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1,266 results on '"Suttorp, Norbert"'

1. Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19

Author

Essex, Morgan, Millet Pascual-Leone, Belén, Löber, Ulrike, Kuhring, Mathias, Zhang, Bowen, Brüning, Ulrike, Fritsche-Guenther, Raphaela, Krzanowski, Marta, Fiocca Vernengo, Facundo, Brumhard, Sophia, Röwekamp, Ivo, Anna Bielecka, Agata, Lesker, Till Robin, Wyler, Emanuel, Landthaler, Markus, Mantei, Andrej, Meisel, Christian, Caesar, Sandra, Thibeault, Charlotte, Corman, Victor M., Marko, Lajos, Suttorp, Norbert, Strowig, Till, Kurth, Florian, Sander, Leif E., Li, Yang, Kirwan, Jennifer A., Forslund, Sofia K., and Opitz, Bastian

Published
2024
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3. Analysis of acute COVID-19 including chronic morbidity: protocol for the deep phenotyping National Pandemic Cohort Network in Germany (NAPKON-HAP)

Author

Steinbeis, Fridolin, Thibeault, Charlotte, Steinbrecher, Sarah, Ahlgrimm, Yvonne, Haack, Ira an, August, Dietrich, Balzuweit, Beate, Bellinghausen, Carla, Berger, Sarah, Chaplinskaya-Sobol, Irina, Cornely, Oliver, Doeblin, Patrick, Endres, Matthias, Fink, Claudia, Finke, Carsten, Frank, Sandra, Hanß, Sabine, Hartung, Tim, Hellmuth, Johannes Christian, Herold, Susanne, Heuschmann, Peter, Heyckendorf, Jan, Heyder, Ralf, Hippenstiel, Stefan, Hoffmann, Wolfgang, Kelle, Sebastian Ulrich, Knape, Philipp, Koehler, Philipp, Kretzler, Lucie, Leistner, David Manuel, Lienau, Jasmin, Lorbeer, Roberto, Lorenz-Depiereux, Bettina, Lüttke, Constanze Dorothea, Mai, Knut, Merle, Uta, Meyer-Arndt, Lil Antonia, Miljukov, Olga, Muenchhoff, Maximilian, Müller-Plathe, Moritz, Neuhann, Julia, Neuhauser, Hannelore, Nieters, Alexandra, Otte, Christian, Pape, Daniel, Pinto, Rafaela Maria, Pley, Christina, Pudszuhn, Annett, Reuken, Philipp, Rieg, Siegberg, Ritter, Petra, Rohde, Gernot, Rönnefarth, Maria, Ruzicka, Michael, Schaller, Jens, Schmidt, Anne, Schmidt, Sein, Schwachmeyer, Verena, Schwanitz, Georg, Seeger, Werner, Stahl, Dana, Stobäus, Nicole, Stubbe, Hans Christian, Suttorp, Norbert, Temmesfeld, Bettina, Thun, Sylvia, Triller, Paul, Trinkmann, Frederik, Vadasz, Istvan, Valentin, Heike, Vehreschild, Maria, von Kalle, Christof, von Lilienfeld-Toal, Marie, Weber, Joachim, Welte, Tobias, Wildberg, Christian, Wizimirski, Robert, Zvork, Saskia, Sander, Leif Erik, Vehreschild, Janne, Zoller, Thomas, Kurth, Florian, and Witzenrath, Martin

Published
2024
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6. Genetic Regulation of Cytokine Response in Patients with Acute Community-acquired Pneumonia

Author

Kühnapfel, Andreas, Horn, Katrin, Klotz, Ulrike, Kiehntopf, Michael, Rosolowski, Maciej, Loeffler, Markus, Ahnert, Peter, Suttorp, Norbert, Witzenrath, Martin, and Scholz, Markus

Subjects
Quantitative Biology - Quantitative Methods, Statistics - Applications
Abstract

Background: Community-acquired pneumonia (CAP) is an acute disease condition with a high risk of rapid deteriorations. We analysed the influence of genetics on cytokine regulation to obtain a better understanding of patient's heterogeneity. Methods: For up to N=389 genotyped participants of the PROGRESS study of hospitalised CAP patients, we performed a genome-wide association study of ten cytokines IL-1b, IL-6, IL-8, IL-10, IL-12, MCP-1 (MCAF), MIP-1a (CCL3), VEGF, VCAM-1, and ICAM-1. Consecutive secondary analyses were performed to identify independent hits and corresponding causal variants. Results: 102 SNPs from 14 loci showed genome-wide significant associations with five of the cytokines. The most interesting associations were found at 6p21.1 for VEGF (p=1.58x10E-20), at 17q21.32 (p=1.51x10E-9) and at 10p12.1 (p=2.76x10E-9) for IL-1b, at 10p13 for MIP-1a (CCL3) (p=2.28x10E-9), and at 9q34.12 for IL-10 (p=4.52x10E-8). Functionally plausible genes could be assigned to the majority of loci including genes involved in cytokine secretion, granulocyte function, and cilial kinetics. Conclusions: This is the first context-specific genetic association study of blood cytokine concentrations in CAP patients revealing numerous biologically plausible candidate genes. Two of the loci were also associated with atherosclerosis with probable common or consecutive pathomechanisms.

Published
2021

7. The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation

Author

Knoll, Rainer, Helbig, Elisa T., Dahm, Kilian, Bolaji, Olufemi, Hamm, Frederik, Dietrich, Oliver, van Uelft, Martina, Müller, Sophie, Bonaguro, Lorenzo, Schulte-Schrepping, Jonas, Petrov, Lev, Krämer, Benjamin, Kraut, Michael, Stubbemann, Paula, Thibeault, Charlotte, Brumhard, Sophia, Theis, Heidi, Hack, Gudrun, De Domenico, Elena, Nattermann, Jacob, Becker, Matthias, Beyer, Marc D., Hillus, David, Georg, Philipp, Loers, Constantin, Tiedemann, Janina, Tober-Lau, Pinkus, Lippert, Lena, Millet Pascual-Leone, Belén, Tacke, Frank, Rohde, Gernot, Suttorp, Norbert, Witzenrath, Martin, Saliba, Antoine-Emmanuel, Ulas, Thomas, Polansky, Julia K., Sawitzki, Birgit, Sander, Leif E., Schultze, Joachim L., Aschenbrenner, Anna C., and Kurth, Florian

Published
2024
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8. ADAM8 signaling drives neutrophil migration and ARDS severity

Author

Conrad, Catharina, Yildiz, Daniela, Cleary, Simon J, Margraf, Andreas, Cook, Lena, Schlomann, Uwe, Panaretou, Barry, Bowser, Jessica L, Karmouty-Quintana, Harry, Li, Jiwen, Berg, Nathaniel K, Martin, Samuel C, Aljohmani, Ahmad, Moussavi-Harami, S Farshid, Wang, Kristin M, Tian, Jennifer J, Magnen, Mélia, Valet, Colin, Qiu, Longhui, Singer, Jonathan P, Eltzschig, Holger K, Bertrams, Wilhelm, Herold, Susanne, Suttorp, Norbert, Schmeck, Bernd, Ball, Zachary T, Zarbock, Alexander, Looney, Mark R, and Bartsch, Jörg W

Subjects
Acute Respiratory Distress Syndrome, Rare Diseases, Pneumonia, Lung, 2.1 Biological and endogenous factors, Aetiology, Respiratory, ADAM Proteins, Animals, Antigens, CD, Cells, Cultured, Disease Models, Animal, Gene Expression Regulation, Humans, Male, Membrane Proteins, Mice, Mice, Inbred C57BL, Microscopy, Confocal, RNA, Respiratory Distress Syndrome, CAPSys Study Group, Inflammation, Innate immunity, Neutrophils, Proteases, Pulmonology
Abstract

Acute respiratory distress syndrome (ARDS) results in catastrophic lung failure and has an urgent, unmet need for improved early recognition and therapeutic development. Neutrophil influx is a hallmark of ARDS and is associated with the release of tissue-destructive immune effectors, such as matrix metalloproteinases (MMPs) and membrane-anchored metalloproteinase disintegrins (ADAMs). Here, we observed using intravital microscopy that Adam8-/- mice had impaired neutrophil transmigration. In mouse pneumonia models, both genetic deletion and pharmacologic inhibition of ADAM8 attenuated neutrophil infiltration and lung injury while improving bacterial containment. Unexpectedly, the alterations of neutrophil function were not attributable to impaired proteolysis but resulted from reduced intracellular interactions of ADAM8 with the actin-based motor molecule Myosin1f that suppressed neutrophil motility. In 2 ARDS cohorts, we analyzed lung fluid proteolytic signatures and identified that ADAM8 activity was positively correlated with disease severity. We propose that in acute inflammatory lung diseases such as pneumonia and ARDS, ADAM8 inhibition might allow fine-tuning of neutrophil responses for therapeutic gain.

Published
2022

9. Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01

Author

Weiner, January, Suwalski, Phillip, Holtgrewe, Manuel, Rakitko, Alexander, Thibeault, Charlotte, Müller, Melina, Patriki, Dimitri, Quedenau, Claudia, Krüger, Ulrike, Ilinsky, Valery, Popov, Iaroslav, Balnis, Joseph, Jaitovich, Ariel, Helbig, Elisa T, Lippert, Lena J, Stubbemann, Paula, Real, Luis M, Macías, Juan, Pineda, Juan A, Fernandez-Fuertes, Marta, Wang, Xiaomin, Karadeniz, Zehra, Saccomanno, Jacopo, Doehn, Jan-Moritz, Hübner, Ralf-Harto, Hinzmann, Bernd, Salvo, Mauricio, Blueher, Anja, Siemann, Sandra, Jurisic, Stjepan, Beer, Juerg H, Rutishauser, Jonas, Wiggli, Benedikt, Schmid, Hansruedi, Danninger, Kathrin, Binder, Ronald, Corman, Victor M, Mühlemann, Barbara, Arkal, Rao Arjun, Fragiadakis, Gabriela K, Mick, Eran, COMET, Consortium, Calfee, Carolyn S, Erle, David J, Hendrickson, Carolyn M, Kangelaris, Kirsten N, Krummel, Matthew F, Woodruff, Prescott G, Langelier, Charles R, Venkataramani, Urmila, García, Federico, Zyla, Joanna, Drosten, Christian, Alice, Braun, Jones, Terry C, Suttorp, Norbert, Witzenrath, Martin, Hippenstiel, Stefan, Zemojtel, Tomasz, Skurk, Carsten, Poller, Wolfgang, Borodina, Tatiana, Pa-COVID, Study Group, Ripke, Stephan, Sander, Leif E, Beule, Dieter, Landmesser, Ulf, Guettouche, Toumy, Kurth, Florian, and Heidecker, Bettina

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Coronaviruses, Emerging Infectious Diseases, Human Genome, Clinical Research, Infectious Diseases, Genetics, 2.1 Biological and endogenous factors, 2.5 Research design and methodologies (aetiology), Good Health and Well Being, SARS-CoV-2, COVID-19, Human Leukocyte Antigen&nbsp, intubation, Human Leukocyte Antigen, Clinical sciences, Health services and systems, Public health
Abstract

BackgroundSince the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there has been increasing urgency to identify pathophysiological characteristics leading to severe clinical course in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human leukocyte antigen alleles (HLA) have been suggested as potential genetic host factors that affect individual immune response to SARS-CoV-2. We sought to evaluate this hypothesis by conducting a multicenter study using HLA sequencing.MethodsWe analyzed the association between COVID-19 severity and HLAs in 435 individuals from Germany (n = 135), Spain (n = 133), Switzerland (n = 20) and the United States (n = 147), who had been enrolled from March 2020 to August 2020. This study included patients older than 18 years, diagnosed with COVID-19 and representing the full spectrum of the disease. Finally, we tested our results by meta-analysing data from prior genome-wide association studies (GWAS).FindingsWe describe a potential association of HLA-C*04:01 with severe clinical course of COVID-19. Carriers of HLA-C*04:01 had twice the risk of intubation when infected with SARS-CoV-2 (risk ratio 1.5 [95% CI 1.1-2.1], odds ratio 3.5 [95% CI 1.9-6.6], adjusted p-value = 0.0074). These findings are based on data from four countries and corroborated by independent results from GWAS. Our findings are biologically plausible, as HLA-C*04:01 has fewer predicted bindings sites for relevant SARS-CoV-2 peptides compared to other HLA alleles.InterpretationHLA-C*04:01 carrier state is associated with severe clinical course in SARS-CoV-2. Our findings suggest that HLA class I alleles have a relevant role in immune defense against SARS-CoV-2.FundingFunded by Roche Sequencing Solutions, Inc.

Published
2021

10. Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study

Author

Lingscheid, Tilman, Lippert, Lena J., Hillus, David, Kruis, Tassilo, Thibeault, Charlotte, Helbig, Elisa T., Tober-Lau, Pinkus, Pfäfflin, Frieder, Müller-Redetzky, Holger, Witzenrath, Martin, Zoller, Thomas, Uhrig, Alexander, Opitz, Bastian, Suttorp, Norbert, Kramer, Tobias S., Sander, Leif E., Stegemann, Miriam S., and Kurth, Florian

Published
2022
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11. Early and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodies

Author

Akbil, Bengisu, Meyer, Tim, Stubbemann, Paula, Thibeault, Charlotte, Staudacher, Olga, Niemeyer, Daniela, Jansen, Jenny, Mühlemann, Barbara, Doehn, Jan, Tabeling, Christoph, Nusshag, Christian, Hirzel, Cédric, Sanchez, David Sökler, Nieters, Alexandra, Lother, Achim, Duerschmied, Daniel, Schallner, Nils, Lieberum, Jan Nikolaus, August, Dietrich, Rieg, Siegbert, Falcone, Valeria, Hengel, Hartmut, Kölsch, Uwe, Unterwalder, Nadine, Hübner, Ralf-Harto, Jones, Terry C., Suttorp, Norbert, Drosten, Christian, Warnatz, Klaus, Spinetti, Thibaud, Schefold, Joerg C., Dörner, Thomas, Sander, Leif Erik, Corman, Victor M., Merle, Uta, Kurth, Florian, von Bernuth, Horst, Meisel, Christian, and Goffinet, Christine

Published
2022
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12. Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19 convalescents

Author

Steinbeis, Fridolin, Knape, Philipp, Mittermaier, Mirja, Helbig, Elisa Theresa, Tober-Lau, Pinkus, Thibeault, Charlotte, Lippert, Lena Johanna, Xiang, Weiwei, Müller-Plathe, Moritz, Steinbrecher, Sarah, Meyer, Hans-Jakob, Ring, Raphaela Maria, Ruwwe-Glösenkamp, Christoph, Alius, Florian, Li, Yaosi, Müller-Redetzky, Holger, Uhrig, Alexander, Lingscheid, Tilman, Grund, Daniel, Temmesfeld-Wollbrück, Bettina, Suttorp, Norbert, Sander, Leif Erik, Kurth, Florian, Witzenrath, Martin, and Zoller, Thomas

Published
2022
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13. Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19

Author

Dannebaum, Richard, Suwalski, Phillip, Asgharian, Hosseinali, Du Zhipei, Gracie, Lin, Hai, Weiner, January, 3rd, Holtgrewe, Manuel, Thibeault, Charlotte, Müller, Melina, Wang, Xiaomin, Karadeniz, Zehra, Saccomanno, Jacopo, Doehn, Jan-Moritz, Hübner, Ralf-Harto, Hinzmann, Bernd, Blüher, Anja, Siemann, Sandra, Telman, Dilduz, Suttorp, Norbert, Witzenrath, Martin, Hippenstiel, Stefan, Skurk, Carsten, Poller, Wolfgang, Sander, Leif E, Beule, Dieter, Kurth, Florian, Guettouche, Toumy, Landmesser, Ulf, Berka, Jan, Luong, Khai, Rubelt, Florian, and Heidecker, Bettina

Published
2022
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14. Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus

Author

Bertrams, Wilhelm, Hönzke, Katja, Obermayer, Benedikt, Tönnies, Mario, Bauer, Torsten T., Schneider, Paul, Neudecker, Jens, Rückert, Jens C., Stiewe, Thorsten, Nist, Andrea, Eggeling, Stephan, Suttorp, Norbert, Wolff, Thorsten, Hippenstiel, Stefan, Schmeck, Bernd, and Hocke, Andreas C.

Published
2022
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15. Human alveolar progenitors generate dual lineage bronchioalveolar organoids

Author

Hoffmann, Karen, Obermayer, Benedikt, Hönzke, Katja, Fatykhova, Diana, Demir, Zeynep, Löwa, Anna, Alves, Luiz Gustavo Teixeira, Wyler, Emanuel, Lopez-Rodriguez, Elena, Mieth, Maren, Baumgardt, Morris, Hoppe, Judith, Firsching, Theresa C., Tönnies, Mario, Bauer, Torsten T., Eggeling, Stephan, Tran, Hong-Linh, Schneider, Paul, Neudecker, Jens, Rückert, Jens C., Gruber, Achim D., Ochs, Matthias, Landthaler, Markus, Beule, Dieter, Suttorp, Norbert, Hippenstiel, Stefan, Hocke, Andreas C., and Kessler, Mirjana

Published
2022
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17. Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months

Author

Steinbeis, Fridolin, Thibeault, Charlotte, Doellinger, Felix, Ring, Raphaela Maria, Mittermaier, Mirja, Ruwwe-Glösenkamp, Christoph, Alius, Florian, Knape, Philipp, Meyer, Hans-Jakob, Lippert, Lena Johanna, Helbig, Elisa Theresa, Grund, Daniel, Temmesfeld-Wollbrück, Bettina, Suttorp, Norbert, Sander, Leif Erik, Kurth, Florian, Penzkofer, Tobias, Witzenrath, Martin, and Zoller, Thomas

Published
2022
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18. Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study

Author

Al-Rim, Ben, Bardtke, Lara, Beheim-Schwarzbach, Jörn Ilmo, Behn, Kerstin, Bergfeld, Leon, Bethke, Norma, Bleicker, Tobias, Briesemeister, Dana, Brumhard, Sophia, Conrad, Claudia, Dieckmann, Sebastian, Frey, Doris, Gabelich, Julie-Anne, Georg, Philipp, Gläser, Ute, Hasler, Lisbeth, Hetey, Andreas, Hiller, Anna Luisa, Horn, Alexandra, Hülso, Claudia, Kegel, Luisa, Koch, Willi, Krannich, Alexander, Kroneberg, Paolo, Lisy, Michelle, Mackeldanz, Petra, Maeß, Birgit, Münn, Friederike, Olk, Nadine, Peiser, Christian, Pohl, Kai, Hermel, Annelie, Rönnefarth, Maria, Rubisch, Carolin, Sanchez Rezza, Angela, Schellenberger, Isabelle, Schenkel, Viktoria, Schlesinger, Jenny, Schmidt, Sein, Schwanitz, Georg, Sinnigen, Anne-Sophie, Stubbemann, Paula, Tesch, Julia, Treue, Denise, Wendisch, Daniel, Zvorc, Saskia, Hillus, David, Schwarz, Tatjana, Tober-Lau, Pinkus, Vanshylla, Kanika, Hastor, Hana, Thibeault, Charlotte, Jentzsch, Stefanie, Helbig, Elisa T, Lippert, Lena J, Tscheak, Patricia, Schmidt, Marie Luisa, Riege, Johanna, Solarek, André, von Kalle, Christof, Dang-Heine, Chantip, Gruell, Henning, Kopankiewicz, Piotr, Suttorp, Norbert, Drosten, Christian, Bias, Harald, Seybold, Joachim, Klein, Florian, Kurth, Florian, Corman, Victor Max, and Sander, Leif Erik

Published
2021
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19. Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01

Author

Weiner, January, 3rd, Suwalski, Phillip, Holtgrewe, Manuel, Rakitko, Alexander, Thibeault, Charlotte, Müller, Melina, Patriki, Dimitri, Quedenau, Claudia, Krüger, Ulrike, Ilinsky, Valery, Popov, Iaroslav, Balnis, Joseph, Jaitovich, Ariel, Helbig, Elisa T, Lippert, Lena J, Stubbemann, Paula, Real, Luis M, Macías, Juan, Pineda, Juan A, Fernandez-Fuertes, Marta, Wang, Xiaomin, Karadeniz, Zehra, Saccomanno, Jacopo, Doehn, Jan-Moritz, Hübner, Ralf-Harto, Hinzmann, Bernd, Salvo, Mauricio, Blueher, Anja, Siemann, Sandra, Jurisic, Stjepan, Beer, Juerg H., Rutishauser, Jonas, Wiggli, Benedikt, Schmid, Hansruedi, Danninger, Kathrin, Binder, Ronald, Corman, Victor M, Mühlemann, Barbara, Arjun Arkal, Rao, Fragiadakis, Gabriela K., Mick, Eran, COMET, Consortium, Calfee, Carolyn S., Erle, David J., Hendrickson, Carolyn M., Kangelaris, Kirsten N., Krummel, Matthew F., Woodruff, Prescott G., Langelier, Charles R., Venkataramani, Urmila, García, Federico, Zyla, Joanna, Drosten, Christian, Alice, Braun, Jones, Terry C, Suttorp, Norbert, Witzenrath, Martin, Hippenstiel, Stefan, Zemojtel, Tomasz, Skurk, Carsten, Poller, Wolfgang, Borodina, Tatiana, Pa-COVID, Study Group, Ripke, Stephan, Sander, Leif E, Beule, Dieter, Landmesser, Ulf, Guettouche, Toumy, Kurth, Florian, and Heidecker, Bettina

Published
2021
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21. A time-resolved proteomic and prognostic map of COVID-19

Author

Kleinschmidt, Malte, Heim, Katrin M., Millet, Belén, Meyer-Arndt, Lil, Hübner, Ralf H., Andermann, Tim, Doehn, Jan M., Opitz, Bastian, Sawitzki, Birgit, Grund, Daniel, Radünzel, Peter, Schürmann, Mariana, Zoller, Thomas, Alius, Florian, Knape, Philipp, Breitbart, Astrid, Li, Yaosi, Bremer, Felix, Pergantis, Panagiotis, Schürmann, Dirk, Temmesfeld-Wollbrück, Bettina, Wendisch, Daniel, Brumhard, Sophia, Haenel, Sascha S., Conrad, Claudia, Georg, Philipp, Eckardt, Kai-Uwe, Lehner, Lukas, Kruse, Jan M., Ferse, Carolin, Körner, Roland, Spies, Claudia, Edel, Andreas, Weber-Carstens, Steffen, Krannich, Alexander, Zvorc, Saskia, Li, Linna, Behrens, Uwe, Schmidt, Sein, Rönnefarth, Maria, Dang-Heine, Chantip, Röhle, Robert, Lieker, Emma, Kretzler, Lucie, Wirsching, Isabelle, Wollboldt, Christian, Wu, Yinan, Schwanitz, Georg, Hillus, David, Kasper, Stefanie, Olk, Nadine, Horn, Alexandra, Briesemeister, Dana, Treue, Denise, Hummel, Michael, Corman, Victor M., Drosten, Christian, von Kalle, Christof, Demichev, Vadim, Tober-Lau, Pinkus, Lemke, Oliver, Nazarenko, Tatiana, Thibeault, Charlotte, Whitwell, Harry, Röhl, Annika, Freiwald, Anja, Szyrwiel, Lukasz, Ludwig, Daniela, Correia-Melo, Clara, Aulakh, Simran Kaur, Helbig, Elisa T., Stubbemann, Paula, Lippert, Lena J., Grüning, Nana-Maria, Blyuss, Oleg, Vernardis, Spyros, White, Matthew, Messner, Christoph B., Joannidis, Michael, Sonnweber, Thomas, Klein, Sebastian J., Pizzini, Alex, Wohlfarter, Yvonne, Sahanic, Sabina, Hilbe, Richard, Schaefer, Benedikt, Wagner, Sonja, Mittermaier, Mirja, Machleidt, Felix, Garcia, Carmen, Ruwwe-Glösenkamp, Christoph, Lingscheid, Tilman, Bosquillon de Jarcy, Laure, Stegemann, Miriam S., Pfeiffer, Moritz, Jürgens, Linda, Denker, Sophy, Zickler, Daniel, Enghard, Philipp, Zelezniak, Aleksej, Campbell, Archie, Hayward, Caroline, Porteous, David J., Marioni, Riccardo E., Uhrig, Alexander, Müller-Redetzky, Holger, Zoller, Heinz, Löffler-Ragg, Judith, Keller, Markus A., Tancevski, Ivan, Timms, John F., Zaikin, Alexey, Hippenstiel, Stefan, Ramharter, Michael, Witzenrath, Martin, Suttorp, Norbert, Lilley, Kathryn, Mülleder, Michael, Sander, Leif Erik, Ralser, Markus, and Kurth, Florian

Published
2021
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22. Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany

Author

Schwarz, Tatjana, Tober-Lau, Pinkus, Hillus, David, Helbig, Elisa T., Lippert, Lena J., Thibeault, Charlotte, Koch, Willi, Landgraf, Irmgard, Michel, Janine, Bergfeld, Leon, Niemeyer, Daniela, Muhlemann, Barbara, Conrad, Claudia, Dang-Heine, Chantip, Kasper, Stefanie, Munn, Friederike, Kappert, Kai, Nitsche, Andreas, Tauber, Rudolf, Schmidt, Sein, Kopankiewicz, Piotr, Bias, Harald, Seybold, Joachim, von Kalle, Christof, Jones, Terry C., Suttorp, Norbert, Drosten, Christian, Sander, Leif Erik, Corman, Victor M., and Kurth, Florian

Subjects
Antigen-antibody reactions -- Health aspects, Aged patients -- Care and treatment, T cells -- Health aspects, Immune response -- Health aspects, Health
Abstract

We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in [...]

Published
2021
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23. Outbreak of SARS-CoV-2 B.1.1.7 Lineage after Vaccination in Long-Term Care Facility, Germany, February-March 2021

Author

Tober-Lau, Pinkus, Schwarz, Tatjana, Hillus, David, Spieckermann, Jana, Helbig, Elisa T., Lippert, Lena J., Thibeault, Charlotte, Koch, Willi, Bergfeld, Leon, Niemeyer, Daniela, Muhlemann, Barbara, Conrad, Claudia, Kasper, Stefanie, Munn, Friederike, Kunitz, Frank, Jones, Terry C., Suttorp, Norbert, Drosten, Christian, Sander, Leif Erik, Kurth, Florian, and Corman, Victor M.

Subjects
Vaccination -- Patient outcomes, Epidemics -- Risk factors -- Demographic aspects -- Control -- Germany, Long-term care facilities -- Management -- Safety and security measures, Company business management, Health
Abstract

One week after second vaccinations were administered, an outbreak of B.1.1.7 lineage severe acute respiratory syndrome coronavirus 2 infections occurred in a long-term care facility in Berlin, Germany, affecting 16/20 [...]

Published
2021
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24. Critical Illness and Systemic Inflammation Are Key Risk Factors of Severe Acute Kidney Injury in Patients With COVID-19

Author

Hardenberg, Jan-Hendrik B., Stockmann, Helena, Aigner, Annette, Gotthardt, Inka, Enghard, Philipp, Hinze, Christian, Balzer, Felix, Schmidt, Danilo, Zickler, Daniel, Kruse, Jan, Körner, Roland, Stegemann, Miriam, Schneider, Thomas, Schumann, Michael, Müller-Redetzky, Holger, Angermair, Stefan, Budde, Klemens, Weber-Carstens, Steffen, Witzenrath, Martin, Treskatsch, Sascha, Siegmund, Britta, Spies, Claudia, Suttorp, Norbert, Rauch, Geraldine, Eckardt, Kai-Uwe, and Schmidt-Ott, Kai M.

Published
2021
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25. CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity

Author

Doehn, Jan-Moritz, Tabeling, Christoph, Biesen, Robert, Saccomanno, Jacopo, Madlung, Elena, Pappe, Eva, Gabriel, Frieder, Kurth, Florian, Meisel, Christian, Corman, Victor M., Hanitsch, Leif G., Treskatsch, Sascha, Heim, Kathrin, Stegemann, Miriam S., Ruwwe-Glösenkamp, Christoph, Müller-Redetzky, Holger C., Uhrig, Alexander, Somasundaram, Rajan, Spies, Claudia, von Bernuth, Horst, Hofmann, Jörg, Drosten, Christian, Suttorp, Norbert, Witzenrath, Martin, Sander, Leif E., and Hübner, Ralf-Harto

Published
2021
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26. Cross-Variant Neutralizing Serum Activity after SARS-CoV-2 Breakthrough Infections

Author

Tober-Lau, Pinkus, Gruell, Henning, Vanshylla, Kanika, Koch, Willi M., Hillus, David, Schommers, Philipp, Suarez, Isabelle, Suttorp, Norbert, Sander, Leif Erik, Klein, Florian, and Kurth, Florian

Subjects
Health
Abstract

The B.1.1.529 (Omicron) variant of concern of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries a high number of nonsynonymous mutations in the spike glycoprotein, relative to that of the [...]

Published
2022
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27. Evaluation of PEEP and prone positioning in early COVID-19 ARDS

Author

Mittermaier, Mirja, Pickerodt, Philipp, Kurth, Florian, de Jarcy, Laure Bosquillon, Uhrig, Alexander, Garcia, Carmen, Machleidt, Felix, Pergantis, Panagiotis, Weber, Susanne, Li, Yaosi, Breitbart, Astrid, Bremer, Felix, Knape, Philipp, Dewey, Marc, Doellinger, Felix, Weber-Carstens, Steffen, Slutsky, Arthur S., Kuebler, Wolfgang M., Suttorp, Norbert, and Müller-Redetzky, Holger

Published
2020
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28. Pemetrexed-Based Chemotherapy Is Inferior to Pemetrexed-Free Regimens in Thyroid Transcription Factor 1 (TTF-1)-Negative, EGFR/ALK-Negative Lung Adenocarcinoma: A Propensity Score Matched Pairs Analysis

Author

Frost, Nikolaj, Zhamurashvili, Tamar, von Laffert, Maximilian, Klauschen, Frederick, Ruwwe-Glösenkamp, Christoph, Raspe, Matthias, Brunn, Matthias, Ochsenreither, Sebastian, Temmesfeld-Wollbrück, Bettina, Suttorp, Norbert, Grohé, Christian, and Witzenrath, Martin

Published
2020
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31. Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

Author

Nouailles, Geraldine, Wyler, Emanuel, Pennitz, Peter, Postmus, Dylan, Vladimirova, Daria, Kazmierski, Julia, Pott, Fabian, Dietert, Kristina, Muelleder, Michael, Farztdinov, Vadim, Obermayer, Benedikt, Wienhold, Sandra-Maria, Andreotti, Sandro, Hoefler, Thomas, Sawitzki, Birgit, Drosten, Christian, Sander, Leif E., Suttorp, Norbert, Ralser, Markus, Beule, Dieter, Gruber, Achim D., Goffinet, Christine, Landthaler, Markus, Trimpert, Jakob, and Witzenrath, Martin

Published
2021
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32. SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Author

Braun, Julian, Loyal, Lucie, Frentsch, Marco, Wendisch, Daniel, Georg, Philipp, Kurth, Florian, Hippenstiel, Stefan, Dingeldey, Manuela, Kruse, Beate, Fauchere, Florent, Baysal, Emre, Mangold, Maike, Henze, Larissa, Lauster, Roland, Mall, Marcus A., Beyer, Kirsten, Röhmel, Jobst, Voigt, Sebastian, Schmitz, Jürgen, Miltenyi, Stefan, Demuth, Ilja, Müller, Marcel A., Hocke, Andreas, Witzenrath, Martin, Suttorp, Norbert, Kern, Florian, Reimer, Ulf, Wenschuh, Holger, Drosten, Christian, Corman, Victor M., Giesecke-Thiel, Claudia, Sander, Leif Erik, and Thiel, Andreas

Published
2020
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33. COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

Author

Chua, Robert Lorenz, Lukassen, Soeren, Trump, Saskia, Hennig, Bianca P., Wendisch, Daniel, Pott, Fabian, Debnath, Olivia, Thürmann, Loreen, Kurth, Florian, Völker, Maria Theresa, Kazmierski, Julia, Timmermann, Bernd, Twardziok, Sven, Schneider, Stefan, Machleidt, Felix, Müller-Redetzky, Holger, Maier, Melanie, Krannich, Alexander, Schmidt, Sein, Balzer, Felix, Liebig, Johannes, Loske, Jennifer, Suttorp, Norbert, Eils, Jürgen, Ishaque, Naveed, Liebert, Uwe Gerd, von Kalle, Christof, Hocke, Andreas, Witzenrath, Martin, Goffinet, Christine, Drosten, Christian, Laudi, Sven, Lehmann, Irina, Conrad, Christian, Sander, Leif-Erik, and Eils, Roland

Published
2020
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34. Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19)

Author

Kurth, Florian, Roennefarth, Maria, Thibeault, Charlotte, Corman, Victor M., Müller-Redetzky, Holger, Mittermaier, Mirja, Ruwwe-Glösenkamp, Christoph, Heim, Katrin M., Krannich, Alexander, Zvorc, Saskia, Schmidt, Sein, Kretzler, Lucie, Dang-Heine, Chantip, Rose, Matthias, Hummel, Michael, Hocke, Andreas, Hübner, Ralf H., Opitz, Bastian, Mall, Marcus A., Röhmel, Jobst, Landmesser, Ulf, Pieske, Burkert, Knauss, Samuel, Endres, Matthias, Spranger, Joachim, Mockenhaupt, Frank P., Tacke, Frank, Treskatsch, Sascha, Angermair, Stefan, Siegmund, Britta, Spies, Claudia, Weber-Carstens, Steffen, Eckardt, Kai-Uwe, Schürmann, Dirk, Uhrig, Alexander, Stegemann, Miriam S., Zoller, Thomas, Drosten, Christian, Suttorp, Norbert, Witzenrath, Martin, Hippenstiel, Stefan, von Kalle, Christof, and Sander, Leif Erik

Published
2020
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36. Preclinical analyses reveal spleen tyrosine kinase as regulator of pulmonary vasoconstriction

Author

Tabeling, Christoph, primary, Herbert, Julia, additional, Boiarina, Ekaterina, additional, Hocke, Andreas C., additional, Danov, Olga, additional, Sewald, Katherina, additional, Gutbier, Birgitt, additional, Russ, Martin, additional, Pickerodt, Philipp A., additional, Spies, Claudia, additional, Li, Mei, additional, Michalick, Laura, additional, Scheffel, Jörg, additional, Maurer, Marcus, additional, Fehrenbach, Heinz, additional, Suttorp, Norbert, additional, Braun, Armin, additional, Weissmann, Norbert, additional, Kuebler, Wolfgang M., additional, and Witzenrath, Martin, additional

Published
2023
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39. Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies

Author

Rabes, Anne, Suttorp, Norbert, Opitz, Bastian, Compans, Richard W, Series editor, Honjo, Tasuku, Series editor, Oldstone, Michael B. A., Series editor, Vogt, Peter K., Series editor, Malissen, Bernard, Series editor, Aktories, Klaus, Series editor, Kawaoka, Yoshihiro, Series editor, Rappuoli, Rino, Series editor, Galan, Jorge E., Series editor, Ahmed, Rafi, Series editor, Palme, Klaus, Series editor, Casadevall, Arturo, Series editor, and Backert, Steffen, editor

Published
2016
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42. Hepatobiliary long-term consequences of COVID-19: dramatically increased rate of secondary sclerosing cholangitis in critically ill COVID-19 patients.

Author

Leonhardt, Silke, Jürgensen, Christian, Frohme, Josephine, Grajecki, Donata, Adler, Andreas, Sigal, Michael, Leonhardt, Julia, Voll, Julian M., Kruse, Jan Matthias, Körner, Roland, Eckardt, Kai-Uwe, Janssen, Hans-Joachim, Gebhardt, Volker, Schmittner, Marc D., Pa-COVID-19 collaborative study group, Hippenstiel, Stefan, Witzenrath, Martin, Suttorp, Norbert, Helbig, Elisa T., and Lippert, Lena J.

Abstract

Background: Increasing evidence suggests that secondary sclerosing cholangitis (SSC), which can lead to cirrhosis or liver failure, may be a hepatobiliary long-term complication of COVID-19. The aim of this study was to estimate the frequency and outcome of this COVID-19 sequela and to identify possible risk factors. Methods: This observational study, conducted at University Hospital Charité Berlin and Unfallkrankenhaus Berlin, Germany, involved hospitalized patients with COVID-19 pneumonia, including 1082 ventilated COVID-19 patients. We compared COVID-19 patients who developed SSC with a COVID-19 control group by univariate and multivariate analyses. Results: SSC occurrence after COVID-19 was observed exclusively in critically ill patients with invasive ventilation, albeit with extreme clustering among them. One in every 43 invasively ventilated COVID-19 patients developed this complication. Risk factors preceding the development of secondary sclerosing cholangitis in critically ill COVID-19 patients (SSC-CIP) were signs of systemic reduced blood oxygen supply (e.g., low PaO2/FiO2, ischemic organ infarctions), multi-organ failure (high SOFA score) at admission, high fibrinogen levels and intravenous ketamine use. Multivariate analysis confirmed fibrinogen and increased plasma lactate dehydrogenase as independent risk factors associated with cholangiopathy onset. The 1-year transplant-free survival rate of COVID-19-associated SSC-CIP was 40%. Conclusions: COVID-19 causes SSC-CIP in a substantial proportion of critically ill patients. SSC-CIP most likely develops due to severe tissue hypoxia and fibrinogen-associated circulatory disturbances. A significant increase of patients with SSC-CIP is to be expected in the post-COVID era. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis

Author

Müller-Redetzky, Holger, Kellermann, Ute, Wienhold, Sandra-Maria, Gutbier, Birgitt, Lienau, Jasmin, Hellwig, Katharina, Reppe, Katrin, Letsiou, Eleftheria, Tschernig, Thomas, Scholz, Markus, Ahnert, Peter, Maasch, Christian, Hoehlig, Kai, Klussmann, Sven, Vater, Axel, Firsching, Theresa C., Hoppe, Judith, Suttorp, Norbert, and Witzenrath, Martin

Published
2020
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45. Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia

Author

Robak, Oliver H., Heimesaat, Markus M., Kruglov, Andrey A., Prepens, Sandra, Ninnemann, Justus, Gutbier, Birgitt, Reppe, Katrin, Hochrein, Hubertus, Suter, Mark, Kirschning, Carsten J., Marathe, Veena, Buer, Jan, Hornef, Mathias W., Schnare, Markus, Schneider, Pascal, Witzenrath, Martin, Bereswill, Stefan, Steinhoff, Ulrich, Suttorp, Norbert, Sander, Leif E., Chaput, Catherine, and Opitz, Bastian

Subjects
Pseudomonas aeruginosa infections -- Drug therapy -- Risk factors, Intensive care units -- Management, Microbiota (Symbiotic organisms) -- Research, Antibiotics -- Usage -- Dosage and administration, Immunoglobulin A -- Health aspects, Pneumonia -- Risk factors -- Diagnosis -- Care and treatment -- Research, Company business management, Health care industry
Abstract

Broad-spectrum antibiotics are widely used with patients in intensive care units (ICUs), many of whom develop hospital- acquired infections with Pseudomonas aeruginosa. Although preceding antimicrobial therapy is known as a major risk factor for P. aeruginosa-induced pneumonia, the underlying mechanisms remain incompletely understood. Here we demonstrate that depletion of the resident microbiota by broad-spectrum antibiotic treatment inhibited TLR-dependent production of a proliferation-inducing ligand (APRIL), resulting in a secondary IgA deficiency in the lung in mice and human ICU patients. Microbiota-dependent local IgA contributed to early antibacterial defense against P. aeruginosa. Consequently, P. aeruginosa-binding IgA purified from lamina propria culture or IgA hybridomas enhanced resistance of antibiotic-treated mice to P. aeruginosa infection after transnasal substitute. Our study provides a mechanistic explanation for the welldocumented risk of P. aeruginosa infection following antimicrobial therapy, and we propose local administration of IgA as a novel prophylactic strategy., Introduction National and international point-prevalence studies show that 64%-71% of all patients in intensive care units (ICUs) receive antibiotics (1, 2) and up to 10%-51% suffer from hospital-acquired infections (HAIs) [...]

Published
2018
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46. Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses

Author

Ugolini, Matteo, Gerhard, Jenny, Burkert, Sanne, Jensen, Kristoffer Jarlov, Georg, Philipp, Ebner, Friederike, Volkers, Sarah M., Thada, Shruthi, Dietert, Kristina, Bauer, Laura, Schäfer, Alexander, Helbig, Elisa T., Opitz, Bastian, Kurth, Florian, Sur, Saubashya, Dittrich, Nickel, Gaddam, Sumanlatha, Conrad, Melanie L., Benn, Christine S., Blohm, Ulrike, Gruber, Achim D., Hutloff, Andreas, Hartmann, Susanne, Boekschoten, Mark V., Müller, Michael, Jungersen, Gregers, Schumann, Ralf R., Suttorp, Norbert, and Sander, Leif E.

Published
2018
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47. Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients

Author

Asmus, Erik, primary, Karle, Weronika, additional, Brack, Markus C., additional, Wittig, Corey, additional, Behrens, Felix, additional, Reinshagen, Leander, additional, Pfeiffer, Moritz, additional, Schulz, Sabrina, additional, Mandzimba-Maloko, Bertina, additional, Erfinanda, Lasti, additional, Perret, Paul L., additional, Michalick, Laura, additional, Smeele, Patrick J., additional, Lim, Endry H.T., additional, van den Brom, Charissa E., additional, Vonk, Alexander B.A., additional, Kaiser, Toralf, additional, Suttorp, Norbert, additional, Hippenstiel, Stefan, additional, Sander, Leif E., additional, Kurth, Florian, additional, Rauch, Ursula, additional, Landmesser, Ulf, additional, Haghikia, Arash, additional, Preissner, Robert, additional, Bogaard, Harm J., additional, Witzenrath, Martin, additional, Kuebler, Wolfgang M., additional, Szulcek, Robert, additional, and Simmons, Szandor, additional

Published
2023
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48. Cenicriviroc for the treatment of COVID-19: first interim results of a randomised, placebo-controlled, investigator-initiated, double-blind phase II trial

Author

Kurth, Florian, primary, Helbig, Elisa T., additional, Lippert, Lena J., additional, Thibeault, Charlotte, additional, Barbone, Gianluca, additional, Eckart, Marius A., additional, Kluge, Martin, additional, Puengel, Tobias, additional, Demir, Münevver, additional, Röhle, Robert, additional, Keller, Theresa, additional, Ruwwe-Glösenkamp, Christoph, additional, Witzenrath, Martin, additional, Suttorp, Norbert, additional, von Kalle, Christof, additional, Sander, Leif E., additional, Jochum, Christoph, additional, and Tacke, Frank, additional

Published
2023
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49. A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection

Author

Parameswarappa, Sharavathi Guddehalli, Reppe, Katrin, Geissner, Andreas, Ménová, Petra, Govindan, Subramanian, Calow, Adam D.J., Wahlbrink, Annette, Weishaupt, Markus W., Monnanda, Bopanna Ponnappa, Bell, Roland Lawrence, Pirofski, Liise-Anne, Suttorp, Norbert, Sander, Leif Erik, Witzenrath, Martin, Pereira, Claney Lebev, Anish, Chakkumkal, and Seeberger, Peter H.

Published
2016
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