg, intercept recalibration, complete updating) can be applied more purposefully. Trial registration number PROSPERO id: CRD42018088129.
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- 2021
33. Discovery of predictors of sudden cardiac arrest in diabetes: rationale and outline of the RESCUED (REcognition of Sudden Cardiac arrest vUlnErability in Diabetes) project
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van Dongen, Laura H, primary, Harms, Peter P, additional, Hoogendoorn, Mark, additional, Zimmerman, Dominic S, additional, Lodder, Elisabeth M, additional, 't Hart, Leen M, additional, Herings, Ron, additional, van Weert, Henk C P M, additional, Nijpels, Giel, additional, Swart, Karin M A, additional, van der Heijden, Amber A, additional, Blom, Marieke T, additional, Elders, Petra J, additional, and Tan, Hanno L, additional
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- 2021
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34. Disentangling the genetics of lean mass
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Karasik, David, Zillikens, M. Carola, Hsu, Yi-Hsiang, Aghdassi, Ali, Akesson, Kristina, Amin, Najaf, Barroso, Ines, Bennett, David A., Bertram, Lars, Bochud, Murielle, Borecki, Ingrid B., Broer, Linda, Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos-Obando, Natalia, Cauley, Jane A., Cawthon, Peggy M., Chambers, John C., Chen, Zhao, Cho, Nam H., Choi, Hyung Jin, Chou, Wen-Chi, Cummings, Steven R., de Groot, Lisette C. P. G. M., De Jager, Phillip L., Demuth, Ilja, Diatchenko, Luda, Econs, Michael J., Eiriksdottir, Gudny, Enneman, Anke W., Eriksson, Joel, Eriksson, Johan G., Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Gieger, Christian, Grallert, Harald, Gudnason, Vilmundur, Lenore, Launer J., Hayward, Caroline, Hofman, Albert, Homuth, Georg, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Johnson, Toby, Biffar, Reiner, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpelainen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S. L., Koller, Daniel L., Kooner, Jaspal S., Kraus, William E., Kritchevsky, Stephen, Kutalik, Zoltan, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Lerch, Markus M., Lewis, Joshua R., Lill, Christina, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Livshits, Gregory, Ljunggren, Östen, Loos, Ruth J. F., Lorentzon, Mattias, Luan, Jian'an, Luben, Robert N., Malkin, Ida, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellstrom, Dan, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Nethander, Maria, Newman, Anne B., O'Connell, Jeffery R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Peacock, Munro, Perola, Markus, Peters, Annette, Prince, Richard L., Psaty, Bruce M., Raikkonen, Katri, Ralston, Stuart H., Ripatti, Samuli, Rivadeneira, Fernando, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schipf, Sabine, Shin, Chan Soo, Smith, Albert V., Smith, Shad B., Soranzo, Nicole, Spector, Timothy D., Stancakova, Alena, Stefansson, Kari, Steinhagen-Thiessen, Elisabeth, Stolk, Lisette, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M. A., Thompson, Patricia, Thomson, Cynthia A., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Uitterlinden, Andre G., van Duijn, Cornelia M., van Schoor, Natasja M., Vandenput, Liesbeth, Vollenweider, Peter, Volzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Wareham, Nicholas J., Waterworth, Dawn, Weedon, Michael N., Wichmann, H-Erich, Widen, Elisabeth, Williams, Frances M. K., Wilson, James F., Wright, Nicole C., Yerges-Armstrong, Laura M., Yu, Lei, Zhang, Weihua, Zhao, Jing Hua, Zhou, Yanhua, Nielson, Carrie M., Harris, Tamara B., Demissie, Serkalem, Kiel, Douglas P., Ohlsson, Claes, Karasik, David, Zillikens, M. Carola, Hsu, Yi-Hsiang, Aghdassi, Ali, Akesson, Kristina, Amin, Najaf, Barroso, Ines, Bennett, David A., Bertram, Lars, Bochud, Murielle, Borecki, Ingrid B., Broer, Linda, Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos-Obando, Natalia, Cauley, Jane A., Cawthon, Peggy M., Chambers, John C., Chen, Zhao, Cho, Nam H., Choi, Hyung Jin, Chou, Wen-Chi, Cummings, Steven R., de Groot, Lisette C. P. G. M., De Jager, Phillip L., Demuth, Ilja, Diatchenko, Luda, Econs, Michael J., Eiriksdottir, Gudny, Enneman, Anke W., Eriksson, Joel, Eriksson, Johan G., Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Gieger, Christian, Grallert, Harald, Gudnason, Vilmundur, Lenore, Launer J., Hayward, Caroline, Hofman, Albert, Homuth, Georg, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Johnson, Toby, Biffar, Reiner, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpelainen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S. L., Koller, Daniel L., Kooner, Jaspal S., Kraus, William E., Kritchevsky, Stephen, Kutalik, Zoltan, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Lerch, Markus M., Lewis, Joshua R., Lill, Christina, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Livshits, Gregory, Ljunggren, Östen, Loos, Ruth J. F., Lorentzon, Mattias, Luan, Jian'an, Luben, Robert N., Malkin, Ida, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellstrom, Dan, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Nethander, Maria, Newman, Anne B., O'Connell, Jeffery R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Peacock, Munro, Perola, Markus, Peters, Annette, Prince, Richard L., Psaty, Bruce M., Raikkonen, Katri, Ralston, Stuart H., Ripatti, Samuli, Rivadeneira, Fernando, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schipf, Sabine, Shin, Chan Soo, Smith, Albert V., Smith, Shad B., Soranzo, Nicole, Spector, Timothy D., Stancakova, Alena, Stefansson, Kari, Steinhagen-Thiessen, Elisabeth, Stolk, Lisette, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M. A., Thompson, Patricia, Thomson, Cynthia A., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Uitterlinden, Andre G., van Duijn, Cornelia M., van Schoor, Natasja M., Vandenput, Liesbeth, Vollenweider, Peter, Volzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Wareham, Nicholas J., Waterworth, Dawn, Weedon, Michael N., Wichmann, H-Erich, Widen, Elisabeth, Williams, Frances M. K., Wilson, James F., Wright, Nicole C., Yerges-Armstrong, Laura M., Yu, Lei, Zhang, Weihua, Zhao, Jing Hua, Zhou, Yanhua, Nielson, Carrie M., Harris, Tamara B., Demissie, Serkalem, Kiel, Douglas P., and Ohlsson, Claes
- Abstract
Background: Lean body mass (LM) plays an important role in mobility and metabolic function. We previously identified five loci associated with LM adjusted for fat mass in kilograms. Such an adjustment may reduce the power to identify genetic signals having an association with both lean mass and fat mass. Objectives: To determine the impact of different fat mass adjustments on genetic architecture of LM and identify additional LM loci. Methods: We performed genome-wide association analyses for whole-body LM (20 cohorts of European ancestry with n = 38,292) measured using dual-energy X-ray absorptiometry) or bioelectrical impedance analysis, adjusted for sex, age, age(2), and height with or without fat mass adjustments (Model 1 no fat adjustment; Model 2 adjustment for fat mass as a percentage of body mass; Model 3 adjustment for fat mass in kilograms). Results: Seven single-nucleotide polymorphisms (SNPs) in separate loci, including one novel LM locus (TNRC6B), were successfully replicated in an additional 47,227 individuals from 29 cohorts. Based on the strengths of the associations in Model 1 vs Model 3, we divided the LM loci into those with an effect on both lean mass and fat mass in the same direction and refer to those as "sumo wrestler" loci (FTO and MC4R). In contrast, loci with an impact specifically on LMwere termed "body builder" loci (VCAN and ADAMTSL3). Using existing available genome-wide association study databases, LM increasing alleles of SNPs in sumo wrestler loci were associated with an adverse metabolic profile, whereas LM increasing alleles of SNPs in "body builder" loci were associated with metabolic protection. Conclusions: In conclusion, we identified one novel LM locus (TNRC6B). Our results suggest that a genetically determined increase in lean mass might exert either harmful or protective effects on metabolic traits, depending on its relation to fat mass.
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- 2019
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35. Disentangling the genetics of lean mass
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Karasik, David, primary, Zillikens, M Carola, additional, Hsu, Yi-Hsiang, additional, Aghdassi, Ali, additional, Akesson, Kristina, additional, Amin, Najaf, additional, Barroso, Inês, additional, Bennett, David A, additional, Bertram, Lars, additional, Bochud, Murielle, additional, Borecki, Ingrid B, additional, Broer, Linda, additional, Buchman, Aron S, additional, Byberg, Liisa, additional, Campbell, Harry, additional, Campos-Obando, Natalia, additional, Cauley, Jane A, additional, Cawthon, Peggy M, additional, Chambers, John C, additional, Chen, Zhao, additional, Cho, Nam H, additional, Choi, Hyung Jin, additional, Chou, Wen-Chi, additional, Cummings, Steven R, additional, de Groot, Lisette C P G M, additional, De Jager, Phillip L, additional, Demuth, Ilja, additional, Diatchenko, Luda, additional, Econs, Michael J, additional, Eiriksdottir, Gudny, additional, Enneman, Anke W, additional, Eriksson, Joel, additional, Eriksson, Johan G, additional, Estrada, Karol, additional, Evans, Daniel S, additional, Feitosa, Mary F, additional, Fu, Mao, additional, Gieger, Christian, additional, Grallert, Harald, additional, Gudnason, Vilmundur, additional, Lenore, Launer J, additional, Hayward, Caroline, additional, Hofman, Albert, additional, Homuth, Georg, additional, Huffman, Kim M, additional, Husted, Lise B, additional, Illig, Thomas, additional, Ingelsson, Erik, additional, Ittermann, Till, additional, Jansson, John-Olov, additional, Johnson, Toby, additional, Biffar, Reiner, additional, Jordan, Joanne M, additional, Jula, Antti, additional, Karlsson, Magnus, additional, Khaw, Kay-Tee, additional, Kilpeläinen, Tuomas O, additional, Klopp, Norman, additional, Kloth, Jacqueline S L, additional, Koller, Daniel L, additional, Kooner, Jaspal S, additional, Kraus, William E, additional, Kritchevsky, Stephen, additional, Kutalik, Zoltán, additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Lahti, Jari, additional, Lang, Thomas, additional, Langdahl, Bente L, additional, Lerch, Markus M, additional, Lewis, Joshua R, additional, Lill, Christina, additional, Lind, Lars, additional, Lindgren, Cecilia, additional, Liu, Yongmei, additional, Livshits, Gregory, additional, Ljunggren, Östen, additional, Loos, Ruth J F, additional, Lorentzon, Mattias, additional, Luan, Jian'an, additional, Luben, Robert N, additional, Malkin, Ida, additional, McGuigan, Fiona E, additional, Medina-Gomez, Carolina, additional, Meitinger, Thomas, additional, Melhus, Håkan, additional, Mellström, Dan, additional, Michaëlsson, Karl, additional, Mitchell, Braxton D, additional, Morris, Andrew P, additional, Mosekilde, Leif, additional, Nethander, Maria, additional, Newman, Anne B, additional, O'Connell, Jeffery R, additional, Oostra, Ben A, additional, Orwoll, Eric S, additional, Palotie, Aarno, additional, Peacock, Munro, additional, Perola, Markus, additional, Peters, Annette, additional, Prince, Richard L, additional, Psaty, Bruce M, additional, Räikkönen, Katri, additional, Ralston, Stuart H, additional, Ripatti, Samuli, additional, Rivadeneira, Fernando, additional, Robbins, John A, additional, Rotter, Jerome I, additional, Rudan, Igor, additional, Salomaa, Veikko, additional, Satterfield, Suzanne, additional, Schipf, Sabine, additional, Shin, Chan Soo, additional, Smith, Albert V, additional, Smith, Shad B, additional, Soranzo, Nicole, additional, Spector, Timothy D, additional, Stančáková, Alena, additional, Stefansson, Kari, additional, Steinhagen-Thiessen, Elisabeth, additional, Stolk, Lisette, additional, Streeten, Elizabeth A, additional, Styrkarsdottir, Unnur, additional, Swart, Karin M A, additional, Thompson, Patricia, additional, Thomson, Cynthia A, additional, Thorleifsson, Gudmar, additional, Thorsteinsdottir, Unnur, additional, Tikkanen, Emmi, additional, Tranah, Gregory J, additional, Uitterlinden, André G, additional, van Duijn, Cornelia M, additional, van Schoor, Natasja M, additional, Vandenput, Liesbeth, additional, Vollenweider, Peter, additional, Völzke, Henry, additional, Wactawski-Wende, Jean, additional, Walker, Mark, additional, J Wareham, Nicholas, additional, Waterworth, Dawn, additional, Weedon, Michael N, additional, Wichmann, H-Erich, additional, Widen, Elisabeth, additional, Williams, Frances M K, additional, Wilson, James F, additional, Wright, Nicole C, additional, Yerges-Armstrong, Laura M, additional, Yu, Lei, additional, Zhang, Weihua, additional, Zhao, Jing Hua, additional, Zhou, Yanhua, additional, Nielson, Carrie M, additional, Harris, Tamara B, additional, Demissie, Serkalem, additional, Kiel, Douglas P, additional, and Ohlsson, Claes, additional
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- 2019
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36. Effect of Genetically Low 25-Hydroxyvitamin D on Mortality Risk: Mendelian Randomization Analysis in 3 Large European Cohorts
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Aspelund, Thor, primary, Grübler, Martin R., additional, Smith, Albert V., additional, Gudmundsson, Elias F., additional, Keppel, Martin, additional, Cotch, Mary Frances, additional, Harris, Tamara B., additional, Jorde, Rolf, additional, Grimnes, Guri, additional, Joakimsen, Ragnar, additional, Schirmer, Henrik, additional, Wilsgaard, Tom, additional, Mathiesen, Ellisiv B., additional, Njølstad, Inger, additional, Løchen, Maja-Lisa, additional, März, Winfried, additional, Kleber, Marcus E., additional, Tomaschitz, Andreas, additional, Grove-Laugesen, Diana, additional, Rejnmark, Lars, additional, Swart, Karin M. A., additional, Brouwer, Ingeborg A., additional, Lips, Paul, additional, Van Schoor, Natasja M., additional, Sempos, Christopher T., additional, Durazo-Arvizu, Ramón A., additional, Škrabáková, Zuzana, additional, Dowling, Kirsten G., additional, Cashman, Kevin D., additional, Kiely, Mairead, additional, Pilz, Stefan, additional, Gudnason, Vilmundur, additional, and Eiriksdottir, Gudny, additional
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- 2019
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37. The association between apathy, decline in physical performance, and falls in older persons
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Henstra, Marieke J., primary, Rhebergen, Didi, additional, Stek, Max L., additional, Swart, Karin M. A., additional, van Dijk, Suzanne C., additional, Zillikens, M. Carola, additional, Oliai Araghi, Sadaf, additional, de Groot, Lisette C. M. G. M., additional, van Schoor, Natasja M., additional, and van der Velde, Nathalie, additional
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- 2019
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38. Erratum:Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (Nature Communications (2017) 8:80 DOI: 10.1038/s41467-017-00031-7)
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Zillikens, M Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M, Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L, Kutalik, Zoltán, Luan, Jian'an, Malkin, Ida, Ried, Janina S, Smith, Albert V, Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J, Barroso, Inês, Bennett, David A, Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A, Cawthon, Peggy M, Cederberg, Henna, Chen, Zhao, Cho, Nam H, Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R, De Jager, Philip L, Demuth, Ilja, Dhonukshe-Rutten, Rosalie A M, Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W, Erdos, Mike, Eriksson, Johan G, Eriksson, Joel, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L, Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L, Hayward, Caroline, Hofman, Albert, Hoffman, Eric P, Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J, Hubbard, Alan, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O, Klopp, Norman, Kloth, Jacqueline S L, Koistinen, Heikki A, Kraus, William E, Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Launer, Lenore J, Lee, Jong-Young, Lerch, Markus M, Lewis, Joshua R, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N, Maixner, William, McGuigan, Fiona E, Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D, Morris, Andrew P, Mosekilde, Leif, Newman, Anne, Nielson, Carrie M, O'Connell, Jeffrey R, Oostra, Ben A, Orwoll, Eric S, Palotie, Aarno, Parker, Stephen C J, Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L, Räikkönen, Katri, Ralston, Stuart H, Ripatti, Samuli, Robbins, John A, Rotter, Jerome I, Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E, Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A, Styrkarsdottir, Unnur, Swart, Karin M A, Tan, Sian-Tsung, Tarnopolsky, Mark A, Thompson, Patricia, Thomson, Cynthia A, Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J, Tuomilehto, Jaakko, van Schoor, Natasja M, Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N, Welch, Ryan, Wichmann, H-Erich, Widen, Elisabeth, Williams, Frances M K, Wilson, James F, Wright, Nicole C, Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C, Döring, Angela, van Duijn, Cornelia M, Econs, Michael J, Gudnason, Vilmundur, Kooner, Jaspal S, Psaty, Bruce M, Spector, Timothy D, Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G, Wareham, Nicholas J, Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J F, Karasik, David, Harris, Tamara B, Ohlsson, Claes, and Kiel, Douglas P
- Subjects
Published Erratum - Abstract
The previously published version of this Article contained typographical errors in the spelling of the author names Stephen C. J. Parker and H.-Erich Wichmann, which were incorrectly given as Stephan Parker and H.-Erich Wichman, respectively. Furthermore, Affiliation 53 was incorrectly given as 'Research Group on Geriatrics, The Berlin Aging Study II, ChariteUniversitätsmedizin Berlin, Berlin 13353, Germany', Affiliation 66 was incorrectly given as 'Department of Botany & Plant Sciences, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA', and Affiliation 152 was incorrectly given as 'Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101, USA'. These errors have been corrected in the PDF and HTML versions of the Article.
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- 2017
39. Beta-blocker use and fall risk in older individuals:Original results from two studies with meta-analysis
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Ham, Annelies C., van Dijk, Suzanne C., Swart, Karin M. A., Enneman, Anke W., van der Zwaluw, Nikita L., Brouwer-Brolsma, Elske M., van Schoor, Natasja M., Carola Zillikens, M., Lips, Paul, de Groot, Lisette C. P. G. M., Hofman, Albert, Witkamp, Renger F., Uitterlinden, André G., Stricker, Bruno H., van der Velde, Nathalie, Epidemiology, Internal Medicine, Surgery, General practice, APH - Aging & Later Life, Epidemiology and Data Science, Internal medicine, Geriatrics, and AMS - Amsterdam Movement Sciences
- Subjects
Global Nutrition ,Wereldvoeding ,Meta-analysis ,CYP2D6 ,β-blockers ,Falls ,Nutritional Biology ,VLAG - Abstract
Aims: To investigate the association between use of β-blockers and β-blocker characteristics – selectivity, lipid solubility, intrinsic sympathetic activity (ISA) and CYP2D6 enzyme metabolism – and fall risk. Methods: Data from two prospective studies were used, including community-dwelling individuals, n = 7662 (the Rotterdam Study) and 2407 (B-PROOF), all aged ≥55 years. Fall incidents were recorded prospectively. Time-varying β-blocker use was determined using pharmacy dispensing records. Cox proportional hazard models adjusted for age and sex were applied to determine the association between β-blocker use, their characteristics – selectivity, lipid solubility, ISA and CYP2D6 enzyme metabolism – and fall risk. The results of the studies were combined using meta-analyses. Results: In total 2917 participants encountered a fall during a total follow-up time of 89 529 years. Meta-analysis indicated no association between use of any β-blocker, compared to nonuse, and fall risk, hazard ratio (HR) = 0.97 [95% confidence interval (CI) 0.88–1.06]. Use of a selective β-blocker was also not associated with fall risk, HR = 0.92 (95%CI 0.83–1.01). Use of a nonselective β-blocker was associated with an increased fall risk, HR = 1.22 (95%CI 1.01–1.48). Other β-blocker characteristics including lipid solubility and CYP2D6 enzyme metabolism were not associated with fall risk. Conclusion: Our study suggests that use of a nonselective β-blocker, contrary to selective β-blockers, is associated with an increased fall risk in an older population. In clinical practice, β-blockers have been shown effective for a variety of cardiovascular indications. However, fall risk should be considered when prescribing a β-blocker in this age group, and the pros and cons for β-blocker classes should be taken into consideration.
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- 2017
40. A closer look at SCOOP: screening for fracture prevention
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Swart, Karin M A, primary, Merlijn, Thomas, additional, Netelenbos, J Coen, additional, and Elders, Petra J M, additional
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- 2018
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41. Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
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Zillikens, M. Carola, primary, Demissie, Serkalem, additional, Hsu, Yi-Hsiang, additional, Yerges-Armstrong, Laura M., additional, Chou, Wen-Chi, additional, Stolk, Lisette, additional, Livshits, Gregory, additional, Broer, Linda, additional, Johnson, Toby, additional, Koller, Daniel L., additional, Kutalik, Zoltán, additional, Luan, Jian’an, additional, Malkin, Ida, additional, Ried, Janina S., additional, Smith, Albert V., additional, Thorleifsson, Gudmar, additional, Vandenput, Liesbeth, additional, Hua Zhao, Jing, additional, Zhang, Weihua, additional, Aghdassi, Ali, additional, Åkesson, Kristina, additional, Amin, Najaf, additional, Baier, Leslie J., additional, Barroso, Inês, additional, Bennett, David A., additional, Bertram, Lars, additional, Biffar, Rainer, additional, Bochud, Murielle, additional, Boehnke, Michael, additional, Borecki, Ingrid B., additional, Buchman, Aron S., additional, Byberg, Liisa, additional, Campbell, Harry, additional, Campos Obanda, Natalia, additional, Cauley, Jane A., additional, Cawthon, Peggy M., additional, Cederberg, Henna, additional, Chen, Zhao, additional, Cho, Nam H., additional, Jin Choi, Hyung, additional, Claussnitzer, Melina, additional, Collins, Francis, additional, Cummings, Steven R., additional, De Jager, Philip L., additional, Demuth, Ilja, additional, Dhonukshe-Rutten, Rosalie A. M., additional, Diatchenko, Luda, additional, Eiriksdottir, Gudny, additional, Enneman, Anke W., additional, Erdos, Mike, additional, Eriksson, Johan G., additional, Eriksson, Joel, additional, Estrada, Karol, additional, Evans, Daniel S., additional, Feitosa, Mary F., additional, Fu, Mao, additional, Garcia, Melissa, additional, Gieger, Christian, additional, Girke, Thomas, additional, Glazer, Nicole L., additional, Grallert, Harald, additional, Grewal, Jagvir, additional, Han, Bok-Ghee, additional, Hanson, Robert L., additional, Hayward, Caroline, additional, Hofman, Albert, additional, Hoffman, Eric P., additional, Homuth, Georg, additional, Hsueh, Wen-Chi, additional, Hubal, Monica J., additional, Hubbard, Alan, additional, Huffman, Kim M., additional, Husted, Lise B., additional, Illig, Thomas, additional, Ingelsson, Erik, additional, Ittermann, Till, additional, Jansson, John-Olov, additional, Jordan, Joanne M., additional, Jula, Antti, additional, Karlsson, Magnus, additional, Khaw, Kay-Tee, additional, Kilpeläinen, Tuomas O., additional, Klopp, Norman, additional, Kloth, Jacqueline S. L., additional, Koistinen, Heikki A., additional, Kraus, William E., additional, Kritchevsky, Stephen, additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Lahti, Jari, additional, Lang, Thomas, additional, Langdahl, Bente L., additional, Launer, Lenore J., additional, Lee, Jong-Young, additional, Lerch, Markus M., additional, Lewis, Joshua R., additional, Lind, Lars, additional, Lindgren, Cecilia, additional, Liu, Yongmei, additional, Liu, Tian, additional, Liu, Youfang, additional, Ljunggren, Östen, additional, Lorentzon, Mattias, additional, Luben, Robert N., additional, Maixner, William, additional, McGuigan, Fiona E., additional, Medina-Gomez, Carolina, additional, Meitinger, Thomas, additional, Melhus, Håkan, additional, Mellström, Dan, additional, Melov, Simon, additional, Michaëlsson, Karl, additional, Mitchell, Braxton D., additional, Morris, Andrew P., additional, Mosekilde, Leif, additional, Newman, Anne, additional, Nielson, Carrie M., additional, O’Connell, Jeffrey R., additional, Oostra, Ben A., additional, Orwoll, Eric S., additional, Palotie, Aarno, additional, Parker, Stephen C. J., additional, Peacock, Munro, additional, Perola, Markus, additional, Peters, Annette, additional, Polasek, Ozren, additional, Prince, Richard L., additional, Räikkönen, Katri, additional, Ralston, Stuart H., additional, Ripatti, Samuli, additional, Robbins, John A., additional, Rotter, Jerome I., additional, Rudan, Igor, additional, Salomaa, Veikko, additional, Satterfield, Suzanne, additional, Schadt, Eric E., additional, Schipf, Sabine, additional, Scott, Laura, additional, Sehmi, Joban, additional, Shen, Jian, additional, Soo Shin, Chan, additional, Sigurdsson, Gunnar, additional, Smith, Shad, additional, Soranzo, Nicole, additional, Stančáková, Alena, additional, Steinhagen-Thiessen, Elisabeth, additional, Streeten, Elizabeth A., additional, Styrkarsdottir, Unnur, additional, Swart, Karin M. A., additional, Tan, Sian-Tsung, additional, Tarnopolsky, Mark A., additional, Thompson, Patricia, additional, Thomson, Cynthia A., additional, Thorsteinsdottir, Unnur, additional, Tikkanen, Emmi, additional, Tranah, Gregory J., additional, Tuomilehto, Jaakko, additional, van Schoor, Natasja M., additional, Verma, Arjun, additional, Vollenweider, Peter, additional, Völzke, Henry, additional, Wactawski-Wende, Jean, additional, Walker, Mark, additional, Weedon, Michael N., additional, Welch, Ryan, additional, Wichmann, H.-Erich, additional, Widen, Elisabeth, additional, Williams, Frances M. K., additional, Wilson, James F., additional, Wright, Nicole C., additional, Xie, Weijia, additional, Yu, Lei, additional, Zhou, Yanhua, additional, Chambers, John C., additional, Döring, Angela, additional, van Duijn, Cornelia M., additional, Econs, Michael J., additional, Gudnason, Vilmundur, additional, Kooner, Jaspal S., additional, Psaty, Bruce M., additional, Spector, Timothy D., additional, Stefansson, Kari, additional, Rivadeneira, Fernando, additional, Uitterlinden, André G., additional, Wareham, Nicholas J., additional, Ossowski, Vicky, additional, Waterworth, Dawn, additional, Loos, Ruth J. F., additional, Karasik, David, additional, Harris, Tamara B., additional, Ohlsson, Claes, additional, and Kiel, Douglas P., additional
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- 2017
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42. Erratum : Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
- Author
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Zillikens, M Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M, Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L, Kutalik, Zoltán, Luan, Jian'an, Malkin, Ida, Ried, Janina S, Smith, Albert V, Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J, Barroso, Inês, Bennett, David A, Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A, Cawthon, Peggy M, Cederberg, Henna, Chen, Zhao, Cho, Nam H, Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R, De Jager, Philip L, Demuth, Ilja, Dhonukshe-Rutten, Rosalie A M, Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W, Erdos, Mike, Eriksson, Johan G, Eriksson, Joel, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L, Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L, Hayward, Caroline, Hofman, Albert, Hoffman, Eric P, Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J, Hubbard, Alan, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O, Klopp, Norman, Kloth, Jacqueline S L, Koistinen, Heikki A, Kraus, William E, Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Launer, Lenore J, Lee, Jong-Young, Lerch, Markus M, Lewis, Joshua R, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N, Maixner, William, McGuigan, Fiona E, Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D, Morris, Andrew P, Mosekilde, Leif, Newman, Anne, Nielson, Carrie M, O'Connell, Jeffrey R, Oostra, Ben A, Orwoll, Eric S, Palotie, Aarno, Parker, Stephen C J, Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L, Räikkönen, Katri, Ralston, Stuart H, Ripatti, Samuli, Robbins, John A, Rotter, Jerome I, Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E, Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A, Styrkarsdottir, Unnur, Swart, Karin M A, Tan, Sian-Tsung, Tarnopolsky, Mark A, Thompson, Patricia, Thomson, Cynthia A, Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J, Tuomilehto, Jaakko, van Schoor, Natasja M, Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N, Welch, Ryan, Wichmann, H-Erich, Widen, Elisabeth, Williams, Frances M K, Wilson, James F, Wright, Nicole C, Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C, Döring, Angela, van Duijn, Cornelia M, Econs, Michael J, Gudnason, Vilmundur, Kooner, Jaspal S, Psaty, Bruce M, Spector, Timothy D, Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G, Wareham, Nicholas J, Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J F, Karasik, David, Harris, Tamara B, Ohlsson, Claes, Kiel, Douglas P, Zillikens, M Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M, Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L, Kutalik, Zoltán, Luan, Jian'an, Malkin, Ida, Ried, Janina S, Smith, Albert V, Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J, Barroso, Inês, Bennett, David A, Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A, Cawthon, Peggy M, Cederberg, Henna, Chen, Zhao, Cho, Nam H, Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R, De Jager, Philip L, Demuth, Ilja, Dhonukshe-Rutten, Rosalie A M, Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W, Erdos, Mike, Eriksson, Johan G, Eriksson, Joel, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L, Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L, Hayward, Caroline, Hofman, Albert, Hoffman, Eric P, Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J, Hubbard, Alan, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O, Klopp, Norman, Kloth, Jacqueline S L, Koistinen, Heikki A, Kraus, William E, Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Launer, Lenore J, Lee, Jong-Young, Lerch, Markus M, Lewis, Joshua R, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N, Maixner, William, McGuigan, Fiona E, Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D, Morris, Andrew P, Mosekilde, Leif, Newman, Anne, Nielson, Carrie M, O'Connell, Jeffrey R, Oostra, Ben A, Orwoll, Eric S, Palotie, Aarno, Parker, Stephen C J, Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L, Räikkönen, Katri, Ralston, Stuart H, Ripatti, Samuli, Robbins, John A, Rotter, Jerome I, Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E, Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A, Styrkarsdottir, Unnur, Swart, Karin M A, Tan, Sian-Tsung, Tarnopolsky, Mark A, Thompson, Patricia, Thomson, Cynthia A, Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J, Tuomilehto, Jaakko, van Schoor, Natasja M, Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N, Welch, Ryan, Wichmann, H-Erich, Widen, Elisabeth, Williams, Frances M K, Wilson, James F, Wright, Nicole C, Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C, Döring, Angela, van Duijn, Cornelia M, Econs, Michael J, Gudnason, Vilmundur, Kooner, Jaspal S, Psaty, Bruce M, Spector, Timothy D, Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G, Wareham, Nicholas J, Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J F, Karasik, David, Harris, Tamara B, Ohlsson, Claes, and Kiel, Douglas P
- Abstract
A correction to this article has been published and is linked from the publisher´s HTML version of the article.
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- 2017
- Full Text
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43. Folate and vitamin B12-related biomarkers in relation to brain volumes
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van der Zwaluw, Nikita L., Brouwer-Brolsma, Elske M., van de Rest, Ondine, van Wijngaarden, Janneke P., In ’t Veld, Paulette H., Kourie, Daniella I., Swart, Karin M A, Enneman, Anke W., van Dijk, Suzanne C., van der Velde, Nathalie, Kessels, Roy P C, Smeets, Paul A M, Kok, Frans J., Dhonukshe-Rutten, Rosalie A M, de Groot, Lisette C P G M, van der Zwaluw, Nikita L., Brouwer-Brolsma, Elske M., van de Rest, Ondine, van Wijngaarden, Janneke P., In ’t Veld, Paulette H., Kourie, Daniella I., Swart, Karin M A, Enneman, Anke W., van Dijk, Suzanne C., van der Velde, Nathalie, Kessels, Roy P C, Smeets, Paul A M, Kok, Frans J., Dhonukshe-Rutten, Rosalie A M, and de Groot, Lisette C P G M
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- 2017
44. Folate and vitamin B12-related biomarkers in relation to brain volumes
- Author
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Brain, Beeldverwerking ISI, van der Zwaluw, Nikita L., Brouwer-Brolsma, Elske M., van de Rest, Ondine, van Wijngaarden, Janneke P., In ’t Veld, Paulette H., Kourie, Daniella I., Swart, Karin M A, Enneman, Anke W., van Dijk, Suzanne C., van der Velde, Nathalie, Kessels, Roy P C, Smeets, Paul A M, Kok, Frans J., Dhonukshe-Rutten, Rosalie A M, de Groot, Lisette C P G M, Brain, Beeldverwerking ISI, van der Zwaluw, Nikita L., Brouwer-Brolsma, Elske M., van de Rest, Ondine, van Wijngaarden, Janneke P., In ’t Veld, Paulette H., Kourie, Daniella I., Swart, Karin M A, Enneman, Anke W., van Dijk, Suzanne C., van der Velde, Nathalie, Kessels, Roy P C, Smeets, Paul A M, Kok, Frans J., Dhonukshe-Rutten, Rosalie A M, and de Groot, Lisette C P G M
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- 2017
45. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
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Zillikens, M Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M, Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L, Kutalik, Zoltán, Luan, Jian'an, Malkin, Ida, Ried, Janina S, Smith, Albert V, Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J, Barroso, Inês, Bennett, David A, Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A, Cawthon, Peggy M, Cederberg, Henna, Chen, Zhao, Cho, Nam H, Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R, De Jager, Philip L, Demuth, Ilja, Dhonukshe-Rutten, Rosalie A M, Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W, Erdos, Mike, Eriksson, Johan G, Eriksson, Joel, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L, Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L, Hayward, Caroline, Hofman, Albert, Hoffman, Eric P, Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J, Hubbard, Alan, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O, Klopp, Norman, Kloth, Jacqueline S L, Koistinen, Heikki A, Kraus, William E, Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Launer, Lenore J, Lee, Jong-Young, Lerch, Markus M, Lewis, Joshua R, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N, Maixner, William, McGuigan, Fiona E, Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D, Morris, Andrew P, Mosekilde, Leif, Newman, Anne, Nielson, Carrie M, O'Connell, Jeffrey R, Oostra, Ben A, Orwoll, Eric S, Palotie, Aarno, Parker, Stephan, Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L, Räikkönen, Katri, Ralston, Stuart H, Ripatti, Samuli, Robbins, John A, Rotter, Jerome I, Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E, Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A, Styrkarsdottir, Unnur, Swart, Karin M A, Tan, Sian-Tsung, Tarnopolsky, Mark A, Thompson, Patricia, Thomson, Cynthia A, Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J, Tuomilehto, Jaakko, van Schoor, Natasja M, Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N, Welch, Ryan, Wichmann, H-Erich, Widen, Elisabeth, Williams, Frances M K, Wilson, James F, Wright, Nicole C, Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C, Döring, Angela, van Duijn, Cornelia M, Econs, Michael J, Gudnason, Vilmundur, Kooner, Jaspal S, Psaty, Bruce M, Spector, Timothy D, Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G, Wareham, Nicholas J, Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J F, Karasik, David, Harris, Tamara B, Ohlsson, Claes, Kiel, Douglas P, Zillikens, M Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M, Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L, Kutalik, Zoltán, Luan, Jian'an, Malkin, Ida, Ried, Janina S, Smith, Albert V, Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J, Barroso, Inês, Bennett, David A, Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A, Cawthon, Peggy M, Cederberg, Henna, Chen, Zhao, Cho, Nam H, Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R, De Jager, Philip L, Demuth, Ilja, Dhonukshe-Rutten, Rosalie A M, Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W, Erdos, Mike, Eriksson, Johan G, Eriksson, Joel, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L, Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L, Hayward, Caroline, Hofman, Albert, Hoffman, Eric P, Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J, Hubbard, Alan, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O, Klopp, Norman, Kloth, Jacqueline S L, Koistinen, Heikki A, Kraus, William E, Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Launer, Lenore J, Lee, Jong-Young, Lerch, Markus M, Lewis, Joshua R, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N, Maixner, William, McGuigan, Fiona E, Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D, Morris, Andrew P, Mosekilde, Leif, Newman, Anne, Nielson, Carrie M, O'Connell, Jeffrey R, Oostra, Ben A, Orwoll, Eric S, Palotie, Aarno, Parker, Stephan, Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L, Räikkönen, Katri, Ralston, Stuart H, Ripatti, Samuli, Robbins, John A, Rotter, Jerome I, Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E, Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A, Styrkarsdottir, Unnur, Swart, Karin M A, Tan, Sian-Tsung, Tarnopolsky, Mark A, Thompson, Patricia, Thomson, Cynthia A, Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J, Tuomilehto, Jaakko, van Schoor, Natasja M, Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N, Welch, Ryan, Wichmann, H-Erich, Widen, Elisabeth, Williams, Frances M K, Wilson, James F, Wright, Nicole C, Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C, Döring, Angela, van Duijn, Cornelia M, Econs, Michael J, Gudnason, Vilmundur, Kooner, Jaspal S, Psaty, Bruce M, Spector, Timothy D, Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G, Wareham, Nicholas J, Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J F, Karasik, David, Harris, Tamara B, Ohlsson, Claes, and Kiel, Douglas P
- Abstract
Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10(-8)) or suggestively genome wide (p < 2.3 × 10(-6)). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.
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- 2017
46. Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium
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Gaksch, Martin, primary, Jorde, Rolf, additional, Grimnes, Guri, additional, Joakimsen, Ragnar, additional, Schirmer, Henrik, additional, Wilsgaard, Tom, additional, Mathiesen, Ellisiv B., additional, Njølstad, Inger, additional, Løchen, Maja-Lisa, additional, März, Winfried, additional, Kleber, Marcus E., additional, Tomaschitz, Andreas, additional, Grübler, Martin, additional, Eiriksdottir, Gudny, additional, Gudmundsson, Elias F., additional, Harris, Tamara B., additional, Cotch, Mary F., additional, Aspelund, Thor, additional, Gudnason, Vilmundur, additional, Rutters, Femke, additional, Beulens, Joline W. J., additional, van ‘t Riet, Esther, additional, Nijpels, Giel, additional, Dekker, Jacqueline M., additional, Grove-Laugesen, Diana, additional, Rejnmark, Lars, additional, Busch, Markus A., additional, Mensink, Gert B. M., additional, Scheidt-Nave, Christa, additional, Thamm, Michael, additional, Swart, Karin M. A., additional, Brouwer, Ingeborg A., additional, Lips, Paul, additional, van Schoor, Natasja M., additional, Sempos, Christopher T., additional, Durazo-Arvizu, Ramón A., additional, Škrabáková, Zuzana, additional, Dowling, Kirsten G., additional, Cashman, Kevin D., additional, Kiely, Mairead, additional, and Pilz, Stefan, additional
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- 2017
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47. Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial.
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Araghi, Sadaf Oliai, Kiefte-de Jong, Jessica C., van Dijk, Suzanne C., Swart, Karin M. A., van Laarhoven, Hanneke W., van Schoor, Natasja M., de Groot, Lisette C. P. G. M., Lemmens, Valery, Stricker, Bruno H., Uitterlinden, André G., and van der Velde, Nathalie
- Abstract
Background: Folic acid and vitamin B12 play key roles in one-carbon metabolism. Disruption of one-carbon metabolism may be involved in the risk of cancer. Our aim was to assess the long-term effect of supplementation with both folic acid and vitamin B12 on the incidence of overall cancer and on colorectal cancer in the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) trial. Methods: Long-term follow-up of B-PROOF trial participants (N = 2,524), a multicenter, double-blind randomized placebo-controlled trial designed to assess the effect of 2 to 3 years daily supplementation with folic acid (400 µg) and vitamin B12 (500 µg) versus placebo on fracture incidence. Information on cancer incidence was obtained from the Netherlands cancer registry (Integraal Kankercentrum Nederland), using the International Statistical Classification of Disease (ICD-10) codes C00-C97 for all cancers (except C44 for skin cancer), and C18-C20 for colorectal cancer. Results: Allocation to B vitamins was associated with a higher risk of overall cancer [171 (13.6%) vs. 143 (11.3%); HR 1.25; 95% confidence interval (CI), 1.00-1.53, P = 0.05]. B vitamins were significantly associated with a higher risk of colorectal cancer [43(3.4%) vs. 25(2.0%); HR 1.77; 95% CI, 1.08-2.90, P = 0.02]. Conclusions: Folic acid and vitamin B12 supplementation was associated with an increased risk of colorectal cancer. Impact: Our findings suggest that folic acid and vitamin B12 supplementation may increase the risk of colorectal cancer. Further confirmation in larger studies and in meta-analyses combining both folic acid and vitamin B12 are needed to evaluate whether folic acid and vitamin B12 supplementation should be limited to patients with a known indication, such as a proven deficiency. [ABSTRACT FROM AUTHOR]
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- 2019
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48. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
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Lu, Yingchang, Day, Felix R, Gustafsson, Stefan, Buchkovich, Martin L, Na, Jianbo, Bataille, Veronique, Cousminer, Diana L, Dastani, Zari, Drong, Alexander W, Esko, Tõnu, Evans, David M, Falchi, Mario, Feitosa, Mary F, Ferreira, Teresa, Hedman, Åsa K, Haring, Robin, Hysi, Pirro G, Iles, Mark M, Justice, Anne E, Kanoni, Stavroula, Lagou, Vasiliki, Li, Rui, Li, Xin, Locke, Adam, Lu, Chen, Mägi, Reedik, Perry, John R B, Pers, Tune H, Qi, Qibin, Sanna, Marianna, Schmidt, Ellen M, Scott, William R, Shungin, Dmitry, Teumer, Alexander, Vinkhuyzen, Anna A E, Walker, Ryan W, Westra, Harm-Jan, Zhang, Mingfeng, Zhang, Weihua, Zhao, Jing Hua, Zhu, Zhihong, Afzal, Uzma, Ahluwalia, Tarunveer Singh, Bakker, Stephan J L, Bellis, Claire, Bonnefond, Amélie, Borodulin, Katja, Buchman, Aron S, Cederholm, Tommy, Choh, Audrey C, Choi, Hyung Jin, Curran, Joanne E, de Groot, Lisette C P G M, De Jager, Philip L, Dhonukshe-Rutten, Rosalie A M, Enneman, Anke W, Eury, Elodie, Evans, Daniel S, Forsen, Tom, Friedrich, Nele, Fumeron, Frédéric, Garcia, Melissa E, Gärtner, Simone, Han, Bok-Ghee, Havulinna, Aki S, Hayward, Caroline, Hernandez, Dena, Hillege, Hans, Ittermann, Till, Kent, Jack W, Kolcic, Ivana, Laatikainen, Tiina, Lahti, Jari, Mateo Leach, Irene, Lee, Christine G, Lee, Jong-Young, Liu, Tian, Liu, Youfang, Lobbens, Stéphane, Loh, Marie, Lyytikäinen, Leo-Pekka, Medina-Gomez, Carolina, Michaëlsson, Karl, Nalls, Mike A, Nielson, Carrie M, Oozageer, Laticia, Pascoe, Laura, Paternoster, Lavinia, Polašek, Ozren, Ripatti, Samuli, Sarzynski, Mark A, Shin, Chan Soo, Narančić, Nina Smolej, Spira, Dominik, Srikanth, Priya, Steinhagen-Thiessen, Elisabeth, Sung, Yun Ju, Swart, Karin M A, Taittonen, Leena, Tanaka, Toshiko, Tikkanen, Emmi, van der Velde, Nathalie, van Schoor, Natasja M, Verweij, Niek, Wright, Alan F, Yu, Lei, Zmuda, Joseph M, Eklund, Niina, Forrester, Terrence, Grarup, Niels, Jackson, Anne U, Kristiansson, Kati, Kuulasmaa, Teemu, Kuusisto, Johanna, Lichtner, Peter, Luan, Jian'an, Mahajan, Anubha, Männistö, Satu, Palmer, Cameron D, Ried, Janina S, Scott, Robert A, Stancáková, Alena, Wagner, Peter J, Demirkan, Ayse, Döring, Angela, Gudnason, Vilmundur, Kiel, Douglas P, Kühnel, Brigitte, Mangino, Massimo, Mcknight, Barbara, Menni, Cristina, O'Connell, Jeffrey R, Oostra, Ben A, Shuldiner, Alan R, Song, Kijoung, Vandenput, Liesbeth, van Duijn, Cornelia M, Vollenweider, Peter, White, Charles C, Boehnke, Michael, Boettcher, Yvonne, Cooper, Richard S, Forouhi, Nita G, Gieger, Christian, Grallert, Harald, Hingorani, Aroon, Jørgensen, Torben, Jousilahti, Pekka, Kivimaki, Mika, Kumari, Meena, Laakso, Markku, Langenberg, Claudia, Linneberg, Allan, Luke, Amy, Mckenzie, Colin A, Palotie, Aarno, Pedersen, Oluf, Peters, Annette, Strauch, Konstantin, Tayo, Bamidele O, Wareham, Nicholas J, Bennett, David A, Bertram, Lars, Blangero, John, Blüher, Matthias, Bouchard, Claude, Campbell, Harry, Cho, Nam H, Cummings, Steven R, Czerwinski, Stefan A, Demuth, Ilja, Eckardt, Rahel, Eriksson, Johan G, Ferrucci, Luigi, Franco, Oscar H, Froguel, Philippe, Gansevoort, Ron T, Hansen, Torben, Harris, Tamara B, Hastie, Nicholas, Heliövaara, Markku, Hofman, Albert, Jordan, Joanne M, Jula, Antti, Kähönen, Mika, Kajantie, Eero, Knekt, Paul B, Koskinen, Seppo, Kovacs, Peter, Lehtimäki, Terho, Lind, Lars, Liu, Yongmei, Orwoll, Eric S, Osmond, Clive, Perola, Markus, Pérusse, Louis, Raitakari, Olli T, Rankinen, Tuomo, Rao, D C, Rice, Treva K, Rivadeneira, Fernando, Rudan, Igor, Salomaa, Veikko, Sørensen, Thorkild I A, Stumvoll, Michael, Tönjes, Anke, Towne, Bradford, Tranah, Gregory J, Tremblay, Angelo, Uitterlinden, André G, van der Harst, Pim, Vartiainen, Erkki, Viikari, Jorma S, Vitart, Veronique, Vohl, Marie-Claude, Völzke, Henry, Walker, Mark, Wallaschofski, Henri, Wild, Sarah, Wilson, James F, Yengo, Loïc, Bishop, D Timothy, Borecki, Ingrid B, Chambers, John C, Cupples, L Adrienne, Dehghan, Abbas, Deloukas, Panos, Fatemifar, Ghazaleh, Fox, Caroline, Furey, Terrence S, Franke, Lude, Han, Jiali, Hunter, David J, Karjalainen, Juha, Karpe, Fredrik, Kaplan, Robert C, Kooner, Jaspal S, McCarthy, Mark I, Murabito, Joanne M, Morris, Andrew P, Bishop, Julia A N, North, Kari E, Ohlsson, Claes, Ong, Ken K, Prokopenko, Inga, Richards, J Brent, Schadt, Eric E, Spector, Tim D, Widén, Elisabeth, Willer, Cristen J, Yang, Jian, Ingelsson, Erik, Mohlke, Karen L, Hirschhorn, Joel N, Pospisilik, John Andrew, Zillikens, M Carola, Lindgren, Cecilia, Kilpeläinen, Tuomas Oskari, Loos, Ruth J F, Lu, Yingchang, Day, Felix R, Gustafsson, Stefan, Buchkovich, Martin L, Na, Jianbo, Bataille, Veronique, Cousminer, Diana L, Dastani, Zari, Drong, Alexander W, Esko, Tõnu, Evans, David M, Falchi, Mario, Feitosa, Mary F, Ferreira, Teresa, Hedman, Åsa K, Haring, Robin, Hysi, Pirro G, Iles, Mark M, Justice, Anne E, Kanoni, Stavroula, Lagou, Vasiliki, Li, Rui, Li, Xin, Locke, Adam, Lu, Chen, Mägi, Reedik, Perry, John R B, Pers, Tune H, Qi, Qibin, Sanna, Marianna, Schmidt, Ellen M, Scott, William R, Shungin, Dmitry, Teumer, Alexander, Vinkhuyzen, Anna A E, Walker, Ryan W, Westra, Harm-Jan, Zhang, Mingfeng, Zhang, Weihua, Zhao, Jing Hua, Zhu, Zhihong, Afzal, Uzma, Ahluwalia, Tarunveer Singh, Bakker, Stephan J L, Bellis, Claire, Bonnefond, Amélie, Borodulin, Katja, Buchman, Aron S, Cederholm, Tommy, Choh, Audrey C, Choi, Hyung Jin, Curran, Joanne E, de Groot, Lisette C P G M, De Jager, Philip L, Dhonukshe-Rutten, Rosalie A M, Enneman, Anke W, Eury, Elodie, Evans, Daniel S, Forsen, Tom, Friedrich, Nele, Fumeron, Frédéric, Garcia, Melissa E, Gärtner, Simone, Han, Bok-Ghee, Havulinna, Aki S, Hayward, Caroline, Hernandez, Dena, Hillege, Hans, Ittermann, Till, Kent, Jack W, Kolcic, Ivana, Laatikainen, Tiina, Lahti, Jari, Mateo Leach, Irene, Lee, Christine G, Lee, Jong-Young, Liu, Tian, Liu, Youfang, Lobbens, Stéphane, Loh, Marie, Lyytikäinen, Leo-Pekka, Medina-Gomez, Carolina, Michaëlsson, Karl, Nalls, Mike A, Nielson, Carrie M, Oozageer, Laticia, Pascoe, Laura, Paternoster, Lavinia, Polašek, Ozren, Ripatti, Samuli, Sarzynski, Mark A, Shin, Chan Soo, Narančić, Nina Smolej, Spira, Dominik, Srikanth, Priya, Steinhagen-Thiessen, Elisabeth, Sung, Yun Ju, Swart, Karin M A, Taittonen, Leena, Tanaka, Toshiko, Tikkanen, Emmi, van der Velde, Nathalie, van Schoor, Natasja M, Verweij, Niek, Wright, Alan F, Yu, Lei, Zmuda, Joseph M, Eklund, Niina, Forrester, Terrence, Grarup, Niels, Jackson, Anne U, Kristiansson, Kati, Kuulasmaa, Teemu, Kuusisto, Johanna, Lichtner, Peter, Luan, Jian'an, Mahajan, Anubha, Männistö, Satu, Palmer, Cameron D, Ried, Janina S, Scott, Robert A, Stancáková, Alena, Wagner, Peter J, Demirkan, Ayse, Döring, Angela, Gudnason, Vilmundur, Kiel, Douglas P, Kühnel, Brigitte, Mangino, Massimo, Mcknight, Barbara, Menni, Cristina, O'Connell, Jeffrey R, Oostra, Ben A, Shuldiner, Alan R, Song, Kijoung, Vandenput, Liesbeth, van Duijn, Cornelia M, Vollenweider, Peter, White, Charles C, Boehnke, Michael, Boettcher, Yvonne, Cooper, Richard S, Forouhi, Nita G, Gieger, Christian, Grallert, Harald, Hingorani, Aroon, Jørgensen, Torben, Jousilahti, Pekka, Kivimaki, Mika, Kumari, Meena, Laakso, Markku, Langenberg, Claudia, Linneberg, Allan, Luke, Amy, Mckenzie, Colin A, Palotie, Aarno, Pedersen, Oluf, Peters, Annette, Strauch, Konstantin, Tayo, Bamidele O, Wareham, Nicholas J, Bennett, David A, Bertram, Lars, Blangero, John, Blüher, Matthias, Bouchard, Claude, Campbell, Harry, Cho, Nam H, Cummings, Steven R, Czerwinski, Stefan A, Demuth, Ilja, Eckardt, Rahel, Eriksson, Johan G, Ferrucci, Luigi, Franco, Oscar H, Froguel, Philippe, Gansevoort, Ron T, Hansen, Torben, Harris, Tamara B, Hastie, Nicholas, Heliövaara, Markku, Hofman, Albert, Jordan, Joanne M, Jula, Antti, Kähönen, Mika, Kajantie, Eero, Knekt, Paul B, Koskinen, Seppo, Kovacs, Peter, Lehtimäki, Terho, Lind, Lars, Liu, Yongmei, Orwoll, Eric S, Osmond, Clive, Perola, Markus, Pérusse, Louis, Raitakari, Olli T, Rankinen, Tuomo, Rao, D C, Rice, Treva K, Rivadeneira, Fernando, Rudan, Igor, Salomaa, Veikko, Sørensen, Thorkild I A, Stumvoll, Michael, Tönjes, Anke, Towne, Bradford, Tranah, Gregory J, Tremblay, Angelo, Uitterlinden, André G, van der Harst, Pim, Vartiainen, Erkki, Viikari, Jorma S, Vitart, Veronique, Vohl, Marie-Claude, Völzke, Henry, Walker, Mark, Wallaschofski, Henri, Wild, Sarah, Wilson, James F, Yengo, Loïc, Bishop, D Timothy, Borecki, Ingrid B, Chambers, John C, Cupples, L Adrienne, Dehghan, Abbas, Deloukas, Panos, Fatemifar, Ghazaleh, Fox, Caroline, Furey, Terrence S, Franke, Lude, Han, Jiali, Hunter, David J, Karjalainen, Juha, Karpe, Fredrik, Kaplan, Robert C, Kooner, Jaspal S, McCarthy, Mark I, Murabito, Joanne M, Morris, Andrew P, Bishop, Julia A N, North, Kari E, Ohlsson, Claes, Ong, Ken K, Prokopenko, Inga, Richards, J Brent, Schadt, Eric E, Spector, Tim D, Widén, Elisabeth, Willer, Cristen J, Yang, Jian, Ingelsson, Erik, Mohlke, Karen L, Hirschhorn, Joel N, Pospisilik, John Andrew, Zillikens, M Carola, Lindgren, Cecilia, Kilpeläinen, Tuomas Oskari, and Loos, Ruth J F
- Abstract
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
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- 2016
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49. Feasibility of using head and neck CT imaging to assess skeletal muscle mass in head and neck cancer patients
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Swartz, Justin E., Pothen, Ajit J., Wegner, Inge, Smid, Ernst J., Swart, Karin M A, de Bree, Remco, Leenen, Loek P H, Grolman, Wilko, Swartz, Justin E., Pothen, Ajit J., Wegner, Inge, Smid, Ernst J., Swart, Karin M A, de Bree, Remco, Leenen, Loek P H, and Grolman, Wilko
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- 2016
50. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
- Author
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University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Clinicum, University of Helsinki, Institute of Behavioural Sciences, University of Helsinki, Hospital for Children and Adolescents, Lu, Yingchang, Day, Felix R., Gustafsson, Stefan, Buchkovich, Martin L., Na, Jianbo, Bataille, Veronique, Cousminer, Diana L., Dastani, Zari, Drong, Alexander W., Esko, Tonu, Evans, David M., Falchi, Mario, Feitosa, Mary F., Ferreira, Teresa, Hedman, Asa K., Haring, Robin, Hysi, Pirro G., Iles, Mark M., Justice, Anne E., Kanoni, Stavroula, Lagou, Vasiliki, Li, Rui, Li, Xin, Locke, Adam, Lu, Chen, Magi, Reedik, Perry, John R. B., Pers, Tune H., Qi, Qibin, Sanna, Marianna, Schmidt, Ellen M., Scott, William R., Shungin, Dmitry, Teumer, Alexander, Vinkhuyzen, Anna A. E., Walker, Ryan W., Westra, Harm-Jan, Zhang, Mingfeng, Zhang, Weihua, Zhao, Jing Hua, Zhu, Zhihong, Afzal, Uzma, Ahluwalia, Tarunveer Singh, Bakker, Stephan J. L., Bellis, Claire, Bonnefond, Amelie, Borodulin, Katja, Buchman, Aron S., Cederholm, Tommy, Choh, Audrey C., Choi, Hyung Jin, Curran, Joanne E., de Groot, Lisette C. P. G. M., De Jager, Philip L., Dhonukshe-Rutten, Rosalie A. M., Enneman, Anke W., Eury, Elodie, Evans, Daniel S., Forsen, Tom, Friedrich, Nele, Fumeron, Frederic, Garcia, Melissa E., Gartner, Simone, Han, Bok-Ghee, Havulinna, Aki S., Hayward, Caroline, Hernandez, Dena, Hillege, Hans, Ittermann, Till, Kent, Jack W., Kolcic, Ivana, Laatikainen, Tiina, Lahti, Jari, Leach, Irene Mateo, Lee, Christine G., Lee, Jong-Young, Liu, Tian, Liu, Youfang, Lobbens, Stephane, Loh, Marie, Lyytikainen, Leo-Pekka, Medina-Gomez, Carolina, Michaelsson, Karl, Nalls, Mike A., Nielson, Carrie M., Oozageer, Laticia, Pascoe, Laura, Paternoster, Lavinia, Polasek, Ozren, Ripatti, Samuli, Sarzynski, Mark A., Shin, Chan Soo, Narancic, Nina Smolej, Spira, Dominik, Srikanth, Priya, Steinhagen-Thiessen, Elisabeth, Sung, Yun Ju, Swart, Karin M. A., Taittonen, Leena, Tanaka, Toshiko, Tikkanen, Emmi, van der Velde, Nathalie, van Schoor, Natasja M., Verweij, Niek, Wright, Alan F., Yu, Lei, Zmuda, Joseph M., Pellikka, Niina, Forrester, Terrence, Grarup, Niels, Jackson, Anne U., Kristiansson, Kati, Kuulasmaa, Teemu, Kuusisto, Johanna, Lichtner, Peter, Luan, Jian'an, Mahajan, Anubha, Mannisto, Satu, Palmer, Cameron D., Ried, Janina S., Scott, Robert A., Stancakova, Alena, Wagner, Peter J., Demirkan, Ayse, Doring, Angela, Gudnason, Vilmundur, Kiel, Douglas P., Kuhnel, Brigitte, Mangino, Massimo, Mcknight, Barbara, Menni, Cristina, O'Connell, Jeffrey R., Oostra, Ben A., Shuldiner, Alan R., Song, Kijoung, Vandenput, Liesbeth, van Duijn, Cornelia M., Vollenweider, Peter, White, Charles C., Boehnke, Michael, Boettcher, Yvonne, Cooper, Richard S., Forouhi, Nita G., Gieger, Christian, Grallert, Harald, Hingorani, Aroon, Jorgensen, Torben, Jousilahti, Pekka, Kivimaki, Mika, Kumari, Meena, Laakso, Markku, Langenberg, Claudia, Linneberg, Allan, Luke, Amy, Mckenzie, Colin A., Palotie, Aarno, Pedersen, Oluf, Peters, Annette, Strauch, Konstantin, Tayo, Bamidele O., Wareham, Nicholas J., Bennett, David A., Bertram, Lars, Blangero, John, Bluher, Matthias, Bouchard, Claude, Campbell, Harry, Cho, Nam H., Cummings, Steven R., Czerwinski, Stefan A., Demuth, Ilja, Eckardt, Rahel, Eriksson, Johan G., Ferrucci, Luigi, Franco, Oscar H., Froguel, Philippe, Gansevoort, Ron T., Hansen, Torben, Harris, Tamara B., Hastie, Nicholas, Heliovaara, Markku, Hofman, Albert, Jordan, Joanne M., Jula, Antti, Kahonen, Mika, Kajantie, Eero, Knekt, Paul B., Koskinen, Seppo, Kovacs, Peter, Lehtimaki, Terho, Lind, Lars, Liu, Yongmei, Orwoll, Eric S., Osmond, Clive, Perola, Markus, Perusse, Louis, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Rivadeneira, Fernando, Rudan, Igor, Salomaa, Veikko, Sorensen, Thorkild I. A., Stumvoll, Michael, Tonjes, Anke, Towne, Bradford, Tranah, Gregory J., Tremblay, Angelo, Uitterlinden, Andre G., van der Harst, Pim, Vartiainen, Erkki, Viikari, Jorma S., Vitart, Veronique, Vohl, Marie-Claude, Volzke, Henry, Walker, Mark, Wallaschofski, Henri, Wild, Sarah, Wilson, James F., Yengo, Loic, Bishop, D. Timothy, Borecki, Ingrid B., Chambers, John C., Cupples, L. Adrienne, Dehghan, Abbas, Deloukas, Panos, Fatemifar, Ghazaleh, Fox, Caroline, Furey, Terrence S., Franke, Lude, Han, Jiali, Hunter, David J., Karjalainen, Juha, Karpe, Fredrik, Kaplan, Robert C., Kooner, Jaspal S., McCarthy, Mark I., Murabito, Joanne M., Morris, Andrew P., Bishop, Julia A. N., North, Kari E., Ohlsson, Claes, Ong, Ken K., Prokopenko, Inga, Richards, J. Brent, Schadt, Eric E., Spector, Tim D., Widen, Elisabeth, Willer, Cristen J., Yang, Jian, Ingelsson, Erik, Mohlke, Karen L., Hirschhorn, Joel N., Pospisilik, John Andrew, Zillikens, M. Carola, Lindgren, Cecilia, Kilpelainen, Tuomas Oskari, Loos, Ruth J. F., University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Clinicum, University of Helsinki, Institute of Behavioural Sciences, University of Helsinki, Hospital for Children and Adolescents, Lu, Yingchang, Day, Felix R., Gustafsson, Stefan, Buchkovich, Martin L., Na, Jianbo, Bataille, Veronique, Cousminer, Diana L., Dastani, Zari, Drong, Alexander W., Esko, Tonu, Evans, David M., Falchi, Mario, Feitosa, Mary F., Ferreira, Teresa, Hedman, Asa K., Haring, Robin, Hysi, Pirro G., Iles, Mark M., Justice, Anne E., Kanoni, Stavroula, Lagou, Vasiliki, Li, Rui, Li, Xin, Locke, Adam, Lu, Chen, Magi, Reedik, Perry, John R. B., Pers, Tune H., Qi, Qibin, Sanna, Marianna, Schmidt, Ellen M., Scott, William R., Shungin, Dmitry, Teumer, Alexander, Vinkhuyzen, Anna A. E., Walker, Ryan W., Westra, Harm-Jan, Zhang, Mingfeng, Zhang, Weihua, Zhao, Jing Hua, Zhu, Zhihong, Afzal, Uzma, Ahluwalia, Tarunveer Singh, Bakker, Stephan J. L., Bellis, Claire, Bonnefond, Amelie, Borodulin, Katja, Buchman, Aron S., Cederholm, Tommy, Choh, Audrey C., Choi, Hyung Jin, Curran, Joanne E., de Groot, Lisette C. P. G. M., De Jager, Philip L., Dhonukshe-Rutten, Rosalie A. M., Enneman, Anke W., Eury, Elodie, Evans, Daniel S., Forsen, Tom, Friedrich, Nele, Fumeron, Frederic, Garcia, Melissa E., Gartner, Simone, Han, Bok-Ghee, Havulinna, Aki S., Hayward, Caroline, Hernandez, Dena, Hillege, Hans, Ittermann, Till, Kent, Jack W., Kolcic, Ivana, Laatikainen, Tiina, Lahti, Jari, Leach, Irene Mateo, Lee, Christine G., Lee, Jong-Young, Liu, Tian, Liu, Youfang, Lobbens, Stephane, Loh, Marie, Lyytikainen, Leo-Pekka, Medina-Gomez, Carolina, Michaelsson, Karl, Nalls, Mike A., Nielson, Carrie M., Oozageer, Laticia, Pascoe, Laura, Paternoster, Lavinia, Polasek, Ozren, Ripatti, Samuli, Sarzynski, Mark A., Shin, Chan Soo, Narancic, Nina Smolej, Spira, Dominik, Srikanth, Priya, Steinhagen-Thiessen, Elisabeth, Sung, Yun Ju, Swart, Karin M. A., Taittonen, Leena, Tanaka, Toshiko, Tikkanen, Emmi, van der Velde, Nathalie, van Schoor, Natasja M., Verweij, Niek, Wright, Alan F., Yu, Lei, Zmuda, Joseph M., Pellikka, Niina, Forrester, Terrence, Grarup, Niels, Jackson, Anne U., Kristiansson, Kati, Kuulasmaa, Teemu, Kuusisto, Johanna, Lichtner, Peter, Luan, Jian'an, Mahajan, Anubha, Mannisto, Satu, Palmer, Cameron D., Ried, Janina S., Scott, Robert A., Stancakova, Alena, Wagner, Peter J., Demirkan, Ayse, Doring, Angela, Gudnason, Vilmundur, Kiel, Douglas P., Kuhnel, Brigitte, Mangino, Massimo, Mcknight, Barbara, Menni, Cristina, O'Connell, Jeffrey R., Oostra, Ben A., Shuldiner, Alan R., Song, Kijoung, Vandenput, Liesbeth, van Duijn, Cornelia M., Vollenweider, Peter, White, Charles C., Boehnke, Michael, Boettcher, Yvonne, Cooper, Richard S., Forouhi, Nita G., Gieger, Christian, Grallert, Harald, Hingorani, Aroon, Jorgensen, Torben, Jousilahti, Pekka, Kivimaki, Mika, Kumari, Meena, Laakso, Markku, Langenberg, Claudia, Linneberg, Allan, Luke, Amy, Mckenzie, Colin A., Palotie, Aarno, Pedersen, Oluf, Peters, Annette, Strauch, Konstantin, Tayo, Bamidele O., Wareham, Nicholas J., Bennett, David A., Bertram, Lars, Blangero, John, Bluher, Matthias, Bouchard, Claude, Campbell, Harry, Cho, Nam H., Cummings, Steven R., Czerwinski, Stefan A., Demuth, Ilja, Eckardt, Rahel, Eriksson, Johan G., Ferrucci, Luigi, Franco, Oscar H., Froguel, Philippe, Gansevoort, Ron T., Hansen, Torben, Harris, Tamara B., Hastie, Nicholas, Heliovaara, Markku, Hofman, Albert, Jordan, Joanne M., Jula, Antti, Kahonen, Mika, Kajantie, Eero, Knekt, Paul B., Koskinen, Seppo, Kovacs, Peter, Lehtimaki, Terho, Lind, Lars, Liu, Yongmei, Orwoll, Eric S., Osmond, Clive, Perola, Markus, Perusse, Louis, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Rivadeneira, Fernando, Rudan, Igor, Salomaa, Veikko, Sorensen, Thorkild I. A., Stumvoll, Michael, Tonjes, Anke, Towne, Bradford, Tranah, Gregory J., Tremblay, Angelo, Uitterlinden, Andre G., van der Harst, Pim, Vartiainen, Erkki, Viikari, Jorma S., Vitart, Veronique, Vohl, Marie-Claude, Volzke, Henry, Walker, Mark, Wallaschofski, Henri, Wild, Sarah, Wilson, James F., Yengo, Loic, Bishop, D. Timothy, Borecki, Ingrid B., Chambers, John C., Cupples, L. Adrienne, Dehghan, Abbas, Deloukas, Panos, Fatemifar, Ghazaleh, Fox, Caroline, Furey, Terrence S., Franke, Lude, Han, Jiali, Hunter, David J., Karjalainen, Juha, Karpe, Fredrik, Kaplan, Robert C., Kooner, Jaspal S., McCarthy, Mark I., Murabito, Joanne M., Morris, Andrew P., Bishop, Julia A. N., North, Kari E., Ohlsson, Claes, Ong, Ken K., Prokopenko, Inga, Richards, J. Brent, Schadt, Eric E., Spector, Tim D., Widen, Elisabeth, Willer, Cristen J., Yang, Jian, Ingelsson, Erik, Mohlke, Karen L., Hirschhorn, Joel N., Pospisilik, John Andrew, Zillikens, M. Carola, Lindgren, Cecilia, Kilpelainen, Tuomas Oskari, and Loos, Ruth J. F.
- Abstract
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P <5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
- Published
- 2016
Catalog
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