4 results on '"Suzan Al Gburi"'
Search Results
2. Molecular mechanisms of vasculopathy and coagulopathy in COVID-19
- Author
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Claudia Günther, Stefan Beissert, and Suzan Al-Gburi
- Subjects
ARDS ,Lupus erythematosus ,business.industry ,Clinical Biochemistry ,COVID-19 ,medicine.disease ,Biochemistry ,Complement system ,Immune system ,Downregulation and upregulation ,Immunology ,medicine ,Coagulopathy ,Humans ,Respiratory system ,business ,Cytokine storm ,Molecular Biology ,Blood Coagulation - Abstract
COVID-19 primarily affects the respiratory system and may lead to severe systemic complications, such as acute respiratory distress syndrome (ARDS), multiple organ failure, cytokine storm, and thromboembolic events. Depending on the immune status of the affected individual early disease control can be reached by a robust type-I-interferon (type-I-IFN) response restricting viral replication. If type-I-IFN upregulation is impaired, patients develop severe COVID-19 that involves profound alveolitis, endothelitis, complement activation, recruitment of immune cells, as well as immunothrombosis. In patients with proper initial disease control there can be a second flare of type-I-IFN release leading to post-COVID manifestation such as chilblain-like lesions that are characterized by thrombosis of small vessels in addition to an inflammatory infiltrate resembling lupus erythematosus (LE). Mechanistically, SARS-CoV-2 invades pneumocytes and endothelial cells by acting on angiotensin-II-converting enzyme 2 (ACE2). It is hypothesized, that viral uptake might downregulate ACE2 bioavailability and enhance angiotensin-II-derived pro-inflammatory and pro-thrombotic state. Since ACE2 is encoded on the X chromosome these conditions might also be influenced by gender-specific regulation. Taken together, SARS-CoV-2 infection affects the vascular compartment leading to variable thrombogenic or inflammatory response depending on the individual immune response status.
- Published
- 2021
3. Sex-difference in expression and function of beta-adrenoceptors in macrovessels: role of the endothelium
- Author
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Irakli Kopaliani, Andreas Deussen, Henning Morawietz, Stephan R Künzel, Silvio Weber, Kristina Lorenz, Maria Cybularz, Suzan Al-Gburi, Birgit Zatschler, and Ali El-Armouche
- Subjects
Male ,0301 basic medicine ,Aging ,medicine.medical_specialty ,Endothelium ,Adrenergic receptor ,Physiology ,medicine.drug_class ,Adrenergic beta-Antagonists ,Adrenergic ,030204 cardiovascular system & hematology ,Biology ,Constriction ,Norepinephrine (medication) ,03 medical and health sciences ,0302 clinical medicine ,Rats, Inbred SHR ,Physiology (medical) ,medicine.artery ,Internal medicine ,Receptors, Adrenergic, beta ,medicine ,Animals ,Humans ,Aged ,Sex Characteristics ,Aorta ,Middle Aged ,Rats ,030104 developmental biology ,Endocrinology ,medicine.anatomical_structure ,Estrogen ,cardiovascular system ,Female ,Endothelium, Vascular ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Vasoconstriction ,medicine.drug - Abstract
Estrogen modulates adrenergic reactivity of macrovessels, resulting in weaker α-adrenergic vasoconstriction in females than males. However, the mechanisms governing this important sex-specific difference are not well understood. We hypothesized that vessels of females express more dilatory β-adrenoceptors, which counteract constrictive effects of α-adrenoceptors. This hypothesis was tested using aortas of normotensive (WKY) and hypertensive rats (SHR), along with human mammary artery. Selective blockade of β1 (CGP20712) or β3 (SR59230A), but not β2 (ICI118,551) adrenoceptors, greatly increased α-adrenergic constriction (norepinephrine) of aorta in female SHRs, but not in male SHRs at 12 weeks of age. Consistently, the selective β1/β2 (isoproterenol) and β3-adrenergic (BRL37344) relaxation was stronger in female SHRs than in males. Removal of endothelium and use of L-NMMA abolished sex-difference in α-adrenergic constriction and β-adrenergic relaxation. Immunostainings revealed endothelial localization of β1- and β3-adrenoceptors. mRNA levels of aortic β1- and β3-, but not β2-adrenoceptors were markedly higher in female than in male SHRs. The sex-specific differences in α-adrenergic constriction and β-adrenoceptor mRNA levels were age-dependent, predominantly present up to 29 weeks and disappeared at 36 weeks of age. The sex-specific difference was not strain-dependent and was similarly present in normotensive WKY rats. Human mammary artery of women showed a weaker α-adrenergic constriction than arteries of men. This sex-specific difference was prominent at 45–65 years and disappeared with aging. Our results convincingly demonstrate that female macrovessels express more dilatory β1- and β3-adrenoreceptors than male vessels with a predominant endothelial localization. This sex-specific difference is functionally relevant in young adults and is attenuated with aging.
- Published
- 2017
4. Sex-specific differences in age-dependent progression of aortic dysfunction and related cardiac remodeling in spontaneously hypertensive rats
- Author
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Roberta Galli, Anja Neisser, Suzan Al-Gburi, Bianca Müller, Birgit Zatschler, Michael H. Muders, Andreas Deussen, and Irakli Kopaliani
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Aging ,Physiology ,Cardiac fibrosis ,Aortic Diseases ,030204 cardiovascular system & hematology ,Rats, Inbred WKY ,Muscle hypertrophy ,03 medical and health sciences ,0302 clinical medicine ,Fibrosis ,Physiology (medical) ,Internal medicine ,medicine.artery ,Rats, Inbred SHR ,Renin–angiotensin system ,medicine ,Animals ,cardiovascular diseases ,Endothelial dysfunction ,Ventricular remodeling ,Aorta ,Sex Characteristics ,Ventricular Remodeling ,business.industry ,medicine.disease ,Rats ,030104 developmental biology ,Endocrinology ,Blood pressure ,Hypertension ,cardiovascular system ,Cardiology ,Disease Progression ,Female ,business - Abstract
Evidence of sex-specific differences in renin-angiotensin-system (RAS) and arterial pressure has been shown in many mammals, including spontaneously hypertensive rats (SHRs). Although SHRs have been used extensively as a leading experimental model of hypertension, the effects of sex-specific differences in RAS on aortic function and related cardiac remodeling during aging and hypertension have not been documented in detail. We examined structural and functional changes in aorta and heart of female and male SHRs at the ages of 5, 14, 29, and 36 wk. SHRs of both sexes were hypertensive from 14 wk. Aortic endothelial dysfunction and fibrosis, left ventricular (LV) hypertrophy, and cardiac fibrosis were evident at the age of 29 wk in male SHRs but first appeared only at the age of 36 wk in female SHRs. There was a pronounced delay of matrix metalloproteinase-2 activity in the aorta and heart of female SHRs, which was associated with preservation of 40% more elastin and less extensive cardiac fibrosis than in males. At 5, 29, and 36 wk of age, female SHRs showed higher levels of aortic and myocardial AT2R and MasR mRNA and decreased ANG II-mediated aortic constriction. Although female SHRs had increased relaxation to AT2R stimulation at 5 and 29 wk compared with males, this difference disappeared at 36 wk of age. This study documents sex-specific differences in the temporal progression of aortic dysfunction and LV hypertrophy in SHRs, which are independent of arterial pressure and are apparently mediated by higher AT2R expression in the heart and aorta of female SHRs.
- Published
- 2016
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