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The purpose of this article is to retrospectively analyze chest CT findings for 15 patients with Middle East respiratory syndrome coronavirus and to identify features associated with survival.Patients were assigned to group 1 if they died (n=9) and to group 2 if they made a full recovery (n=6). Two reviewers scored chest radiographs and CT examinations for segmental involvement, ground-glass opacities, consolidation, and interstitial thickening.Eight patients had ground-glass opacity (53%), five had ground-glass and consolidation in combination (33%), five had pleural effusion (33%), and four patients had interlobular thickening (27%). Of 281 CT findings, 151 (54%) were peripheral, 68 (24%) were central, and 62 (22%) had a mixed location. The number of involved lung segments was higher in group 1. The lower lobe was more commonly involved (mean, 12.2 segments) than in the upper and middle lobes combined (mean, 6.3 segments). The mean number of lung segments involved was 12.3 segments in group 1 and 3.4 segments in group 2. The CT lung score (mean±SD, 15.78±7.9 vs 7.3±5.7, p=0.003), chest radiographic score (20.8±1.7 vs 5.6±5.4; p=0.001), and mechanical ventilation duration (13.11±8.3 vs 0.5±1.2 days; p=0.002) were higher in group 1. All nine group 1 patients and three of six group 2 patients had pleural effusion (p=0.52).CT of patients with Middle East respiratory syndrome coronavirus predominantly showed ground-glass opacities, with peripheral lower lobe preference. Pleural effusion and higher CT lung and chest radiographic scores correlate with poor prognosis and short-term mortality.

Williams-Beuren syndrome (WBS) affects young infants and children. The underlying etiopathogenesis of this rare disease is due to the mutation of the elastin gene that is responsible for the elasticity of the arterial wall. As a result of inadequate elastin production, the major systemic arteries become abnormally rigid and can be manifested by an impediment to the blood flow. The most common cardiovascular abnormalities encountered in WBS are supravalvular aortic stenosis, pulmonary arterial stenosis, and mitral valve prolapse. Less frequently observed cardiovascular abnormalities include coarctation of the aorta, ventricular septal defect, patent ductus, subaortic stenosis, and hypertrophic cardiomyopathy. Coronary artery stenosis and severe impediment to the bi-ventricular outflow as a result of supravalvular aortic and pulmonary artery stenosis predispose patients to sudden death. Patients with progressed arterial stenosis and severe stenosis are likely to require intervention to prevent serious complications. Rarely, imaging findings may precede clinical presentation, which allows the radiologist to participate in the patient care. However, to be more prudent, the radiologist must be accustomed to the imaging characteristics of WBS as well as the patient's clinical information, which could raise the suspicion of WBS. We performed a retrospective analysis of all the available images from patients diagnosed with WBS in last 4 years at our institution, and present key imaging findings along with a review of the literature to summarize the clinically relevant features as demonstrated by multidetector computed tomography in WBS. Cross-sectional imaging plays a vital role in the diagnosis of WBS cases with equivocal clinical features. MDCT evaluation of complex cardiovascular abnormalities of WBS including coronary artery disease is feasible with modern MDCT scanners and in the future, this approach could provide accurate information for planning, navigation, and noninvasive assessment of the secondary arterial changes in WBS and thus reducing the dependence upon invasive contrast catherization techniques.

Purpose: To evaluate the follow-up chest radiographic findings in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) who were discharged from the hospital following improved clinical symptoms. Materials and Methods: Thirty-six consecutive patients (9 men, 27 women; age range 21–73 years, mean ± SD 42.5 ± 14.5 years) with confirmed MERS-CoV underwent follow-up chest radiographs after recovery from MERS-CoV. The 36 chest radiographs were obtained at 32 to 230 days with a median follow-up of 43 days. The reviewers systemically evaluated the follow-up chest radiographs from 36 patients for lung parenchymal, airway, pleural, hilar and mediastinal abnormalities. Lung parenchyma and airways were assessed for consolidation, ground-glass opacity (GGO), nodular opacity and reticular opacity (i.e., fibrosis). Follow-up chest radiographs were also evaluated for pleural thickening, pleural effusion, pneumothorax and lymphadenopathy. Patients were categorized into two groups: group 1 (no evidence of lung fibrosis) and group 2 (chest radiographic evidence of lung fibrosis) for comparative analysis. Patient demographics, length of ventilations days, number of intensive care unit (ICU) admission days, chest radiographic score, chest radiographic deterioration pattern (Types 1-4) and peak lactate dehydrogenase level were compared between the two groups using the student t-test, Mann-Whitney U test and Fisher's exact test. Results: Follow-up chest radiographs were normal in 23 out of 36 (64%) patients. Among the patients with abnormal chest radiographs (13/36, 36%), the following were found: lung fibrosis in 12 (33%) patients GGO in 2 (5.5%) patients, and pleural thickening in 2 (5.5%) patients. Patients with lung fibrosis had significantly greater number of ICU admission days (19 ± 8.7 days; P value = 0.001), older age (50.6 ± 12.6 years; P value = 0.02), higher chest radiographic scores [10 (0-15.3); P value = 0.04] and higher peak lactate dehydrogenase levels (315-370 U/L; P value = 0.001) when compared to patients without lung fibrosis. Conclusion: Lung fibrosis may develop in a substantial number of patients who have recovered from Middle East respiratory syndrome coronavirus (MERS-CoV). Significantly greater number of ICU admission days, older age, higher chest radiographic scores, chest radiographic deterioration patterns and peak lactate dehydrogenase levels were noted in the patients with lung fibrosis on follow-up chest radiographs after recovery from MERS-CoV.

OBJECTIVE. The overarching goal of this article is to provide radiologists with the most up-to-date information regarding the underlying epidemiology, pathophysiology, clinical features, and imaging findings related to Middle East respiratory syndrome coronavirus (MERS-CoV), a potentially deadly new infection. CONCLUSION. An increased awareness of MERS-CoV and an understanding of the radiologic features of MERS-CoV can improve the early assessment and monitoring of this new infection. Radiologists can provide information based on chest radiographic and CT scores that can be helpful for patient management and predicting prognosis.

The objective of our study was to describe lung changes on serial chest radiographs from patients infected with the acute Middle East respiratory syndrome corona-virus (MERS-CoV) and to compare the chest radiographic findings and final outcomes with those of health care workers (HCWs) infected with the same virus. Chest radiographic scores and comorbidities were also examined as indicators of a fatal outcome to determine their potential prognostic value.Chest radiographs of 33 patients and 22 HCWs infected with MERS-CoV were examined for radiologic features indicative of disease and for evidence of radiographic deterioration and progression. Chest radiographic scores were estimated after dividing each lung into three zones. The scores (1 [mild] to 4 [severe]) for all six zones per chest radiographic examination were summed to provide a cumulative chest radiographic score (range, 0-24). Serial radiographs were also examined to assess for radiographic deterioration and progression from type 1 (mild) to type 4 (severe) disease. Multivariate logistic regression analysis, Kaplan-Meier survival curve analysis, and the Mann-Whitney U test were used to compare data of deceased patients with those of individuals who recovered to identify prognostic radiographic features.Ground-glass opacity was the most common abnormality (66%) followed by consolidation (18%). Overall mortality was 35% (19/55). Mortality was higher in the patient group (55%, 18/33) than in the HCW group (5%, 1/22). The mean chest radiographic score for deceased patients was significantly higher than that for those who recovered (13 ± 2.6 [SD] vs 5.8 ± 5.6, respectively; p = 0.001); in addition, higher rates of pneumothorax (deceased patients vs patients who recovered, 47% vs 0%; p = 0.001), pleural effusion (63% vs 14%; p = 0.001), and type 4 radiographic progression (63% vs 6%; p = 0.001) were seen in the deceased patients compared with those who recovered. Univariate and logistic regression analyses identified the chest radiographic score as an independent predictor of mortality (odds ratio [OR], 1.38; 95% CI, 1.07-1.77; p = 0.01). The number of comorbidities in the patient group (n = 33) was significantly higher than that in the HCW group (n = 22) (mean number of comorbidities, 1.90 ± 1.27 vs 0.17 ± 0.65, respectively; p = 0.001). The Kaplan-Meier analysis revealed a median survival time of 15 days (95% CI, 4-26 days).Ground-glass opacity in a peripheral location was the most common abnormality noted on chest radiographs. A higher chest radiographic score coupled with a high number of medical comorbidities was associated with a poor prognosis and higher mortality in those infected with MERS-CoV. Younger HCWs with few or no comorbidities had a higher survival rate.

This retrospective study aimed to determine the superior vena cava (SVC) and left innominate vein (INV) normative cross-sectional area in children noninvasively using age as a predictor and also to compare the correlation of the area measured with the diameter on multidetector computed tomography (MDCT). Analysis of the SVC-INV cross-sectional area was performed for 73 consecutive patients. The cross-sectional area of the SVC-INV was manually estimated. A regression analysis was performed for the cross-sectional area and age separately, and regression equations were compared. One-way analysis of variance (ANOVA) was performed to evaluate significant differences in the area means according to age groups. Regression analysis showed that age can be a predictor for the area of the SVC (50.6 mm(2) + 1.01 × age), te INV (48.3 mm(2) + 0.93 × age), and the left SVC-INV junction (47.2 mm(2) + 0.92 × age), with respective R(2) values of 93, 88 and 94%. The comparative evaluation of the cross-sectional area and the diameter measurement of SVC showed that the cross-sectional area was more closely associated with the increasing age of the cohort (R(2) of 68 vs. 61%) than the measured diameter. For a cohort of patients without congenital or acquired heart disease, MDCT can be used as a complementary test for a normative cross-sectional normogram area database of SVC-INV using age as a predictor.

A broad spectrum of pathologies that involve the laryngotracheobronchial airway and imaging plays a crucial role in evaluating these abnormalities. Computed tomography with virtual bronchoscopy has been found to be very helpful in defining the location, extent, and nature of these lesions, and is increasingly being used even in patients with contraindications for fiberoptic bronchoscopy and laryngoscopy. Ionizing radiation, associated with virtual bronchoscopy, can be minimized by using low-dose multidetector computed tomography and hybrid iterative reconstruction techniques. Furthermore, retrospectively generated virtual bronchoscopy from a routinely acquired computed tomography data set eliminates additional cost and radiation. In the future, virtual bronchoscopy assisted with advanced navigational techniques will broaden the diagnostic and therapeutic landscape. This article presents the characteristic features of common and rare laryngotracheobronchial pathologies seen with virtual bronchoscopy.

To study the complex anatomy of the pericardium and the pericardial recesses, notably the transverse sinus and the recess behind and under the common pulmonary artery, cryomicrotomy sections of 4 frozen cadaver specimens were correlated with CT and MR imaging in multiple planes. In addition, CT chest studies of 254 patients and MR chest studies from 78 patients were reviewed. Epicardial fat interposed between the transverse sinus of the pericardium and the ascending aorta was a normal finding confirmed by cryomicrotomy studies and seen by CT in 23 of 245 patients and in MR imaging in 3 of 78 patients. Epicardial fat indenting the pericardial sac below the common pulmonary artery caused an inhomogeneous signal, mimicking lymphadenopathy on coronal T1 weighted MR images in 4 patients.

The visibility of the pericardium as well as of the space between the dorsal aspect of the sternal surface and the pericardial surface after cardiac surgery was determined by CT and/or MR with electrocardiographic (ECG)-gated spin-echo (SE) and gradient-echo sequences. Seventeen patients who had undergone cardiac operations and who were admitted for cardiac reoperation were investigated with CT and/or MR prior to sternal reentry. Five patients were investigated with CT alone, ten with both CT and MR, and two with MR only. At reoperation, retrosternal adhesions were classified as present or absent, and intrapericardial adhesions were classified as absent, minimal, moderate, or severe. A similar classification was applied to the CT and MR findings. In 14 of 15 patients, the CT findings were in agreement with those found at operation regarding postoperative retrosternal extrapericardial adhesions in the cranial retrosternal space and in 12 of 15 in the caudal retrosternal space. Computed tomography could not detect intrapericardial adhesions. Magnetic resonance was sensitive to metal artifacts from sternal sutures in both sequences and could therefore not be used to detect postoperative retrosternal extrapericardial adhesions. On the other hand, MR with ECG-gated SE sequences confirmed intrapericardial adhesions in 44 of 57 locations.

Thirty-three patients with pericardial effusion after open heart surgery were investigated with computed tomography (CT). Twelve of the 33 patients also underwent echocardiography prior to pericardiocentesis. The effusions were typed according to the results of the CT investigation. Because of postoperative adhesions, typical patterns of localized pericardial effusions were found in 16 patients. The localized compartments were seen on the right and left side of the heart and around the aorta and the pulmonary artery. CT was therefore shown to be of value for selecting the approach for drainage with catheter pericardiocentesis.

Pseudoaneurysms of the heart have a propensity to rupture and surgery is indicated. Usually in these cases diagnostic imaging is based on angiographic and/or echocardiographic studies. We have attempted to determine in pre- and postoperative studies the value of CT and ECG-gated MRI in patients with pseudoaneurysm. Seven patients with a pseudoaneurysm and/or dyskinesia of the posterolateral or diaphragmatic wall of the left ventricle were investigated with CT and/or ECG-gated MR studies, in addition to angiography, echocardiography, and radionuclide studies, prior to cardiac surgery. Postoperative follow-up studies with CT in six and MR in five patients were also carried out. Both CT and ECG-gated MRI allowed us to visualize the neck and CT also confirmed the communication between the cavities with or without demonstrating the conduit. In addition, disruption of the epicardial fat layer by the pseudoaneurysm was seen on both CT and MR, and the presence of intrapericardial adhesions was visualized on MR. Finally, CT and MRI, in postoperative follow-up studies, may indicate a myocardial discontinuity adjacent to the surgical patch.

Computed tomography can show hemiatrophy of the tongue and the floor of the mouth. The normal neuroanatomy of this region with regard to its motor supply is reviewed. In theory six variants of motor nerve lesions with hemiatrophy can be encountered, three of which are illustrated in this report. Knowledge of the muscular anatomy and the motor nerve supply to the tongue and floor of the mouth is helpful when evaluating lesions of the base of the skull with CT. This is particularly true for the lesions involving the trigeminal and hypoglossal nerves.

Anomalies of the anterior bellies of the digastric muscles were described during the 19th century and have been of little clinical significance. However, new imaging modalities, such as ultrasound, CT, and magnetic resonance (MR) imaging, can easily depict muscle anatomy without having to rely on dissection studies. The anterior bellies of the digastric muscles were evaluated in 40 patients having CT and 35 patients having MR imaging of the oropharynx. An accessory muscle crossing the midline between two normal digastric muscles was found in a patient in the MR imaging group. In the CT group, one patient showed absence of one anterior belly; in its place a small muscle was seen passing from the hyoid bone to the midline raphe of the mylohyoid muscle. It is necessary to recognize that muscle variants of the digastric muscle occur, to avoid confusion with abnormal lesions of the floor of the mouth and the submental space.

Primary amyloidosis is a systemic disease that may cause diffuse enlargement of the tongue or macroglossia. Obvious macroglossia is easily detected by clinical inspection. There is no agreement, however, on an objective measure of tongue enlargement. Computed tomography of the base of the tongue was performed in 12 patients with primary amyloidosis. Tongue width and width of the hyoglossus and genioglossus muscles were measured. Based on normal measurements it was concluded that macroglossia is present if the tongue is wider than 50 mm and the genioglossus wider than 11 mm. This should be accompanied by a midline cleft of the tongue surface and outward displacement of normal-size submandibular glands.

A prospective study of 34 consecutive patients with the sleep apnea syndrome was undertaken to evaluate the effectiveness and complications of, and predictors of, results in a conservative type of uvulopalatopharyngoplasty (UPPP). At six months, 65% of the patients had a 50% or greater reduction in the number of apneas and hypopneas per hour (responders). The responders to UPPP were less severely affected preoperatively regarding apneas and hypopneas, the mean number of which (+/- SD) were 32.7 +/- 20.8 compared with 64.6 +/- 26.0. They also had a lower body mass index before UPPP (31.3 +/- 4.1 vs 36.0 +/- 7.0 kg/m2). Preoperative computed tomography and cephalometry indicated that the nonresponders had narrower upper airways. It is concluded that UPPP is the treatment of choice for mild to moderate sleep apnea syndrome, but not for severely affected, heavily overweight patients with an increased tongue width.

• Aspiration cytologic examination, as distinguished from needle biopsy, may be performed with 22- to 25-gauge needles with an extremely low complication rate. For deep-seated lesions, computed tomography guidance is helpful to ensure that the needle tip is correctly within the tumor mass and that vital structures have been avoided. Lesions of the skull base, nasopharyngeal region, and infratemporal fossae are readily accessible with this approach. ( Arch Otolaryngol 1984;110:604-607)

The frontal process of the maxilla together with the anterior wall of the antrum constitute a major support of the midface. If this is fractured and goes unrecognized, serious facial deformities result. Fractures through this process occurred in 13 of 50 patients who received computed tomographic examination for facial trauma. The fracture had been missed on plain film examination in all but three of the 13 patients. The frontal process is usually displaced directly posteriorly in the more complex midface fractures. It may rotate about its long axis when associated with trimalar fractures and in some of the isolated injuries of the medial maxilla. Computed tomography is the ideal technique for demonstrating these fractures because of ease of examination, optimal anatomical display for demonstrating rotational and posterior displacements, and superior contrast in the severely traumatized facial skeleton.

A prospective evaluation of the paranasal sinuses was performed on a consecutive series of 137 pediatric patients referred for cranial CT. Approximately one-half of the patients less than 13 years of age had some degree of maxillary or ethmoid sinus opacification. The prevalence and severity of opacification was approximately the same for the maxillary and ethmoid sinuses. Sphenoid sinus abnormality was less common (16% of patients) and was usually minimal or mild. No incidental frontal sinus abnormalities were observed. This study confirms previous reports, based on plain film radiography, of the prevalence of incidental maxillary sinus opacification in children. However, contrary to some prior studies, we did not find a relatively higher rate of opacification in children less than 1 year of age. This may be due to overdiagnosis of maxillary sinus opacification on plain films, in small children. The diagnosis of sinusitis in childhood must take into account not only the radiographic findings but clinical signs and symptoms. Correlation is needed to avoid overdiagnosis in patients referred for sinus radiography for nonspecific indications or who have incidental opacification noted on radiographic or CT studies of the skull and brain.

Fine needle aspiration (FNA) biopsy is a safe, reliable, and cost-effective technique available for the evaluation of head and neck masses. Its utility is enhanced by the use of CT-directed aspiration. Candidates for CT-directed FNA include patients with: 1. deep-seated lesions; 2. distorted anatomy as a result of surgery or irradiation; 3. medical problems which contraindicate general anesthesia. The initial UCLA experience with this modality is reviewed. In certain clinical settings, CT-directed FNA can be a highly productive source of clinical information.