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1. Ten‐Year Outcome of Recanalization or Medical Therapy for Concomitant Chronic Total Occlusion After Myocardial Infarction

Author

van Veelen, Anna, primary, Coerkamp, Casper F., additional, Somsen, Yvemarie B.O., additional, Råmunddal, Truls, additional, Ioanes, Dan, additional, Laanmets, Peep, additional, van der Schaaf, René J., additional, Eriksen, Erlend, additional, Bax, Matthijs, additional, Suttorp, Maarten Jan, additional, Strauss, Bradley H., additional, Barbato, Emanuele, additional, Marques, Koen M., additional, Meuwissen, Martijn, additional, Bertrand, Olivier, additional, van der Ent, Martin, additional, Knaapen, Paul, additional, Tijssen, Jan G.P., additional, Claessen, Bimmer E.P.M., additional, Hoebers, Loes P.C., additional, Elias, Joëlle, additional, Henriques, José P.S., additional, Henriques, J.P.S., additional, Piek, J.J., additional, de Winter, R.J., additional, Koch, K.T., additional, Vis, M.M., additional, Baan, J., additional, Wykrzykowska, J., additional, Marques, K.M., additional, Meuwissen, M., additional, Koolen, J., additional, Bax, M., additional, Schotborgh, C.E., additional, van der Ent, M., additional, van der Schaaf, R.J., additional, Slagboom, T., additional, Amoroso, G., additional, Suttorp, M.J., additional, Råmunddal, T., additional, Ioanes, D., additional, Laanmets, P., additional, Eriksen, E., additional, Tuseth, V., additional, Strauss, B.H., additional, Bertrand, O., additional, and Barbato, E., additional

Published
2024
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2. TCT-417 10-Year Clinical Outcomes After Randomization to PCI of a Concurrent Chronic Total Coronary Occlusion or Optimal Medical Therapy Alone in Patients with STEMI: Extended Follow-Up of the EXPLORE Trial

Author

van Veelen, Anna, primary, Coerkamp, Casper, additional, Elias, Joëlle, additional, Somsen, Yvemarie, additional, Laanmets, Peep, additional, Van der Schaaf, René, additional, Eriksen, Erlend, additional, Bax, Matthijs, additional, Suttorp, Maarten Jan, additional, Strauss, Bradley, additional, Barbato, Emanuele, additional, Meuwissen, Martijn, additional, Knaapen, Paul, additional, Hoebers, Loes, additional, Claessen, Bimmer, additional, and Henriques, Jose, additional

Published
2023
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5. Multivessel Coronary Revascularization in Patients With and Without Diabetes Mellitus: 3-Year Follow-Up of the ARTS-II (Arterial Revascularization Therapies Study–Part II) Trial

Author

Daemen, Joost, Kuck, Karl Heinz, Macaya, Carlos, LeGrand, Victor, Vrolix, Maarten, Carrie, Didier, Sheiban, Imad, Suttorp, Maarten Jan, Vranckx, Pascal, Rademaker, Tessa, Goedhart, Dick, Schuijer, Monique, Wittebols, Kristel, Macours, Nathalie, Stoll, Hans Peter, and Serruys, Patrick W.

Published
2008
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7. Cytomegalovirus and Chlamydia pneumoniae as predictors for adverse events and angina pectoris after percutaneous coronary intervention

Author

Rahel, Braim, M., Visseren, Frank, L.J., Suttorp, Maarten-Jan, Plokker, H.W., Kelder, Johannes C., de Jongh, Bartelt M., Diepersloot, Rob J.A., Verkooyen, Roel P.A.J., and Bouter, K. Paul

Subjects
Heart attack -- Risk factors, Angina pectoris -- Risk factors, Chlamydia -- Physiological aspects, Cytomegaloviruses -- Physiological aspects, Health
Published
2004

8. A randomized trial assessing the effect of coumarins started before coronary angioplasty on restenosis: Results of the 6-month angiographic substudy of the Balloon Angioplasty and anticoagulation study (BAAS)

Author

Berg, Jurrien M. ten, Kelder, Johannes C., Suttorp, Maarten Jan, Verheugt, Freek W. A., and Plokker, H. W. Thijs

Subjects
Anticoagulants (Medicine) -- Research, Transluminal angioplasty -- Patient outcomes, Transluminal angioplasty -- Research, Coumarins -- Research, Coumarins -- Patient outcomes, Health
Published
2003

15. Percutaneous coronary intervention versus coronary artery bypass grafting in patients with three-vessel or left main coronary artery disease: 10-year follow-up of the multicentre randomised controlled SYNTAX trial

Author

Thuijs, Daniel J F M, primary, Kappetein, A Pieter, additional, Serruys, Patrick W, additional, Mohr, Friedrich-Wilhelm, additional, Morice, Marie-Claude, additional, Mack, Michael J, additional, Holmes, David R, additional, Curzen, Nick, additional, Davierwala, Piroze, additional, Noack, Thilo, additional, Milojevic, Milan, additional, Dawkins, Keith D, additional, da Costa, Bruno R, additional, Jüni, Peter, additional, Head, Stuart J, additional, Casselman, Filip, additional, de Bruyne, Bernard, additional, Høj Christiansen, Evald, additional, Ruiz-Nodar, Juan M., additional, Vermeersch, Paul, additional, Schultz, Werner, additional, Sabaté, Manel, additional, Guagliumi, Giulio, additional, Grubitzsch, Herko, additional, Stangl, Karl, additional, Darremont, Olivier, additional, Bentala, M., additional, den Heijer, Peter, additional, Preda, Istvan, additional, Stoler, Robert, additional, Mack, Michael J., additional, Szerafin, Tamás, additional, Buckner, John K., additional, Guber, Myles S., additional, Verberkmoes, Niels, additional, Akca, Ferdi, additional, Feldman, Ted, additional, Beyersdorf, Friedhelm, additional, Drieghe, Benny, additional, Oldroyd, Keith, additional, Berg, Geoff, additional, Jeppsson, Anders, additional, Barber, Kimberly, additional, Wolschleger, Kevin, additional, Heiser, John, additional, van der Harst, Pim, additional, Mariani, Massimo A., additional, Reichenspurner, Hermann, additional, Stark, Christoffer, additional, Laine, Mika, additional, Ho, Paul C., additional, Chen, John C., additional, Zelman, Richard, additional, Horwitz, Phillip A., additional, Bochenek, Andrzej, additional, Krauze, Agata, additional, Grothusen, Christina, additional, Dudek, Dariusz, additional, Heyrich, George, additional, Kolh, Philippe, additional, LeGrand, Victor, additional, Coelho, Pedro, additional, Ensminger, Stephan, additional, Nasseri, Boris, additional, Ingemansson, Richard, additional, Olivecrona, Goran, additional, Escaned, Javier, additional, Guera, Reddy, additional, Berti, Sergio, additional, Chieffo, Alaide, additional, Burke, Nicholas, additional, Mooney, Michael, additional, Spolaor, Alvise, additional, Hagl, Christian, additional, Näbauer, Michael, additional, Suttorp, Maarten Jan, additional, Stine, Ronald A., additional, McGarry, Thomas, additional, Lucas, Scott, additional, Endresen, Knut, additional, Taussig, Andrew, additional, Accola, Kevin, additional, Canosi, Umberto, additional, Horvath, Ivan, additional, Cannon, Louis, additional, Talbott, John D., additional, Akins, Chris W., additional, Kramer, Robert, additional, Aschermann, Michael, additional, Killinger, William, additional, Narbute, Inga, additional, Holmes, David R., additional, Burzotta, Francesco, additional, Bogers, Ad, additional, Zijlstra, Felix, additional, Eltchaninoff, Helene, additional, Berland, Jacques, additional, Stefanini, Giulio, additional, Cruz Gonzalez, Ignacio, additional, Hoppe, Uta, additional, Kiesz, Stefan, additional, Gora, Bartlomiej, additional, Ahlsson, Anders, additional, Corbascio, Matthias, additional, Bilfinger, Thomas, additional, Carrie, Didier, additional, Tchétché, Didier, additional, Hauptman, Karl-Eugen, additional, Stahle, Elisabeth, additional, James, Stefan, additional, Sandner, Sigrid, additional, Laufer, Günther, additional, Lang, Irene, additional, Witkowski, Adam, additional, Thourani, Vinod, additional, Suryapranata, Harry, additional, Redwood, Simon, additional, Knight, Charles, additional, MacCarthy, Philip, additional, de Belder, Adam, additional, Banning, Adrian, additional, and Gershlick, Anthony, additional

Published
2019
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18. Long-term impact of chronic total occlusion recanalisation in patients with ST-elevation myocardial infarction

Author

Elias, Joëlle, primary, van Dongen, Ivo M, additional, Råmunddal, Truls, additional, Laanmets, Peep, additional, Eriksen, Erlend, additional, Meuwissen, Martijn, additional, Michels, H Rolf, additional, Bax, Matthijs, additional, Ioanes, Dan, additional, Suttorp, Maarten Jan, additional, Strauss, Bradley H, additional, Barbato, Emanuele, additional, Marques, Koen M, additional, Claessen, Bimmer E P M, additional, Hirsch, Alexander, additional, van der Schaaf, René J, additional, Tijssen, Jan G P, additional, Henriques, José P S, additional, and Hoebers, Loes P, additional

Published
2018
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19. Initial experience with therapeutic geometric modification of the carotid bulb for true resistant hypertension

Author

Habib Najibullah, A S Van der Heyden Jan, K Mahmoodi Bakhtawar, C Bates Mark, Suttorp Maarten Jan, W Bos Willem Jan, and C Tromp Selma

Subjects
medicine.medical_specialty, Baroreceptor, Pulsatile flow, Resistant hypertension, Drug Resistance, Blood Pressure, Electric Stimulation Therapy, Pressoreceptors, Carotid sinus nerve, Prosthesis Design, Mechanotransduction, Cellular, Carotid bulb, Prosthesis Implantation, Internal medicine, Medicine, Humans, cardiovascular diseases, Antihypertensive Agents, business.industry, Baroreflex, Middle Aged, Surgery, Radiography, Blood pressure, Carotid Sinus, Implantable Neurostimulators, Treatment Outcome, nervous system, Hypertension, cardiovascular system, Cardiology, Female, Implant, Cardiology and Cardiovascular Medicine, business
Abstract

The contribution of carotid baroreceptor feedback in preventing or potentially contributing to the essential hypertensive cascade is poorly understood. It is clear the carotid sinus nerve action potentials are triggered by carotid bulb stretch rather than pressure and are only sustained during pulsatile increases in pressure. In addition, the carotid baroreceptor negative feedback is gradually extinguished in hypertension patients (a phenomenon known as "resetting"). We report a case of significant reduction in blood pressure in a patient with true resistant hypertension after change in the carotid bulb pulsatile strain patterns following the implant of an intravascular prosthesis.

Published
2015

22. The effect of revascularization of a chronic total coronary occlusion on electrocardiographic variables. A sub-study of the EXPLORE trial.

Author

van Dongen, Ivo M., Kolk, Maarten Z.H., Elias, Joëlle, Meijborg, Veronique M.F., Coronel, Ruben, de Bakker, Jacques M.T., Claessen, Bimmer E.P.M., Delewi, Ronak, Ouweneel, Dagmar M., Scheunhage, Esther M., van der Schaaf, René J., Suttorp, Maarten-Jan, Bax, Matthijs, Marques, Koen M., Postema, Pieter G., Wilde, Arthur A.M., Henriques, José P.S., Elias, Joëlle, van der Schaaf, René J, and Henriques, José P S

Abstract

Introduction: Chronic total coronary occlusions (CTOs) have been associated with a higher prevalence of ventricular arrhythmias compared to patients without a CTO. We evaluated the effect of CTO revascularization on electrocardiographic (ECG) variables.Methods: We studied a selection of ST-elevation myocardial infarction patients with a concomitant CTO enrolled in the EXPLORE trial. ECG variables and cardiac function were analysed at baseline and at 4 months follow-up.Results: Patients were randomized to percutaneous coronary intervention (PCI) of their CTO (n = 77) or to no-CTO PCI (n = 81). At follow-up, median QT dispersion was significantly lower in the CTO PCI group compared to the no-CTO PCI group (46 ms [33-58] vs. 54 ms [37-68], P = 0.043). No independent association was observed between ECG variables and cardiac function.Conclusion: Revascularization of a CTO after STEMI significantly shortened QT dispersion at 4 months follow-up. These findings support the hypothesis that CTO revascularization reduces the pro-arrhythmic substrate in CTO patients. [ABSTRACT FROM AUTHOR]

Published
2018
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23. Arterial occlusion after repetitive angio-seal device closure

Author

Broek, Theo van den, Lung, Paul F. Liqui, Suttorp, Maarten-Jan, Eefting, Frank D., Schipper, Marguerite E.I., and Vink, Aryan

Subjects
Arterial catheterization -- Usage, Femoral artery -- Diseases, Arteries -- Stenosis, Arteries -- Case studies, Arteries -- Diagnosis, Blood vessels -- Surgery, Blood vessels -- Methods, Blood vessels -- Usage, Health
Published
2007

24. Long-Term Clinical Outcome After a First Angiographically Confirmed Coronary Stent Thrombosis

Author

van Werkum, Jochem W., primary, Heestermans, Antonius A.C.M., additional, de Korte, Fleur I., additional, Kelder, Johannes C., additional, Suttorp, Maarten-Jan, additional, Rensing, Benno J.W.M., additional, Zwart, Bastiaan, additional, Brueren, B. R. Guus, additional, Koolen, Jacques J., additional, Dambrink, Jan-Henk E., additional, van't Hof, Arnoud W.J., additional, Verheugt, Freek W.A., additional, and ten Berg, Jurriën M., additional

Published
2009
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27. Carotid Angioplasty and Stent Placement: Comparison of Transcranial Doppler US Data and Clinical Outcome with and without Filtering Cerebral Protection Devices in 509 Patients

Author

Vos, Jan Albert, primary, van den Berg, Jos C., additional, Ernst, Sjef M. P. G., additional, Suttorp, Maarten Jan, additional, Overtoom, Timotheus T. C., additional, Mauser, Henk W., additional, Vogels, Oscar J. M., additional, van Heesewijk, Hans P. M., additional, Moll, Frans L., additional, van der Graaf, Yolanda, additional, Mali, Willem P. T., additional, and Ackerstaff, Rob G. A., additional

Published
2005
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34. Combined assessment of technetium-99m SESTAMIBI planar myocardial perfusion images at rest and during exercise with rest/exercise left ventricular wall motion studies evaluated from gated myocardial perfusion studies

Author

Verzijlbergen, J.Fred, primary, Suttorp, Maarten Jan, additional, Ascoop, Carl A.P.L., additional, Zwinderman, Aelko H., additional, Niemeyer, Menco G., additional, van der Wall, Ernst E., additional, and Pauwels, Ernest K.J., additional

Published
1992
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35. Preprocedural serum levels of acute-phase reactants and prognosis after percutaneous coronary intervention

Author

Rahel, Braim M., Visseren, Frank L.J., Suttorp, Maarten-Jan, Plokker, Thijs H.W., Kelder, Johannes C., de Jongh, Bartelt M., Bouter, K. Paul, and Diepersloot, Rob J.A.

Subjects
CORONARY disease, FIBRINOGEN, CORONARY restenosis
Abstract

Objective: In this study we evaluate the value of baseline concentrations of acute-phase reactants on prognosis after percutaneous coronary intervention (PCI). Methods: Blood samples were drawn immediately before PCI to measure baseline concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), lipoprotein(a) (Lp(a)), and fibrinogen. Follow-up data were collected at 8 months. Repeat PCI, CABG, myocardial infarction, and death were recorded as major adverse clinical events (MACE). Furthermore the recurrence of angina pectoris was noted. Results: The study included 600 consecutive patients after a successful PCI. Sixty-four percent of the patients were stented. The mean age was 61.6 years and 68.9% were male. CRP levels were significantly higher in patients who were to have repeat angina as compared with those who were not (P=0.0322). IL-6 levels were not correlated with angina or MACE. Lp(a) and fibrinogen concentrations were both significantly related to MACE (P=0.0337 and P=0.0253, respectively). Conclusion: Our study clearly supports the role of inflammation in restenosis after PCI as measured in statistically higher levels of Lp(a) and fibrinogen in patients with MACE and CRP in patients with repeat angina. [Copyright &y& Elsevier]

Published
2003
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36. Provisional stenting in the real world: results in 1058 consecutive patients undergoing percutaneous coronary angioplasty.

Author

ten Berg, Jurriën M, Kelder, Johannes C, Suttorp, Maarten Jan, and Plokker, Thijs HW

Subjects
TRANSLUMINAL angioplasty, SURGICAL stents, CORONARY heart disease surgery
Abstract

OBJECTIVE: To study a strategy of aggressive coronary balloon angioplasty with provisional stenting in allcomers. In randomized trials, stenting has improved the outcome of patients undergoing coronary intervention. However, whether these results hold up in clinical practice is largely unknown. Furthermore, the results of balloon angioplasty have also improved dramatically. It is therefore essential to evaluate the current results of balloon angioplasty and to assess whether stents are required in all patients. METHODS: The authors prospectively studied the occurrence of death, myocardial infarction (MI) and target lesion revascularization (TLR) of a large consecutive group of patients undergoing aggressive balloon angioplasty with provisional stenting. None of the patients received a platelet glycoprotein IIb/IIIa receptor blocker. The results were compared with the outcome of routine stenting in recent randomized trials. RESULTS: Angioplasty was performed in 1058 patients of whom 369 (34.9%) received a stent. The angiographic success rate was 98.9%. During hospital stay, 4.8% of the patients suffered any cardiac event. At one-year follow-up, death occurred in 1.1%, MI in 3.3%, TLR in 12.4% and any event in 16.7% of the patients. Event-free survival at one-year was 82.3%. These results compare favorably with routine stenting in recent trials. CONCLUSIONS: Aggressive balloon angioplasty with provisional stenting yields excellent results in a general patient population. [ABSTRACT FROM AUTHOR]

Published
2001
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37. Percutaneous transcatheter closure of atrial septal defects: initial single-centre experience and follow-up results. Initial experience with three-dimensional echocardiography.

Author

Ridder, Serge De, Suttorp, Maarten-Jan, Ernst, Sjef M.P.G., Six1, Jacob A., Mannaerts, Herman F.J., Kamp, Otto, Plokker, Thijs H.W.M., and Jaarsma1, Wybren

Abstract

Objective— Registry to report our single-centre experience in closing defects of the atrial septum.Methods— Between 1996 and 2001, transcatheter device closure of significant atrial septal defects was performed in 32 adults (mean age 45.1 years, range from 15 to 76 years), using different device types. Six patients had a patent foramen ovale (PFO) and 26 patients had a secundum atrial septal defect (ASD II). Defects were selected by means of two-dimensional transoesophageal echocardiography (2D TOE). For 12 defects additional three-dimensional transoesophageal echocardiography (3D TOE) was performed.Results— Mean balloon-stretched diameter was 19.3 mm (range from 11 to 24 mm). A device was successfully placed in all PFO patients (100%) without complications at follow-up. Successful immediate device placement occurred in 24 out of 26 ASD patients.Two immediate placement failures, 1 device embolisation and 1 device non-fixation, occurred and required urgent surgery. There was 1 patient with pericardial effusion after the intervention, requiring pericardiocentesis. Three late placement failures occurred: 2 device embolisations and 1 device dislocation. Clinical success after 3 to 6 months follow-up, defined as the absence of shunt or small shunt, was achieved in all 6 PFO patients and in 21 out of 23 ASD patients (1 device embolisation, requiring surgery, occurred before follow-up was completed).Two patients with significant shunt, 1 late device dislocation and 1 late device embolisation, underwent elective surgery. For patient selection, 3D TOE proved useful in the evaluation of large and/or complex defects.Conclusion— Transcatheter device closure of carefully selected atrial septal defects is an alternative to surgery. Although the results are promising, surgical back-up is often needed.

Published
2005
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38. Provisional stenting in the real world: results in 1058 consecutive patients undergoing percutaneous coronary angioplasty

Author

Berg, Jurriën M ten, Kelder, Johannes, Suttorp, Maarten Jan, and Plokker, Thijs HW

Abstract

OBJECTIVE: To study a strategy of aggressive coronary balloon angioplasty with provisional stenting in allcomers. In randomized trials, stenting has improved the outcome of patients undergoing coronary intervention. However, whether these results hold up in clinical practice is largely unknown. Furthermore, the results of balloon angioplasty have also improved dramatically. It is therefore essential to evaluate the current results of balloon angioplasty and to assess whether stents are required in all patients. METHODS: The authors prospectively studied the occurrence of death, myocardial infarction (MI) and target lesion revascularization (TLR) of a large consecutive group of patients undergoing aggressive balloon angioplasty with provisional stenting. None of the patients received a platelet glycoprotein IIb/IIIa receptor blocker. The results were compared with the outcome of routine stenting in recent randomized trials. RESULTS: Angioplasty was performed in 1058 patients of whom 369 (34.9%) received a stent. The angiographic success rate was 98.9%. During hospital stay, 4.8% of the patients suffered any cardiac event. At one-year follow-up, death occurred in 1.1%, MI in 3.3%, TLR in 12.4% and any event in 16.7% of the patients. Event-free survival at one-year was 82.3%. These results compare favorably with routine stenting in recent trials. CONCLUSIONS: Aggressive balloon angioplasty with provisional stenting yields excellent results in a general patient population.

Published
2001
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39. Influence of planned six-month follow-up angiography on late outcome after percutaneous coronary intervention A randomized study

Author

ten Berg, Jurriën M, Kelder, Johannes C, Suttorp, Maarten Jan, Verheugt, Freek W.A, and Thijs Plokker, H.W

Abstract

OBJECTIVESThe goal of this research was to study the effect of planned angiography on late clinical outcome after percutaneous coronary intervention.BACKGROUNDIt is still largely unknown whether planned follow-up angiography after coronary angioplasty influences late outcome.METHODSRandomization assigned 527 patients to clinical follow-up alone and 531 to clinical and six-month angiographic follow-up. The effect of planned angiography on clinical outcome at one and three years after coronary angioplasty was studied.RESULTSThe two groups were well matched. At one year, more events occurred in the angiographic group than in the clinical group: 122 (23.2%) versus 88 (16.7%) (p = 0.01). While the incidence of death or myocardial infarction (MI) was similar at one year, the revascularization rate was higher in the angiographic group: 113 (21.3%) versus 67 (12.7%) (relative risk = 1.7, 95% confidence interval: 1.3 to 2.3, p = 0.0003). At three years, still more events had occurred in the angiographic group (146 [34.5%] vs. 114 [26.3%], p = 0.03). More reinterventions did not improve late survival. However, there was a nonsignificant reduction in MI (7 [1.3%] vs. 13 [2.5%], p = NS) and a significant improvement in functional class at the end of follow-up (freedom from angina 81% vs. 74%, p = 0.03). The effect of follow-up angiography on the reintervention rate was similar for stented and nonstented patients.CONCLUSIONSPlanned follow-up angiography to evaluate the late results of coronary intervention led to a 1.7 times higher reintervention rate. This effect was similar for stented and nonstented patients. More reinterventions did not improve survival but tended to reduce the incidence of MI and led to a significantly better functional class at follow-up.

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42. Long-term impact of chronic total occlusion recanalisation in patients with ST-elevation myocardial infarction

Author

Joëlle, Elias, Ivo M, van Dongen, Truls, Råmunddal, Peep, Laanmets, Erlend, Eriksen, Martijn, Meuwissen, H Rolf, Michels, Matthijs, Bax, Dan, Ioanes, Maarten Jan, Suttorp, Bradley H, Strauss, Emanuele, Barbato, Koen M, Marques, Bimmer E P M, Claessen, Alexander, Hirsch, René J, van der Schaaf, Jan G P, Tijssen, José P S, Henriques, Loes P, Hoebers, G Van, Houwelingen, Cardiology, Radiology & Nuclear Medicine, ACS - Atherosclerosis & ischemic syndromes, Graduate School, ACS - Microcirculation, ACS - Pulmonary hypertension & thrombosis, ACS - Heart failure & arrhythmias, Elias, Joëlle, van Dongen, Ivo M, Råmunddal, Trul, Laanmets, Peep, Eriksen, Erlend, Meuwissen, Martijn, Michels, H Rolf, Bax, Matthij, Ioanes, Dan, Suttorp, Maarten Jan, Strauss, Bradley H, Barbato, Emanuele, Marques, Koen M, Claessen, Bimmer E P M, Hirsch, Alexander, van der Schaaf, René J, Tijssen, Jan G P, Henriques, José P S, and Hoebers, Loes P

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Myocardial Ischemia, Long Term Adverse Effects, Magnetic Resonance Imaging, Cine, 030204 cardiovascular system & hematology, Coronary Angiography, acute coronary syndrome, Angina, 03 medical and health sciences, 0302 clinical medicine, Percutaneous Coronary Intervention, Postoperative Complications, All institutes and research themes of the Radboud University Medical Center, Internal medicine, medicine, Clinical endpoint, Ventricular Dysfunction, Humans, 030212 general & internal medicine, Myocardial infarction, cardiovascular diseases, Aged, business.industry, chronic coronary disease, Percutaneous coronary intervention, Middle Aged, medicine.disease, Coronary Vessels, Clinical trial, medicine.anatomical_structure, Treatment Outcome, surgical procedures, operative, Coronary Occlusion, Conventional PCI, Chronic Disease, Cardiology, ST Elevation Myocardial Infarction, Female, Cardiology and Cardiovascular Medicine, business, Mace, Artery
Abstract

BackgroundDuring primary percutaneous coronary intervention (PCI), a concurrent chronic total occlusion (CTO) is found in 10% of patients with ST-elevation myocardial infarction (STEMI). Long-term benefits of CTO-PCI have been suggested; however, randomised data are lacking. Our aim was to determine mid-term and long-term clinical outcome of CTO-PCI versus CTO-No PCI in patients with STEMI with a concurrent CTO.MethodsThe Evaluating Xience and left ventricular function in PCI on occlusiOns afteR STEMI (EXPLORE) was a multicentre randomised trial that included 302 patients with STEMI after successful primary PCI with a concurrent CTO. Patients were randomised to either CTO-PCI or CTO-No PCI. The primary end point of the current study was occurrence of major adverse cardiac events (MACE): cardiac death, coronary artery bypass grafting and MI. Other end points were 1-year left ventricular function (LVF); LV-ejection fraction and LV end-diastolic volume and angina status.ResultsThe median long-term follow-up was 3.9 (2.1–5.0) years. MACE was not significantly different between both arms (13.5% vs 12.3%, HR 1.03, 95% CI 0.54 to 1.98; P=0.93). Cardiac death was more frequent in the CTO-PCI arm (6.0% vs 1.0%, P=0.02) with no difference in all-cause mortality (12.9% vs 6.2%, HR 2.07, 95% CI 0.84 to 5.14; P=0.11). One-year LVF did not differ between both arms. However, there were more patients with freedom of angina in the CTO-PCI arm at 1 year (94% vs 87%, P=0.03).ConclusionsIn this randomised trial involving patients with STEMI with a concurrent CTO, CTO-PCI was not associated with a reduction in long-term MACE compared to CTO-No PCI. One-year LVF was comparable between both treatment arms. The finding that there were more patients with freedom of angina after CTO-PCI at 1-year follow-up needs further investigation.Clinical trial registrationEXPLORE trial number NTR1108 www.trialregister.nl.

Published
2018

43. Open surgical retrieval of a migrated patent foramen ovale closure device from the descending aorta following failed percutaneous retrieval from the aortic arch: a case report with a word of caution.

Author

Berk TA, Kroeze S, Suttorp MJ, and Heijmen RH

Abstract

Background: Percutaneous patent foramen ovale (PFO) closure is considered safe and has been used widely for over 25 years. A rare but potentially life-threatening complication is device migration, especially to the aorta., Case Summary: We present a 30-year-old male with a PFO occlusion device implanted for cryptogenic stroke, which asymptomatically migrated to the aortic arch. A percutaneous retrieval attempt failed at complete removal but relocated the device to the proximal descending aorta. It was then successfully removed by open surgery. Severe intimal damage necessitated resection and interposition grafting., Discussion: Manipulation of migrated intravascular devices can cause intimal damage and subsequent complications, such as local dissections. We advocate caution with percutaneous removal of such large, migrated closure devices to avoid additional intimal damage, especially after endothelialization has occurred. The interventional cardiologist should be aware of the risk of intimal damage as a result, and surgical removal, though invasive, should always be considered., Competing Interests: Conflict of interest: None declared., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2023
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44. Time does not heal every wound: coronary stent thrombosis of a bare-metal stent more than one decade after its implantation.

Author

Zomer AC, Zwart B, van Werkum JW, and Suttorp MJ

Subjects
Adenosine Diphosphate blood, Angioplasty, Balloon, Coronary, Clopidogrel, Coronary Angiography, Coronary Thrombosis diagnosis, Coronary Thrombosis therapy, Humans, Male, Middle Aged, Platelet Aggregation Inhibitors therapeutic use, Ticlopidine analogs & derivatives, Ticlopidine therapeutic use, Blood Vessel Prosthesis adverse effects, Coronary Thrombosis etiology, Stents adverse effects
Abstract

In the present report, we describe a unique case of very late stent thrombosis with a bare-metal stent that occurred more than a decade after stent implantation. Potential explanations for the late stent thrombosis are non-compliance to aspirin, late acquired malapposition of the stent, progression of atherosclerosis or in-stent restenosis. In our patient, none of these explanations seems to have played a role. Although the occurrence of (very) late stent thrombosis is not uncommon with drug-eluting stent (DES), it is rather unusual with bare-metal stent (BMS). Nevertheless, cardiologists should be aware of the potential complication of late stent thrombosis, even with bare-metal stents.

Published
2009
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45. One-year results of coronary revascularization in diabetic patients with multivessel coronary artery disease.Sirolimus stent vs. coronary artery bypass surgery and bare metal stent: insights from ARTS-II and ARTS-I.

Author

Macaya C, García-García HM, Colombo A, Morice MC, Legrand V, Kuck KH, Sheiban I, Suttorp MJ, Carrie D, Vrolix M, Wittebols K, Stoll HP, Donohoe D, Bressers M, and Serruys PW

Abstract

Background: ARTS-II was designed to evaluate the sirolimus-eluting stent (SES) versus ARTS-I. The objective of this analysis is to assess the safety and efficacy of the SES in diabetic patients with multivessel disease (MVD) versus both arms of ARTS-I., Methods and Results: The ARTS studies included 367 diabetic patients (ARTS-II: 159; ARTS-I-CABG: 96; ARTS-I-PCI: 112). Baseline characteristics showed a more diseased patient population in the ARTS-II study: 50.3% with 3VD vs. 35.4% (ARTS-I-CABG) and 30.8% (ARTS-I-PCI) (p=0.003). Treated or anastomosed lesions were 3.2+/-1.2 (ARTS-II), 2.8+/-0.8 (ARTS-I-CABG) and 2.5+/-1.1 (ARTS-I-PCI). At 30 days there was a significant difference in MACCE between ARTS-II (4.4%) and ARTS-I-PCI (12.5%) (p=0.02). At 1-year, the death rate was 2.5% (ARTS-II) vs. 3.1% (ARTS-I-CABG) and 6.3% (ARTS-I-PCI) without significant differences. Myocardial infarction rate was 0.6% (ARTS-II) vs. 2.1% (ARTS-I-CABG; p=0.56) and 6.3% (ARTS-I-PCI; p=0.01). The need for repeat revascularization was 12.6% (ARTS-II) vs. 4.2% (ARTS-I-CABG; p=0.027) and 22.3% (ARTS-I-PCI; p= 0.046). MACCE-free survival was 84.3% (ARTS-II) vs. 85.4% (ARTS-I-CABG; p=0.86) and 63.4% (ARTS-I-PCI; p<0.001). Also at 1 year, the overall MACCE rate in patients with diabetes was significantly higher than in nondiabetic patients, 15.7% vs. 8.5%, respectively [RR 1.85, 95%CI (1.16,2.97), p=0.015), due to a higher incidence of death and need for repeat revascularization, 2.5% vs. 0.4 and 12.5% vs. 5.6% in diabetes vs. nondiabetes groups, respectively., Conclusion: Despite more extensive and treated disease, the overall MACCE-free survival in diabetic patients at 1 year in ARTS-II is similar to ARTS-I-CABG.

Published
2006

46. Percutaneous transcatheter closure of atrial septal defects: initial single-centre experience and follow-up results. Initial experience with three-dimensional echocardiography.

Author

De Ridder S, Suttorp MJ, Ernst SM, Six JA, Mannaerts HF, Kamp O, Plokker TH, and Jaarsma W

Subjects
Adolescent, Adult, Aged, Echocardiography, Three-Dimensional, Female, Heart Septal Defects, Atrial diagnostic imaging, Humans, Male, Middle Aged, Cardiac Catheterization, Heart Septal Defects, Atrial therapy, Prostheses and Implants
Abstract

Objective: Registry to report our single-centre experience in closing defects of the atrial septum., Methods: Between 1996 and 2001, transcatheter device closure of significant atrial septal defects was performed in 32 adults (mean age 45.1 years, range from 15 to 76 years), using different device types. Six patients had a patent foramen ovale (PFO) and 26 patients had a secundum atrial septal defect (ASD II). Defects were selected by means of two-dimensional transoesophageal echocardiography (2D TOE). For 12 defects additional three-dimensional transoesophageal echocardiography (3D TOE) was performed., Results: Mean balloon-stretched diameter was 19.3 mm (range from 11 to 24 mm). A device was successfully placed in all PFO patients (100%) without complications at follow-up. Successful immediate device placement occurred in 24 out of 26 ASD patients. Two immediate placement failures, 1 device embolisation and 1 device non-fixation, occurred and required urgent surgery. There was 1 patient with pericardial effusion after the intervention, requiring pericardiocentesis. Three late placement failures occurred: 2 device embolisations and 1 device dislocation. Clinical success after 3 to 6 months follow-up, defined as the absence of shunt or small shunt, was achieved in all 6 PFO patients and in 21 out of 23 ASD patients (1 device embolisation, requiring surgery, occurred before follow-up was completed). Two patients with significant shunt, 1 late device dislocation and 1 late device embolisation, underwent elective surgery. For patient selection, 3D TOE proved useful in the evaluation of large and/or complex defects., Conclusion: Transcatheter device closure of carefully selected atrial septal defects is an alternative to surgery. Although the results are promising, surgical back-up is often needed.

Published
2005
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