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We present measurements and simulations of semiconductor-superconductor heterostructure devices that are consistent with the observation of topological superconductivity and Majorana zero modes. The devices are fabricated from high-mobility two-dimensional electron gases in which quasi-one-dimensional wires are defined by electrostatic gates. These devices enable measurements of local and non-local transport properties and have been optimized via extensive simulations to ensure robustness against non-uniformity and disorder. Our main result is that several devices, fabricated according to the design's engineering specifications, have passed the topological gap protocol defined in Pikulin et al. [arXiv:2103.12217]. This protocol is a stringent test composed of a sequence of three-terminal local and non-local transport measurements performed while varying the magnetic field, semiconductor electron density, and junction transparencies. Passing the protocol indicates a high probability of detection of a topological phase hosting Majorana zero modes as determined by large-scale disorder simulations. Our experimental results are consistent with a quantum phase transition into a topological superconducting phase that extends over several hundred millitesla in magnetic field and several millivolts in gate voltage, corresponding to approximately one hundred micro-electron-volts in Zeeman energy and chemical potential in the semiconducting wire. These regions feature a closing and re-opening of the bulk gap, with simultaneous zero-bias conductance peaks at both ends of the devices that withstand changes in the junction transparencies. The extracted maximum topological gaps in our devices are 20-60 $\mu$eV. This demonstration is a prerequisite for experiments involving fusion and braiding of Majorana zero modes., Comment: Final version

We develop a protocol to determine the presence and extent of a topological phase with Majorana zero modes in a hybrid superconductor-semiconductor device. The protocol is based on conductance measurements in a three-terminal device with two normal leads and one superconducting lead. A radio-frequency technique acts as a proxy for the measurement of local conductance, allowing a rapid, systematic scan of the large experimental phase space of the device. Majorana zero modes cause zero bias conductance peaks at each end of the wire, so we identify promising regions of the phase space by filtering for this condition. To validate the presence of a topological phase, a subsequent measurement of the non-local conductance in these regions is used to detect a topological transition via the closing and reopening of the bulk energy gap. We define data analysis routines that allow for an automated and unbiased execution of the protocol. Our protocol is designed to screen out false positives, especially trivial Andreev bound states that mimic Majorana zero modes in local conductance. We apply the protocol to several examples of simulated data illustrating the detection of topological phases and the screening of false positives., Comment: 28 pages, 18 figures, 1 table