29 results on '"Suzanne Tucker"'
Search Results
2. Acute Megakaryoblastic Leukemia with Trisomy 21 and Tetrasomy 21 Clones in a Phenotypically Normal Child with Mosaic Trisomy 21
- Author
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Eric Won, Tanja A. Gruber, Suzanne Tucker, and Deborah E. Schiff
- Subjects
Pediatrics ,RJ1-570 - Abstract
Pediatric acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia (AML) that may be divided into two subgroups: (1) Down syndrome- (DS-) related AMKL which generally has a favorable prognosis and (2) non-DS-related AMKL which generally has a poorer outcome. We report a phenotypically normal child with AMKL with trisomy 21 (T21) and tetrasomy 21 clones. Subsequently, she was diagnosed with mosaic T21. She underwent reduced-intensity therapy with good outcome. We review the literature regarding AMKL-associated cytogenetic abnormalities and AMKL in association with DS. We suggest evaluation for mosaic T21 in phenotypically normal pediatric patients with T21-positive AML.
- Published
- 2020
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3. Novel KRAS mutation in an unusual tectal low-grade glioma
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Suzanne Tucker, John R. Crawford, Sharon Wulfovich, and Michael J. Levy
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0301 basic medicine ,Weakness ,Pediatrics ,medicine.medical_specialty ,genetic structures ,Images In… ,Physical examination ,030105 genetics & heredity ,Proto-Oncogene Proteins p21(ras) ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Medical history ,Family history ,Tectum Mesencephali ,medicine.diagnostic_test ,business.industry ,Brain Neoplasms ,Neurooncology ,General Medicine ,Glioma ,eye diseases ,Decreased Visual Acuity ,Mutation ,Vomiting ,Headaches ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
An 8-year-old boy with no significant medical history or family history presented with 1–2 weeks of decreased visual acuity and blurry vision. The patient denied any headaches, vomiting, dizziness, seizures or weakness. Physical examination was significant for poorly reactive pupils, constricted
- Published
- 2023
4. Neonatal Myocardial Infarction: A Proposed Algorithm for Coronary Arterial Thrombus Management
- Author
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Hannah El-Sabrout, Srujan Ganta, Peter Guyon, Kanishka Ratnayaka, Gabrielle Vaughn, James Perry, Amy Kimball, Justin Ryan, Courtney D. Thornburg, Suzanne Tucker, Jun Mo, Sanjeet Hegde, John Nigro, and Howaida El-Said
- Subjects
Nitroglycerin ,Treatment Outcome ,Heparin ,Coronary Thrombosis ,Infant, Newborn ,Myocardial Infarction ,Humans ,Infant ,Mitral Valve Insufficiency ,Cardiology and Cardiovascular Medicine ,Coronary Vessels ,Algorithms - Abstract
Background: Neonatal myocardial infarction is rare and is associated with a high mortality of 40% to 50%. We report our experience with neonatal myocardial infarction, including presentation, management, outcomes, and our current patient management algorithm. Methods: We reviewed all infants admitted with a diagnosis of coronary artery thrombosis, coronary ischemia, or myocardial infarction between January 2015 and May 2021. Results: We identified 21 patients (median age, 1 [interquartile range (IQR), 0.25–9.00] day; weight, 3.2 [IQR, 2.9–3.7] kg). Presentation included respiratory distress (16), shock (3), and murmur (2). Regional wall motion abnormalities by echocardiogram were a key criterion for diagnosis and were present in all 21 with varying degrees of depressed left ventricular function (severe [8], moderate [6], mild [2], and low normal [5]). Ejection fraction ranged from 20% to 54% (median, 43% [IQR, 34%–51%]). Mitral regurgitation was present in 19 (90%), left atrial dilation in 15 (71%), and pulmonary hypertension in 18 (86%). ECG was abnormal in 19 (90%). Median troponin I was 0.18 (IQR, 0.12–0.56) ng/mL. Median BNP (B-type natriuretic peptide) was 2100 (IQR, 924–2325) pg/mL. Seventeen had documented coronary thrombosis by cardiac catheterization. Seventeen (81%) were treated with intracoronary tPA (tissue-type plasminogen activator) followed by systemic heparin, AT (antithrombin), and intravenous nitroglycerin, and 4 (19%) were treated with systemic heparin, AT, and intravenous nitroglycerin alone. Nineteen of 21 recovered. One died (also had infradiaphragmatic total anomalous pulmonary venous return). One patient required a ventricular assist device and later underwent heart transplant; this patient was diagnosed late at 5 weeks of age and did not respond to tPA. Nineteen of 21 (90%) regained normal left ventricular function (ejection fraction, 60%–74%; mean, 65% [IQR, 61%–67%]) at latest follow-up (median, 6.8 [IQR, 3.58–14.72] months). Two of 21 (10%) had residual trivial mitral regurgitation. After analysis of these results, we present our current algorithm, which developed and matured over time, to manage neonatal myocardial infarction. Conclusions: We experienced a lower mortality rate for infants with neonatal infarction than that reported in the literature. We propose a post hoc algorithm that may lead to improvement in patient outcomes following coronary artery thrombus.
- Published
- 2022
5. USP6 rearrangement in pediatric nodular fasciitis
- Author
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Rachel Sennett, Sheila Friedlander, Suzanne Tucker, Brian Hinds, and George Hightower
- Subjects
Chromosome Aberrations ,Gene Rearrangement ,Histology ,Proto-Oncogene Proteins ,Humans ,Female ,Dermatology ,Fibroma ,Fasciitis ,Child ,Ubiquitin Thiolesterase ,In Situ Hybridization, Fluorescence ,Pathology and Forensic Medicine - Abstract
Nodular fasciitis (NF) is a myofibroblastic proliferation that is uncommonly present in pediatric patients. These benign neoplasms can masquerade as more insidious sarcomatous proliferations on both clinical exam and initial histopathologic review, often prompting undue concern in patients, parents, and providers. While immunohistochemical analysis of NF can be variable, adding to the diagnostic uncertainty, molecular analysis documenting ubiquitin-specific protease 6 (USP6) gene rearrangement can help confirm the diagnosis as an association between NF and USP6 overexpression was first identified 10 years ago in an analysis that found rearrangements of the involved locus in over 90% of studied samples. In this report, we review one case of NF located on the chin of a nine-year-old girl in which molecular testing was essential to secure the correct diagnosis, and provide a summary of documented cases of USP6 overexpression in transient pediatric neoplasms.
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- 2022
6. Aortopulmonary window in tetralogy of Fallot with absent conal septum
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David Aurigemma, Christopher K. Davis, Suzanne Tucker, Chandler M Dixon, and Norman H. Silverman
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Aortic valve ,medicine.medical_specialty ,business.industry ,Diastole ,030204 cardiovascular system & hematology ,medicine.disease ,Aortopulmonary window ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Internal medicine ,Conotruncal defect ,Cardiology ,medicine ,Radiology, Nuclear Medicine and imaging ,Systole ,Semilunar valves ,Cardiology and Cardiovascular Medicine ,business ,Sinus (anatomy) ,Tetralogy of Fallot - Abstract
BACKGROUND Aortopulmonary window is a rare conotruncal defect that is often associated with other congenital heart defects. We present a patient with a previously unreported combination of aortopulmonary window with tetralogy of Fallot with an absent conal septum. CASE PRESENTATION A term, 2.4 kg newborn male infant presented at a community hospital with cyanosis unresponsive to supplemental oxygen. Transthoracic echocardiography demonstrated a conotruncal defect with a large conoventricular ventricular septal defect and an over-riding, dysplastic aortic valve. The main pulmonary artery (MPA) appeared to arise from left facing sinus of the aortic valve, with confluent yet hypoplastic right and left branch pulmonary arteries. There was no evidence of prograde flow into the MPA in systole, though there did appear to be retrograde flow in diastole from the patent ductus. The patient underwent multiple advanced imaging studies, and the diagnosis was not fully elucidated. Postmortem examination demonstrated morphology consistent with Tetralogy of Fallot with the absence of the conal septum. There were two distinct semilunar valves in fibrous continuity with an aortopulmonary window immediately cephalad to the valve. DISCUSSION The rare combination of defects and the patient's size made the anatomic diagnosis by conventional imaging challenging. However, retrospective review of imaging studies did demonstrate anatomic features seen by direct examination of the specimen.
- Published
- 2018
7. Congenital cutaneous non‐neural granular cell tumor mimicking herpetic infection: Case report and review of the literature
- Author
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Wynnis L. Tom, Suzanne Tucker, Ellen S. Haddock, Brian Hinds, Robert O. Newbury, and Jennifer Brescoll Mancuso
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Herpes simplex virus infection ,Granular cell tumor ,Punch Biopsy ,Pathology ,medicine.medical_specialty ,integumentary system ,Right forearm ,business.industry ,Dermatology ,medicine.disease ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Granular cell ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Medicine ,Dermatopathology ,business ,Immunostaining - Abstract
We present a case of a female neonate with a cluster of six skin colored to yellowish pseudovesicular papules on her right forearm present since birth, initially thought to be a herpes simplex virus infection. Punch biopsy with immunostaining revealed a diagnosis of S100-negative, CD163-positive congenital cutaneous non-neural granular cell tumor. Only four other reports are presented in the literature of this entity, three of which also presented on the arm with somewhat similar clinical findings. We briefly reviewed the subtypes of classic and S100-negative non-neural granular cell tumors.
- Published
- 2021
8. Rare case of BRAF V600E mutant anaplastic pleomorphic xanthroastrocytoma in a 5-year survivor of acute lymphoblastic leukaemia
- Author
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John R. Crawford, Jennifer H. Yang, Suzanne Tucker, and Michael J. Levy
- Subjects
0301 basic medicine ,Oncology ,Proto-Oncogene Proteins B-raf ,medicine.medical_specialty ,endocrine system diseases ,Images In… ,medicine.medical_treatment ,030105 genetics & heredity ,Astrocytoma ,03 medical and health sciences ,0302 clinical medicine ,hemic and lymphatic diseases ,Internal medicine ,Rare case ,medicine ,Humans ,Survivors ,Chemotherapy ,business.industry ,Brain Neoplasms ,Neurooncology ,General Medicine ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,BRAF V600E ,Mutation ,Vomiting ,Lymphoblastic leukaemia ,Mature Ovarian Teratoma ,medicine.symptom ,Headaches ,business ,030217 neurology & neurosurgery - Abstract
A 20-year-old woman with a history of acute lymphoblastic leukaemia treated at 13 years old with radiation and chemotherapy and a benign cystic mature ovarian teratoma diagnosed at 18 years old presented with 6 weeks of headaches and vomiting. She did not report vision changes or other
- Published
- 2021
9. Acute Megakaryoblastic Leukemia with Trisomy 21 and Tetrasomy 21 Clones in a Phenotypically Normal Child with Mosaic Trisomy 21
- Author
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Suzanne Tucker, Tanja A. Gruber, Deborah Schiff, and Eric Won
- Subjects
Oncology ,0303 health sciences ,medicine.medical_specialty ,Down syndrome ,business.industry ,Myeloid leukemia ,Case Report ,General Medicine ,Favorable prognosis ,medicine.disease ,Pediatrics ,Pediatric Acute Megakaryoblastic Leukemia ,RJ1-570 ,03 medical and health sciences ,Acute megakaryoblastic leukemia ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,hemic and lymphatic diseases ,Tetrasomy ,medicine ,Good outcome ,Trisomy ,business ,030304 developmental biology - Abstract
Pediatric acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia (AML) that may be divided into two subgroups: (1) Down syndrome- (DS-) related AMKL which generally has a favorable prognosis and (2) non-DS-related AMKL which generally has a poorer outcome. We report a phenotypically normal child with AMKL with trisomy 21 (T21) and tetrasomy 21 clones. Subsequently, she was diagnosed with mosaic T21. She underwent reduced-intensity therapy with good outcome. We review the literature regarding AMKL-associated cytogenetic abnormalities and AMKL in association with DS. We suggest evaluation for mosaic T21 in phenotypically normal pediatric patients with T21-positive AML.
- Published
- 2020
10. Hereditary Spherocytosis as an Atypical Presentation of Anemia in Ulcerative Colitis
- Author
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Lillian Choi, Suzanne Tucker, and Moo Cho
- Subjects
medicine.medical_specialty ,Anemia ,business.industry ,medicine ,Presentation (obstetrics) ,medicine.disease ,business ,Dermatology ,Ulcerative colitis ,Hereditary spherocytosis - Published
- 2021
11. Updates and review of neoplastic paediatric neuropathology
- Author
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Suzanne Tucker and Sanda Alexandrescu
- Subjects
0301 basic medicine ,Medulloblastoma ,Pathology ,medicine.medical_specialty ,Histology ,Central nervous system ,Neuropathology ,Biology ,Malignancy ,medicine.disease ,Pathology and Forensic Medicine ,BRAF V600E ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,medicine ,Who classification ,Grading (tumors) ,030217 neurology & neurosurgery ,Paediatric population - Abstract
Tumours of the central nervous system are the second most common type of malignancy in the paediatric population, after haematopoietic malignancies. With the 2016 edition of the WHO Classification of the Tumours of the Central Nervous System (CNS), a diagnostic approach to paediatric CNS malignancies has been adopted, which increasingly incorporates molecular parameters, as well as histologic features. This classification system represents a major restructuring of many paediatric central nervous system tumours. This review aims to highlight the areas in the WHO 2016 classification system that have undergone the greatest changes in paediatric tumours of the central nervous system, as well as to review the key histologic and clinical components of these entities. The greatest changes in classification were adopted in embryonal tumours and paediatric diffuse midline gliomas with histone H3 mutations, while low grade astrocytic and glioneuronal tumours also underwent important grading changes.
- Published
- 2016
12. A review of molecular alterations with clinical impact in adult and paediatric gliomas
- Author
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Suzanne Tucker and Sanda Alexandrescu
- Subjects
0301 basic medicine ,BRAF V600E ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Histology ,Neuropathology ,Biology ,Medical diagnosis ,Bioinformatics ,030217 neurology & neurosurgery ,World health ,Pathology and Forensic Medicine - Abstract
The practice of neuropathology underwent major changes due to the discovery of molecular alterations with diagnostic, prognostic, and therapeutic implications. Many of these alterations are incorporated in the updated 2016 edition of the World Health Organization (WHO) Classification of Tumours of the Central Nervous System (CNS), which represents a shift from the principle that neuropathology diagnosis is based entirely on microscopy. Molecularly defined entities were introduced, and a diagnosis that integrates the histology and molecular results is strongly recommended. This complex approach is timely because the neuro-oncologists seek specific diagnoses that can lead to more precise treatment. In the current review, we present the most common molecular alterations with known clinical implications in gliomas, and provide a practical guide to an integrated diagnosis.
- Published
- 2016
13. Longer lives and greater wealth: solutions to the gifting dilemma.
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Plybon, Suzanne Tucker and Ware, Jeremy T.
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Living trusts -- Usage ,Transfer taxes -- Management ,Estate planning -- Methods ,Company business management - Published
- 2008
14. Incidental cerebellar dermoid cyst mimicking low grade glioma in a teenager
- Author
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John R. Crawford, Sharon Wulfovich, Suzanne Tucker, and Michael J. Levy
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0301 basic medicine ,medicine.medical_specialty ,Adolescent ,Images In… ,030105 genetics & heredity ,03 medical and health sciences ,0302 clinical medicine ,Neuroimaging ,Cerebellum ,Concussion ,medicine ,Humans ,Medical history ,Family history ,Dermoid Cyst ,business.industry ,Neurooncology ,Glioma ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Cerebellar lesion ,Dermoid cyst ,Low-Grade Glioma ,Radiology ,business ,030217 neurology & neurosurgery - Abstract
A 16-year-old boy with no significant medical history or family history sustained a concussion after an altercation. CT revealed an incidental finding of a heavily mineralised left inferior paramedian cerebellar lesion demonstrating cystic components ([figure 1A][1]). MRI revealed minimal peripheral
- Published
- 2021
15. Two pediatric cases of ANCA-negative eosinophilic granulomatosis with polyangiitis successfully treated with dupilumab
- Author
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Praveen Akuthota, Matejka Cernelc-Kohan, Javan Nation, Jessica Galant-Swafford, Sydney Leibel, Suzanne Tucker, Akilah A. Jefferson, Robert Sheets, and Bob Geng
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medicine.medical_specialty ,business.industry ,Granulomatosis with Polyangiitis ,Churg-Strauss Syndrome ,Antibodies, Monoclonal, Humanized ,medicine.disease ,Dupilumab ,Dermatology ,Antibodies, Antineutrophil Cytoplasmic ,Eosinophilic ,medicine ,Humans ,Immunology and Allergy ,Anca negative ,Child ,Granulomatosis with polyangiitis ,business - Published
- 2020
16. Estate planning stragtegies for clients who wait until the last minute.
- Author
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Plybon, Suzanne Tucker and Robinson, James R.
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Estate planning -- Management ,Grantor trusts -- Laws, regulations and rules ,Employee benefits -- Laws, regulations and rules ,Individual retirement accounts -- Laws, regulations and rules - Abstract
The authors outline estate planning strategies that depend on the condition of the client or the client's survival for a specified term, such as grantor retained annuity trusts. Income tax considerations and planning with employee benefits and IRAs are also discussed.
- Published
- 2001
17. Estate planning for procrastinators: those who wait until the last minute.
- Author
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Plybon, Suzanne Tucker and Robinson, James R.
- Subjects
Estate planning -- Analysis ,Tax planning -- Analysis ,Gift tax -- Management ,Limited partnership -- Taxation - Abstract
Strategies for gaining tax savings advantages for clients facing diminished capacity or a terminal illness are outlined. Gift-tax-free gifts, split ownership of property, and familial limited partnerships are discussed.
- Published
- 2001
18. Hyaline Droplets in Kupffer Cells
- Author
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Antonio R. Perez-Atayde, Suzanne Tucker, and Maureen M. Jonas
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Adult ,Male ,Hyalin ,medicine.medical_specialty ,Pathology ,Adolescent ,Kupffer Cells ,H&E stain ,Autoimmune hepatitis ,Gastroenterology ,Pathology and Forensic Medicine ,Young Adult ,Lymphoplasmacytic Infiltrate ,Internal medicine ,Biopsy ,medicine ,Humans ,Child ,Hyaline ,Retrospective Studies ,Inclusion Bodies ,Hepatitis ,medicine.diagnostic_test ,business.industry ,Hepatitis B ,medicine.disease ,Immunohistochemistry ,eye diseases ,Hepatitis, Autoimmune ,Child, Preschool ,Immunoglobulin G ,Female ,Surgery ,Histopathology ,Anatomy ,business - Abstract
Pediatric autoimmune hepatitis (AIH) is relatively common and has a characteristic but relatively nonspecific histopathology with a usually prominent lymphoplasmacytic infiltrate. Herein, we describe for the first time the presence of characteristic hyaline droplets in the cytoplasm of Kupffer cells on routine hematoxylin and eosin (HE) sections in AIH. The medical records and pathologic material over a 20-year period (1992 to 2012) were reviewed from children with AIH (n=30), hepatitis B virus (n=30), and hepatitis C virus (n=30) from the pathology files at Boston Children's Hospital. All children had percutaneous needle liver biopsies. We reviewed sections stained with HE, PAS, and PAS with diastase for the presence of hyaline droplets in all 90 biopsies. We also performed immunohistochemical analysis for IgG, IgA, and IgD in 6 biopsies with AIH. Hyaline droplets were identified in Kupffer cells throughout the lobules in 15 of 30 biopsies (easily found in 13 and rare in 2); conversely, no droplets were identified in 15. Droplets were identified in 10 AIH type 1 biopsies, 1 in AIH type 2, 3 in overlap syndrome, and 1 in unclassified. Serum IgG levels, when available, were correlated with biopsy findings. Seventeen patients had serum IgG levels available for review. The average IgG level in patients without droplets in their biopsies was 1364 mg/dL, in contrast to 3424 mg/dL in patients with droplets (P=0.021). Immunohistochemical analysis performed in 6 biopsies revealed that droplets were nearly always positive for IgG, occasionally for IgA, and rarely for IgD. None of the biopsies in patients with hepatitis C contained hyaline droplets. One biopsy of a patient with hepatitis B revealed hyaline droplets; this biopsy had an unusually prominent plasmacytic infiltrate, and the patient was found to have an elevated IgG serum level and antibodies to smooth muscle actin. As far as we are aware, hyaline droplets in Kupffer cells on routine HE sections have never been described. They should be distinguished from the nonspecific granular lysosomal structures frequently found in Kupffer cells in a variety of chronic liver diseases and from erythrophagocytosis. Hyaline droplets may occur in AIH regardless of the type and correlate with a2-fold increase in serum level of IgG as compared with patients without droplets in their biopsies. Identification of hyaline droplets in Kupffer cells provides a useful diagnostic clue to distinguish AIH from other forms of chronic hepatitis.
- Published
- 2015
19. Estate planning with electing small business trusts.
- Author
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Plybon, Suzanne Tucker and Parker, Stephen E.
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Small business -- Taxation ,S corporations -- Taxation ,Trusts and trustees -- Laws, regulations and rules ,Estate planning -- Methods ,Small Business Job Protection Act of 1996 ,Internal Revenue Code (I.R.C. 1361) - Published
- 1997
20. Metastatic Cardiac Angiosarcoma to the Lung, Spine, and Brain: A Case Report and Review of the Literature
- Author
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Chih-Ta Lin, Katrina Ducis, Bruce I. Tranmer, and Suzanne Tucker
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Oncology ,Male ,medicine.medical_specialty ,Systemic disease ,Lung Neoplasms ,medicine.medical_treatment ,Central nervous system ,Hemangiosarcoma ,Metastasis ,Heart Neoplasms ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Angiosarcoma ,neoplasms ,Chemotherapy ,Lung ,Spinal Neoplasms ,business.industry ,Brain Neoplasms ,Middle Aged ,medicine.disease ,digestive system diseases ,Radiation therapy ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Surgery ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Brain metastasis - Abstract
Background Metastatic angiosarcoma to the brain is a rare entity without an established management protocol. Case Description A man with primary cardiac angiosarcoma presented with a rare brain metastasis. The patient underwent successful resection of the brain metastasis and was initiated on chemotherapy only for his systemic disease. The patient did not develop local recurrence. A review of primary and metastatic central nervous system angiosarcoma, its pathologic features, clinical disease course, treatment strategies, and genomics is also provided. Conclusions Angiosarcomas are rare tumors that are difficult to treat. Gross total resection of a central nervous system metastasis is recommended before initiation of adjuvant chemotherapy or radiation therapy. Close follow-up is still required given the propensity for continued metastasis of these tumors. Future treatments may be developed based on the genomics of angiosarcomas.
- Published
- 2017
21. Anaplastic pleomorphic xanthoastrocytoma with leptomeningeal dissemination responsive to BRAF inhibition and bevacizumab
- Author
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Susan R. Durham, Alan Homans, Carl J. Nelson, Alissa A. Thomas, Suzanne Tucker, and Joshua P. Nickerson
- Subjects
0301 basic medicine ,Bevacizumab ,business.industry ,Hematology ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Text mining ,Oncology ,Pediatrics, Perinatology and Child Health ,Mutation (genetic algorithm) ,medicine ,Cancer research ,Anaplastic pleomorphic xanthoastrocytoma ,business ,030217 neurology & neurosurgery ,medicine.drug - Published
- 2018
22. RARE-30. ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA WITH LEPTOMENINGEAL DISSEMINATION RESPONSIVE TO BRAF INHIBITION AND BEVACIZUMAB
- Author
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Joshua P. Nickerson, Suzanne Tucker, Alan Homans, Carl Nelson, Alissa Thomas, and Susan R Durham
- Subjects
Trametinib ,Pleomorphic xanthoastrocytoma ,Cancer Research ,Temozolomide ,Palliative care ,Bevacizumab ,business.industry ,Dabrafenib ,medicine.disease ,Abstracts ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,030220 oncology & carcinogenesis ,Glioma ,medicine ,Cancer research ,Neurology (clinical) ,business ,Leptomeningeal Neoplasm ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Anaplastic pleomorphic xanthoastrocytoma (PXA) is a newly recognized entity in the 2016 WHO classification of CNS tumors, characterized by elevated mitotic activity with or without necrosis, and shorter survival when compared with WHO grade II PXAs. BRAF V600E mutations are frequent. While grade II PXAs can often be managed surgically, there is no consensus on the optimal treatment for anaplastic PXA. Rarely, anaplastic PXA can present with leptomeningeal dissemination (LMD), which is associated with poor prognosis. We present a case of a 16-year-old girl diagnosed with a left frontal anaplastic PXA with BRAF V600E mutations and high grade features of necrosis. Following subtotal resection, cranial radiation, and temozolomide chemotherapy her tumor recurred with bulky, nodular LMD throughout the cervical, thoracic, and lumbar spine. She received palliative radiation to the thoracic spine and then started targeted therapy with dabrafenib with a partial radiographic response and then trametinib was added to dabrafenib with sustained response for 5 months. When the leptomeningeal tumor progressed, bevacizumab was added to the dabrafenib and trametinib therapy, and the patient remained stable for an additional 4 months. The combined therapy was very well tolerated; the patient experienced a grade II rash with initiation of dabrafenib, but no other side effects. To our knowledge this is the first time dabrafenib, trametinib, and bevacizumab have been combined to treat a pediatric high grade glioma. This is also the first report of BRAF inhibition in glial LMD. Our experience suggests that targeted therapy with dabrafenib and trametinib can be safely combined with anti-angiogenic therapy and may improve quality of life and survival in patients with LMD associated with high grade PXA. The growing experience with targeted therapy in rare pediatric gliomas may justify a need for a larger clinical trial.
- Published
- 2017
23. Urea transporter UT-A1 and aquaporin-2 proteins decrease in response to angiotensin II or norepinephrine-induced acute hypertension
- Author
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Brian P. Murrell, Suzanne Tucker, Janet D. Klein, Young-Hee Kim, and Jeff M. Sands
- Subjects
Male ,medicine.medical_specialty ,Hypertension, Renal ,Sodium-Potassium-Chloride Symporters ,Physiology ,Urea transporter ,Sodium ,Drinking ,chemistry.chemical_element ,Blood Pressure ,Spironolactone ,Rats, Sprague-Dawley ,Norepinephrine (medication) ,Norepinephrine ,chemistry.chemical_compound ,Internal medicine ,medicine ,Animals ,Urea ,Vasoconstrictor Agents ,Aldosterone ,Mineralocorticoid Receptor Antagonists ,Solute Carrier Family 12, Member 1 ,Kidney ,Aquaporin 2 ,biology ,urogenital system ,Chemistry ,Angiotensin II ,Membrane Transport Proteins ,Water ,Transporter ,Rats ,medicine.anatomical_structure ,Endocrinology ,Acute Disease ,biology.protein ,Thirst ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
The kidney responds to high levels of ANG II, as may occur during malignant hypertension, by increasing sodium and water excretion. To study whether kidney medullary transporters contribute to this response, rats were made hypertensive using ANG II. Within 3 days of being given ANG II, systolic blood pressure (BP) was increased (200 mmHg), vs control (130 mmHg), and remained high through day 14. Kidney inner medullary (IM) tip and base and outer medulla were analyzed for transporter protein abundance. There were significant decreases in UT-A1 urea transporter, aquaporin-2 (AQP2) water channel, and NKCC2/BSC1 Na+-K+-2Cl−cotransporter. To determine whether the decreases were a response to hypertension, ANG II, or an ANG II-induced increase in aldosterone, rats were given 1) norepinephrine (to increase BP) and 2) ANG II plus spironolactone (to block the mineralocorticoid receptor). Norepinephrine (7 days) increased BP, urine volume, sodium excretion, and decreased urine osmolality and UT-A1, AQP2, and NKCC2/BSC1 abundances, similar to ANG II. ANG II alone or with spironolactone yielded similar increases in BP, urine volume, and urine osmolality, and decreases in UT-A1 and AQP2 proteins in the IM tip. Plasma vasopressin was unaffected by treatment. Water diuresis did not change UT-A1 but decreased AQP2 and NKCC2/BSC1 abundances. We conclude that decreases in UT-A1, AQP2, and NKCC2/BSC1 proteins may contribute to the diuresis and natriuresis that occur following ANG II or norepinephrine-induced acute hypertension and do not appear to involve ANG II stimulation of aldosterone or thirst.
- Published
- 2006
24. EPID-29DURAL PRIMARY MARGINAL ZONE LYMPHOMA WITH LARGE B-CELLS PRESENT: A CASE REPORT AND REVIEW OF THE LITERATURE
- Author
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Suzanne Tucker and Christopher Trevino
- Subjects
Cancer Research ,Solitary fibrous tumor ,Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Marginal zone ,Lymphoma ,Meningioma ,Immunophenotyping ,Oncology ,Biopsy ,medicine ,Marginal zone B-cell lymphoma ,Neurology (clinical) ,Differential diagnosis ,business ,Abstracts from the 20th Annual Scientific Meeting of the Society for Neuro-Oncology - Abstract
A 64-year-old female presented with personality changes, acalculia, falls, headache and nausea. CT and MR imaging of the head revealed a homogeneously contrast-enhancing 7 cm x 4.4 cm x 4.4 cm right frontal dural-based mass, concerning for a meningioma. She underwent a right frontal craniotomy with complete resection. Post-operative pathology demonstrated sheets of lymphocytes and plasma cells with small numbers of germinal cells present. The infiltrate was limited to the dura and leptomeninges. Immunophenotype as demonstrated by immunohistochemistry and flow cytometry was diagnostic of an extranodal marginal zone lymphoma with extensive plasmacytic differentiation. Given the normal bone marrow biopsy and absence of disease on CT chest, abdomen, and pelvis, she was diagnosed with an extranodal primary dural-based marginal zone B-cell lymphoma (MZL) with plasmacytic differentiation. Primary dural lymphomas are a well-described subset of primary central nervous system (CNS) lymphomas that most commonly present as low grade lymphomas. MZLs generally carry a much better prognosis than typical diffuse large B-cell lymphomas. This case illustrates that hematopoietic malignancies should be considered in the differential diagnosis of dural based masses in addition to meningiomas or less common dural metastases, solitary fibrous tumors, leiomyosarcomas, and hemangiopericytomas. Typically dural based lymphomas have increased vasogenic edema compared to meningiomas. Unlike other extranodal MZLs, dural based MZLs have no strong association with chronic inflammatory conditions, infections, or immunosuppression. The literature supports that MLZs are very radiosensitive; with excision and low dose-localized radiation therapy, patients may remain disease free locally. However, systemic recurrence may occur, possibly because the dura is outside the blood brain barrier. Appropriate diagnosis is important as it has both prognostic and treatment implications.
- Published
- 2015
25. Embryonal (undifferentiated) sarcoma of the liver with peripheral angiosarcoma differentiation arising in a mesenchymal hamartoma in an adult patient
- Author
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Kumarasen Cooper, Suzanne Tucker, Sara Brownschidle, and Rebecca Wilcox
- Subjects
CD31 ,Pathology ,medicine.medical_specialty ,Hamartoma ,Liver Diseases ,Liver Neoplasms ,CD34 ,Sarcoma ,Biology ,medicine.disease ,Immunohistochemistry ,Pathology and Forensic Medicine ,Peripheral ,Sinusoid ,medicine ,Humans ,Surgery ,Angiosarcoma ,Female ,Anatomy ,Hyaline ,Aged - Abstract
Embryonal (undifferentiated) sarcoma of the liver (ESL) is a rare malignant neoplasm composed of undifferentiated sarcomatous tissue. We are presenting a case of a 74-year-old woman diagnosed with an ESL arising from a mesenchymal hamartoma of the liver (MHL). Both lesions occur typically in childhood, with only rare reported cases in adults. Histologically, the mass consisted primarily of loose myxoid stroma admixed with bland spindle cells and extensive, cystic (lymphangioma-like) degeneration. However, also present peripherally were markedly atypical cells (including multi-nucleated forms) and hyaline globules. Additionally, atypical cells with a sinusoid tectorial growth pattern were identified, which were positive for CD31, CD34 and Factor VIII. The tumor cells of ESL are classically described as being negative for tissue-specific immunohistochemical markers. However our case demonstrated focal positivity for vascular markers CD31, CD34 and Factor VIII and this along with the sinusoidal tectorial growth pattern, mimicked an angiosarcoma.
- Published
- 2011
26. Improving quality of care for mental illness in an uninsured, low-income primary care population
- Author
-
Randall Reitz, Suzanne Tucker, Joan Russo, Wayne Katon, Steve Hurd, and Larry B. Mauksch
- Subjects
Adult ,medicine.medical_specialty ,Population ,Underserved Population ,Psychiatric medication ,medicine ,Humans ,Psychiatry ,education ,Socioeconomic status ,Poverty ,Health policy ,Quality of Health Care ,education.field_of_study ,Medical Audit ,Medically Uninsured ,Primary Health Care ,business.industry ,Public health ,Mental Disorders ,Mental illness ,medicine.disease ,Mental health ,United States ,Psychiatry and Mental health ,Family medicine ,Female ,business - Abstract
We assessed if an ongoing, multifaceted quality improvement program improved mental health care in a low-income, uninsured primary care clinic.We reviewed the charts of 500 consecutive patients in 1999 and 500 consecutive patients in 2004 to compare the number of mental health visits; the percentage of patients with more than three follow-up visits; the percentage withor = 1 visit with a prescribing provider and the percentage with a psychiatric medication prescribed. We also assessed whether patients with more than one charted mental illness received more care than patients with one mental illness.Compared to 1999, patients in 2004 had significantly more visits in the first 120 days (acute phase) of treatment (3.16 vs. 4.81, P.001) and more visits in up to 9 months post acute phase (3.76 vs. 4.88, P.012). A higher percentage of patients in the acute phase (28.9% vs. 49.5%, P.001) had three follow-up visits, saw a medical provider and received a prescription. Patients with multiple charted mental illnesses had more visits than patients with one mental illness in 2004 but not in 1999 (P.001).An ongoing, multifaceted intervention improved the quality of mental health care in a primary care population with a high prevalence of mental illness.
- Published
- 2006
27. The content of a low-income, uninsured primary care population: including the patient agenda
- Author
-
Suzanne Tucker, Wayne Katon, Edward A. Walker, Larry B. Mauksch, Janet Cameron, and Joan Russo
- Subjects
Research design ,Biopsychosocial model ,Adult ,Male ,medicine.medical_specialty ,Adolescent ,Population ,Comorbidity ,Health Services Accessibility ,Surveys and Questionnaires ,medicine ,Odds Ratio ,Humans ,education ,Psychiatry ,Poverty ,education.field_of_study ,Health Services Needs and Demand ,Medically Uninsured ,Primary Health Care ,business.industry ,Public Health, Environmental and Occupational Health ,Middle Aged ,Mental illness ,medicine.disease ,Mental health ,Patient Health Questionnaire ,Mood ,Research Design ,Family medicine ,Florida ,Female ,Family Practice ,business - Abstract
Poor and uninsured people have increased risk of medical and psychiatric illness, but they might be more reluctant to seek care than those with higher incomes. Little information exists about the biopsychosocial problems and concerns of this population in primary care.We surveyed 500 consecutive patients (aged 18 to 64 years) in a primary care clinic serving only uninsured, low-income patients. We used self-report questions about why patients were coming to the clinic, a chronic illness questionnaire, the Primary Care Evaluation of Mental Disorders Patient Health Questionnaire, and items from the Childhood Trauma Questionnaire. Providers completed a questionnaire naming problems elicited from patients.Patients reported their most common chronic medical problems to be headaches, chronic back problems, and arthritis. The most common concerns patients wanted to discuss with providers and that providers elicited from patients were problems with mood. Compared with patients without current major mental illness, patients with a current major mental illness reported significantly (P.001) more concerns, chronic illnesses, stressors, forms of maltreatment and physical symptoms.The illness content of this uninsured, low-income population is dominated by emotional distress and physical pain. These needs place a serious burden on providers and can complicate management of chronic medical illnesses. Recommendations for specialized interview training and integrating mental health services are discussed.
- Published
- 2003
28. Improvement in Depressive Symptoms With Felbamate
- Author
-
Suzanne Tucker, Mahliqha Qasimyar, Ashish Sharma, and Jamie Drake
- Subjects
Psychiatry and Mental health ,medicine.medical_specialty ,business.industry ,Alternative medicine ,medicine ,Letters to the Editor ,business ,Psychiatry ,Depressive symptoms ,Felbamate ,medicine.drug - Published
- 2008
29. Diurnal migration and responses to simulated rainfall in desert soil microarthropods and nematodes
- Author
-
L. W. Parker, Walter G. Whitford, Suzanne Tucker, Diana W. Freckman, Ned Z. Elkins, Janice Phillips, and Rob Parmalee
- Subjects
Nematode ,Agronomy ,Moisture ,Simulated rainfall ,biology ,Abundance (ecology) ,Litter ,Soil Science ,Species diversity ,Plant litter ,biology.organism_classification ,Microbiology ,Water content - Abstract
Diurnal patterns of microarthropod abundance in surface leaf litter were related to its moisture content. Leaf litter moisture was nearly 7% by weight at 0800h but fell to less than 1% by mid-day. Oribatid and tydeid mites moved into litter in the early morning and back into the soil before mid-day. There were no significant differences in numbers of nematodes in litter or soil and 78–98% of the nematodes were anhydrobiotic (coiled) in soil and litter at all times sampled. Following simulated rainfall there were fewer microarthropods in litter at mid-day in the absence of marked decreases in soil and litter moisture content. During drying, there were gradual reductions in numbers and species diversity of litter microarthropods. Nematode numbers did not change as litter dried. Anhydrobiotic nematodes in the soil increased from 14% on day 1 to 85% on day 4. Between 24 and 36 h after simulated rainfall, the proportion of anhydrobiotic litter nematodes increased from 35 to 80%,. Within 1 h after simulated rainfall, there were marked increases in numbers and diversity of microarthropods in surface litter. No collembolans were extracted from dry litter controls but the wet litter was dominated by isotomid, sminthurid and onychiurid collembolans. There were increases in numbers and diversity of oribatid, tydeid and gamasid mites in the wet surface litter within l h after wetting compared to controls.
- Published
- 1981
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