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Background and Objective: The effect of the hormonal changes associated with menopause on the serum lipid levels may play an important role in most cardiac related disorders associated with menopause. The aim of the present study was to investigate the correlation between the lipid profile and estrogen level in premenopausal and postmenopausal women. Materials and Methods: The premenopausal females of 25 - 35 yrs in their follicular phase of menstrual cycle were selected and two groups of post menopausal women, 10 yrs of menopause were selected. About 6ml of blood sample was drawn for the estimation of estrogen and 4ml of blood for the estimation of lipid profile. The data were expressed as Mean ± SD. The correlation of estrogen level with lipid profile was done using correlation test and P value less than 0.05 was considered significant. Results: HDL cholesterol was found to be significantly declined in postmenopausal (p 0.1) in all the three groups. Conclusion: Estrogen may be the protective factor that is causing lesser incidence of these diseases in premenopausal women.