Author: "Susaki Y" - Searchworks@Jio Institute Digital Library Search Results

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1. The Physics of the B Factories

Author: Bevan, A. J., Golob, B., Mannel, Th., Prell, S., Yabsley, B. D., Abe, K., Aihara, H., Anulli, F., Arnaud, N., Aushev, T., Beneke, M., Beringer, J., Bianchi, F., Bigi, I. I., Bona, M., Brambilla, N., rodzicka, J. B, Chang, P., Charles, M. J., Cheng, C. H., Cheng, H. -Y., Chistov, R., Colangelo, P., Coleman, J. P., Drutskoy, A., Druzhinin, V. P., Eidelman, S., Eigen, G., Eisner, A. M., Faccini, R., Flood, K. T ., Gambino, P., Gaz, A., Gradl, W., Hayashii, H., Higuchi, T., Hulsbergen, W. D., Hurth, T., Iijima, T., Itoh, R., Jackson, P. D., Kass, R., Kolomensky, Yu. G., Kou, E., Križan, P., Kronfeld, A., Kumano, S., Kwon, Y. J., Latham, T. E., Leith, D. W. G. S., Lüth, V., Martinez-Vidal, F., Meadows, B. T., Mussa, R., Nakao, M., Nishida, S., Ocariz, J., Olsen, S. L., Pakhlov, P., Pakhlova, G., Palano, A., Pich, A., Playfer, S., Poluektov, A., Porter, F. C., Robertson, S. H., Roney, J. M., Roodman, A., Sakai, Y., Schwanda, C., Schwartz, A. J., Seidl, R., Sekula, S. J., Steinhauser, M., Sumisawa, K., Swanson, E. S., Tackmann, F., Trabelsi, K., Uehara, S., Uno, S., van der Water, R., Vasseur, G., Verkerke, W., Waldi, R., Wang, M. Z., Wilson, F. F., Zupan, J., Zupanc, A., Adachi, I., Albert, J., Banerjee, Sw., Bellis, M., Ben-Haim, E., Biassoni, P., Cahn, R. N., Cartaro, C., Chauveau, J., Chen, C., Chiang, C. C., Cowan, R., Dalseno, J., Davier, M., Davies, C., Dingfelder, J. C., nard, B. Eche, Epifanov, D., Fulsom, B. G., Gabareen, A. M., Gary, J. W., Godang, R., Graham, M. T., Hafner, A., Hamilton, B., Hartmann, T., Hayasaka, K., Hearty, C., Iwasaki, Y., Khodjamirian, A., Kusaka, A., Kuzmin, A., Lafferty, G. D., Lazzaro, A., Li, J., Lindemann, D., Long, O., Lusiani, A., Marchiori, G., Martinelli, M., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Muller, D. R., Nakazawa, H., Ongmongkolkul, P., Pacetti, S., Palombo, F., Pedlar, T. K., Piilonen, L. E., Pilloni, A., Poireau, V., Prothmann, K., Pulliam, T., Rama, M., Ratcliff, B. N., Roudeau, P., Schrenk, S., Schroeder, T., Schubert, K. R., Shen, C. P., Shwartz, B., Soffer, A., Solodov, E. P., Somov, A., Starič, M., Stracka, S., Telnov, A. V., Todyshev, K. Yu., Tsuboyama, T., Uglov, T., Vinokurova, A., Walsh, J. J., Watanabe, Y., Won, E., Wormser, G., Wright, D. H., Ye, S., Zhang, C. C., Abachi, S., Abashian, A., Abe, N., Abe, R., Abe, T., Abrams, G. S., Adam, I., Adamczyk, K., Adametz, A., Adye, T., Agarwal, A., Ahmed, H., Ahmed, M., Ahmed, S., Ahn, B. S., Ahn, H. S., Aitchison, I. J. R., Akai, K., Akar, S., Akatsu, M., Akemoto, M., Akhmetshin, R., Akre, R., Alam, M. S., Albert, J. N., Aleksan, R., Alexander, J. P., Alimonti, G., Allen, M. T., Allison, J., Allmendinger, T., Alsmiller, J. R. G., Altenburg, D., Alwyn, K. E., An, Q., Anderson, J., Andreassen, R., Andreotti, D., Andreotti, M., Andress, J. C., Angelini, C., Anipko, D., Anjomshoaa, A., Anthony, P. L., Antillon, E. A., Antonioli, E., Aoki, K., Arguin, J. F., Arinstein, K., Arisaka, K., Asai, K., Asai, M., Asano, Y., Asgeirsson, D. J., Asner, D. M., Aso, T., Aspinwall, M. L., Aston, D., Atmacan, H., Aubert, B., Aulchenko, V., Ayad, R., Azemoon, T., Aziz, T., Azzolini, V., Azzopardi, D. E., Baak, M. A., Back, J. J., Bagnasco, S., Bahinipati, S., Bailey, D. S., Bailey, S., Bailly, P., van Bakel, N., Bakich, A. M., Bala, A., Balagura, V., Baldini-Ferroli, R., Ban, Y., Banas, E., Band, H. R., Banerjee, S., Baracchini, E., Barate, R., Barberio, E., Barbero, M., Bard, D. J., Barillari, T., Barlow, N. R., Barlow, R. J., Barrett, M., Bartel, W., Bartelt, J., Bartoldus, R., Batignani, G., Battaglia, M., Bauer, J. M., Bay, A., Beaulieu, M., Bechtle, P., Beck, T. W., Becker, J., Becla, J., Bedny, I., Behari, S., Behera, P. K., Behn, E., Behr, L., Beigbeder, C., Beiline, D., Bell, R., Bellini, F., Bellodi, G., Belous, K., Benayoun, M., Benelli, G., Benitez, J. F., Benkebil, M., Berger, N., Bernabeu, J., Bernard, D., Bernet, R., Bernlochner, F. U., Berryhill, J. W., Bertsche, K., Besson, P., Best, D. S., Bettarini, S., Bettoni, D., Bhardwaj, V., Bhimji, W., Bhuyan, B., Biagini, M. E., Biasini, M., van Bibber, K., Biesiada, J., Bingham, I., Bionta, R. M., Bischofberger, M., Bitenc, U., Bizjak, I., Blanc, F., Blaylock, G., Blinov, V. E., Bloom, E., Bloom, P. C., Blount, N. L., Blouw, J., Bly, M., Blyth, S., Boeheim, C. T., Bomben, M., Bondar, A., Bondioli, M., Bonneaud, G. R., Bonvicini, G., Booke, M., Booth, J., Borean, C., Borgland, A. W., Borsato, E., Bosi, F., Bosisio, L., Botov, A. A., Bougher, J., Bouldin, K., Bourgeois, P., Boutigny, D., Bowerman, D. A., Boyarski, A. M., Boyce, R. F., Boyd, J. T., Bozek, A., Bozzi, C., Bračko, M., Brandenburg, G., Brandt, T., Brau, B., Brau, J., Breon, A. B., Breton, D., Brew, C., Briand, H., Bright-Thomas, P. G., Brigljević, V., Britton, D. I., Brochard, F., Broomer, B., Brose, J., Browder, T. E., Brown, C. L., Brown, C. M., Brown, D. N., Browne, M., Bruinsma, M., Brunet, S., Bucci, F., Buchanan, C., Buchmueller, O. L., Bünger, C., Bugg, W., Bukin, A. D., Bula, R., Bulten, H., Burchat, P. R., Burgess, W., Burke, J. P., Button-Shafer, J., Buzykaev, A. R., Buzzo, A., Cai, Y., Calabrese, R., Calcaterra, A., Calderini, G., Camanzi, B., Campagna, E., Campagnari, C., Capra, R., Carassiti, V., Carpinelli, M., Carroll, M., Casarosa, G., Casey, B. C. K., Cason, N. M., Castelli, G., Cavallo, N., Cavoto, G., Cecchi, A., Cenci, R., Cerizza, G., Cervelli, A., Ceseracciu, A., Chai, X., Chaisanguanthum, K. S., Chang, M. C., Chang, Y. H., Chang, Y. W., Chao, D. S., Chao, M., Chao, Y., Charles, E., Chavez, C. A., Cheaib, R., Chekelian, V., Chen, A., Chen, E., Chen, G. P., Chen, H. F., Chen, J. -H., Chen, J. C., Chen, K. F., Chen, P., Chen, S., Chen, W. T., Chen, X., Chen, X. R., Chen, Y. Q., Cheng, B., Cheon, B. G., Chevalier, N., Chia, Y. M., Chidzik, S., Chilikin, K., Chistiakova, M. V., Cizeron, R., Cho, I. S., Cho, K., Chobanova, V., Choi, H. H. F., Choi, K. S., Choi, S. K., Choi, Y., Choi, Y. K., Christ, S., Chu, P. H., Chun, S., Chuvikov, A., Cibinetto, G., Cinabro, D., Clark, A. R., Clark, P. J., Clarke, C. K., Claus, R., Claxton, B., Clifton, Z. C., Cochran, J., Cohen-Tanugi, J., Cohn, H., Colberg, T., Cole, S., Colecchia, F., Condurache, C., Contri, R., Convert, P., Convery, M. R., Cooke, P., Copty, N., Cormack, C. M., Corso, F. Dal, Corwin, L. A., Cossutti, F., Cote, D., Ramusino, A. Cotta, Cottingham, W. N., Couderc, F., Coupal, D. P., Covarelli, R., Cowan, G., Craddock, W. W., Crane, G., Crawley, H. B., Cremaldi, L., Crescente, A., Cristinziani, M., Crnkovic, J., Crosetti, G., Cuhadar-Donszelmann, T., Cunha, A., Curry, S., D'Orazio, A., Dû, S., Dahlinger, G., Dahmes, B., Dallapiccola, C., Danielson, N., Danilov, M., Das, A., Dash, M., Dasu, S., Datta, M., Daudo, F., Dauncey, P. D., David, P., Davis, C. L., Day, C. T., De Mori, F., De Domenico, G., De Groot, N., De la Vaissière, C., de la Vaissière, Ch., de Lesquen, A., De Nardo, G., de Sangro, R., De Silva, A., DeBarger, S., Decker, F. J., Sanchez, P. del Amo, Del Buono, L., Del Gamba, V., del Re, D., Della Ricca, G., Denig, A. G., Derkach, D., Derrington, I. M., DeStaebler, H., Destree, J., Devmal, S., Dey, B., Di Girolamo, B., Di Marco, E., Dickopp, M., Dima, M. O., Dittrich, S., Dittongo, S., Dixon, P., Dneprovsky, L., Dohou, F., Doi, Y., Doležal, Z., Doll, D. A., Donald, M., Dong, L., Dong, L. Y., Dorfan, J., Dorigo, A., Dorsten, M. P., Dowd, R., Dowdell, J., Drásal, Z., Dragic, J., Drummond, B. W., Dubitzky, R. S., Dubois-Felsmann, G. P., Dubrovin, M. S., Duh, Y. C., Duh, Y. T., Dujmic, D., Dungel, W., Dunwoodie, W., Dutta, D., Dvoretskii, A., Dyce, N., Ebert, M., Eckhart, E. A., Ecklund, S., Eckmann, R., Eckstein, P., Edgar, C. L., Edwards, A. J., Egede, U., Eichenbaum, A. M., Elmer, P., Emery, S., Enari, Y., Enomoto, R., Erdos, E., Erickson, R., Ernst, J. A., Erwin, R. J., Escalier, M., Eschenburg, V., Eschrich, I., Esen, S., Esteve, L., Evangelisti, F., Everton, C. W., Eyges, V., Fabby, C., Fabozzi, F., Fahey, S., Falbo, M., Fan, S., Fang, F., Fanin, C., Farbin, A., Farhat, H., Fast, J. E., Feindt, M., Fella, A., Feltresi, E., Ferber, T., Fernholz, R. E., Ferrag, S., Ferrarotto, F., Ferroni, F., Field, R. C., Filippi, A., Finocchiaro, G., Fioravanti, E., da Costa, J. Firmino, Fischer, P. -A., Fisher, A., Fisher, P. H., Flacco, C. J., Flack, R. L., Flaecher, H. U., Flanagan, J., Flanigan, J. M., Ford, K. E., Ford, W. T., Forster, I. J., Forti, A. C., Forti, F., Fortin, D., Foster, B., Foulkes, S. D., Fouque, G., Fox, J., Franchini, P., Sevilla, M. Franco, Franek, B., Frank, E. D., Fransham, K. B., Fratina, S., Fratini, K., Frey, A., Frey, R., Friedl, M., Fritsch, M., Fry, J. R., Fujii, H., Fujikawa, M., Fujita, Y., Fujiyama, Y., Fukunaga, C., Fukushima, M., Fullwood, J., Funahashi, Y., Funakoshi, Y., Furano, F., Furman, M., Furukawa, K., Futterschneider, H., Gabathuler, E., Gabriel, T. A., Gabyshev, N., Gaede, F., Gagliardi, N., Gaidot, A., Gaillard, J. -M., Gaillard, J. R., Galagedera, S., Galeazzi, F., Gallo, F., Gamba, D., Gamet, R., Gan, K. K., Gandini, P., Ganguly, S., Ganzhur, S. F., Gao, Y. Y., Gaponenko, I., Garmash, A., Tico, J. Garra, Garzia, I., Gaspero, M., Gastaldi, F., Gatto, C., Gaur, V., Geddes, N. I., Geld, T. L., Genat, J. -F., George, K. A., George, M., George, S., Georgette, Z., Gershon, T. J., Gill, M. S., Gillard, R., Gilman, J. D., Giordano, F., Giorgi, M. A., Giraud, P. -F., Gladney, L., Glanzman, T., Glattauer, R., Go, A., Goetzen, K., Goh, Y. M., Gokhroo, G., Goldenzweig, P., Golubev, V. B., Gopal, G. P., Gordon, A., Gorišek, A., Goriletsky, V. I., Gorodeisky, R., Gosset, L., Gotow, K., Gowdy, S. J., Graffin, P., Grancagnolo, S., Grauges, E., Graziani, G., Green, M. G., Greene, M. G., Grenier, G. J., Grenier, P., Griessinger, K., Grillo, A. A., Grinyov, B. V., Gritsan, A. V., Grosdidier, G., Perdekamp, M. Grosse, Grosso, P., Grothe, M., Groysman, Y., Grünberg, O., Guido, E., Guler, H., Gunawardane, N. J. W., Guo, Q. H., Guo, R. S., Guo, Z. J., Guttman, N., Ha, H., Ha, H. C., Haas, T., Haba, J., Hachtel, J., Hadavand, H. K., Hadig, T., Hagner, C., Haire, M., Haitani, F., Haji, T., Haller, G., Halyo, V., Hamano, K., Hamasaki, H., de Monchenault, G. Hamel, Hamilton, J., Hamilton, R., Hamon, O., Han, B. Y., Han, Y. L., Hanada, H., Hanagaki, K., Handa, F., Hanson, J. E., Hanushevsky, A., Hara, K., Hara, T., Harada, Y., Harrison, P. F., Harrison, T. J., Harrop, B., Hart, A. J., Hart, P. A., Hartfiel, B. L., Harton, J. L., Haruyama, T., Hasan, A., Hasegawa, Y., Hast, C., Hastings, N. C., Hasuko, K., Hauke, A., Hawkes, C. M., Hayashi, K., Hazumi, M., Hee, C., Heenan, E. M., Heffernan, D., Held, T., Henderson, R., Henderson, S. W., Hertzbach, S. S., Hervé, S., Heß, M., Heusch, C. A., Hicheur, A., Higashi, Y., Higasino, Y., Higuchi, I., Hikita, S., Hill, E. J., Himel, T., Hinz, L., Hirai, T., Hirano, H., Hirschauer, J. F., Hitlin, D. G., Hitomi, N., Hodgkinson, M. C., Höcker, A., Hoi, C. T., Hojo, T., Hokuue, T., Hollar, J. J., Hong, T. M., Honscheid, K., Hooberman, B., Hopkins, D. A., Horii, Y., Hoshi, Y., Hoshina, K., Hou, S., Hou, W. S., Hryn'ova, T., Hsiung, Y. B., Hsu, C. L., Hsu, S. C., Hu, H., Hu, T., Huang, H. C., Huang, T. J., Huang, Y. C., Huard, Z., Huffer, M. E., Hufnagel, D., Hung, T., Hutchcroft, D. E., Hyun, H. J., Ichizawa, S., Igaki, T., Igarashi, A., Igarashi, S., Igarashi, Y., Igonkina, O., Ikado, K., Ikeda, H., Ikeda, K., Ilic, J., Inami, K., Innes, W. R., Inoue, Y., Ishikawa, A., Ishino, H., Itagaki, K., Itami, S., Itoh, K., Ivanchenko, V. N., Iverson, R., Iwabuchi, M., Iwai, G., Iwai, M., Iwaida, S., Iwamoto, M., Iwasaki, H., Iwasaki, M., Iwashita, T., Izen, J. M., Jackson, D. J., Jackson, F., Jackson, G., Jackson, P. S., Jacobsen, R. G., Jacoby, C., Jaegle, I., Jain, V., Jalocha, P., Jang, H. K., Jasper, H., Jawahery, A., Jayatilleke, S., Jen, C. M., Jensen, F., Jessop, C. P., Ji, X. B., John, M. J. J., Johnson, D. R., Johnson, J. R., Jolly, S., Jones, M., Joo, K. K., Joshi, N., Joshi, N. J., Judd, D., Julius, T., Kadel, R. W., Kadyk, J. A., Kagan, H., Kagan, R., Kah, D. H., Kaiser, S., Kaji, H., Kajiwara, S., Kakuno, H., Kameshima, T., Kaminski, J., Kamitani, T., Kaneko, J., Kang, J. H., Kang, J. S., Kani, T., Kapusta, P., Karbach, T. M., Karolak, M., Karyotakis, Y., Kasami, K., Katano, G., Kataoka, S. U., Katayama, N., Kato, E., Kato, Y., Kawai, H., Kawai, M., Kawamura, N., Kawasaki, T., Kay, J., Kay, M., Kelly, M. P., Kelsey, M. H., Kent, N., Kerth, L. T., Khan, A., Khan, H. R., Kharakh, D., Kibayashi, A., Kichimi, H., Kiesling, C., Kikuchi, M., Kikutani, E., Kim, B. H., Kim, C. H., Kim, D. W., Kim, H., Kim, H. J., Kim, H. O., Kim, H. W., Kim, J. B., Kim, J. H., Kim, K. T., Kim, M. J., Kim, P., Kim, S. K., Kim, S. M., Kim, T. H., Kim, Y. I., Kim, Y. J., King, G. J., Kinoshita, K., Kirk, A., Kirkby, D., Kitayama, I., Klemetti, M., Klose, V., Klucar, J., Knecht, N. S., Knoepfel, K. J., Knowles, D. J., Ko, B. R., Kobayashi, N., Kobayashi, S., Kobayashi, T., Kobel, M. J., Koblitz, S., Koch, H., Kocian, M. L., Kodyš, P., Koeneke, K., Kofler, R., Koike, S., Koishi, S., Koiso, H., Kolb, J. A., Kolya, S. D., Kondo, Y., Konishi, H., Koppenburg, P., Koptchev, V. B., Kordich, T. M. B., Korol, A. A., Korotushenko, K., Korpar, S., Kouzes, R. T., Kovalskyi, D., Kowalewski, R., Kozakai, Y., Kozanecki, W., Kral, J. F., Krasnykh, A., Krause, R., Kravchenko, E. A., Krebs, J., Kreisel, A., Kreps, M., Krishnamurthy, M., Kroeger, R., Kroeger, W., Krokovny, P., Kronenbitter, B., Kroseberg, J., Kubo, T., Kuhr, T., Kukartsev, G., Kulasiri, R., Kulikov, A., Kumar, R., Kumar, S., Kumita, T., Kuniya, T., Kunze, M., Kuo, C. C., Kuo, T. -L., Kurashiro, H., Kurihara, E., Kurita, N., Kuroki, Y., Kurup, A., Kutter, P. E., Kuznetsova, N., Kvasnička, P., Kyberd, P., Kyeong, S. H., Lacker, H. M., Lae, C. K., Lamanna, E., Lamsa, J., Lanceri, L., Landi, L., Lang, M. I., Lange, D. J., Lange, J. S., Langenegger, U., Langer, M., Lankford, A. J., Lanni, F., Laplace, S., Latour, E., Lau, Y. P., Lavin, D. R., Layter, J., Lebbolo, H., LeClerc, C., Leddig, T., Leder, G., Diberder, F. Le, Lee, C. L., Lee, J., Lee, J. S., Lee, M. C., Lee, M. H., Lee, M. J., Lee, S. -J., Lee, S. E., Lee, S. H., Lee, Y. J., Lees, J. P., Legendre, M., Leitgab, M., Leitner, R., Leonardi, E., Leonidopoulos, C., Lepeltier, V., Leruste, Ph., Lesiak, T., Levi, M. E., Levy, S. L., Lewandowski, B., Lewczuk, M. J., Lewis, P., Li, H., Li, H. B., Li, S., Li, X., Li, Y., Gioi, L. Li, Libby, J., Lidbury, J., Lillard, V., Lim, C. L., Limosani, A., Lin, C. S., Lin, J. Y., Lin, S. W., Lin, Y. S., Lindquist, B., Lindsay, C., Lista, L., Liu, C., Liu, F., Liu, H., Liu, H. M., Liu, J., Liu, R., Liu, T., Liu, Y., Liu, Z. Q., Liventsev, D., Vetere, M. Lo, Locke, C. B., Lockman, W. S., Di Lodovico, F., Lombardo, V., London, G. W., Pegna, D. Lopes, Lopez, L., Lopez-March, N., Lory, J., LoSecco, J. M., Lou, X. C., Louvot, R., Lu, A., Lu, C., Lu, M., Lu, R. S., Lueck, T., Luitz, S., Lukin, P., Lund, P., Luppi, E., Lutz, A. M., Lutz, O., Lynch, G., Lynch, H. L., Lyon, A. J., Lyubinsky, V. R., MacFarlane, D. B., Mackay, C., MacNaughton, J., Macri, M. M., Madani, S., Mader, W. F., Majewski, S. A., Majumder, G., Makida, Y., Malaescu, B., Malaguti, R., Malclès, J., Mallik, U., Maly, E., Mamada, H., Manabe, A., Mancinelli, G., Mandelkern, M., Mandl, F., Manfredi, P. F., Mangeol, D. J. J., Manoni, E., Mao, Z. P., Margoni, M., Marker, C. E., Markey, G., Marks, J., Marlow, D., Marques, V., Marsiske, H., Martellotti, S., Martin, E. C., Martin, J. P., Martin, L., Martinez, A. J., Marzolla, M., Mass, A., Masuzawa, M., Mathieu, A., Matricon, P., Matsubara, T., Matsuda, T., Matsumoto, H., Matsumoto, S., Matsumoto, T., Matsuo, H., Mattison, T. S., Matvienko, D., Matyja, A., Mayer, B., Mazur, M. A., Mazzoni, M. A., McCulloch, M., McDonald, J., McFall, J. D., McGrath, P., McKemey, A. K., McKenna, J. A., Mclachlin, S. E., McMahon, S., McMahon, T. R., McOnie, S., Medvedeva, T., Melen, R., Mellado, B., Menges, W., Menke, S., Merchant, A. M., Merkel, J., Messner, R., Metcalfe, S., Metzler, S., Meyer, N. T., Meyer, T. I., Meyer, W. T., Michael, A. K., Michelon, G., Michizono, S., Micout, P., Miftakov, V., Mihalyi, A., Mikami, Y., Milanes, D. A., Milek, M., Mimashi, T., Minamora, J. S., Mindas, C., Minutoli, S., Mir, L. M., Mishra, K., Mitaroff, W., Miyake, H., Miyashita, T. S., Miyata, H., Miyazaki, Y., Moffitt, L. C., Mohapatra, A., Mohapatra, A. K., Mohapatra, D., Moll, A., Moloney, G. R., Mols, J. P., Mommsen, R. K., Monge, M. R., Monorchio, D., Moore, T. B., Moorhead, G. F., de Freitas, P. Mora, Morandin, M., Morgan, N., Morgan, S. E., Morganti, M., Morganti, S., Mori, S., Mori, T., Morii, M., Morris, J. P., Morsani, F., Morton, G. W., Moss, L. J., Mouly, J. P., Mount, R., Mueller, J., Müller-Pfefferkorn, R., Mugge, M., Muheim, F., Muir, A., Mullin, E., Munerato, M., Murakami, A., Murakami, T., Muramatsu, N., Musico, P., Nagai, I., Nagamine, T., Nagasaka, Y., Nagashima, Y., Nagayama, S., Nagel, M., Naisbit, M. T., Nakadaira, T., Nakahama, Y., Nakajima, M., Nakajima, T., Nakamura, I., Nakamura, T., Nakamura, T. T., Nakano, E., Nakayama, H., Nam, J. W., Narita, S., Narsky, I., Nash, J . 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M., Zhulanov, V., Ziegler, T., Ziegler, V., Zioulas, G., Zisman, M., Zito, M., Zürcher, D., Zwahlen, N., Zyukova, O., Živko, T., and Žontar, D.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C. Please note that version 3 on the archive is the auxiliary version of the Physics of the B Factories book. This uses the notation alpha, beta, gamma for the angles of the Unitarity Triangle. The nominal version uses the notation phi_1, phi_2 and phi_3. Please cite this work as Eur. Phys. J. C74 (2014) 3026., Comment: 928 pages, version 3 (arXiv:1406.6311v3) corresponds to the alpha, beta, gamma version of the book, the other versions use the phi1, phi2, phi3 notation
Published: 2014
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2. A non-perturbative study of non-commutative U(1) gauge theory

Author: Nishimura, J., Bietenholz, W., Susaki, Y., and Volkholz, J.
Subjects: High Energy Physics - Theory, High Energy Physics - Lattice
Abstract: We study U(1) gauge theory on a 4d non-commutative torus, where two directions are non-commutative. Monte Carlo simulations are performed after mapping the regularized theory onto a U(N) lattice gauge theory in d=2. At intermediate coupling strength, we find a phase in which open Wilson lines acquire non-zero vacuum expectation values, which implies the spontaneous breakdown of translational invariance. In this phase, various physical quantities obey clear scaling behaviors in the continuum limit with a fixed non-commutativity parameter theta, which provides evidence for a possible continuum theory. In the weak coupling symmetric phase, the dispersion relation involves a negative IR-singular term, which is responsible for the observed phase transition., Comment: 7 pages, 4 figures, Talk presented by J. Nishimura at the 21st Nishinomiya-Yukawa Memorial Symposium on Theoretical Physics: ``Noncommutative Geometry and Quantum Spacetime in Physics'', Nishinomiya and Kyoto (2006)
Published: 2007
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3. The Scaling of QED in a Non-Commutative Space-Time

Author: Volkholz, J., Bietenholz, W., Nishimura, J., and Susaki, Y.
Subjects: High Energy Physics - Lattice, High Energy Physics - Theory
Abstract: We present results of numerical simulations for pure U(1) gauge theory in a non-commutative space. The theory is mapped onto a dimensionally reduced matrix model, which renders its numerical treatment feasible. New data on large lattices reveal the scaling of Wilson loops and their correlation functions in the simultaneous limit to the continuum and to infinite volume, at fixed non-commutativity. In this on-going project we are particularly interested in the IR behaviour, the ``photo-ball'' spectrum and in the photon dispersion relation., Comment: 6 pages, 3 figures, talk presented at LATTICE05
Published: 2005

4. Numerical Results for U(1) Gauge Theory on 2d and 4d Non-Commutative Spaces

Author: Bietenholz, W., Bigarini, A., Hofheinz, F., Nishimura, J., Susaki, Y., and Volkholz, J.
Subjects: High Energy Physics - Theory, High Energy Physics - Lattice
Abstract: We present non-perturbative results for U(1) gauge theory in spaces, which include a non-commutative plane. In contrast to the commutative space, such gauge theories involve a Yang-Mills term, and the Wilson loop is complex on the non-perturbative level. We first consider the 2d case: small Wilson loops follows an area law, whereas for large Wilson loops the complex phase rises linearly with the area. In four dimensions the behavior is qualitatively similar for loops in the non-commutative plane, whereas the loops in other planes follow closely the commutative pattern. In d=2 our results can be extrapolated safely to the continuum limit, and in d=4 we report on recent progress towards this goal., Comment: 9 pages, 7 figures, talk presented at "Ahrenshoop 2004"
Published: 2005
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5. First Simulation Results for the Photon in a Non-Commutative Space

Author: Bietenholz, W., Hofheinz, F., Nishimura, J., Susaki, Y., and Volkholz, J.
Subjects: High Energy Physics - Lattice, High Energy Physics - Theory
Abstract: We present preliminary simulation results for QED in a non-commutative 4d space-time, which is discretized to a fuzzy lattice. Its numerical treatment becomes feasible after its mapping onto a dimensionally reduced twisted Eguchi-Kawai matrix model. In this formulation we investigate the Wilson loops and in particular the Creutz ratios. This is an ongoing project which aims at non-perturbative predictions for the photon, which can be confronted with phenomenology in order to verify the possible existence of non-commutativity in nature., Comment: 3 pages, 4 figures, talk presented by J. Volkholz at Lattice2004(theory)
Published: 2004
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6. Evaluation of the inhibitory and induction potential of YM758, a novel If channel inhibitor, for human P450-mediated metabolism

Author: Umehara, K-I., Susaki, Y., van Teylingen, R. H. J., Neat, J. N., Ndikum-moffor, F., Noguchi, K., Usui, T., Parkinson, A., and Kamimura, H.
Published: 2008
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7. Gradient-based PIV using neural networks

Author: Kimura I., Susaki Y., Kiyohara R., Kaga A., and Kuroe Y.
Published: 2002
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8. First Simulation Results for the Photon in a Non-Commutative Space

Author: Bietenholz, W., Hofheinz, F., Nishimura, J., Susaki, Y., and Volkholz, J.
Published: 2005
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9. The Physics of the B Factories

Author: Bevan, A, Golob, B, Mannel, T, Prell, S, Yabsley, B, Aihara, H, Anulli, F, Arnaud, N, Aushev, T, Beneke, M, Beringer, J, Bianchi, F, Bigi, I, Bona, M, Brambilla, N, Brodzicka, J, Chang, P, Charles, M, Cheng, C, Cheng, H, Chistov, R, Colangelo, P, Coleman, J, Drutskoy, A, Druzhinin, V, Eidelman, S, Eigen, G, Eisner, A, Faccini, R, Flood, K, Gambino, P, Gaz, A, Gradl, W, Hayashii, H, Higuchi, T, Hulsbergen, W, Hurth, T, Iijima, T, Itoh, R, Jackson, P, Kass, R, Kolomensky, Y, Kou, E, Križan, P, Kronfeld, A, Kumano, S, Kwon, Y, Latham, T, Leith, D, Lüth, V, Martinez-Vidal, F, Meadows, B, Mussa, R, Nakao, M, Nishida, S, Ocariz, J, Olsen, S, Pakhlov, P, Pakhlova, G, Palano, A, Pich, A, Playfer, S, Poluektov, A, Porter, F, Robertson, S, Roney, J, Roodman, A, Sakai, Y, Schwanda, C, Schwartz, A, Seidl, R, Sekula, S, Steinhauser, M, Sumisawa, K, Swanson, E, Tackmann, F, Trabelsi, K, Uehara, S, Uno, S, van de Water, R, Vasseur, G, Verkerke, W, Waldi, R, Wang, M, Wilson, F, Zupan, J, Zupanc, A, Adachi, I, Albert, J, Banerjee, S, Bellis, M, Ben-Haim, E, Biassoni, P, Cahn, R, Cartaro, C, Chauveau, J, Chen, C, Chiang, C, Cowan, R, Dalseno, J, Davier, M, Davies, C, Dingfelder, J, Echenard, B, Epifanov, D, Fulsom, B, Gabareen, A, Gary, J, Godang, R, Graham, M, Hafner, A, Hamilton, B, Hartmann, T, Hayasaka, K, Hearty, C, Iwasaki, Y, Khodjamirian, A, Kusaka, A, Kuzmin, A, Lafferty, G, Lazzaro, A, Li, J, Lindemann, D, Long, O, Lusiani, A, Marchiori, G, Martinelli, M, Miyabayashi, K, Mizuk, R, Mohanty, G, Muller, D, Nakazawa, H, Ongmongkolkul, P, Pacetti, S, Palombo, F, Pedlar, T, Piilonen, L, Pilloni, A, Poireau, V, Prothmann, K, Pulliam, T, Rama, M, Ratcliff, B, Roudeau, P, Schrenk, S, Schroeder, T, Schubert, K, Shen, C, Shwartz, B, Soffer, A, Solodov, E, Somov, A, Starič, M, Stracka, S, Telnov, A, Todyshev, K, Tsuboyama, T, Uglov, T, Vinokurova, A, Walsh, J, Watanabe, Y, Won, E, Wormser, G, Wright, D, Ye, S, Zhang, C, Abachi, S, Abashian, A, Abe, K, Abe, N, Abe, R, Abe, 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Kukartsev, G., Kulasiri, R., Kulikov, A., Kumar, R., Kumar, S., Kumita, T., Kuniya, T., Kunze, M., Kuo, C., Kuo, T., Kurashiro, H., Kurihara, E., Kurita, N., Kuroki, Y., Kurup, A., Kutter, P., Kuznetsova, N., Kvasnička, P., Kyberd, P., Kyeong, S., Lacker, H., Lae, C., Lamanna, E., Lamsa, J., Lanceri, L., Landi, L., Lang, M., Lange, D., Lange, J., Langenegger, U., Langer, M., Lankford, A., Lanni, F., Laplace, S., Latour, E., Lau, Y., Lavin, D., Layter, J., Lebbolo, H., LeClerc, C., Leddig, T., Leder, G., Le Diberder, F., Lee, C., Lee, J., Lee, M., Lee, S., Lee, Y., Lees, J., Legendre, M., Leitgab, M., Leitner, R., Leonardi, E., Leonidopoulos, C., Lepeltier, V., Leruste, P., Lesiak, T., Levi, M., Levy, S., Lewandowski, B., Lewczuk, M., Lewis, P., Li, H., Li, S., Li, X., Li, Y., Gioi, L., Libby, J., Lidbury, J., Lillard, V., Lim, C., Limosani, A., Lin, C., Lin, J., Lin, S., Lin, Y., Lindquist, B., Lindsay, C., Lista, L., Liu, C., Liu, F., Liu, H., Liu, J., Liu, R., Liu, T., Liu, Y., Liu, Z., Liventsev, D., Lo Vetere, M., Locke, C., Lockman, W., Di Lodovico, F., Lombardo, V., London, G., Lopes Pegna, D., Lopez, L., Lopez-March, N., Lory, J., LoSecco, J., Lou, X., Louvot, R., Lu, A., Lu, C., Lu, M., Lu, R., Lueck, T., Luitz, S., Lukin, P., Lund, P., Luppi, E., Lutz, A., Lutz, O., Lynch, G., Lynch, H., Lyon, A., Lyubinsky, V., MacFarlane, D., Mackay, C., MacNaughton, J., Macri, M., Madani, S., Mader, W., Majewski, S., Majumder, G., Makida, Y., Malaescu, B., Malaguti, R., Malclés, J., Mallik, U., Maly, E., Mamada, H., Manabe, A., Mancinelli, G., Mandelkern, M., Mandl, F., Manfredi, P., Mangeol, D., Manoni, E., Mao, Z., Margoni, M., Marker, C., Markey, G., Marks, J., Marlow, D., Marques, V., Marsiske, H., Martellotti, S., Martin, E., Martin, J., Martin, L., Martinez, A., Marzolla, M., Mass, A., Masuzawa, M., Mathieu, A., Matricon, P., Matsubara, T., Matsuda, T., Matsumoto, H., Matsumoto, S., Matsumoto, T., Matsuo, H., Mattison, T., Matvienko, D., Matyja, A., Mayer, B., Mazur, M., Mazzoni, M., McCulloch, M., McDonald, J., McFall, J., McGrath, P., McKemey, A., McKenna, J., Mclachlin, S., McMahon, S., McMahon, T., McOnie, S., Medvedeva, T., Melen, R., Mellado, B., Menges, W., Menke, S., Merchant, A., Merkel, J., Messner, R., Metcalfe, S., Metzler, S., Meyer, N., Meyer, T., Meyer, W., Michael, A., Michelon, G., Michizono, S., Micout, P., Miftakov, V., Mihalyi, A., Mikami, Y., Milanes, D., Milek, M., Mimashi, T., Minamora, J., Mindas, C., Minutoli, S., Mir, L., Mishra, K., Mitaroff, W., Miyake, H., Miyashita, T., Miyata, H., Miyazaki, Y., Moffitt, L., Mohapatra, A., Mohapatra, D., Moll, A., Moloney, G., Mols, J., Mommsen, R., Monge, M., Monorchio, D., Moore, T., Moorhead, G., Mora de Freitas, P., Morandin, M., Morgan, N., Morgan, S., Morganti, M., Morganti, S., Mori, S., Mori, T., Morii, M., Morris, J., Morsani, F., Morton, G., Moss, L., Mouly, J., Mount, R., Mueller, J., Müller-Pfefferkorn, R., Mugge, M., Muheim, F., Muir, A., Mullin, E., Munerato, M., Murakami, A., Murakami, T., Muramatsu, N., Musico, P., Nagai, I., Nagamine, T., Nagasaka, Y., Nagashima, Y., Nagayama, S., Nagel, M., Naisbit, M., Nakadaira, T., Nakahama, Y., Nakajima, M., Nakajima, T., Nakamura, I., Nakamura, T., Nakano, E., Nakayama, H., Nam, J., Narita, S., Narsky, I., Nash, J., Natkaniec, Z., Nauenberg, U., Nayak, M., Neal, H., Nedelkovska, E., Negrini, M., Neichi, K., Nelson, D., Nelson, S., Neri, N., Nesom, G., Neubauer, S., Newman-Coburn, D., Ng, C., Nguyen, X., Nicholson, H., Niebuhr, C., Nief, J., Niiyama, M., Nikolich, M., Nisar, N., Nishimura, K., Nishio, Y., Nitoh, O., Nogowski, R., Noguchi, S., Nomura, T., Nordby, M., Nosochkov, Y., Novokhatski, A., Nozaki, S., Nozaki, T., Nugent, I., O’Grady, C., O’Neale, S., O’Neill, F., Oberhof, B., Oddone, P., Ofte, I., Ogawa, A., Ogawa, K., Ogawa, S., Ogawa, Y., Ohkubo, R., Ohmi, K., Ohnishi, Y., Ohno, F., Ohshima, T., Ohshima, Y., Ohuchi, N., Oide, K., Oishi, N., Okabe, T., Okazaki, N., Okazaki, T., Okuno, S., Olaiya, E., Olivas, A., Olley, P., Olsen, J., Ono, S., Onorato, G., Onuchin, A., Onuki, Y., Ooba, T., Orimoto, T., Oshima, T., Osipenkov, I., Ostrowicz, W., Oswald, C., Otto, S., Oyang, J., Oyanguren, A., Ozaki, H., Ozcan, V., Paar, H., Padoan, C., Paick, K., Palka, H., Pan, B., Pan, Y., Panduro Vazquez, W., Panetta, J., Panova, A., Panvini, R., Panzenböck, E., Paoloni, E., Paolucci, P., Pappagallo, M., Paramesvaran, S., Park, C., Park, H., Park, K., Park, W., Parry, R., Parslow, N., Passaggio, S., Pastore, F., Patel, P., Patrignani, C., Patteri, P., Pavel, T., Pavlovich, J., Payne, D., Peak, L., Peimer, D., Pelizaeus, M., Pellegrini, R., Pelliccioni, M., Peng, C., Peng, J., Peng, K., Peng, T., Penichot, Y., Pennazzi, S., Pennington, M., Penny, R., Penzkofer, A., Perazzo, A., Perez, A., Perl, M., Pernicka, M., Perroud, J., Peruzzi, I., Pestotnik, R., Peters, K., Peters, M., Petersen, B., Petersen, T., Petigura, E., Petrak, S., Petrella, A., Petrič, M., Petzold, A., Pia, M., Piatenko, T., Piccolo, D., Piccolo, M., Piemontese, L., Piemontese, M., Pierini, M., Pierson, S., Pioppi, M., Piredda, G., Pivk, M., Plaszczynski, S., Polci, F., Pompili, A., Poropat, P., Posocco, M., Potter, C., Potter, R., Prasad, V., Prebys, E., Prencipe, E., Prendki, J., Prepost, R., Prest, M., Prim, M., Pripstein, M., Prudent, X., Pruvot, S., Puccio, E., Purohit, M., Qi, N., Quinn, H., Raaf, J., Rabberman, R., Raffaelli, F., Ragghianti, G., Rahatlou, S., Rahimi, A., Rahmat, R., Rakitin, A., Randle-Conde, A., Rankin, P., Rashevskaya, I., Ratkovsky, S., Raven, G., Re, V., Reep, M., Regensburger, J., Reidy, J., Reif, R., Reisert, B., Renard, C., Renga, F., Ricciardi, S., Richman, J., Ritchie, J., Ritter, M., Rivetta, C., Rizzo, G., Roat, C., Robbe, P., Roberts, D., Robertson, A., Robutti, E., Rodier, S., Rodriguez, D., Rodriguez, J., Rodriguez, R., Roe, N., Röhrken, M., Roethel, W., Rolquin, J., Romanov, L., Romosan, A., Ronan, M., Rong, G., Ronga, F., Roos, L., Root, N., Rosen, M., 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Zhu, R., Zhu, Y., Zhu, Z., Zhulanov, V., Ziegler, T., Ziegler, V., Zioulas, G., Zisman, M., Zito, M., Zürcher, D., Zwahlen, N., Zyukova, O., Živko, T., and Žontar, D.
Published: 2014

10. [Review to:] The Physics of the B Factories

Author: Bevan, A. J., Golob, B., Mannel, Th., Prell, S., Yabsley, B. D., Aihara, H., Anulli, F., Arnaud, N., Aushev, T., Beneke, M., Beringer, J., Bianchi, F., Bigi, I. I., Bona, M., Brambilla, N., Brodzicka, J., Chang, P., Charles, M. J., Cheng, C. H., Cheng, H. -Y., Chistov, R., Colangelo, P., Coleman, J. P., Drutskoy, A., Druzhinin, V. P., Eidelman, S., Eigen, G., Eisner, A. M., Faccini, R., Flood, K. T., Gambino, P., Gaz, A., Gradl, W., Hayashii, H., Higuchi, T., Hulsbergen, W. D., Hurth, T., Iijima, T., Itoh, R., Jackson, P. D., Kass, R., Kolomensky, Yu. G., Kou, E., Križan, P., Kronfeld, A., Kumano, S., Kwon, Y. J., Latham, T. E., Leith, D. W. G. S., Lüth, V., Martinez-Vidal, F., Meadows, B. T., Mussa, R., Nakao, M., Nishida, S., Ocariz, J., Olsen, S. L., Pakhlov, P., Pakhlova, G., Palano, A., Pich, A., Playfer, S., Poluektov, A., Porter, F. C., Robertson, S. H., Roney, J. M., Roodman, A., Sakai, Y., Schwanda, C., Schwartz, A. J., Seidl, R., Sekula, S. J., Steinhauser, M., Sumisawa, K., Swanson, E. S., Tackmann, F., Trabelsi, K., Uehara, S., Uno, S., van de Water, R., Vasseur, G., Verkerke, W., Waldi, R., Wang, M. Z., Wilson, F. F., Zupan, J., Zupanc, A., Adachi, I., Albert, J., Banerjee, Sw., Bellis, M., Ben-Haim, E., Biassoni, P., Cahn, R. N., Cartaro, C., Chauveau, J., Chen, C., Chiang, C. C., Cowan, R., Dalseno, J., Davier, M., Davies, C., Dingfelder, J. C., Echenard, B., Epifanov, D., Fulsom, B. G., Gabareen, A. M., Gary, J. W., Godang, R., Graham, M. T., Hafner, A., Hamilton, B., Hartmann, T., Hayasaka, K., Hearty, C., Iwasaki, Y., Khodjamirian, A., Kusaka, A., Kuzmin, A., Lafferty, G. D., Lazzaro, A., Li, J., Lindemann, D., Long, O., Lusiani, A., Marchiori, G., Martinelli, M., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Muller, D. R., Nakazawa, H., Ongmongkolkul, P., Pacetti, S., Palombo, F., Pedlar, T. K., Piilonen, L. E., Pilloni, A., Poireau, V., Prothmann, K., Pulliam, T., Rama, M., Ratcliff, B. N., Roudeau, P., Schrenk, S., Schroeder, T., Schubert, K. R., Shen, C. P., Shwartz, B., Soffer, A., Solodov, E. P., Somov, A., Starič, M., Stracka, S., Telnov, A. V., Todyshev, K. Yu., Tsuboyama, T., Uglov, T., Vinokurova, A., Walsh, J. J., Watanabe, Y., Won, E., Wormser, G., Wright, D. H., Ye, S., Zhang, C. C., Abachi, S., Abashian, A., Abe, K., Abe, N., Abe, R., Abe, T., Abrams, G. S., Adam, I., Adamczyk, K., Adametz, A., Adye, T., Agarwal, A., Ahmed, H., Ahmed, M., Ahmed, S., Ahn, B. S., Ahn, H. S., Aitchison, I. J. R., Akai, K., Akar, S., Akatsu, M., Akemoto, M., Akhmetshin, R., Akre, R., Alam, M. S., Albert, J. N., Aleksan, R., Alexander, J. P., Alimonti, G., Allen, M. T., Allison, J., Allmendinger, T., Alsmiller, J. R. G., Altenburg, D., Alwyn, K. E., An, Q., Anderson, J., Andreassen, R., Andreotti, D., Andreotti, M., Andress, J. C., Angelini, C., Anipko, D., Anjomshoaa, A., Anthony, P. L., Antillon, E. A., Antonioli, E., Aoki, K., Arguin, J. 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M., Zhulanov, V., Ziegler, T., Ziegler, V., Zioulas, G., Zisman, M., Zito, M., Zürcher, D., Zwahlen, N., Zyukova, O., Živko, T., and Žontar, D.
Subjects: Physics and Astronomy (miscellaneous), Engineering (miscellaneous), Settore ING-INF/01 - Elettronica
Published: 2014

11. Solitary pulmonary nodules due to non-tuberculous mycobacteriosis among 28 resected cases

Author: Ose, N., primary, Maeda, H., additional, Takeuchi, Y., additional, Susaki, Y., additional, Kobori, Y., additional, Taniguchi, S., additional, and Maekura, R., additional
Published: 2016
Full Text: View/download PDF

12. The Physics of the B Factories

Author: Bevan, A. J., primary, Golob, B., additional, Mannel, Th., additional, Prell, S., additional, Yabsley, B. D., additional, Aihara, H., additional, Anulli, F., additional, Arnaud, N., additional, Aushev, T., additional, Beneke, M., additional, Beringer, J., additional, Bianchi, F., additional, Bigi, I. I., additional, Bona, M., additional, Brambilla, N., additional, Brodzicka, J., additional, Chang, P., additional, Charles, M. J., additional, Cheng, C. H., additional, Cheng, H.-Y., additional, Chistov, R., additional, Colangelo, P., additional, Coleman, J. P., additional, Drutskoy, A., additional, Druzhinin, V. P., additional, Eidelman, S., additional, Eigen, G., additional, Eisner, A. M., additional, Faccini, R., additional, Flood, K. T., additional, Gambino, P., additional, Gaz, A., additional, Gradl, W., additional, Hayashii, H., additional, Higuchi, T., additional, Hulsbergen, W. D., additional, Hurth, T., additional, Iijima, T., additional, Itoh, R., additional, Jackson, P. D., additional, Kass, R., additional, Kolomensky, Yu. G., additional, Kou, E., additional, Križan, P., additional, Kronfeld, A., additional, Kumano, S., additional, Kwon, Y. J., additional, Latham, T. E., additional, Leith, D. W. G. S., additional, Lüth, V., additional, Martinez-Vidal, F., additional, Meadows, B. T., additional, Mussa, R., additional, Nakao, M., additional, Nishida, S., additional, Ocariz, J., additional, Olsen, S. L., additional, Pakhlov, P., additional, Pakhlova, G., additional, Palano, A., additional, Pich, A., additional, Playfer, S., additional, Poluektov, A., additional, Porter, F. C., additional, Robertson, S. H., additional, Roney, J. M., additional, Roodman, A., additional, Sakai, Y., additional, Schwanda, C., additional, Schwartz, A. J., additional, Seidl, R., additional, Sekula, S. J., additional, Steinhauser, M., additional, Sumisawa, K., additional, Swanson, E. S., additional, Tackmann, F., additional, Trabelsi, K., additional, Uehara, S., additional, Uno, S., additional, van de Water, R., additional, Vasseur, G., additional, Verkerke, W., additional, Waldi, R., additional, Wang, M. Z., additional, Wilson, F. F., additional, Zupan, J., additional, Zupanc, A., additional, Adachi, I., additional, Albert, J., additional, Banerjee, Sw., additional, Bellis, M., additional, Ben-Haim, E., additional, Biassoni, P., additional, Cahn, R. N., additional, Cartaro, C., additional, Chauveau, J., additional, Chen, C., additional, Chiang, C. C., additional, Cowan, R., additional, Dalseno, J., additional, Davier, M., additional, Davies, C., additional, Dingfelder, J. C., additional, Echenard, B., additional, Epifanov, D., additional, Fulsom, B. G., additional, Gabareen, A. M., additional, Gary, J. W., additional, Godang, R., additional, Graham, M. T., additional, Hafner, A., additional, Hamilton, B., additional, Hartmann, T., additional, Hayasaka, K., additional, Hearty, C., additional, Iwasaki, Y., additional, Khodjamirian, A., additional, Kusaka, A., additional, Kuzmin, A., additional, Lafferty, G. D., additional, Lazzaro, A., additional, Li, J., additional, Lindemann, D., additional, Long, O., additional, Lusiani, A., additional, Marchiori, G., additional, Martinelli, M., additional, Miyabayashi, K., additional, Mizuk, R., additional, Mohanty, G. B., additional, Muller, D. R., additional, Nakazawa, H., additional, Ongmongkolkul, P., additional, Pacetti, S., additional, Palombo, F., additional, Pedlar, T. K., additional, Piilonen, L. E., additional, Pilloni, A., additional, Poireau, V., additional, Prothmann, K., additional, Pulliam, T., additional, Rama, M., additional, Ratcliff, B. N., additional, Roudeau, P., additional, Schrenk, S., additional, Schroeder, T., additional, Schubert, K. R., additional, Shen, C. P., additional, Shwartz, B., additional, Soffer, A., additional, Solodov, E. P., additional, Somov, A., additional, Starič, M., additional, Stracka, S., additional, Telnov, A. V., additional, Todyshev, K. Yu., additional, Tsuboyama, T., additional, Uglov, T., additional, Vinokurova, A., additional, Walsh, J. J., additional, Watanabe, Y., additional, Won, E., additional, Wormser, G., additional, Wright, D. H., additional, Ye, S., additional, Zhang, C. C., additional, Abachi, S., additional, Abashian, A., additional, Abe, K., additional, Abe, N., additional, Abe, R., additional, Abe, T., additional, Abrams, G. S., additional, Adam, I., additional, Adamczyk, K., additional, Adametz, A., additional, Adye, T., additional, Agarwal, A., additional, Ahmed, H., additional, Ahmed, M., additional, Ahmed, S., additional, Ahn, B. S., additional, Ahn, H. S., additional, Aitchison, I. J. 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M., additional, Aso, T., additional, Aspinwall, M. L., additional, Aston, D., additional, Atmacan, H., additional, Aubert, B., additional, Aulchenko, V., additional, Ayad, R., additional, Azemoon, T., additional, Aziz, T., additional, Azzolini, V., additional, Azzopardi, D. E., additional, Baak, M. A., additional, Back, J. J., additional, Bagnasco, S., additional, Bahinipati, S., additional, Bailey, D. S., additional, Bailey, S., additional, Bailly, P., additional, van Bakel, N., additional, Bakich, A. M., additional, Bala, A., additional, Balagura, V., additional, Baldini-Ferroli, R., additional, Ban, Y., additional, Banas, E., additional, Band, H. R., additional, Banerjee, S., additional, Baracchini, E., additional, Barate, R., additional, Barberio, E., additional, Barbero, M., additional, Bard, D. J., additional, Barillari, T., additional, Barlow, N. R., additional, Barlow, R. 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A., additional, Bougher, J., additional, Bouldin, K., additional, Bourgeois, P., additional, Boutigny, D., additional, Bowerman, D. A., additional, Boyarski, A. M., additional, Boyce, R. F., additional, Boyd, J. T., additional, Bozek, A., additional, Bozzi, C., additional, Bračko, M., additional, Brandenburg, G., additional, Brandt, T., additional, Brau, B., additional, Brau, J., additional, Breon, A. B., additional, Breton, D., additional, Brew, C., additional, Briand, H., additional, Bright-Thomas, P. G., additional, Brigljević, V., additional, Britton, D. I., additional, Brochard, F., additional, Broomer, B., additional, Brose, J., additional, Browder, T. E., additional, Brown, C. L., additional, Brown, C. M., additional, Brown, D. N., additional, Browne, M., additional, Bruinsma, M., additional, Brunet, S., additional, Bucci, F., additional, Buchanan, C., additional, Buchmueller, O. L., additional, Bünger, C., additional, Bugg, W., additional, Bukin, A. D., additional, Bula, R., additional, Bulten, H., additional, Burchat, P. R., additional, Burgess, W., additional, Burke, J. P., additional, Button-Shafer, J., additional, Buzykaev, A. R., additional, Buzzo, A., additional, Cai, Y., additional, Calabrese, R., additional, Calcaterra, A., additional, Calderini, G., additional, Camanzi, B., additional, Campagna, E., additional, Campagnari, C., additional, Capra, R., additional, Carassiti, V., additional, Carpinelli, M., additional, Carroll, M., additional, Casarosa, G., additional, Casey, B. C. K., additional, Cason, N. M., additional, Castelli, G., additional, Cavallo, N., additional, Cavoto, G., additional, Cecchi, A., additional, Cenci, R., additional, Cerizza, G., additional, Cervelli, A., additional, Ceseracciu, A., additional, Chai, X., additional, Chaisanguanthum, K. S., additional, Chang, M. C., additional, Chang, Y. H., additional, Chang, Y. W., additional, Chao, D. S., additional, Chao, M., additional, Chao, Y., additional, Charles, E., additional, Chavez, C. A., additional, Cheaib, R., additional, Chekelian, V., additional, Chen, A., additional, Chen, E., additional, Chen, G. P., additional, Chen, H. F., additional, Chen, J.-H., additional, Chen, J. C., additional, Chen, K. F., additional, Chen, P., additional, Chen, S., additional, Chen, W. T., additional, Chen, X., additional, Chen, X. R., additional, Chen, Y. Q., additional, Cheng, B., additional, Cheon, B. G., additional, Chevalier, N., additional, Chia, Y. M., additional, Chidzik, S., additional, Chilikin, K., additional, Chistiakova, M. V., additional, Cizeron, R., additional, Cho, I. S., additional, Cho, K., additional, Chobanova, V., additional, Choi, H. H. F., additional, Choi, K. S., additional, Choi, S. K., additional, Choi, Y., additional, Choi, Y. K., additional, Christ, S., additional, Chu, P. 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H., additional, Schwanke, U., additional, Schwarz, H., additional, Schwiening, J., additional, Schwierz, R., additional, Schwitters, R. F., additional, Sciacca, C., additional, Sciolla, G., additional, Scott, I. J., additional, Seeman, J., additional, Seiden, A., additional, Seitz, R., additional, Seki, T., additional, Sekiya, A.I., additional, Semenov, S., additional, Semmler, D., additional, Sen, S., additional, Senyo, K., additional, Seon, O., additional, Serbo, V. V., additional, Serednyakov, S. I., additional, Serfass, B., additional, Serra, M., additional, Serrano, J., additional, Settai, Y., additional, Seuster, R., additional, Sevior, M. E., additional, Shakhova, K. V., additional, Shang, L., additional, Shapkin, M., additional, Sharma, V., additional, Shebalin, V., additional, Shelkov, V. G., additional, Shen, B. C., additional, Shen, D. Z., additional, Shen, Y. T., additional, Sherwood, D. J., additional, Shibata, T., additional, Shibata, T. 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Published: 2014
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13. Clinical predictor of pre- or minimally invasive pulmonary adenocarcinoma: possibility of sub-classification of clinical T1a

Author: Sawabata, N., primary, Kanzaki, R., additional, Sakamoto, T., additional, Kusumoto, H., additional, Kimura, T., additional, Nojiri, T., additional, Kawamura, T., additional, Susaki, Y., additional, Funaki, S., additional, Nakagiri, T., additional, Shintani, Y., additional, Inoue, M., additional, Minami, M., additional, and Okumura, M., additional
Published: 2013
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14. P-133CLINICAL PREDICTOR OF PRE- OR MINIMALLY-INVASIVE PULMONARY ADENOCARCINOMA: A PROPOSAL FOR SUB-CLASSIFICATION OF CLINICAL T1a

Author: Sawabata, Noriyoshi, primary, Sakamoto, T., additional, Kusumoto, H., additional, Kimura, T., additional, Kanzaki, R., additional, Mojiri, T., additional, Kawamura, T., additional, Susaki, Y., additional, Funaki, S., additional, Nakagiri, T., additional, Shintani, Y., additional, Inoue, M., additional, Minami, M., additional, and Okumura, M., additional
Published: 2013
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15. Numerical results for U(1) gauge theory on 2d and 4d non‐commutative spaces

Author: Bietenholz, W., primary, Bigarini, A., additional, Hofheinz, F., additional, Nishimura, J., additional, Susaki, Y., additional, and Volkholz, J., additional
Published: 2005
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16. Functional properties of murine macrophages promoted by nerve growth factor

Author: Susaki, Y, primary, Shimizu, S, additional, Katakura, K, additional, Watanabe, N, additional, Kawamoto, K, additional, Matsumoto, M, additional, Tsudzuki, M, additional, Furusaka, T, additional, Kitamura, Y, additional, and Matsuda, H, additional
Published: 1996
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17. Inhibitory effects of a novel aromatase inhibitor, YM511, on growth of endometrial explants and insulin-like growth Factor-I gene expression in rats with experimental endometriosis

Author: Kudoh, M., Susaki, Y., Ideyama, Y., Nanya, T., Mori, M., and Shikama, H.
Published: 1997
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18. Topological aspects of gauge theory on noncommutative geometry

Author: Aoki, H., Nishimura, J., Susaki, Y., Satoshi Iso, Maeda, T., and Nagao, K.

19. The Physics of the B Factories

Author: Bevan, A. J., Golob, B., Mannel, Th., Prell, S., Yabsley, B. D., Abe, K., Aihara, H., Anulli, F., Arnaud, N., Aushev, T., Beneke, M., Beringer, J., Bianchi, F., Bigi, I. I., Bona, M., Brambilla, N., Brodzicka, J., Chang, P., Charles, M. J., Cheng, C. H., Cheng, H. -Y., Chistov, R., Colangelo, P., Coleman, J. P., Drutskoy, A., Druzhinin, V. P., Eidelman, S., Eigen, G., Eisner, A. M., Faccini, R., Flood, K. T., Gambino, P., Gaz, A., Gradl, W., Hayashii, H., Higuchi, T., Hulsbergen, W. D., Hurth, T., Iijima, T., Itoh, R., Jackson, P. D., Kass, R., Kolomensky, Yu. G., Kou, E., Križan, P., Kronfeld, A., Kumano, S., Kwon, Y. J., Latham, T. E., Leith, D. W. G. S., Lüth, V., Martinez-Vidal, F., Meadows, B. T., Mussa, R., Nakao, M., Nishida, S., Ocariz, J., Olsen, S. L., Pakhlov, P., Pakhlova, G., Palano, A., Pich, A., Playfer, S., Poluektov, A., Porter, F. C., Robertson, S. H., Roney, J. M., Roodman, A., Sakai, Y., Schwanda, C., Schwartz, A. J., Seidl, R., Sekula, S. J., Steinhauser, M., Sumisawa, K., Swanson, E. S., Tackmann, F., Trabelsi, K., Uehara, S., Uno, S., van der Water, R., Vasseur, G., Verkerke, W., Waldi, R., Wang, M. Z., Wilson, F. F., Zupan, J., Zupanc, A., Adachi, I., Albert, J., Banerjee, Sw., Ben-Haim, E., Biassoni, P., Cahn, R. N., Cartaro, C., Chauveau, J., Chen, C., Chiang, C. C., Cowan, R., Dalseno, J., Davier, M., Davies, C., Dingfelder, J. C., Echenard, B., Epifanov, D., Fulsom, B. G., Gabareen, A. M., Gary, J. W., Godang, R., Graham, M. T., Hafner, A., Hamilton, B., Hartmann, T., Hayasaka, K., Hearty, C., Iwasaki, Y., Khodjamirian, A., Kusaka, A., Kuzmin, A., Lafferty, G. D., Lazzaro, A., Li, J., Lindemann, D., Long, O., Lusiani, A., Marchiori, G., Martinelli, M., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Muller, D. R., Nakazawa, H., Ongmongkolkul, P., Pacetti, S., Palombo, F., Pedlar, T. K., Piilonen, L. E., Pilloni, A., Poireau, V., Prothmann, K., Pulliam, T., Rama, M., Ratcliff, B. N., Roudeau, P., Schrenk, S., Schroeder, T., Schubert, K. R., Shen, C. P., Shwartz, B., Soffer, A., Solodov, E. P., Somov, A., Starič, M., Stracka, S., Telnov, A. V., Todyshev, K. Yu., Tsuboyama, T., Uglov, T., Vinokurova, A., Walsh, J. J., Watanabe, Y., Won, E., Wormser, G., Wright, D. H., Ye, S., Zhang, C. C., Abachi, S., Abashian, A., Abe, N., Abe, R., Abe, T., Abrams, G. S., Adam, I., Adamczyk, K., Adametz, A., Adye, T., Agarwal, A., Ahmed, H., Ahmed, M., Ahmed, S., Ahn, B. S., Ahn, H. S., Aitchison, I. J. R., Akai, K., Akar, S., Akatsu, M., Akemoto, M., Akhmetshin, R., Akre, R., Alam, M. S., Albert, J. N., Aleksan, R., Alexander, J. P., Alimonti, G., Allen, M. T., Allison, J., Allmendinger, T., Alsmiller, J. R. G., Altenburg, D., Alwyn, K. E., An, Q., Anderson, J., Andreassen, R., Andreotti, D., Andreotti, M., Andress, J. C., Angelini, C., Anipko, D., Anjomshoaa, A., Anthony, P. L., Antillon, E. A., Antonioli, E., Aoki, K., Arguin, J. 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M., Zhulanov, V., Ziegler, T., Ziegler, V., Zioulas, G., Zisman, M., Zito, M., Zürcher, D., Zwahlen, N., Zyukova, O., Živko, T., and Žontar, D.
Abstract: This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C.

20. The Potent and Selective Inhibition of Estrogen Production by Non-steroidal Aromatase Inhibitor, YM511

Author: Kudoh, M., Susaki, Y., Ideyama, Y., and Nanya, T.
Published: 1995
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21. Formation of pulmonary vein stump thrombus after anatomical lung resection and anticoagulant therapy.

Author: Okami J, Higashiyama M, Tokunaga T, Susaki Y, Kusu T, Nakagiri T, Oe H, and Nakanishi K
Subjects: Humans, Female, Male, Middle Aged, Aged, Risk Factors, Tomography, X-Ray Computed, Venous Thrombosis etiology, Venous Thrombosis diagnostic imaging, Retrospective Studies, Adult, Incidence, Aged, 80 and over, Anticoagulants therapeutic use, Pneumonectomy adverse effects, Pneumonectomy methods, Pulmonary Veins surgery, Postoperative Complications epidemiology, Postoperative Complications etiology, Lung Neoplasms surgery
Abstract: Objective: It has recently been suggested that the formation of pulmonary vein stump thrombus (PVST) after anatomical lung resection is an underlying cause of arterial thromboembolism including cerebrovascular infarction. This study aimed to investigate the incidence and risk factors of PVST and to evaluate the efficacy and safety of anticoagulant therapy for PVST., Methods: Patients who underwent anatomical lung resection for malignant lung tumors were eligible for inclusion in this study. Chest contrast-enhanced (CE) computed tomography (CT) was performed after surgery to detect PVST. If PVST was observed, patients received anticoagulant therapy. The size of the PVST was followed-up by repeated chest CE-CT., Results: In total, 176 patients were enrolled in this study. Chest CE-CT was performed on postoperative day 1-13 (median, postoperative day 6). PVST was detected in 22 (12.5%) patients. The median size of PVST was 9.5 (4.1-33.4) mm. Thrombus was most commonly observed in patients who underwent left upper lobectomy (9/36, 25.0%). Hypertension, dyslipidemia, arteriosclerosis, and arrhythmia were not associated with PVST formation. Anticoagulant therapy was administered to all 22 patients with PVST until the PVST disappeared. The median duration between the detection and disappearance of PVST was 77 days (range: 6-146 days). During the period between the detection and disappearance of PVST, cerebrovascular infarction or arterial thromboembolic events were not observed., Conclusions: Postoperative PVST is commonly observed, especially in patients who undergo left upper lobectomy. Anticoagulant therapy for PVST was safely introduced and was efficient to improve PVST without subsequent arterial thromboembolic events., (© 2024 International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC).)
Published: 2024
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22. Outcomes of surgical resection for pulmonary metastasis from pancreatic cancer.

Author: Miyashita Y, Ose N, Okami J, Takami K, Sakamaki Y, Ikeda N, Hayakawa M, Higashiyama M, Kodama K, Susaki Y, Funakoshi Y, Maeda J, and Shintani Y
Subjects: Humans, Treatment Outcome, Retrospective Studies, Prognosis, Survival Rate, Pneumonectomy, Pancreatic Neoplasms, Pancreatic Neoplasms pathology, Cancer Survivors, Lung Neoplasms
Abstract: Purpose: As the number of long-term survivors of pancreatic cancer is expected to increase thanks to recent advances in multidisciplinary treatment and earlier diagnoses of pancreatic cancer, we are likely to encounter more cases of postoperative pulmonary nodules. We analyzed the clinical course and prognosis of resection of pulmonary metastases from pancreatic cancer to clarify the prognostic implication of pulmonary metastasectomy for pancreatic cancer., Method: We retrospectively analyzed 35 patients who underwent resection of lung metastases after pancreatic cancer surgery. Short- and long-term outcomes and factors associated with the prognosis were analyzed., Results: The observation period was 20 (range, 1-101) months, with 3- and 5-year survival rates of 88.3% and 64.5% from pancreatectomy and 44.1% and 28.3% from lung resection, respectively. A univariate analysis revealed that a period from pancreatic cancer resection to pulmonary nodule shadow detection of < 15 months was associated with a significantly lower overall survival from pancreatic resection than a longer period. Conversely, histological type, stage, size of lung metastases, and resection technique were not associated with the overall survival., Conclusion: A long-term prognosis may be expected in some cases with a disease-free interval of ≥ 15 months. Our findings suggest that the disease-free interval may influence the prognosis., (© 2023. The Author(s).)
Published: 2023
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23. Surgical treatment for non-tuberculous mycobacterial pulmonary disease: analysis of prognostic factors.

Author: Ose N, Takeuchi Y, Kitahara N, In K, Susaki Y, and Shintani Y
Subjects: Aged, Humans, Middle Aged, Nontuberculous Mycobacteria, Prognosis, Retrospective Studies, Lung Diseases microbiology, Mycobacterium Infections, Nontuberculous drug therapy
Abstract: BACKGROUND: The surgical treatment for non-tuberculous mycobacterial pulmonary disease (NTM-PD) has an important adjunctive role and reported outcomes have been generally good; however, the prognostic factors remain unclear. METHODS: Sixty-one patients with NTM-PD who underwent surgical resection for a therapeutic purpose from January 2000 to March 2017 at five affiliated institutions were enrolled. We explored the factors that influence complications and prognosis by retrospectively referring to the medical records. RESULTS: The mean age of the present cohort was 61.8 ± 11.4 years. The pathogen was Mycobacterium avium complex in 49 patients, M. abscessus in 5. The most common indications were refractory to medication in 39. The surgical techniques employed were lobectomy or further resection in 49, sublobar resection in 8, with video-assisted thoracoscopic surgery in 21. Sputum culture conversion rate was 95.1%. Univariate analysis of factors associated with deterioration revealed significant differences related to age ( P = 0.025), pre-operative albumin level ( P = 0.001) and development of postoperative complications ( P = 0.037), while pre-operative albumin level alone was a significant factor in multivariate analysis ( P = 0.009). CONCLUSION: Outcomes after resection were generally good in the present cases. Nutritional status, as indicated by albumin level, may affect prognosis after surgical treatment.
Published: 2022
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24. [A Case of Pancreatic Pseudocyst Recurrence after Surgery for Remnant Pancreatic Cancer].

Author: Shimaoka T, Takiuchi D, Hama N, Morimoto O, Harada S, Eguchi S, Ikeshima R, Munakata K, Wada N, Susaki Y, Azama T, Akamaru Y, Ota H, Ohashi H, and Shibata K
Subjects: Aged, Humans, Male, Neoplasm Recurrence, Local drug therapy, Neoplasm Recurrence, Local surgery, Pancreas, Pancreatectomy, Carcinoma, Pancreatic Ductal surgery, Pancreatic Neoplasms drug therapy, Pancreatic Neoplasms surgery, Pancreatic Pseudocyst etiology, Pancreatic Pseudocyst surgery
Abstract: The patient was a 72-year-old man with a history of pancreatic cancer and IPMA treated with distal pancreatectomy. He had recurrence-free period after adjuvant chemotherapy with S-1. But 6 years after the surgery, a diameter of 1 cm mass was noted in the remnant pancreas on MRI examination after hepatocellular carcinoma treatment. The mass was diagnosed as remnant pancreatic cancer, and he had undergone partial pancreatectomy of remnant pancreas. The pathological diagnosis was pancreatic ductal carcinoma with negative margin. However, 6 months after the reoperation, epigastric pain appeared, and CT scan showed a pseudocyst of 10 cm in size. The diagnosis was local recurrence with positive cytology, and then puncture drainage was performed. After repeated drainages, adhesion of the cystic lesion, and chemotherapy, the cytology became negative and the cystic lesion disappeared, but peritoneal dissemination metastasis also appeared. The patient died of the primary disease 7 years and 8 months after the first surgery and 1 year and 11 months after the second surgery. There has been no report of local recurrence in the form of pancreatic pseudocyst after pancreatic cancer surgery, and we report this case with literature discussion.
Published: 2021

25. Analysis of pulmonary nodules caused by nontuberculous mycobacteriosis in 101 resected cases: multi-center retrospective study.

Author: Ose N, Takeuchi Y, Kitahara N, Matumura A, Kodama K, Shiono H, Susaki Y, Funakoshi Y, Takabatake H, and Shintani Y
Abstract: Background: Solitary pulmonary nodules caused by nontuberculous mycobacteriosis are included as a category of pulmonary nontuberculous mycobacterium disease. Clinical characteristics, treatments and prognosis are not fully known because there are a few related reports., Methods: This was a multi-center retrospective study of 101 cases diagnosed as solitary nodular type of nontuberculous mycobacteriosis from January 2000 to March 2017 that underwent resection at 9 related facilities belonging to the Thoracic Surgery Study Group of Osaka., Results: The most common pathogen was Mycobacterium avium complex (n=77, 87.5%), followed by Mycobacterium kansasii (n=8, 9.1%). Chest computed tomography results showed subpleural locations that were difficult to distinguish from lung cancer. Fluorodeoxyglucose positron emission tomography/computed tomography was performed in 58 cases and positive results were obtained in 35 (60.3%), with an average maximum standardized uptake value of 3.87. The purpose of resection in most cases was for diagnosis. The surgical procedure was wedge resection in 87, segmentectomy in 3, and lobectomy in 11, while 77 underwent thoracoscopic surgery. Postoperative complications occurred in 7 cases, though no infections caused by nontuberculous mycobacteriosis were noted. The median observation period was 27 months. A worsened condition occurred in 10 (9.9%) with Mycobacterium avium complex , though none had local recurrence., Conclusions: Solitary pulmonary nodules due to nontuberculous mycobacteriosis is difficult to diagnose based on preoperative examination results or distinguish from lung cancer. Among the present cases, none had local complications or recurrence, even in those that underwent a wedge resection, thus postoperative chemotherapy was not considered necessary if a complete resection was performed. On the other hand, some cases showed reinfection after a long period following resection, thus patients should be informed of that future possibility., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/jtd-20-3108). The authors have no conflicts of interest to declare., (2021 Journal of Thoracic Disease. All rights reserved.)
Published: 2021
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26. Long-Term Outcomes of Pulmonary Metastasectomy for Uterine Malignancies: A Multi-institutional Study in the Current Era.

Author: Kanzaki R, Susaki Y, Takami K, Funakoshi Y, Sakamaki Y, Kodama K, Yokouchi H, Ikeda N, Kadota Y, Iwasaki T, Ose N, and Shintani Y
Subjects: Female, Humans, Middle Aged, Neoplasm Recurrence, Local surgery, Pneumonectomy, Prognosis, Retrospective Studies, Survival Rate, Treatment Outcome, Lung Neoplasms surgery, Metastasectomy, Uterine Neoplasms surgery
Abstract: Background: Information on pulmonary metastasectomy (PM) for uterine malignancies in the current era is limited. In the present study, we analyzed the clinical course and results of PM for uterine malignancies in the era of modern imaging diagnostics to clarify the role of PM in the current era in a multi-institutional setting., Methods: Fifty-seven patients who underwent PM for uterine malignancies between 2006 and 2015 were retrospectively reviewed. The short- and long-term outcomes, along with factors associated with the prognosis, were analyzed. Details of the clinical course after PM were described., Results: The mean age of patients was 59.4 years. The primary tumor was located in the uterus corpus in 34 cases (60%) and in the uterus cervix in 23 cases (40%). The median disease-free interval (DFI) was 32 months. Forty patients (70%) received fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography before PM, and complete resection was achieved in 52 patients (91%). Postoperative complications occurred in 4 patients (7%). Of the 52 patients who underwent complete resection of pulmonary metastases, 28 experienced recurrence, and among these, 17 (60%) underwent local therapy, including six repeat PMs. Among the 52 patients who underwent complete resection, the 5-year relapse-free survival rate was 40.7% and the 5-year overall survival (OS) rate was 68.8%. The univariate analysis revealed that a DFI of ≤ 24 months was associated with significantly poorer OS., Conclusions: PM for uterine malignancies is safe and provides favorable long-term outcomes in selected patients. Patients with a DFI of > 24 months have better OS and are good candidates for PM.
Published: 2020
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27. Cluster circulating tumor cells in surgical cases of lung cancer.

Author: Sawabata N, Susaki Y, Nakamura T, Kawaguchi T, Yasukawa M, and Taniguchi S
Subjects: Aged, Biomarkers, Tumor metabolism, Female, Humans, Lung Neoplasms metabolism, Lung Neoplasms pathology, Male, Prognosis, Lung Neoplasms surgery, Neoplasm Staging methods, Neoplastic Cells, Circulating pathology, Pneumonectomy
Abstract: Objectives: A cancer lesion sheds tumor cells into the circulating blood as circulating tumor cells (CTCs). Since cluster CTCs have been considered as precursor lesions of metastasis, their clinical implication was investigated in this study according to the preoperative status of cluster CTC detection in surgical cases of clinically early-stage lung cancer., Methods: Among 104 surgical patients of early-stage lung cancer, CTCs were extracted from the peripheral blood before surgery using a micro-pore size selection method (ScreenCell ® ) and diagnosed microscopically. Implications of detecting cluster CTC were assessed according to the prognosis and clinicopathological characteristics., Results: The status of CTC detection was not detected in 77 cases (74.0%), single CTC only detection in 7 cases (6.7%), and cluster CTC detected in 20 cases (19.2%). Patients with cluster CTCs exhibited significantly lower recurrence-free survival and overall survival than did patients of other groups. In addition, in hazard ratio analysis, the hazard ratios were independent of other predictors of poor prognosis, and detection of cluster CTCs was associated with predictors of poor prognosis., Conclusion: Cluster CTCs were detected in cases where the original lung cancer lesion had clinical predictors of poor prognosis and were independent negative predictors of survival.
Published: 2020
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28. Development of a Fried Frailty Phenotype Questionnaire for Use in Screening Community-Dwelling Older Adults.

Author: Chen S, Chen T, Kishimoto H, Susaki Y, and Kumagai S
Subjects: Aged, Cross-Sectional Studies, Humans, Japan, Phenotype, Prospective Studies, Reproducibility of Results, Surveys and Questionnaires, Frail Elderly, Frailty diagnosis, Geriatric Assessment, Independent Living
Abstract: Objectives: The aim of this study was to develop a Fried Frailty Phenotype Questionnaire (FFPQ) and a Japanese FRAIL (fatigue, resistance, ambulation, illnesses, and loss of weight) scale (FRAIL-J) and to evaluate the reliability and validity of both questionnaires in Japanese community-dwelling older adults., Design: Cross-sectional analysis of Itoshima Frail Study (IFS)., Setting: The IFS is an ongoing community-based prospective study in Itoshima (Japan)., Participants: A total of 858 older adults age 65-75 years., Methods: The FRAIL-J comprises 5 existing items comparable to those in original FRAIL scale but with broader utilization in the Japanese healthcare system. In FFPQ, resistance, ambulation, and loss of weight were the same as those in FRAIL-J. Fatigue was the same with exhaustion in FFP and inactivity was assessed using a yes or no question. Data including demographics, and physical and cognitive functions, and objective physical activity was collected and analyzed in relation to both questionnaires., Results: The FFPQ and FRAIL-J showed low internal consistency (Kuder-Richardson formula 20 coefficients = 0.32 and 0.29) and good test-retest reliability (intraclass correlation coefficients = 0.79 and 0.72). The correlations ranged from -0.22 to 0.49 when correlating each item with cross-sectional outcomes. Using FFP as a criterion, the ares under the curve for FRAIL-J and FFPQ were 0.86 and 0.88, respectively. The optimal cut-off for FRAIL-J was 2, with a higher Youden index (66.7% vs 20.3% for 3) and a high negative predictive value (99.5%) but low positive predictive value (13.1%). As for FFPQ, either 2 or 3 was evaluated as cut-off because the Youden index (62.2% vs 58.5%) and negative predictive value (99.7% vs 99.2%) were similar although the positive predictive value was low (9.7% vs 33.3%). Using a 2-point cut-off, both questionnaires had slight agreement with FFP. The highest agreement (kappa = 0.42) was found between FFP and FFPQ using a 3-point cut-off., Conclusions/implications: The FFPQ and FRAIL-J can be used for frailty screening in Japanese community-dwelling older adults., (Copyright © 2019 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.)
Published: 2020
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29. Desaturation during the stair-climbing test for patients who will undergo pulmonary resection: an indicator of postoperative complications.

Author: Nakamura T, Sawabata N, Susaki Y, and Muro S
Subjects: Aged, Electrocardiography, Female, Humans, Length of Stay statistics & numerical data, Male, Oximetry, Oxygen administration & dosage, Pneumonectomy adverse effects, Risk Assessment, Exercise Test methods, Postoperative Complications etiology
Abstract: Objective: It is widely accepted that exercise tolerance tests are applicable in perioperative risk assessment for patients who undergo pulmonary resection; however, the relevance of desaturation during the test is unclear. The purpose of this study was to investigate whether the occurrence of desaturation during a stair-climbing test can be a predictor of postoperative complications among patients who will undergo pulmonary resection and are considered "normal risk" according to published guidelines., Methods: Desaturation was defined as a depression of more than 4% points on a pulse oximeter during stair climbing. Among 186 consecutive patients who underwent pulmonary resection, 162 patients who could climb to the 6th floor were selected for the study (excluding 21 patients who could not stair-climb and 3 patients who could not climb from the first floor to the sixth floor). The relationship of desaturation with postoperative complication was investigated using parameters of cardio-pulmonary status associated with additional foci of oxygen supply duration, intensive care unit stay duration, and hospital stay duration., Results: The occurrence ratio of postoperative complications > grade 3 (Clavien-Dindo classification) was 0.75% (1/133) among patients without desaturation and 17.2% (5/29) in patients with desaturation (difference: p = 0.0002). In addition, DS was an indicator of prolonged oxygen supply duration, intensive care unit stay duration, and hospital stay duration., Conclusion: The occurrence of desaturation during a stair-climbing test for patients who will undergo pulmonary resection can be a predictor of postoperative complications among patients who are classified as having normal risk.
Published: 2020
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30. Effect of Cardiac Expansion on Postsurgical Pulmonary Resection Recovery.

Author: Tamura Y, Sawabata N, Susaki Y, Nakamura T, and Taniguchi S
Subjects: Aged, Female, Humans, Length of Stay, Male, Postoperative Complications physiopathology, Postoperative Period, Ventricular Dysfunction, Left physiopathology, Ventricular Function, Left physiology, Heart physiopathology, Heart Ventricles physiopathology, Lung physiopathology
Abstract: Background/aim: In patients undergoing lung resection, even when lung and ventricular function are normal, there may be a prolonged delay in postoperative recovery. The effect of left ventricular extension disorders on recovery after pulmonary resection was investigated., Materials and Methods: The postoperative recovery of ninety patients with normal left ventricular ejection fraction and exercise tolerance who underwent anatomical pulmonary resection was evaluated according to the grade of left ventricular expansion (E/e')., Results: Left ventricular extension was normal (≤8) in 53 cases, moderately restricted (8-12) in 36 cases and severely restricted (>12) in 9 cases. No significant difference was found in the postoperative complication rate. However, the severely restricted group had a significantly higher duration of oxygen administration, intensive care unit stay, and postoperative hospital stay, which were found to be independent predictors of ventricular expansion., Conclusion: Left ventricular expansion dysfunction had a negative effect on postoperative recovery., (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Published: 2019
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31. Absorption, Distribution, Metabolism, and Excretion of the Novel Helicase-Primase Inhibitor, Amenamevir (ASP2151), in Rodents.

Author: Ohtsu Y, Susaki Y, and Noguchi K
Subjects: Acyclovir blood, Animals, Biological Availability, Carbon Radioisotopes pharmacokinetics, Male, Mice, Oxadiazoles blood, Rats, Tissue Distribution, Valacyclovir blood, Acyclovir pharmacokinetics, Oxadiazoles pharmacokinetics, Valacyclovir pharmacokinetics
Abstract: Background and Objectives: The helicase-primase inhibitor amenamevir (ASP2151) is a novel therapeutic agent which has been approved for the treatment of herpes zoster. The present study examined the pharmacokinetic profile of amenamevir in rodents and compared it with data from the literature of past and current established therapies (acyclovir and valaciclovir) to provide additional data to facilitate drug discovery and proper drug use., Methods: In situ absorption, blood and plasma radioactivity concentrations, tissue distribution, and excretion were determined using liquid scintillation counting. Plasma amenamevir concentrations were measured using a validated chromatographic method. Chemical structures of in vivo metabolites were investigated using liquid chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy., Results: Amenamevir, after single intravenous administration to mice, had an elimination half-life of 2 h. Bioavailability was 40% after single oral administration. In situ absorption data indicated that amenamevir is mainly absorbed in the small intestine. The main component in mouse plasma was amenamevir, accounting for 87.9% of amenamevir-derived components. Our results suggest that the main elimination pathway in mice is oxidative metabolism at a methyl group and a 1,2,3-trisubstituted benzene ring followed by biliary and fecal excretion. Following oral administration of 14 C-amenamevir to mice, 100.63% of the dose (10.06% in urine and 90.46% in feces) was excreted by 96 h post-dose., Conclusions: The underlying mechanism of the improved pharmacokinetic profile of amenamevir was linked to an improved absorption ratio (not hepatic availability) compared to acyclovir, and qualitative differences in elimination (slow metabolism of amenamevir vs rapid urinary excretion of acyclovir/valaciclovir).
Published: 2018
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32. HER3 expression is enhanced during progression of lung adenocarcinoma without EGFR mutation from stage 0 to IA1.

Author: Kumagai T, Tomita Y, Nakatsuka SI, Kimura M, Kunimasa K, Inoue T, Tamiya M, Nishino K, Susaki Y, Kusu T, Tokunaga T, Okami J, Higashiyama M, and Imamura F
Subjects: Adenocarcinoma of Lung classification, Adenocarcinoma of Lung diagnostic imaging, Adenocarcinoma of Lung pathology, Adult, Aged, Disease Progression, ErbB Receptors genetics, Female, Gene Expression Regulation, Neoplastic genetics, Humans, Immunohistochemistry, Male, Middle Aged, Mutation, Neoplasm Invasiveness genetics, Neoplasm Invasiveness pathology, Neoplasm Staging, Tomography, X-Ray Computed, Adenocarcinoma of Lung genetics, Receptor, ErbB-2 genetics, Receptor, ErbB-3 genetics
Abstract: Background: Activating EGFR mutations, HER2, and HER3 are implicated in lung cancer; however, with the exception of EGFR gene amplification in lung adenocarcinoma harboring EGFR mutations, their involvement in disease progression during the early stages is poorly understood. In this paper, we focused on which receptor is correlated with lung adenocarcinoma progression in the presence or absence of EGFR mutation from stage 0 to IA1., Methods: HER2 and HER3 expression and activating EGFR mutations in surgically resected lung adenocarcinoma exhibiting ground glass nodules on chest computed tomography and re-classified to stage 0 and IA1 were examined by immunohistochemistry and peptide nucleic acid-locked nucleic acid PCR clamp method, respectively., Results: HER2 and HER3 expression was detected in 22.2% and 86.1% of samples, respectively. The frequency of EGFR mutation was 45.7% and was not significantly different between stage 0 and IA1 (40.0% and 48.0%, respectively), suggesting that EGFR mutation does not correlate with cancer progression from stage 0 to IA1. HER2 expression also did not correlate to progression. However, not only the frequency, but also the intensity of HER3 expression was increased in stage IA1 lung adenocarcinoma, particularly in lung adenocarcinoma without EGFR mutation., Conclusion: HER3 tends to be intensively expressed during the progression of lung adenocarcinoma without EGFR mutation from carcinoma in situ to invasive carcinoma., (© 2018 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.)
Published: 2018
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33. Colopleural fistula caused by aspergillus: an extremely rare complication after lung resection-case report.

Author: Hayashi A, Susaki Y, Ose N, Takeuchi Y, and Maeda H
Abstract: A colopleural fistula is a rare condition reported to be caused by Crohn's disease, a malignant tumor of the gastrointestinal tract, and other clinical conditions. Some studies have noted that a sub-diaphragmatic abscess, usually organized following abdominal surgery, may play some role in the formation of this type of fistula. Therefore, a colopleural fistula is a complication very rarely encountered by thoracic surgeons after lung resection.We experienced an extremely rare case of colopleural fistula following a left lower lobectomy for lung aspergillosis. Here, we report a 71-year-old man with a surgical history of proximal gastrectomy for gastric cancer. He underwent left lower lobectomy of the lung for aspergillosis, and a colopleural fistula occurred on the second operative day as a complication. Aspergillus might be responsible for forming a fistula between the colon and lung via the diaphragm, and lung surgery manifested this rare condition. Although some reports suggest that surgical treatment is mandatory to cure this fistula, an immediate colostomy in our case reduced the internal pressure of the colon, thus enabling spontaneous closure of the fistula with appropriate drainage and antibiotics. The patient was discharged in a good condition.
Published: 2016
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34. Cavernous hemangioma in the thymus: a case report.

Author: Ose N, Kobori Y, Takeuchi Y, Susaki Y, Taniguchi S, and Maeda H
Abstract: Cavernous hemangioma is not a neoplasm, but rather a congenital venous malformation with the potential to develop in all parts of the body, though it is very rarely seen in the thymus. We report a case of cavernous hemangioma in the thymus partially resected. A 71-year-old woman presented with pericardial discomfort, and chest computed tomography (CT) showed a left lateral mediastinal mass which was 2.0 × 1.2 × 1.8 cm in size, with border regularity and without calcification. Its interior was partially enhanced. Three-dimensional chest computed tomography image showed a tortuous vessel connecting to the tumor. Surgical resection was performed for the purpose of providing a definitive diagnosis and treatment because a mediastinal tumor such as thymoma or teratoma was suspected. Partial resection of the thymus including the mass was done by utilizing a three-port, left-sided video-assisted thoracic surgery (VATS) approach with hoisting of the third rib with the patient in a spinal position. A wine-colored mass bulging from the surface of the left lobe of the thymus was identified along with the communicating vessel which could only be cut with an energy device. It is considered that thymic partial resection using VATS is a better option for small and non-infiltrative lesions.
Published: 2016
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35. A Double-Blind Placebo-Controlled Study of the Effects of Olprinone, a Specific Phosphodiesterase III Inhibitor, for Preventing Postoperative Atrial Fibrillation in Patients Undergoing Pulmonary Resection for Lung Cancer.

Author: Nojiri T, Yamamoto K, Maeda H, Takeuchi Y, Ose N, Susaki Y, Inoue M, and Okumura M
Subjects: Aged, Atrial Fibrillation epidemiology, Atrial Fibrillation etiology, Dose-Response Relationship, Drug, Double-Blind Method, Female, Follow-Up Studies, Humans, Incidence, Japan epidemiology, Male, Phosphodiesterase 3 Inhibitors administration & dosage, Prospective Studies, Treatment Outcome, Atrial Fibrillation prevention & control, Imidazoles administration & dosage, Lung Neoplasms surgery, Pneumonectomy adverse effects, Postoperative Complications, Pyridones administration & dosage
Abstract: Background: We previously reported that patients with elevated preoperative B-type natriuretic peptide (BNP) levels have an increased risk for postoperative atrial fibrillation following lung cancer surgery. The present study evaluated whether the specific phosphodiesterase III inhibitor olprinone can reduce the incidence of postoperative atrial fibrillation in patients with elevated BNP levels undergoing pulmonary resection for lung cancer., Methods: A prospective randomized study was conducted with 40 patients who had elevated preoperative BNP levels (≥ 30 pg/mL) and underwent scheduled lung cancer surgery. All patients were in sinus rhythm at surgery. Low-dose olprinone or placebo was continuously infused for 24 h and started just before anesthesia induction. The primary end point was the incidence of postoperative atrial fibrillation. The secondary end points were perioperative hemodynamics and levels of BNP, WBC counts, and C-reactive protein., Results: The incidence of postoperative atrial fibrillation was significantly lower in the olprinone group than in the placebo group (10% vs 60%, P < .001). Patients in the olprinone group showed significantly lower BNP, WBC counts, and C-reactive protein levels after surgery., Conclusions: Continuous infusion of olprinone during lung cancer surgery was safe and reduced the incidence of postoperative atrial fibrillation following pulmonary resection in patients with elevated preoperative BNP levels., Trial Registry: Japan Primary Registries Network; No.: JPRN-UMIN2404; URL: http://www.umin.ac.jp/ctr/.
Published: 2015
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36. Clinical effect of real time pulse rate monitoring with a portable pulsimeter on physical exercise therapy for male patients with type 2 diabetes.

Author: Sumitani Y, Hosaka T, Susaki Y, Fujisawa Y, Kuriyama K, Tsukada Y, Yokoyama T, Ogasawara J, Nishida S, Inukai K, Okajima Y, Ohno H, and Ishida H
Abstract: In patients with type 2 diabetes, it is recommended that exercise therapy is performed using heart rate as an index of exercise intensity. This study was designed to clinically evaluate whether continuous exercise therapy with a portable pulsimeter for self-monitoring of the pulse rate influences glycemic control in patients with type 2 diabetes. We randomly assigned 23 male patients to a pulse displayed group (in which the portable pulsimeter displayed a pulse rate) or a pulse non-displayed group (in which the portable pulsimeter only recorded the data and did not display a pulse rate). The patients then received exercise therapy for 1 month. Patients in the pulse displayed group were instructed to regulate their walking speed by maintaining their portable pulsimeter in the target pulse rate zone, whereas patients in the pulse non-displayed group were instructed to regulate their walking speed while taking their pulse rate and using the Borg scale to maintain the target pulse rate zone using the conventional method. We found the mean walking time within the target pulse rate zone during exercise therapy was significantly increased in the pulse displayed group ( p < 0.01). Similarly, glycoalbumin and 1,5-anhydro-D-glucitol improved significantly in the pulse displayed group after 1 month of exercise therapy ( p < 0.01, respectively). Our results suggest that this therapeutic device might be useful for improving glycemic control in patients with type 2 diabetes., Competing Interests: Author Ishida received a research grant from Seiko Epson Corporation.All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later revision. Informed consent or an acceptable substitute was obtained from all patients prior to inclusion in the study. Additional informed consent was obtained from all patients for whom identifying information is included in this article.
Published: 2015
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37. Absorption, distribution, metabolism and excretion of novel phosphodiesterase type 4 inhibitor ASP3258 in rats.

Author: Ohtsu Y, Sonoda T, Susaki Y, Tohda T, Fukunaga Y, Iwatsubo T, and Noguchi K
Subjects: Administration, Oral, Animals, Biological Availability, Chromatography, Liquid, Magnetic Resonance Spectroscopy, Male, Naphthyridines administration & dosage, Phosphodiesterase 4 Inhibitors administration & dosage, Rats, Rats, Inbred F344, Tissue Distribution, Bile metabolism, Intestinal Absorption, Naphthyridines pharmacokinetics, Phosphodiesterase 4 Inhibitors pharmacokinetics
Abstract: The potent and selective phosphodiesterase 4 inhibitor ASP3258 is a novel therapeutic agent for asthma and chronic obstructive pulmonary disease (COPD). After a single oral administration to rats, ASP3258 is rapidly absorbed with a bioavailability of 106%. In situ absorption data indicated that ASP3258 is mainly absorbed in the small intestine. Tissue distribution data after oral administration of (14)C-ASP3258 showed rapid and extensive distribution to various tissues. Excluding the gastrointestinal tract, the tissues with the highest concentrations were liver, heart and plasma. Liquid chromatography-nuclear magnetic resonance spectroscopy data revealed that O-glucuronidation of the carboxylic acid moiety of ASP3258 (formation of an acyl glucuronide) plays a key role in metabolism. No indication was found that the acyl glucuronide reacted with proteins in plasma or tissues. When (14)C-ASP3258 was orally administered to intact rats, urinary and fecal excretion accounted for 1.3% and 100.6% of the administered radioactivity, respectively. After a single oral administration of (14)C-ASP3258 to bile-cannulated rats, urinary and biliary excretion accounted for 0.7% and 93.8% of the administered radioactivity, respectively. These findings suggest that fecal excretion via bile plays an important role in the elimination of ASP3258-derived radioactivity. In vitro metabolic profiles were relatively similar among the species examined, suggesting that our findings in rats may help us to understand pharmacokinetics, efficacy and safety profiles in humans and other species., (Copyright © 2014 John Wiley & Sons, Ltd.)
Published: 2015
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38. Association of cigarette smoking with the expression of nuclear survivin in pathological Stage IA lung adenocarcinomas.

Author: Hirano H, Maeda H, Takeuchi Y, Susaki Y, Kobayashi R, Hayashi A, Ose N, Nakazawa Y, Yamaguchi T, Yokota S, and Mori M
Subjects: Adenocarcinoma etiology, Adenocarcinoma pathology, Adenocarcinoma of Lung, Aged, Female, Humans, Lung Neoplasms etiology, Lung Neoplasms pathology, Male, Middle Aged, Neoplasm Staging, Smoking metabolism, Survivin, Adenocarcinoma metabolism, Cell Nucleus metabolism, Inhibitor of Apoptosis Proteins metabolism, Lung Neoplasms metabolism, Smoking adverse effects
Abstract: Survivin is expressed in the cytoplasm and/or nucleus of various types of malignant tumor cells. Cytoplasmic survivin functions as an apoptosis inhibitor, while nuclear survivin is indispensable for complete mitosis completion. To investigate the effect of cigarette smoking on the survivin expression in lung adenocarcinomas at the early developmental stage, we examined the expression of nuclear and cytoplasmic survivin in pathological Stage IA lung adenocarcinomas resected from 38 non-smokers and 44 smokers (current smokers and ex-smokers) using an immunohistochemical method. Labeling indices of nuclear survivin in tumors of smokers were significantly greater than those of non-smokers. The labeling index of nuclear survivin was above 3 % in only 1 (2.6 %) of the 38 tumors of the non-smokers, while the labeling indices in 19 (43.2 %) of 44 tumors of the smokers were above 3 % with a significantly greater frequency. There was no significant difference in the labeling index of nuclear survivin between current smokers and ex-smokers. There was no significant difference in the labeling index of cytoplasmic survivin between tumors of the non-smokers and the smokers. The present results show that cigarette smoking is associated with the higher nuclear surviving expression in lung adenocarcinomas at the early stage, suggesting that cigarette smoking affects the nuclear survivin expression in lung adenocarcinomas at the early developmental stage.
Published: 2014
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39. Lymphatic invasion of micropapillary cancer cells is associated with a poor prognosis of pathological stage IA lung adenocarcinomas.

Author: Hirano H, Maeda H, Takeuchi Y, Susaki Y, Kobayashi R, Hayashi A, Ose N, Yamaguchi T, Yokota S, and Mori M
Abstract: The cancer cells of lung adenocarcinoma with a micropapillary pattern (MPP) have been found to frequently invade lymphatic vessels, and the prognosis of patients with lung adenocarcinoma with an MPP is poor. In the present study, the cancer cells of lung adenocarcinomas containing an MPP were found to express vimentin more extensively than those in lung adenocarcinoma without an MPP. The contribution of cancer cells in the MPP component to adenocarcinoma lymphatic invasion was assessed using vimentin as a marker. Vimentin expression was analyzed in the cancer cells present in each lymphatic vessel and compared with the expression of vimentin in the cancer cells in the adenocarcinomas without an MPP component. The results showed that the cancer cells in the lymphatic vessels expressed vimentin more extensively than those in the adenocarcinoma components without an MPP, suggesting that cancer cells derived from an MPP component are present in the lymphatic vessels. By contrast, the area of the MPP component in each adenocarcinoma was <25%. These findings suggest that cancer cells in MPP components have a high capacity to invade lymphatic vessels and that their high invasive capacity may be associated with a poor prognosis in patients with adenocarcinoma with an MPP component.
Published: 2014
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40. Clinical predictor of pre- or minimally invasive pulmonary adenocarcinoma: possibility of sub-classification of clinical T1a.

Author: Sawabata N, Kanzaki R, Sakamoto T, Kusumoto H, Kimura T, Nojiri T, Kawamura T, Susaki Y, Funaki S, Nakagiri T, Shintani Y, Inoue M, Minami M, and Okumura M
Subjects: Adenocarcinoma classification, Adenocarcinoma diagnostic imaging, Adenocarcinoma surgery, Adenocarcinoma of Lung, Adult, Aged, Area Under Curve, Carcinoma, Non-Small-Cell Lung classification, Carcinoma, Non-Small-Cell Lung diagnostic imaging, Carcinoma, Non-Small-Cell Lung surgery, Disease-Free Survival, Female, Humans, Logistic Models, Lung Neoplasms classification, Lung Neoplasms diagnostic imaging, Lung Neoplasms surgery, Male, Middle Aged, Multivariate Analysis, ROC Curve, Retrospective Studies, Tomography, X-Ray Computed, Adenocarcinoma pathology, Carcinoma, Non-Small-Cell Lung pathology, Lung Neoplasms pathology
Abstract: Objectives: A new pathological classification for pre- and minimally invasive adenocarcinoma has been established, with distinction prior to surgery crucial because of the extremely good prognosis., Methods: Of 412 patients who underwent surgery for lung cancer from 2008 to 2011, 110 classified as c-stage I had each of the following four parameters assessed for predictive power for pre- or minimally invasive adenocarcinoma and relapse-free survival (RFS): (i) whole tumour size (WS) shown by computed tomography (CT) , (ii) size of the solid (SS) component in CT findings, (iii) maximum standard uptake value in fluorodeoxyglucose positron emission tomography (FDG-PET)/CT scan images (SUVmax) and (iv) serum level of carcinoembryonic antigen., Results: For prediction of pre- or minimally invasive adenocarcinoma, the area under the receiver-operating curve was >0.7 for all the four parameters, while only SS was found to be an independent factor in multivariate logistic regression analysis. In Cox proportional hazard model analysis, SS and SUVmax were statistically significant, and SS was exclusively independent in multivariate analysis. Differences in RFS between T1a and T1b were more pronounced when using SS compared with WS. In the sub-classification of T1a, we used a breakpoint of 1.0 cm in SS (T1a-α and T1a-β), which resulted in a 2-year RFS rate of 1.00 for T1a-α (n=21), 0.89 for T1a-β (n=27) and 0.68 for T1b (n=26) (P=0.002 between T1a-β and T1b)., Conclusions: The SS parameter was useful to distinguish pre- and minimally invasive adenocarcinoma from other types of lung cancer, and set a T1a sub-classification.
Published: 2014
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41. Ectopic cervical thymoma accompanied by Good's syndrome.

Author: Nagoya A, Kanzaki R, Nakagiri T, Inoue M, Susaki Y, Inoue S, and Okumura M
Subjects: Adult, Biopsy, Choristoma diagnosis, Choristoma therapy, Common Variable Immunodeficiency diagnosis, Common Variable Immunodeficiency therapy, Diagnostic Errors, Humans, Infusions, Intravenous, Male, Neoplasm Staging, Paraneoplastic Syndromes diagnosis, Paraneoplastic Syndromes therapy, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma diagnosis, Predictive Value of Tests, Thoracic Surgery, Video-Assisted, Thymectomy, Thymoma diagnosis, Thymoma therapy, Thymus Neoplasms diagnosis, Thymus Neoplasms therapy, Tomography, X-Ray Computed, Treatment Outcome, gamma-Globulins administration & dosage, Choristoma complications, Common Variable Immunodeficiency etiology, Paraneoplastic Syndromes etiology, Thymoma complications, Thymus Gland, Thymus Neoplasms complications
Abstract: Ectopic cervical thymoma (ECT) is a rare tumor that is frequently misdiagnosed as a thyroid tumor or other malignancy. A 34-year-old male with a right palpable neck mass had been mistakenly diagnosed with T-cell lymphoblastic lymphoma even after an open biopsy. The atypical clinical course, including hypogammaglobulinemia, led us to the correct diagnosis; ECT accompanied by Good's syndrome (GS). After the intravenous infusion of gammaglobulin, tumor resection and a subsequent video-assisted thoracoscopic extended thymectomy were performed. The final diagnosis was type AB thymoma, Masaoka stage I. This report is, to the best of our knowledge, the first description of this extremely rare combination.
Published: 2014
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42. Multiple-input and visible-output logic gates using signal-converting DNA machines and gold nanoparticle aggregation.

Author: Ogawa A and Susaki Y
Subjects: DNA chemistry, Gold chemistry, Metal Nanoparticles chemistry
Abstract: We report a facile design method for constructing multiple-input and visible-output logic gates by combining signal-converting DNA machines and the gold nanoparticle aggregation-based foundational AND gate.
Published: 2013
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43. IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation.

Author: Lee J, Nakagiri T, Kamimura D, Harada M, Oto T, Susaki Y, Shintani Y, Inoue M, Miyoshi S, Morii E, Hirano T, Murakami M, and Okumura M
Subjects: Bronchi pathology, Bronchiolitis Obliterans pathology, Epithelial Cells pathology, Female, Humans, Middle Aged, Transplantation, Homologous, Bronchi metabolism, Bronchiolitis Obliterans metabolism, Bronchiolitis Obliterans therapy, Epithelial Cells metabolism, Interleukin-6 metabolism, Lung Transplantation
Abstract: The IL-6 amplifier, a positive feedback loop for NFκB signaling, which was originally found to be activated by IL-17A and IL-6 stimulation in non-immune cells, is molecularly a simultaneous activator of NFκB and signal transducer and activator of transcription 3 (STAT3), functionally a local chemokine inducer and pathologically a machinery for inflammation development. It has been shown that IL-6 amplifier activation in epithelial cells contributes to rejection responses in a mouse chronic rejection model that develops a bronchiolitis obliterans (BO)-like disease. We investigated whether the IL-6 amplifier is activated in BO regions of a human lung graft after allogeneic transplantation. NFκB and STAT3 molecules were phosphorylated in the epithelial regions of bronchi that localized in the BO regions. Additionally, chemokine ligand 2 (CCL2), and CD4(+) T cells and macrophages increased in these regions. Furthermore, human lung epithelial cells expressed CCL2 after stimulation by IFNγ in the presence of IL-6 and epidermal growth factor via enhanced STAT3 signaling, which parallels behavior seen in the mouse model. Thus, our results suggest that the IL-6 amplifier in the epithelial cells of grafts is involved in chronic rejection after lung transplantation, suggesting that the amplifier may be a valuable therapeutic target to prevent chronic rejection after lung transplantation.
Published: 2013
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44. Multidrug resistance in mucoepidermoid carcinoma of the parotid gland--immunohistochemical investigations of P-glycoprotein expression.

Author: Furusaka T, Sasaki CT, Matsuda A, Susaki Y, Matsuda H, and Ikeda M
Subjects: Adult, Aged, Aged, 80 and over, Antineoplastic Agents therapeutic use, Carcinoma, Mucoepidermoid therapy, Child, Cohort Studies, Female, Humans, Male, Middle Aged, Neoplasm Grading, Neoplasm Staging, Parotid Neoplasms therapy, Tumor Burden, ATP Binding Cassette Transporter, Subfamily B, Member 1 metabolism, Carcinoma, Mucoepidermoid metabolism, Carcinoma, Mucoepidermoid pathology, Drug Resistance, Multiple, Parotid Neoplasms metabolism, Parotid Neoplasms pathology
Abstract: Unlabelled: Abstract Conclusion: P-glycoprotein is abundantly expressed in certain parotid mucoepidermoid carcinoma tissues, known historically to be multidrug resistant. This discovery may be important in incrementally advancing our ability to develop alternative pharmacologic strategies to improve multi-modality tumor control., Objective: P-glycoprotein plays a functional role in promoting the efflux of drug metabolites in certain malignant tumors. With this understanding we immunohistochemically investigated the expression of P-glycoprotein in parotid mucoepidermoid carcinoma tissues and examined prognostic factors that contribute to the treatment of parotid cancer., Methods: Thirteen patients with mucoepidermoid carcinoma of the parotid gland were included. P-glycoprotein expression was immunohistochemically investigated by a modified avidin-biotin-peroxidase complex method using four different antibodies., Results: P-glycoprotein expression was observed in a higher percentage of patients with higher grade malignancy. The tumor size-related difference in P-glycoprotein expression was only significant for staining with one antibody, and no significant differences were observed with or without induction chemotherapy.
Published: 2013
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45. Long-term follow-up and salvage surgery in patients with T2N0M0 squamous cell carcinoma of the glottic larynx following concurrent chemoradiation therapy with cisplatin and 5-fluorouracil for laryngeal preservation.

Author: Furusaka T, Susaki Y, Saito T, Katsura Y, and Ikeda M
Subjects: Adult, Aged, Aged, 80 and over, Antineoplastic Agents administration & dosage, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell pathology, Cisplatin administration & dosage, Disease-Free Survival, Female, Fluorouracil administration & dosage, Follow-Up Studies, Humans, Laryngeal Neoplasms mortality, Laryngeal Neoplasms pathology, Laryngectomy, Male, Middle Aged, Survival Rate, Treatment Outcome, Carcinoma, Squamous Cell therapy, Chemoradiotherapy, Glottis, Laryngeal Neoplasms therapy, Salvage Therapy
Abstract: Conclusion: Patients who received concurrent chemoradiation therapy or radiation therapy alone were followed over a long term. The complete response (CR), 10-year survival, and 10-year larynx preservation rates were 87.5%, 95.3%, and 75.1%, respectively. Statistically, concurrent chemoradiation therapy contributes to laryngeal preservation but not to the survival rate., Objective: To determine the additive and synergistic effects of anticancer chemotherapy combined with chemoradiation therapy for squamous cell carcinoma (SCC) of the glottic larynx., Methods: Eighty-nine patients with untreated T2N0M0 SCC of the glottic larynx were included. Thirty-two patients received treatment cycles consisting of intravenous cisplatin (CDDP) on day 1 (80 mg/m(2)) and intravenous 5-fluorouracil (5-FU) over 120 h on days 2-6 (600 mg/m(2)/day) every 4 weeks. Radiotherapy was delivered by a 4 MV linac X-ray machine at a dose of 66 Gy. Fifty-seven patients received radiotherapy alone., Results: After chemoradiation therapy, the overall response, CR, 10-year survival, and 10-year larynx preservation rates were 100%, 87.5%, 95.3%, and 75.1%, respectively. Side effects included leukopenia, neutropenia, mucositis, and dermatitis. Seven patients (21.9%) required salvage surgery. Pathological findings confirmed that the treatment regimen caused marked cancer tissue degeneration. Histologic examination of surgical specimens suggested that the safety margin for partial laryngectomy was 4 mm from the gross tumor.
Published: 2013
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46. An accurate and rapid detection of lymph node metastasis in non-small cell lung cancer patients based on one-step nucleic acid amplification assay.

Author: Inoue M, Hiyama K, Nakabayashi K, Morii E, Minami M, Sawabata N, Shintani Y, Nakagiri T, Susaki Y, Maeda J, Higashiyama M, Okami J, Yoshida Y, Ding J, Otomo Y, and Okumura M
Subjects: Adenocarcinoma metabolism, Adenocarcinoma secondary, Aged, Aged, 80 and over, Biomarkers, Tumor metabolism, Carcinoma, Non-Small-Cell Lung metabolism, Carcinoma, Non-Small-Cell Lung secondary, Female, Humans, Intraoperative Period, Keratin-19 genetics, Keratin-19 metabolism, Keratin-7 genetics, Keratin-7 metabolism, Lung Neoplasms metabolism, Lung Neoplasms pathology, Lymph Nodes metabolism, Lymph Nodes pathology, Lymphatic Metastasis, Male, Middle Aged, Molecular Diagnostic Techniques, Mucoproteins, Oncogene Proteins, Proteins genetics, Proteins metabolism, RNA, Messenger genetics, RNA, Messenger metabolism, Adenocarcinoma diagnosis, Biomarkers, Tumor genetics, Carcinoma, Non-Small-Cell Lung diagnosis, Lung Neoplasms diagnosis, Nucleic Acid Amplification Techniques methods
Abstract: A sublobar resection is currently recognized as an option for early small-sized non-small cell lung cancer (NSCLC), and intraoperative rapid and accurate lymph node assessment is required for a complete resection. To solve this issue, we investigated the clinical utility of one-step nucleic acid amplification (OSNA) assay, an automated rapid molecular diagnostic method and its optimal mRNA marker for detection of lymph node metastasis in lung cancer. We extracted 16 target candidate mRNA markers with high expression in lung cancer from a genetic database, and then quantified their expression levels by quantitative RT-PCR using surgically dissected lymph nodes with or without metastasis. Cytokeratin 19 (CK19), cytokeratin 7 (CK7), stratifin (SFN), and anterior gradient homolog 2 (AGR2) showed significant differences for mRNA expression between metastasis-negative and -positive lymph nodes in quantitative-RT-PCR screening. CK19 and CK7 were finally selected as potential target markers and were quantified using OSNA assay findings of 165 dissected lymph nodes obtained from 49 lung cancer patients. The OSNA assay with CK19 and CK7 were completed within 40 min and their positive predictive value, negative predictive value, and accuracy comparing to pathological diagnosis with hematoxylin-eosin staining and immunohistochemistry were shown to be 95.0%, 99.3%, and 98.8%, and 85.0%, 97.9%, and 96.4%, respectively, using a cut-off value of 250 copies/μL. Among the 165 lymph nodes tested, 1 false negative result was due to massive necrosis of cancer cells and 1 false positive was caused by the allocation bias of cancer cells in the sampling in patient with pleural dissemination. The best performance was observed when CK19 was used as a marker, while the addition of CK7 mRNA as a marker did not increase sensitivity or specificity. In conclusion, an OSNA assay using CK19 could be effective for molecular diagnosis of lymph node metastasis in lung cancer. This is the first report suggesting the potential clinical utility of OSNA assay for intraoperative rapid diagnosis of nodal status in lung cancer., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
Published: 2012
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47. Inhibitory effect of PPARγ on NR0B1 in tumorigenesis of lung adenocarcinoma.

Author: Susaki Y, Inoue M, Minami M, Sawabata N, Shintani Y, Nakagiri T, Funaki S, Aozasa K, Okumura M, and Morii E
Subjects: Adenocarcinoma pathology, Adenocarcinoma of Lung, Aldehyde Dehydrogenase genetics, Amino Acid Motifs genetics, Apoptosis genetics, Cell Line, Tumor, DAX-1 Orphan Nuclear Receptor genetics, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms pathology, PPAR gamma antagonists & inhibitors, PPAR gamma genetics, Protein Binding, Adenocarcinoma genetics, Carcinogenesis genetics, DAX-1 Orphan Nuclear Receptor metabolism, Lung Neoplasms genetics, PPAR gamma metabolism
Abstract: NR0B1, an orphan nuclear receptor, is expressed in side population cells and its knockdown reduces tumorigenic and anti-apoptotic potential in lung adenocarcinoma. Peroxisome proliferator-activated receptor γ (PPARγ) is another member of the nuclear receptor family which induces apoptosis in lung cancer. The interaction of NR0B1 with PPARγ was examined. The transactivation ability of PPARγ was inhibited by NR0B1 in lung adenocarcinoma, and the N-terminal region of NR0B1 containing LxxLL motifs mediated its inhibition. Co-immunoprecipitation experiments revealed that this N-terminal region of NR0B1 was essential for the physical interaction with PPARγ. Aldehyde dehydrogenase (ALDH) activity and ALDH3A1 expression, which are correlated with tumorigenic potential of lung adenocarcinoma, increased when NR0B1 expression was induced, but its increase was inhibited by PPARγ overexpression. ALDH activity increased by treatment with PPARγ inhibitor, and the increase was further enhanced when the expression of NR0B1 was induced. Furthermore, the high NR0B1 and low PPARγ expression was a negative prognostic factor in Pathological-Stage IA clinical cases. These results indicate the reciprocal relationship between NR0B1 and PPARγ on the malignant grade of lung adenocarcinoma.
Published: 2012
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48. Single-lung transplantation in a chronic pulmonary emphysema patient with a marginal donor who was ABO blood group nonidentical but compatible.

Author: Susaki Y, Inoue M, Minami M, Shintani Y, Nakagiri T, Sawabata N, and Okumura M
Subjects: Chronic Disease, Donor Selection, Histocompatibility Testing, Humans, Immunosuppressive Agents therapeutic use, Male, Middle Aged, Pulmonary Emphysema complications, Respiratory Insufficiency etiology, Treatment Outcome, Waiting Lists, ABO Blood-Group System immunology, Histocompatibility, Lung Transplantation immunology, Pulmonary Emphysema surgery, Respiratory Insufficiency surgery, Tissue Donors supply & distribution
Abstract: Because the number of ideal brain-dead donors is limited, active use of marginal donors is currently one of the major issues discussed in regard to lung transplantation. We report a case in which the patient underwent single-lung transplantation for chronic pulmonary emphysema. The lung came from a marginal, ABO blood group nonidentical, compatible donor. Because the donor was marginal (pneumonia in the right lung and lobar atelectasis in both lungs), all recipient candidates with ABO blood group identical declined. Thus, a nonidentical, compatible recipient had a chance to receive a lung transplant. This 49-year-old man underwent single-lung transplantation for chronic pulmonary emphysema with severe respiratory failure. He had a good postoperative clinical course.
Published: 2012
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49. YM116, 2-(1H-imidazol-4-ylmethyl)-9H-carbazole, decreases adrenal androgen synthesis by inhibiting C17-20 lyase activity in NCI-H295 human adrenocortical carcinoma cells.

Author: Ideyama Y, Kudoh M, Tanimoto K, Susaki Y, Nanya T, Nakahara T, Ishikawa H, Fujikura T, Akaza H, and Shikama H
Subjects: Adrenal Cortex Hormones metabolism, Androstenedione biosynthesis, Dehydroepiandrosterone biosynthesis, Humans, Male, Microsomes drug effects, Microsomes enzymology, Testis enzymology, Tumor Cells, Cultured, Adrenocortical Carcinoma metabolism, Androgens biosynthesis, Carbazoles pharmacology, Enzyme Inhibitors pharmacology, Imidazoles pharmacology, Ketoconazole pharmacology, Steroid 17-alpha-Hydroxylase antagonists & inhibitors
Abstract: The concentrations of androstenedione and dehydroepiandrosterone, products of C17-20 lyase, in the medium after a 6-hr incubation of NCI-H295 cells were decreased by YM116 (2-(1H-imidazol-4-ylmethyl)-9H-carbazole) (IC50: 3.6 and 2.1 nM) and ketoconazole (IC50: 54.9 and 54.2 nM). 17Alpha-hydroxyprogesterone, a product of 17alpha-hydroxylase, was increased by YM116 (1-30 nM) and by ketoconazole (10-300 nM) and then was decreased at higher concentrations of both agents (IC50: 180 nM for YM116, 906 nM for ketoconazole), indicating that YM116 and ketoconazole were 50- and 16.5-fold more specific inhibitors of C17-20 lyase, respectively, than 17alpha-hydroxylase. Compatible with these findings, progesterone, a substrate of 17alpha-hydroxylase, was increased by these agents. Cortisol production was inhibited by YM116 and ketoconazole (IC50: 50.4 and 80.9 nM, respectively). YM116 was a 14-fold more potent inhibitor of androstenedione production than cortisol production, whereas ketoconazole was a nonselective inhibitor of the production of both steroids. YM116 and ketoconazole inhibited the C17-20 lyase activity in human testicular microsomes (IC50: 4.2 and 17 nM, respectively). These results demonstrate that YM116 reduces the synthesis of adrenal androgens by preferentially inhibiting C17-20 lyase activity.
Published: 1999
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50. Novel nonsteroidal inhibitor of cytochrome P450(17alpha) (17alpha-hydroxylase/C17-20 lyase), YM116, decreased prostatic weights by reducing serum concentrations of testosterone and adrenal androgens in rats.

Author: Ideyama Y, Kudoh M, Tanimoto K, Susaki Y, Nanya T, Nakahara T, Ishikawa H, Yoden T, Okada M, Fujikura T, Akaza H, and Shikama H
Subjects: Abiraterone Acetate, Adrenal Glands physiology, Adrenocorticotropic Hormone pharmacology, Androgens biosynthesis, Androstadienes pharmacology, Animals, Gonadotropin-Releasing Hormone pharmacology, Guinea Pigs, Ketoconazole pharmacology, Male, Orchiectomy, Organ Size, Rats, Seminal Vesicles anatomy & histology, Steroid 17-alpha-Hydroxylase metabolism, Testosterone biosynthesis, Androgens blood, Carbazoles pharmacology, Enzyme Inhibitors pharmacology, Imidazoles pharmacology, Prostate anatomy & histology, Steroid 17-alpha-Hydroxylase antagonists & inhibitors, Testosterone blood
Abstract: Background: The purpose of this study was to determine the effects of a nonsteroidal C17-20 lyase inhibitor, 2-(1H-imidazol-4-ylmethyl)-9H-carbazole (YM116), on serum concentrations of androgens and ventral prostatic weight in rats., Methods: Serum concentrations of testosterone and of dehydroepiandrosterone sulfate and prostatic weights were measured in rats treated with YM116., Results: YM116 inhibited testicular C17-20 lyase competitively (Ki, 0.38 nM), and decreased the serum testosterone concentration in gonadotropin-releasing hormone-treated rats (ED50, 0.7 mg/kg), indicating that YM116 was about 21-24 times more potent than other C17-20 lyase inhibitors such as ketoconazole and liarozole, and was twice as potent as CB7630. YM116 also reduced dehydroepiandrosterone sulfate levels in ACTH-treated castrated rats (ED50, 11 mg/kg). YM116 (40 mg/kg, p.o., for 2 weeks) was almost comparable to bilateral orchiectomy with respect to the time course and magnitude of the reduction in prostatic weight. Each of these two treatments decreased the prostatic weight 3 days following the treatment. Contrarily, leuprolide transiently increased the prostatic weight and then decreased it. YM116 (100 mg/kg) had no effect on the serum cortisol level in guinea pigs, and slightly decreased the serum aldosterone level in rats., Conclusions: YM116 is a selective C17-20 lyase inhibitor which decreases rat prostatic weight by reducing androgen production in the testes and adrenal glands.
Published: 1998
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