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31 results on '"Suzuki, Fumihito"'

3. An open-label, randomized controlled trial of sulfamethoxazole-trimethoprim for Pneumocystis prophylaxis: results of 52-week follow-up

Author

Utsunomiya, Masako, Dobashi , Hiroaki, Odani, Toshio, Saito, Kazuyoshi, Yokogawa, Naoto, Nagasaka, Kenji, Takenaka , Kenchi, Soejima , Makoto, Sugihara, Takahiko, Hagiyama, Hiroyuki, Hirata, Shinya, Matsui, Kazuo, Nonomura, Yoshinori, KONDO, Masahiro, Suzuki, Fumihito, Nawata, Yasushi, Tomita, Makoto, Kihara, Mari, Yokoyama-Kokuryo, Waka, Hirano, Fumio, Yamazaki, Hayato, Sakai, Ryoko, Nanki , Toshihiro, Koike, Ryuji, Miyasaka, Nobuyuki, Harigai, Masayoshi, Utsunomiya, Masako, Dobashi , Hiroaki, Odani, Toshio, Saito, Kazuyoshi, Yokogawa, Naoto, Nagasaka, Kenji, Takenaka , Kenchi, Soejima , Makoto, Sugihara, Takahiko, Hagiyama, Hiroyuki, Hirata, Shinya, Matsui, Kazuo, Nonomura, Yoshinori, KONDO, Masahiro, Suzuki, Fumihito, Nawata, Yasushi, Tomita, Makoto, Kihara, Mari, Yokoyama-Kokuryo, Waka, Hirano, Fumio, Yamazaki, Hayato, Sakai, Ryoko, Nanki , Toshihiro, Koike, Ryuji, Miyasaka, Nobuyuki, and Harigai, Masayoshi

Published
2020

5. An open-label, randomized controlled trial of sulfamethoxazole–trimethoprim for Pneumocystis prophylaxis: results of 52-week follow-up

Author

Utsunomiya, Masako, primary, Dobashi, Hiroaki, additional, Odani, Toshio, additional, Saito, Kazuyoshi, additional, Yokogawa, Naoto, additional, Nagasaka, Kenji, additional, Takenaka, Kenchi, additional, Soejima, Makoto, additional, Sugihara, Takahiko, additional, Hagiyama, Hiroyuki, additional, Hirata, Shinya, additional, Matsui, Kazuo, additional, Nonomura, Yoshinori, additional, Kondo, Masahiro, additional, Suzuki, Fumihito, additional, Nawata, Yasushi, additional, Tomita, Makoto, additional, Kihara, Mari, additional, Yokoyama-Kokuryo, Waka, additional, Hirano, Fumio, additional, Yamazaki, Hayato, additional, Sakai, Ryoko, additional, Nanki, Toshihiro, additional, Koike, Ryuji, additional, Miyasaka, Nobuyuki, additional, and Harigai, Masayoshi, additional

Published
2020
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8. Additional file 1: of Optimal regimens of sulfamethoxazole-trimethoprim for chemoprophylaxis of Pneumocystis pneumonia in patients with systemic rheumatic diseases: results from a non-blinded, randomized controlled trial

Author

Utsunomiya, Masako, Dobashi, Hiroaki, Odani, Toshio, Saito, Kazuyoshi, Yokogawa, Naoto, Nagasaka, Kenji, Kenchi Takenaka, Soejima, Makoto, Sugihara, Takahiko, Hagiyama, Hiroyuki, Hirata, Shinya, Matsui, Kazuo, Nonomura, Yoshinori, Kondo, Masahiro, Suzuki, Fumihito, Tomita, Makoto, Kihara, Mari, Waka Yokoyama, Hirano, Fumio, Yamazaki, Hayato, Sakai, Ryoko, Nanki, Toshihiro, Koike, Ryuji, Kohsaka, Hitoshi, Miyasaka, Nobuyuki, and Harigai, Masayoshi

Abstract

List of ethics committees that approved this study. (DOCX 13 kb)

Published
2017
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9. Optimal regimens of sulfamethoxazole-trimethoprim for chemoprophylaxis of Pneumocystis pneumonia in patients with systemic rheumatic diseases: results from a non-blinded, randomized controlled trial

Author

Utsunomiya Masako, Dobashi Hiroaki, Odani Toshio, Saito Kazuyoshi, Yokogawa Naoto, Nagasaka Kenji, Takenaka Kenchi, Soejima Makoto, Sugihara Takahiko, Hagiyama Hiroyuki, Hirata Shinya, Matsui Kazuo, Nonomura Yoshinori, KONDO, Masahiro, Suzuki Fumihito, Tomita Makoto, Kihara Mari, Yokoyama Waka, Hirano Fumio, Yamazaki Hayato, Sakai Ryoko, Nanki Toshihiro, Koike Ryuji, Kohsaka Hitoshi, Miyasaka Nobuyuki, Harigai Masayoshi, Utsunomiya Masako, Dobashi Hiroaki, Odani Toshio, Saito Kazuyoshi, Yokogawa Naoto, Nagasaka Kenji, Takenaka Kenchi, Soejima Makoto, Sugihara Takahiko, Hagiyama Hiroyuki, Hirata Shinya, Matsui Kazuo, Nonomura Yoshinori, KONDO, Masahiro, Suzuki Fumihito, Tomita Makoto, Kihara Mari, Yokoyama Waka, Hirano Fumio, Yamazaki Hayato, Sakai Ryoko, Nanki Toshihiro, Koike Ryuji, Kohsaka Hitoshi, Miyasaka Nobuyuki, and Harigai Masayoshi

Published
2017

10. Optimal regimens of sulfamethoxazole-trimethoprim for chemoprophylaxis of Pneumocystis pneumonia in patients with systemic rheumatic diseases: results from a non-blinded, randomized controlled trial

Author

Utsunomiya, Masako, primary, Dobashi, Hiroaki, additional, Odani, Toshio, additional, Saito, Kazuyoshi, additional, Yokogawa, Naoto, additional, Nagasaka, Kenji, additional, Takenaka, Kenchi, additional, Soejima, Makoto, additional, Sugihara, Takahiko, additional, Hagiyama, Hiroyuki, additional, Hirata, Shinya, additional, Matsui, Kazuo, additional, Nonomura, Yoshinori, additional, Kondo, Masahiro, additional, Suzuki, Fumihito, additional, Tomita, Makoto, additional, Kihara, Mari, additional, Yokoyama, Waka, additional, Hirano, Fumio, additional, Yamazaki, Hayato, additional, Sakai, Ryoko, additional, Nanki, Toshihiro, additional, Koike, Ryuji, additional, Kohsaka, Hitoshi, additional, Miyasaka, Nobuyuki, additional, and Harigai, Masayoshi, additional

Published
2017
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11. Optimal regimens of sulfamethoxazole-trimethoprim for chemoprophylaxis of Pneumocystispneumonia in patients with systemic rheumatic diseases: results from a non-blinded, randomized controlled trial

Author

Utsunomiya, Masako, Dobashi, Hiroaki, Odani, Toshio, Saito, Kazuyoshi, Yokogawa, Naoto, Nagasaka, Kenji, Takenaka, Kenchi, Soejima, Makoto, Sugihara, Takahiko, Hagiyama, Hiroyuki, Hirata, Shinya, Matsui, Kazuo, Nonomura, Yoshinori, Kondo, Masahiro, Suzuki, Fumihito, Tomita, Makoto, Kihara, Mari, Yokoyama, Waka, Hirano, Fumio, Yamazaki, Hayato, Sakai, Ryoko, Nanki, Toshihiro, Koike, Ryuji, Kohsaka, Hitoshi, Miyasaka, Nobuyuki, and Harigai, Masayoshi

Abstract

Sulfamethoxazole-trimethoprim (SMX/TMP) is a standard drug for the prophylaxis of Pneumocystispneumonia (PJP) in immunosuppressed patients with systemic rheumatic diseases, but is sometimes discontinued due to adverse events (AEs). The objective of this non-blinded, randomized, 52-week non-inferiority trial was to quest an effective chemoprophylaxis regimen for PJP with a low drug discontinuation rate. Results at week 24 were reported. Adult patients with systemic rheumatic diseases who started prednisolone ≥0.6 mg/kg/day were randomized into three dosage groups: a single-strength group (SS, SMX/TMP of 400/80 mg daily), half-strength group (HS, 200/40 mg daily), and escalation group (ES, started with 40/8 mg daily, increasing incrementally to 200/40 mg daily). The primary endpoint was non-incidence rates (non-IR) of PJP at week 24. Of 183 patients randomly allocated at a 1:1:1 ratio into the three groups, 58 patients in SS, 59 in HS, and 55 in ES started SMX/TMP. A total of 172 patients were included in the analysis. No cases of PJP were reported up to week 24. Estimated non-IR of PJP in patients who received daily SMX/TMP of 200/40 mg, either starting at this dose or increasing incrementally, was 96.8–100% using the exact confidence interval as a post-hoc analysis. The overall discontinuation rate was significantly lower with HS compared to SS (p= 0.007). The discontinuation rates due to AEs were significantly lower with HS (p= 0.006) and ES (p= 0.004) compared to SS. The IR of AEs requiring reduction in the dose of SMX/TMP (p= 0.009) and AEs of special interest (p= 0.003) were different among the three groups with significantly higher IR in SS compared to HS and ES. Although there were no PJP cases, the combined group of HS and ES had an excellent estimated non-IR of PJP and both were superior in safety to SS. From the perspective of feasibility and drug discontinuation rates, the daily half-strength regimen was suggested to be optimal for prophylaxis of PJP in patients with systemic rheumatic diseases. The University Hospital Medical Information Network Clinical Trials Registry number is UMIN000007727, registered 10 April 2012.

Published
2017
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12. Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity

Author

Suzuki, Fumihito, primary, Kubota, Tetsuo, additional, Miyazaki, Yasunari, additional, Ishikawa, Kinya, additional, Ebisawa, Masashi, additional, Hirohata, Shunsei, additional, Ogura, Takashi, additional, Mizusawa, Hidehiro, additional, Imai, Toshio, additional, Miyasaka, Nobuyuki, additional, and Nanki, Toshihiro, additional

Published
2012
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13. A case report of hypertrophic pachymeningitis associated with systemic lupus erythematosus, showing a headache and hearing loss resembling intracranial hypotension

Author

OCHI, Sae, primary, NANKI, Toshihiro, additional, KOMANO, Yukiko, additional, SUZUKI, Fumihito, additional, OGAWA, Jun, additional, SUGIHARA, Takehiko, additional, NAGASAKA, Kenji, additional, NONOMURA, Yoshinori, additional, HAGIYAMA, Hiroyuki, additional, and MIYASAKA, Nobuyuki, additional

Published
2007
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24. Practica Oto-Rhino-Laryngologica

Author

Hozawa, Jiro, primary, Saito, Hisaki, additional, Suzuki, Fumihito, additional, Kamata, Shigeki, additional, Hakamada, Masaru, additional, Kasahara, Masaaki, additional, Takagi, Akiko, additional, Ishida, Takashi, additional, Nakamura, Kiyozumi, additional, Nagai, Masao, additional, Mori, Isao, additional, Ishikawa, Kaoru, additional, Kimura, Noriko, additional, Fukuoka, Keiji, additional, Yamagami, Minako, additional, Kawamoto, Kazutomo, additional, Takasaka, Tomonori, additional, Sato, Masahiro, additional, Shinkawa, Shuichi, additional, and Shibahara, Yoshihiro, additional

Published
1982
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29. Achieving simplified disease activity index remission in patients with active rheumatoid arthritis is associated with subsequent good functional and structural outcomes in a real-world clinical setting under a treat-to-target strategy.

Author

Hirano F, Yokoyama W, Yamazaki H, Amano K, Kawakami A, Hayashi T, Tamura N, Yasuda S, Dobashi H, Fujii T, Ito S, Kaneko Y, Matsui T, Okuda Y, Saito K, Suzuki F, Yoshimi R, Sakai R, Koike R, Kohsaka H, Miyasaka N, and Harigai M

Subjects
Adult, Aged, Female, Humans, Japan, Male, Middle Aged, Patient Acuity, Predictive Value of Tests, Prognosis, Prospective Studies, Recovery of Function, Remission Induction methods, Severity of Illness Index, Treatment Outcome, Antirheumatic Agents therapeutic use, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid drug therapy, Arthritis, Rheumatoid physiopathology
Abstract

Objective: To verify predictive validity of simplified disease activity index (SDAI) remission for subsequent functional and structural outcomes in real-world clinical settings under a treat-to-target strategy (T2T)., Methods: In this multicenter, prospective cohort study, T2T was implemented in rheumatoid arthritis (RA) patients with moderate-to-high disease activity. SDAI or clinical disease activity index (CDAI) was assessed every 12 weeks, and treatment was adjusted to achieve clinical remission or low disease activity (LDA). Multivariate logistic regression models were used to examine the associations of SDAI remission (≤3.3) at week 24 with the health assessment questionnaire-disability index (HAQ-DI) ≤ 0.5 or with the delta van der Heijde-modified total Sharp score (ΔvdH-mTSS) -7 ], and baseline vdH-mTSS [0.986 (0.976-0.996), p = 0.009]. A factor associated with ΔvdH-mTSS < SDC was SDAI remission at week 24 [3.53 (1.62-7.71), p = 0.002]., Conclusion: Predictive validity of SDAI remission for good outcomes was verified in a T2T-implementing cohort in the current clinical settings.

Published
2017
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30. [A case report of hypertrophic pachymeningitis associated with systemic lupus erythematosus, showing a headache and hearing loss resembling intracranial hypotension].

Author

Ochi S, Nanki T, Komano Y, Suzuki F, Ogawa J, Sugihara T, Nagasaka K, Nonomura Y, Hagiyama H, and Miyasaka N

Subjects
Adult, Diagnosis, Differential, Female, Headache etiology, Hearing Loss etiology, Humans, Hypertrophy, Meningitis pathology, Intracranial Hypotension diagnosis, Lupus Erythematosus, Systemic complications, Lupus Erythematosus, Systemic diagnosis, Meningitis etiology
Abstract

We report a case of systemic lupus erythematosus (SLE) complicated with hypertrophic pachymeningitis. A 34-year old woman who was diagnosed as SLE in 1985 was admitted to our hospital for a high grade fever and a headache. Laboratory findings showed increased titer of anti-double strand DNA antibody and decreased number of platelets. She complained a severe headache and hearing loss which were worsened by head-up position, resembling the symptoms of intracranial hypotension. MRI findings revealed thickened dura and she was diagnosed as hypertrophic pachymeningitis. Both clinical symptoms and laboratory findings were resolved after methyl-prednisolone pulse therapy followed by a high dose of prednisolone. Although hypertrophic pachymeningitis is a rare complication with SLE, it should be considered in SLE patients with severe headache.

Published
2007
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31. [An autopsy case of intestinal Behcet's disease with sacroiliitis accompanied by myelodysplastic syndrome with trisomy 8. ].

Author

Tsubata R, Suzuki F, Sugihara T, Ogawa J, Hagiyama H, Nanki T, Kohsaka H, Kubota T, and Miyasaka N

Subjects
Aged, Anemia, Refractory, with Excess of Blasts genetics, Humans, Male, Anemia, Refractory, with Excess of Blasts complications, Behcet Syndrome complications, Chromosomes, Human, Pair 8, Ileal Diseases complications, Sacrum, Spondylitis complications, Trisomy, Ulcer complications
Abstract

Here we described an autopsy case of intestinal Behcet's disease with sacroiliitis associated with myelodysplastic syndrome (RAEB-t, 8+). Over twenty cases of Behcet's disease associated with myelodysplastic syndrome have been reported in preliterature so far. The majority of them are incomplete type of Behcet's disease having intestinal ulceration. Of those, trisomy 8 is the most common chromosomal abnormality. We reviewed similar cases reported and investigated the association of intestinal Behcet's disease with trisomy 8. The association of sacroiliitis with Behcet's disease is also studied.

Published
2005
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