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6. Integration of ζ-deficient CARs into the CD3ζ gene conveys potent cytotoxicity in T and NK cells

Author

Kath, Jonas, Franke, Clemens, Drosdek, Vanessa, Du, Weijie, Glaser, Viktor, Fuster-Garcia, Carla, Stein, Maik, Zittel, Tatiana, Schulenberg, Sarah, Porter, Caroline E., Andersch, Lena, Künkele, Annette, Alcaniz, Joshua, Hoffmann, Jens, Abken, Hinrich, Abou-el-Enein, Mohamed, Pruß, Axel, Suzuki, Masataka, Cathomen, Toni, Stripecke, Renata, Volk, Hans-Dieter, Reinke, Petra, Schmueck-Henneresse, Michael, and Wagner, Dimitrios L.

Published
2024
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13. Author response: A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters

Author

Wiriyasermkul, Pattama, primary, Moriyama, Satomi, additional, Suzuki, Masataka, additional, Kongpracha, Pornparn, additional, Nakamae, Nodoka, additional, Takeshita, Saki, additional, Tanaka, Yoko, additional, Matsuda, Akina, additional, Miyasaka, Masaki, additional, Hamase, Kenji, additional, Tomonori, Kimura, additional, Mita, Masashi, additional, Sasabe, Jumpei, additional, and Nagamori, Shushi, additional

Published
2024
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14. A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters

Author

Wiriyasermkul, Pattama, primary, Moriyama, Satomi, additional, Suzuki, Masataka, additional, Kongpracha, Pornparn, additional, Nakamae, Nodoka, additional, Takeshita, Saki, additional, Tanaka, Yoko, additional, Matsuda, Akina, additional, Miyasaka, Masaki, additional, Hamase, Kenji, additional, Kimura, Tomonori, additional, Mita, Masashi, additional, Sasabe, Jumpei, additional, and Nagamori, Shushi, additional

Published
2024
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16. Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells

Author

Kath, Jonas, primary, Franke, Clemens, additional, Drosdek, Vanessa, additional, Du, Weijie, additional, Glaser, Viktor, additional, Fuster-Garcia, Carla, additional, Stein, Maik, additional, Zittel, Tatiana, additional, Schulenberg, Sarah, additional, Porter, Caroline E, additional, Andersch, Lena, additional, Künkele, Annette, additional, Alcaniz, Joshua, additional, Hoffmann, Jens, additional, Abken, Hinrich, additional, Abou-el-Enein, Mohamed, additional, Pruß, Axel, additional, Suzuki, Masataka, additional, Cathomen, Toni, additional, Stripecke, Renata, additional, Volk, Hans-Dieter, additional, Reinke, Petra, additional, Schmueck-Henneresse, Michael, additional, and Wagner, Dimitrios Laurin, additional

Published
2024
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21. Supplementary Figures from LILRB3 Modulates Acute Myeloid Leukemia Progression and Acts as an Effective Target for CAR T-cell Therapy

Author

Mai, Sunny, primary, Hodges, Alan, primary, Chen, Hui-Ming, primary, Zhang, Jilu, primary, Wang, Yi-Ling, primary, Liu, Yongbin, primary, Nakatsu, Fumiko, primary, Wang, Xiaoxuan, primary, Fang, Jing, primary, Xu, Yitian, primary, Davidov, Vitaliy, primary, Kang, Kyeongah, primary, Pingali, Sai Ravi, primary, Ganguly, Siddhartha, primary, Suzuki, Masataka, primary, Konopleva, Marina, primary, Prinzing, Brooke, primary, Zu, Youli, primary, Gottschalk, Stephen, primary, Lu, Yong, primary, Chen, Shu-Hsia, primary, and Pan, Ping-Ying, primary

Published
2023
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22. Table S1. LILRB1-4 surface expression in AML patient samples from LILRB3 Modulates Acute Myeloid Leukemia Progression and Acts as an Effective Target for CAR T-cell Therapy

Author

Mai, Sunny, primary, Hodges, Alan, primary, Chen, Hui-Ming, primary, Zhang, Jilu, primary, Wang, Yi-Ling, primary, Liu, Yongbin, primary, Nakatsu, Fumiko, primary, Wang, Xiaoxuan, primary, Fang, Jing, primary, Xu, Yitian, primary, Davidov, Vitaliy, primary, Kang, Kyeongah, primary, Pingali, Sai Ravi, primary, Ganguly, Siddhartha, primary, Suzuki, Masataka, primary, Konopleva, Marina, primary, Prinzing, Brooke, primary, Zu, Youli, primary, Gottschalk, Stephen, primary, Lu, Yong, primary, Chen, Shu-Hsia, primary, and Pan, Ping-Ying, primary

Published
2023
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23. Table S2. Ingenuity Pathway Analysis of LILRB3 antibody treated U937 cells from LILRB3 Modulates Acute Myeloid Leukemia Progression and Acts as an Effective Target for CAR T-cell Therapy

Author

Mai, Sunny, primary, Hodges, Alan, primary, Chen, Hui-Ming, primary, Zhang, Jilu, primary, Wang, Yi-Ling, primary, Liu, Yongbin, primary, Nakatsu, Fumiko, primary, Wang, Xiaoxuan, primary, Fang, Jing, primary, Xu, Yitian, primary, Davidov, Vitaliy, primary, Kang, Kyeongah, primary, Pingali, Sai Ravi, primary, Ganguly, Siddhartha, primary, Suzuki, Masataka, primary, Konopleva, Marina, primary, Prinzing, Brooke, primary, Zu, Youli, primary, Gottschalk, Stephen, primary, Lu, Yong, primary, Chen, Shu-Hsia, primary, and Pan, Ping-Ying, primary

Published
2023
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26. Sex Determination Cascade in Insects: A Great Treasure House of Alternative Splicing

Author

Suzuki, Masataka G., Asami, Takahiro, Series Editor, Kajihara, Hiroshi, Series Editor, Kobayashi, Kazuya, Series Editor, Koizumi, Osamu, Series Editor, Motokawa, Masaharu, Series Editor, Naruse, Kiyoshi, Series Editor, Satoh, Akiko, Series Editor, Takamune, Kazufumi, Series Editor, Takeuchi, Hideaki, Series Editor, Yoshikuni, Michiyasu, Series Editor, Kitano, Takeshi, editor, Iwao, Yasuhiro, editor, and Kondo, Mariko, editor

Published
2018
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27. Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells

Author

Kath, Jonas, primary, Franke, Clemens, additional, Drosdek, Vanessa, additional, Du, Weijie, additional, Glaser, Viktor, additional, Fuster-Garcia, Carla, additional, Stein, Maik, additional, Zittel, Tatiana, additional, Schulenberg, Sarah, additional, Porter, Caroline E, additional, Andersch, Lena, additional, Kuenkele, Annette, additional, Alcaniz, Joshua, additional, Hoffmann, Jens, additional, Abken, Hinrich, additional, Abou-el-Enein, Mohamed, additional, Pruss, Axel, additional, Suzuki, Masataka, additional, Cathomen, Toni, additional, Stripecke, Renata, additional, Volk, Hans-Dieter, additional, Reinke, Petra, additional, Schmueck-Henneresse, Michael, additional, and Wagner, Dimitrios Laurin, additional

Published
2023
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28. A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters

Author

Wiriyasermkul, Pattama, primary, Moriyama, Satomi, additional, Suzuki, Masataka, additional, Kongpracha, Pornparn, additional, Nakamae, Nodoka, additional, Takeshita, Saki, additional, Tanaka, Yoko, additional, Matsuda, Akina, additional, Miyasaka, Masaki, additional, Hamase, Kenji, additional, Kimura, Tomonori, additional, Mita, Masashi, additional, Sasabe, Jumpei, additional, and Nagamori, Shushi, additional

Published
2023
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38. Genetic and immune determinants of E. coli liver abscess formation

Author

Hullahalli, Karthik, Dailey, Katherine G., Hasegawa, Yuko, Suzuki, Masataka, Zhang, Hailong, Threadgill, David W., and Waldor, Matthew K.

Subjects
Article
Abstract

Systemic infections can yield distinct outcomes in different tissues. In mice, intravenous inoculation of E . coli leads to bacterial replication within liver abscesses while other organs such as the spleen largely clear the pathogen. Abscesses are macroscopic necrotic regions that comprise the vast majority of the bacterial burden in the animal, yet little is known about the processes underlying their formation. Here, we characterize E. coli liver abscesses and identify host determinants of abscess susceptibility. Spatial transcriptomics revealed that liver abscesses are associated with heterogenous immune cell clusters comprised of macrophages, neutrophils, dendritic cells, innate lymphoid cells, and T-cells that surround necrotic regions of the liver. Susceptibility to liver abscesses is heightened in the C57BL/6 lineage, particularly in C57BL/6N females. Backcross analyses demonstrated that abscess susceptibility is a polygenic trait inherited in a sex-dependent manner without direct linkage to sex chromosomes. As early as one day post infection, the magnitude of E. coli replication in the liver distinguishes abscess-susceptible and abscess-resistant strains of mice, suggesting that the immune pathways that regulate abscess formation are induced within hours. We characterized the early hepatic response with single-cell RNA sequencing and found that mice with reduced activation of early inflammatory responses, such as those lacking the LPS receptor TLR4, are resistant to abscess formation. Experiments with barcoded E. coli revealed that TLR4 mediates a tradeoff between abscess formation and bacterial clearance. Together, our findings define hallmarks of E. coli liver abscess formation and suggest that hyperactivation of the hepatic innate immune response drives liver abscess susceptibility. IMPORTANCE: Animal models of disseminating bacterial infections are critical for developing therapeutic interventions. Following systemic dissemination in mice, E. coli undergo dramatic replication within abscesses in the liver but not in other organs. Although liver abscesses are the largest reservoir of bacteria within the animal, the processes that lead to abscess formation are not known. Here, we characterize E. coli liver abscess formation and identify several determinants of abscess susceptibility, including sex, mouse genotype, and innate immune factors. By combining spatial and single-cell transcriptomics with genetic and phenotypic analyses, we delineate critical host pathways that underlie abscess formation. Our findings define several avenues for future studies to unravel how abscess susceptibility determinants interact to modulate clearance of systemic infections and govern tissue-specific bacterial replication.

Published
2023

40. Efficacy of myocardial washout of ⁹⁹ᵐTc-MIBI/Tetrofosmin for the evaluation of inflammation in patients with cardiac sarcoidosis: comparison with ¹⁸F-fluorodeoxyglucose positron emission tomography findings

Author

Suzuki, Masataka, Izawa, Yu, Fujita, Hiroshi, Miwa, Keisuke, Takahashi, Yu, Toh, Hiroyuki, Toba, Takayoshi, Fujiwara, Sei, Hashimura, Hiromi, Kono, Atsushi K., and Hirata, Ken-ichi

Subjects
Cardiac sarcoidosis, ⁹⁹ᵐTc-labeled tracer, SPECT, FDG PET, Washout
Abstract

Objective Both myocardial perfusion scintigraphy and ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG PET) are useful for the diagnosis of cardiac sarcoidosis (CS). However, the association between the washout of ⁹⁹ᵐTc-labeled tracer and FDG PET has not been established. This study aimed to evaluate the association between the washout of ⁹⁹ᵐTc-labeled tracer and FDG PET findings in patients with CS. Methods We retrospectively analyzed 64 patients (65.0 ± 11.2 years, 53% male) with suspected CS who underwent myocardial single-photon emission computed tomography (SPECT) with ⁹⁹ᵐTc-labeled tracer and FDG PET. The SPECT images were acquired at 15 min (early images) and 3 h (delayed images) after injection and scored visually using a 17-segment model with a 5-point scoring system. The washout score was defined as the difference between the early and delayed total defect scores. FDG positivity was considered as focal or focal on diffuse patterns on visual assessment, and FDG uptake was quantified by measuring the standardized uptake value (SUV) of each of the 17 segments. Results The washout score was significantly higher for the CS group than for the non-CS group (3.0 [−1.0–5.0] vs. 0.0 [−0.5–1.0], p = 0.010). Receiver operating characteristic analysis showed that a washout score of ≥ 2 had the best accuracy for detecting CS (88% sensitivity and 56% specificity) and FDG positivity (71% sensitivity and 89% specificity). In the segment-based analysis of 833 segments from 49 patients, excluding 15 patients with diffuse FDG uptake, the median SUVs for FDG uptake for the washout scores of ≤ 0, 1, and 2 were 2.3 (1.8–3.6), 4.2 (2.9–7.8), and 8.3 (6.5–9.4), respectively (p

Published
2022

41. Mammals sustain amino acid homochirality against chiral conversion by symbiotic microbes

Author

Gonda, Yusuke, primary, Matsuda, Akina, additional, Adachi, Kenichiro, additional, Ishii, Chiharu, additional, Suzuki, Masataka, additional, Osaki, Akina, additional, Mita, Masashi, additional, Nishizaki, Naoto, additional, Ohtomo, Yoshiyuki, additional, Shimizu, Toshiaki, additional, Yasui, Masato, additional, Hamase, Kenji, additional, and Sasabe, Jumpei, additional

Published
2023
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50. Ultralow-dose binary oncolytic/helper-dependent adenovirus promotes antitumor activity in preclinical and clinical studies

Author

Wang, Daniel, primary, Porter, Caroline E., additional, Lim, Bora, additional, Rosewell Shaw, Amanda, additional, Robertson, Catherine S., additional, Woods, Mae L., additional, Xu, Ya, additional, Biegert, Greyson G.W., additional, Morita, Daisuke, additional, Wang, Tao, additional, Grilley, Bambi J., additional, Heslop, Helen, additional, Brenner, Malcolm K., additional, and Suzuki, Masataka, additional

Published
2023
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