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1. Clinical Characteristics, Treatments and Outcomes of 18 Lung Transplant Recipients with COVID-19

Author

René Hage, Carolin Steinack, Fiorenza Gautschi, Susan Pfister, Ilhan Inci, and Macé M. Schuurmans

Subjects
SARS-CoV-2, viral infection, hyperinflammation, cytokine storm syndrome, dexamethasone, remdesivir, Surgery, RD1-811
Abstract

We report clinical features, treatments and outcomes in 18 lung transplant recipients with laboratory confirmed SARS-CoV-2 infection. We performed a single center, retrospective case series study of lung transplant recipients, who tested positive for SARS-CoV-2 between 1 February 2020 and 1 March 2021. Clinical, laboratory and radiology findingswere obtained. Treatment regimens and patient outcome data were obtained by reviewing the electronic medical record. Mean age was 49.9 (22–68) years, and twelve (67%) patients were male. The most common symptoms were fever (n = 9, 50%), nausea/vomiting (n = 7, 39%), cough (n = 6, 33%), dyspnea (n = 6, 33%) and fatigue (n = 6, 33%). Headache was reported by five patients (28%). The most notable laboratory findings were elevated levels of C-reactive protein (CRP) and lactate dehydrogenase (LDH). Computed Tomography (CT) of the chest was performed in all hospitalized patients (n = 11, 7%), and showed ground-glass opacities (GGO) in 11 patients (100%), of whom nine (82%) had GGO combined with pulmonary consolidations. Six (33%) patients received remdesivir, five (28%) intravenous dexamethasone either alone or in combination with remdesivir, and 15 (83%) were treated with broad spectrum antibiotics including co-amoxicillin, tazobactam-piperacillin and meropenem. Four (22%) patients were transferred to the intensive care unit, two patients (11%) required invasive mechanical ventilation who could not be successfully extubated and died. Eighty-nine percent of our patients survived COVID-19 and were cured. Two patients with severe COVID-19 did not survive.

Published
2021
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2. Konsequenzen aversiver Kindheitserfahrungen: Auswirkungen auf das neuroendokrine System

Author

Niklaus Egloff, Susan Pfister, Kyrill Schwegler, Vanessa Bürgy, and En-Young Wagner

Subjects
medicine.medical_specialty, business.industry, media_common.quotation_subject, Stressor, General Medicine, Neglect, Sexual abuse, Epidemiology, Life expectancy, Endocrine system, Medicine, business, Clinical psychology, media_common
Abstract

Zusammenfassung. Kindliche Stresserfahrungen durch Vernachlässigung, körperliche, psychische oder sexuelle Misshandlung führen oftmals zu dauerhaften Veränderungen der stressregulatorischen neuroendokrinen Prozessabläufe. Epidemiologische Untersuchungen zeigten bereits vor 20 Jahren, dass das Ausmass der kindlichen Stressoren mit dem Auftreten von diversen somatischen, funktionellen und psychischen Erkrankungen im Erwachsenenalter korreliert und sich kumulierte Stressoren auch in einer deutlich erniedrigten durchschnittlichen Lebenserwartung widerspiegeln. Dem veränderten stressendokrinen System kommt eine massgebliche Bedeutung hinsichtlich Pathogenese der erwähnten somatischen, funktionellen und psychischen Folgestörungen zu.

Published
2020

3. Prävention aversiver Kindheitserfahrungen: gesellschaftliche und gesundheitspolitische Konsequenzen

Author

Niklaus Egloff, Susan Pfister, En-Young Wagner, Vanessa Bürgy, Stefanie Julia Schmidt, and Martin Grosse Holtforth

Subjects
medicine.medical_specialty, Health consequences, business.industry, Prevention model, media_common.quotation_subject, MEDLINE, General Medicine, Neglect, Sexual abuse, Health care, Medicine, Social consciousness, business, Psychiatry, Health policy, media_common
Abstract

Zusammenfassung. Vernachlässigung, körperliche, psychische oder sexuelle Misshandlung erhöhen das Risiko für Entwicklungsstörungen wie auch das Risiko gesundheitlicher Langzeitfolgen im Erwachsenenalter. Die Prävention von Misshandlungen ist deshalb wichtig. In der Schweiz zeigt sich ein mehrschichtiges Präventionsmodell, dessen Hauptfokus auf der Stützung der Familie liegt. Ein verbessertes gesellschaftliches Bewusstsein hinsichtlich der wichtigen Bedeutung einer adäquaten kindlichen Betreuung steht sowohl im Interesse jedes Einzelnen wie auch im Interesse des Gesundheitssystems und der Gesellschaft als Ganzes.

Published
2020

4. Langzeitkonsequenzen aversiver Kindheitserfahrungen: Auswirkungen auf die Schmerzverarbeitung

Author

Kyrill Schwegler, En-Young Wagner, Vanessa Bürgy, Niklaus Egloff, and Susan Pfister

Subjects
General Medicine
Abstract

Zusammenfassung. Kindliche Stresserfahrungen durch Vernachlässigung, körperliche, psychische oder sexuelle Misshandlung führen oftmals zu nachhaltigen Veränderungen der Schmerzverarbeitung. Klinisch zeigt sich dies unter anderem in einer erhöhten Schmerzempfindlichkeit, einer verstärkten negativ-affektiven Konnotation von Schmerz und letztlich einem erhöhten Risiko für Schmerzerkrankungen im Erwachsenenalter. Dass kindliche Stresserfahrung sich auf das spätere Schmerzverhalten auswirken kann, hat George L. Engel bereits in den 1960er Jahren postuliert. Diese narrative Übersichtsarbeit möchte den aktuellen Stand des Wissens zusammenfassen.

Published
2020

5. Langzeitkonsequenzen aversiver Kindheitserfahrungen: Auswirkungen auf zerebrale Strukturen

Author

Kyrill Schwegler, Susan Pfister, Niklaus Egloff, Vanessa Bürgy, and En-Young Wagner

Subjects
business.industry, media_common.quotation_subject, Central nervous system, Cognition, General Medicine, Developmental psychology, Neglect, medicine.anatomical_structure, Sexual abuse, medicine, sense organs, Early childhood, business, media_common
Abstract

Long-term consequences of aversive childhood experiences: effects on cerebral structures Abstract. Early childhood stress experiences due to neglect, and physical, psychological or sexual abuse can lead to permanent changes in central nervous structures. The central nervous system generally shows a very high plasticity in early childhood. Objectively, these influences are reflected in functional and structural-morphological changes in certain brain areas. Subjectively, they are manifested through changes in cognitive, emotional, perceptive and social experiencing. This review aims to summarize the current status of the limited number of studies with human subjects on the consequences of early childhood stress experiences with focus on the central nervous system.

Published
2020

10. The Impact of Erythropoietin on Short- and Long-Term Kidney-Related Outcomes in Neonates of Extremely Low Gestational Age. Results of a Multicenter, Double-Blind, Placebo-Controlled Randomized Clinical Trial

Author

David J. Askenazi, Patrick J. Heagerty, Robert H. Schmicker, Patrick Brophy, Sandra E. Juul, Stuart L. Goldstein, Sangeeta Hingorani, Bryan A. Comstock, Rajan Wadhawan, Dennis E. Mayock, Sherry E. Courtney, Tonya Robinson, Kaashif A. Ahmad, Ellen Bendel-Stenzel, Mariana Baserga, Edmund F. LaGamma, L. Corbin Downey, Raghavendra Rao, Nancy Fahim, Andrea Lampland, Ivan D. Frantz, Janine Y. Khan, Michael Weiss, Maureen M. Gilmore, Robin Ohls, Nishant Srinivasan, Jorge E. Perez, Victor McKay, Phuong T. Vu, Billy Thomas, Nahed Elhassan, Sarah Mulkey, Philip Dydynski, Vivek K. Vijayamadhavan, Neil Mulrooney, Bradley Yoder, Jordan S. Kase, Jennifer Check, Semsa Gogcu, Erin Osterholm, Sara Ramel, Catherine Bendel, Cheryl Gale, Thomas George, Michael Georgieff, Tate Gisslen, Sixto Guiang, Anne Hall, Dana Johnson, Katie Pfister, Heather Podgorski, Kari Roberts, Erin Stepka, Melissa Engel, Heidi Kamrath, Johannah Scheurer, Angela Hanson, Katherine Satrom, Susan Pfister, Ann Simones, Erin Plummer, Elizabeth Zorn, Camilia R. Martin, Deirdre O'Reilly, Nicolas Porta, Catalina Bazacliu, Jonathan Williams, Dhanashree Rajderkar, Frances Northington, Raul Chavez Valdez, Sandra Beauman, Patel Saurabhkumar, Magaly Diaz-Barbosa, Arturo Serize, Jorge Jordan, Debbie Ott, Ariana Franco Mora, Pamela Hedrick, Vicki Flynn, Amy Silvia, Bailey Clopp, John B. Feltner, Isabella Esposito, Stephanie Hauge, Samantha Nikirk, Andrea Purnell, Emilie Loy, Natalie Sikes, Melanie Mason, Jana McConnell, Tiffany Brown, Henry Harrison, Denise Pearson, Tammy Drake, Jocelyn Wright, Debra Walden, Annette Guy, Jennifer Nason, Morgan Talbot, Kristen Lee, Sarah Penny, Terri Boles, Melanie Drummond, Katy Kohlleppel, Charmaine Kathen, Brian Kaletka, Shania Gonzales, Cathy Worwa, Molly Fisher, Tyler Richter, Alexander Ginder, Brixen Reich, Carrie Rau, Manndi Loertscher, Laura Bledsoe, Kandace McGrath, Kimberlee Weaver Lewis, Jill Burnett, Susan Schaefer, Karie Bird, Clare Giblin, Rita Daly, Kristi Lanier, Kelly Warden, Jenna Wassenaar, Jensina Ericksen, Bridget Davern, Mary Pat Osborne, Brittany Gregorich, Neha Talele, Evelyn Obregon, Tiglath Ziyeh, Molly Clarke, Rachel E. Wegner, Palak Patel, Molly Schau, Annamarie Russow, Kelly Curry, Susan Sinnamon, Lisa Barnhart, Charlamaine Parkinson, Mary Hanson, Elizabeth Kuan, Conra Backstrom Lacy, Edshelee M. Galvis, Susana Bombino, Denise Martinez, Suzi Bell, Corrie Long, Cathy Longa, Michael Westerveld, Stacy McConkey, Anne Hay, Niranjana Natarajan, Shari Gaudette, Sarah Cobb, Gregory Sharp, Elizabeth Schumacher, Leslie Schuschke, Charlotte Frey, Mario Fierro, Lois Gilmore, Pamela Lundequam, Ronald Hoekstra, Anastasia Ketko, Nina Perdue, Sean Cunningham, Kelly Stout, Becky Hall, Galina Morshedzadeh, Betsy Ostrander, Sarah Winter, Lauren Cox, Matthew A. Rainaldi, Sarah Hensley, Melissa Morris, Dia Roberts, Melissa Tuttle, Christopher Boys, Solveig Hultgren, Elizabeth I. Pierpont, Tom George, Kelly E. King, Katherine Bataglia, Cathy Neis, Mark Bergeron, Cristina Miller, Cara Accomando, Jennifer Anne Gavin, Elizabeth Maczek, Susan Marakovitz, Aimee Knorr, Vincent C. Smith, Jane E. Stewart, Marie Weissbourd, Raye-Ann deRegnier, Nana Matoba, Shelly C. Heaton, Erika M. Cascio, Janet Brady, Suman Ghosh, Jessica Ditto, Mary Leppert, Jean Lowe, Janell Fuller, Tara DuPont, Pamela Kloska, Saurabh Patel, Lauren Carbonell, Anna Maria Patino-Fernandez, Carmen de Lerma, Kelly McDonough, Maiana De Cortada, Lacy Chavis, Jane Shannon, Mark A. Konodi, Christopher Nefcy, Karl C.K. Kuban, Jean R. Lowe, T. Michael O'Shea, Manjiri Dighe, Todd Richards, Dennis W.W. Shaw, Colin Studholme, Christopher M. Traudt, Roberta Ballard, Adam Hartman, Scott Janis, T. Robin Ohls, Michael O'Shea, Ronnie Guillet, M. Bethany Ball, Hannah Glass, Ben Saville, and Michael Schreiber

Subjects
Male, medicine.medical_specialty, Renal function, Gestational Age, Infant, Premature, Diseases, Placebo, Article, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Double-Blind Method, law, 030225 pediatrics, Internal medicine, medicine, Albuminuria, Humans, 030212 general & internal medicine, Renal Insufficiency, Chronic, Erythropoietin, business.industry, Acute kidney injury, Infant, Newborn, Gestational age, Acute Kidney Injury, medicine.disease, Recombinant Proteins, Blood pressure, Infant, Extremely Premature, Pediatrics, Perinatology and Child Health, Hypertension, Female, medicine.symptom, business, medicine.drug, Glomerular Filtration Rate
Abstract

OBJECTIVE: To evaluate whether extremely low gestational age neonates (ELGANs) randomized to erythropoietin have better or worse kidney-related outcomes during hospitalization and at 22–26 months corrected gestational age (cGA) compared with those randomized to placebo. STUDY DESIGN: We performed an ancillary study to a multicenter double-blind, placebo-controlled randomized clinical trial of erythropoietin in ELGANs. RESULTS: The prevalence of severe (stage 2 or 3) acute kidney injury (AKI) was 18.2%. We did not find a statistically significant difference between those randomized to erythropoietin vs. placebo for in-hospital primary (severe AKI) or secondary outcomes (any AKI and serum creatinine [SCr]/ cystatin C values at days 0, 7, 9 and 14). At 22–26 months cGA, 16% of the cohort had an estimated glomerular filtration rate (eGFR) 30 mg/g, 23% had a systolic blood pressure (SBP) >95(th) percentile for age, and 40% had a diastolic blood pressure (DBP) >95(th) percentile for age. SBP >90(th) percentile occurred less often among recipients of erythropoietin (p95(th) percentile or DBP >90(th) or >95(th) percentiles. CONCLUSIONS: ELGANs have high rates of in-hospital AKI and kidney-related problems at 22–26 months cGA. Recombinant erythropoietin (rhEpo) may protect ELGANs against long-term elevated SBP, but does not appear to protect from AKI, low eGFR, albuminuria or elevated DBP at 22–26 months cGA.

Published
2020

12. Ratings by Counselors Without Teaching Experience And Their Principals Regarding Performance of Guidance Functions

Author

Duane Brown, Susan Pfister, and Gordon Hopper

Subjects
Social work, health care facilities, manpower, and services, education, School psychology, Significant difference, Applied psychology, Principal (computer security), behavioral disciplines and activities, Education, Clinical Psychology, Rating scale, mental disorders, Self evaluation, Developmental and Educational Psychology, Psychology, psychological phenomena and processes
Abstract

This study compared principal and self ratings of performance of guidance functions for practicing counselors who did not have teaching experience. The sample consisted of 43 counselors and their principals from throughout the United States. The ratings indicate better-than-average initial counselor acceptance by administrators, teachers, students, and parents with the degree of acceptance being greater after they had counseled for a while. Principal and self ratings differed significantly on initial acceptance by students and present acceptance by other counselors. Ratings of acceptance by both school psychologists and social workers were below average. There was no significant difference in counselor and principal ratings of counselor understanding of various school procedures and policies or of their ability to perform basic guidance activities. A majority of the principals who had worked with the counselors with non-teaching backgrounds indicated they would recommend the hiring of such a person to their school board.

Published
1970

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