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In this article I explore the dual impact of framing egg donation and surrogacy as work in Ukraine’s fertility market. Egg donors, surrogates, and ART professionals use the labor narrative to legitimize these practices, albeit with differing aims. Women emphasize their economic role as worker-mothers, demanding fair treatment and recognition, while clinics employ the framework to market surrogates and donors and hold them accountable for outcomes. Without legal labor protections, this discourse empowers women to claim dignity and rights yet imposes disciplinary demands and shifts risks onto them, reflecting the precarities of their work. [ABSTRACT FROM AUTHOR]

Copyright of Dilemas Contemporáneos: Educación, Política y Valores is the property of Dilemas Contemporaneos: Educacion, Politica y Valores and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This article focuses on Israeli single gay fathers' reproductive choices. Thematic analysis of 13 in-depth semi-structured interviews with Israeli single gay fathers yielded two themes related to their reproductive choice. The first theme pertains to their decision to become single fathers. Three dimensions were prominent in the participants' decision to pursue lone parenthood: the choice to fulfill parenthood as gay men; the choice to separate parenthood from couplehood; and the view of single parenthood as empowerment. The second theme pertained to the fathers' decision to use surrogacy, which was influenced by three key factors: the desire to parent a biological child, the desire for exclusive fatherhood, and the perceived advantages of surrogacy for single fathers. The findings indicate that the fathers narrated their reproductive experiences in terms of choice and autonomy, while negotiating with dominant concepts of parenthood as a two-parent, heteronormative and biogenetic phenomenon. These men referred to the challenge they posed to some of these concepts and the social barriers they encountered as factors that facilitated their coping skills in lone parenthood, thereby enhancing their agency. These findings highlight the contextual, multidimensional and relational nature of the reproductive choices of men from minority groups like single gay fathers. [ABSTRACT FROM AUTHOR]

STUDY QUESTION How do surrogates think, feel, and reflect on their experiences of being a surrogate over time? SUMMARY ANSWER Despite continuing to require physical, emotional, and interpersonal labour, surrogates in this study reflected positively on their experiences of being a surrogate decades later. WHAT IS KNOWN ALREADY Research on families created through surrogacy shows that it can be a positive experience for both the intended parents and the surrogate. No existing research has examined the experiences of surrogacy for surrogates beyond 10 years post-birth. STUDY DESIGN, SIZE, DURATION Semi-structured, qualitative interviews were conducted with 21 women who had completed a total of 71 surrogacy arrangements. Participants had given birth to their first surrogate child on average 20 years previously. PARTICIPANTS/MATERIALS, SETTINGS METHODS Data were collected about (i) surrogates' relationships with the families they had helped, (ii) how important being a surrogate was to their own identity, and (iii) how they felt surrogacy was perceived by the public. Data were analysed according to the principles of reflexive thematic analysis. MAIN RESULTS AND THE ROLE OF CHANCE Surrogates' reflections on their experiences were constructed into two themes: (i) hard work but worth it and (ii) part of who I am. Surrogacy had taken a physical toll on some participants, and for most, being a surrogate continued to involve emotional labour and effort to maintain relationships with the families. Making friends through the process and feeling proud of what they had done to help someone meant that overall, surrogates reflected positively on surrogacy and had incorporated their experiences as surrogates into a stable aspect of their identity. LIMITATIONS, REASONS FOR CAUTION There is a risk of selection bias, with surrogates who had a more positive experience being more likely to continue to participate in the research. All surrogacies occurred within the UK. While the sample is relatively diverse in terms of surrogates' ages, current employment status, and relationship status, the sample lacks ethnic diversity. Most participants had been surrogates for heterosexual couples, and thus long-term relationships involving gay couples or single men may differ. WIDER IMPLICATIONS OF THE FINDINGS The findings from this study show the importance of understanding surrogacy as a 'relational' process and suggest to prospective surrogates and intended parents what they may expect from their relationship over time. Given the findings that even as the children grow up, being a surrogate continues to require emotional labour, support should be made available to surrogates over the longer term if required. STUDY FUNDING/COMPETING INTEREST(S) This project was funded by the Wellcome Trust [grant number 208013/Z/17/Z] and the University of Cambridge Returning Carers Scheme. The authors have no competing interests to declare. TRIAL REGISTRATION NUMBER N/A. [ABSTRACT FROM AUTHOR]

This review article focusses on child development and family relationships in families formed through third-party assisted reproductive technologies (ART). First, we provide an overview of the existing developmental research on families formed through sperm donation, egg donation, embryo donation, and surrogacy, respectively. We then consider some of the cross-cutting themes and issues in families following different types of ART, such as the role of openness and disclosure, and making donor connections, that relate to family relationships and children’s outcomes. Finally, we reflect on some of the conceptual and methodological limitations of the current research, including its dependence on relatively homogenous samples, and its relative inattention to culture. We conclude by outlining some of the new directions for research in this area. [ABSTRACT FROM AUTHOR]

STUDY QUESTION Which decision-making factors influence family building among permanently infertile couples? SUMMARY ANSWER Ethical, legal, and financial considerations outweigh genetic relatedness in decision-making, favouring domestic gestational surrogacy, if this were possible, over international options. WHAT IS KNOWN ALREADY Permanent infertility affects 4–5% of people in the fertile age. Their family-building options include adoption, surrogacy, uterus transplantation, foster care, and intentional multiple parenthood. However, in most countries, including Denmark, legal barriers constrain these methods due to surrogacy restrictions, suspended international adoptions, and the experimental status of uterus transplantation. Despite existing research on surrogacy, adoption, and specific causes of permanent infertility, a significant gap remains in our understanding of how couples with permanent infertility make family-building decisions within these limited frameworks. STUDY DESIGN, SIZE, DURATION This cross-sectional study with 150 permanently infertile Danish participants was conducted from June to November 2023 using an online questionnaire. Multiple strategies, such as online forums, fertility clinics, hospital departments, and snowballing, were used to recruit a diverse sample. PARTICIPANTS/MATERIALS, SETTING, METHODS The study included couples aged 26–50 years facing permanent infertility due to the following primary causes: women without a uterus (15%), women with a non-functional uterus (47%) or women for whom pregnancy would be life-threatening (9%), male couples (16%), transgender partner couples (2%), and other causes (11%). The survey collected data on demographics, reproductive history, family-building choices, and communication strategies. Closed questions were analysed using descriptive statistics. MAIN RESULTS AND THE ROLE OF CHANCE Among 150 respondents, 41% had used transnational surrogacy, 27% adoption, 14% chose to remain childless, and 19% were undecided. Critical factors on family-building decisions were ethical, legal, and financial concerns which ranked higher than genetic relatedness. Despite the complexity of family building, most participants were open about their child's origin and received social support. If all family-building methods were legal and available in Denmark, domestic gestational surrogacy would be the preferred method, with uterus transplantation and remaining childless being least popular. LIMITATIONS, REASONS FOR CAUTION The sample size is relatively small, despite the use of a variety of recruitment strategies. Nevertheless, this has ensured a diverse cohort representing the different reasons for infertility and family-building choices. It is important to note that the strategies may have favoured individuals achieving parenthood. WIDER IMPLICATIONS OF THE FINDINGS The finding of our study reveals a notable gap between available family-building options in Denmark and the preferences of couples facing permanent infertility. These insights could be instrumental for organizations reviewing and developing family-building frameworks. Furthermore, for healthcare professionals guiding couples experiencing infertility issues in their attempts to build a family, an understanding of these preferences is essential to facilitate informed decisions about their future family plans. STUDY FUNDING/COMPETING INTEREST(S) The project was financed by the Independent Research Fund Denmark. The authors have no conflict of interest to declare. TRIAL REGISTRATION NUMBER N/A. [ABSTRACT FROM AUTHOR]

This study examines the legal dilemma of surrogacy in the novel Frog by the Nobel prize winner Mo Yan, which was written in the context of China's past one-child policy. This study offers a tri-tier exploration of how surrogacy led to conflicts and tensions in Frog: first, it traces how the intended parents' demand for surrogacy developed under the one-child policy in China while clarifying the application of "the principle of public order"; second, it explores the predicament of the surrogate mother Chen Mei regarding the violation of her rights and dignity, and delves into the interpretation of "the principle of human dignity"; third, it focuses on the custody dispute between the surrogate mother and the intended parents to explore the controversies over the concept of parentage in surrogacy and consider the principle of "best interest of the child." This study concludes that despite all the legal and ethical controversies, the spirit of law demands a response to the growing practice of surrogacy and an extension of our exploration of legal principles. [ABSTRACT FROM AUTHOR]

Background: This paper explores the legal field of surrogacy from a Central European perspective, focusing on how countries such as Austria, Germany, and Switzerland address the recognition of parental status established abroad. While the prevailing attitude among Central European states is to prohibit surrogacy within their national laws, there is an increasing tendency to bypass these bans by seeking surrogacy services abroad. This phenomenon, termed reproductive tourism, raises complex legal questions about the recognition of foreign parental status determinations. Methods: The methods used include a comprehensive review of international and autonomous national legal rules as well as a comparative analysis of case law from Central European courts regarding cross-border surrogacy and parenthood recognition. The study examines legal controversies employing Austrian family law as an example to assess highly topical issues arising from surrogacy. It incorporates data from various legal sources, including the Austrian Constitutional Court, the German Federal Court of Justice, the Swiss Federal Supreme Court, and the European Court of Human Rights. Results and conclusions: The findings reveal significant differences between Austria, Germany, and Switzerland regarding the recognition of parental status established by way of surrogacy abroad. While supreme court decisions in these countries tend to prioritise the best interests of the child - often recognising foreign surrogacy arrangements to avoid leaving children without legal parents - their judicial approaches differ considerably. The Austrian Constitutional Court adopts a more inclusive approach by accepting foreign determinations from any authority, such as birth certificates, under the concept of automatic recognition. In contrast, the German and Swiss supreme courts acknowledge only formal court decisions. For cross-border surrogacy cases that do not fulfil this requirement, these countries apply the national law of the child's habitual residence or, as a fallback, the law of the intended parents' country of origin. Since both German and Swiss law categorically forbid surrogacy, only the genetic father is typically recognised, while the intended mother is directed to adoption. This aligns with the opinion of the ECtHR, which still considers the method of establishing parenthood to be within the sovereignty of a state. This article advocates for a balanced approach that respects both the legal principles of national states and the fundamental rights of children born through an arrangement with a surrogate mother in another country. [ABSTRACT FROM AUTHOR]

In the case of commercial surrogacy, a portion of the monetary transfer between the intended parent(s) and the surrogate is given to the latter to compensate for her contribution. Based on a study of the practices of the 10 most important intermediation agencies for surrogacy in the Unites States, the paper studies the amount, form, legal status and use of such compensations, and shows that it cannot be equated with real payment for work. Surrogacy work can thus be interpreted as a form of 'contested labour', i.e. an activity that has all the characteristics of work, but actually takes place in a sector where socio-economic institutions prevent the activity from being recognized as such. [ABSTRACT FROM AUTHOR]

Since the early 2000s, India has been a world leading hub for cross border reproductive treatments, in particular surrogacy, with the nation positioning itself as the "mother destination" for transnational commercial surrogacy, offering "First world services at Third world prices". State policies, lack of legal regulation, state of the art medical infrastructure and a steady supply of women ready to take on the role as surrogate mothers against meager remuneration have been key factors behind the Indian success story. Yet, a gradual process of regulation in recent years, culminating in the introduction of the Surrogacy (Regulation) Bill 2020, has forced the industry to reinvent itself in order to maintain its role as a market leader in a booming global bioeconomy. This article takes the 2020 bill as a starting point for an exploration of the key trajectories that the Indian reproductive industry has taken since. This includes moving into new market segments, such as the unregulated practice of oocyte donation, and expanding globally into new geo-political contexts. Through these practices, India has successfully rebranded itself as a world leading "pre-conception assemblage hub" where embryos are assembled and implanted into surrogates who carry their pregnancies to term in countries with no protective legislation. The article begins to map the emerging links between the reproductive industry in India and East Africa - where diasporic networks are mobilized in the creation of new reproductive markets, dominated by Indian IVF providers. In particular, we discuss the current expansion in Kenya, which we situate against the backdrop of the colonial entanglements between the two countries. While the ART industry in Kenya is still young, we suggest that these emerging developments illuminate the effect of the ban on commercial surrogacy in India, which appears to have resulted in a partial relocation to countries that lack regulation, shifting the precarious conditions of surrogates in India to other women, elsewhere, in ways that rearticulate colonial racial hierarchies and migration patterns. [ABSTRACT FROM AUTHOR]

Surrogacy is increasing in African countries such as Nigeria as more people who are unable to have children rely on this practice to become parents. The unregulated nature of surrogacy in Nigeria has resulted in several cases of human rights violations due to the lack of legal frameworks to oversee the practice, as well as significant problems related to the well-being of surrogates owing to the associated reproductive risks. It is imperative to regulate surrogacy and establish legal frameworks that protect the rights and interests of all parties involved, especially surrogate mothers. Although the mere existence of laws regulating surrogacy does not guarantee widespread compliance, these laws can serve as a reference point for the protection of women's human rights. Regulating surrogacy in Nigeria will improve standards of practice and monitor agencies' activities, thereby protecting the rights and interests of all participants. This article argues that legislation is the only way to address issues of informed consent and legal representation in human reproduction. Surrogacy agreements should include mechanisms to ensure that surrogate mothers have adequate legal representation and receive the necessary information to make informed decisions and consider potential psychosocial vulnerabilities. By addressing surrogates' vulnerability, legislation can protect them from being unfairly exploited and subjected to health risks, in addition to fostering thoughtful and insightful policymaking in this area. [ABSTRACT FROM AUTHOR]

This article examines the interplay of queer reproduction and private assisted reproductive technologies (ART) companies in urban China. While same-sex marriage has not gained legal recognition in mainland China and childbirth outside heterosexual marriage has been restricted, queer parents who have children through ART have gradually become visible. ART has emerged as an ideal way for Chinese queer citizens to have children, though they are not legally permitted to use ART services in domestic hospitals. Consequently, an increasing number of queer intended parents turned to underground ART businesses, with some of them becoming salespeople or business owners themselves. My ethnographic analysis comes from fieldworks conducted in Guangdong province, China, from 2018 to 2021. This paper shows that the legal and moral debates brought by queer people's use of ART are perceived differently among diverse gender and sexual groups in Chinese society. It founds that queer parents' participation in the ART industry has demonstrated the potential for queer forms of parenthood and family, while reinforcing stratified reproduction and gender inequalities. The tendency to reduce IVF/surrogacy to "womb-for-rent" business among Chinese ART businesses continues to impact queer people's reproductive and parenting rights. This paper hopes to offer insights into queer reproductive justice and reproductive technologies across the globe. [ABSTRACT FROM AUTHOR]

Prospective gay fathers must carefully prepare, plan, and think about parenting—often for years—before they become parents. This article explores how different paths to parenthood provide opportunities for Canadian gay men to reflect upon their preferences for surrogacy or adoption, the meaning of fatherhood in the absence of a woman as a primary caregiver, and the opportunities and potential shortcomings of gay fatherhood. Based on analysis of 23 in-depth, semi-structured interviews with Canadian prospective gay fathers, I show that adoption and surrogacy foster different degrees of reflection along the journey to fatherhood. I argue that gay men who pursue surrogacy express masculine competence and draw upon scripts of conventional fatherhood, while gay men who pursue adoption experience a disruption in their masculine competence and must reflect on their potential inadequacies as male parents. Further, I include a brief discussion of some counterevidence: these pressures on the journey to gay fatherhood can be resisted through a queer, anti-racist, and feminist consciousness. [ABSTRACT FROM AUTHOR]

Some feminists hold that surrogacy contracts should be unenforceable or illegal because they contribute to and perpetuate unjust gender inequalities. I argue that in developed countries, surrogacy contracts either wouldn't have these negative effects or that these effects could be mitigated via regulation. Furthermore, the existence of a regulated surrogacy market is preferable on consequentialist grounds. [ABSTRACT FROM AUTHOR]

Gestational surrogacy is ethically complex, generating very different responses in law and policy worldwide. This paper argues that contemporary surrogacy law and policy, across many jurisdictions, fail to give sufficient attention to the significance of the relationship between the child and the gestational surrogate. This failure risks repeating the mistakes of historical, discredited approaches to adoption and donor‐assisted conception. This paper argues that proper recognition of the significance of gestation must be an organising principle in surrogacy law and policy. The paper begins by pointing to examples of surrogacy law and practice where the role of the gestator is unacceptably minimised, most notably the framing of the surrogate as a mere 'carrier'. It goes on to examine the nature of gestation, including consideration of contemporary scholarship on the metaphysics of pregnancy and emerging work in epigenetics, and argues that current evidence supports the view that the gestational relationship must be taken more seriously than it currently is. The paper then draws analogies with parenthood in donor‐assisted conception and adoption to argue that approaches to parental status in novel family formations that fail to promote transparency and seek to deny the truth of familial relationships are doomed to fail. The paper concludes by suggesting some implications for law and policy that flow from placing sufficient emphasis on the gestational role. The overarching thesis of this paper is that gestational surrogacy is ethically permissible when these fundamental requirements are adhered to, and that surrogacy law should proceed on this basis. [ABSTRACT FROM AUTHOR]

Many individuals with systemic lupus erythematosus (SLE) face significant challenges manifesting their family planning goals due to numerous factors, including disease-related complications, treatment-induced effects, immunological factors, self-imposed limitations, and the socioeconomic impacts of having a chronic disease. Instances of unexplained infertility are also prevalent. Encouragingly, advancements in treatment modalities, risk factor management, specialized training within the medical community, and enhanced patient/provider education have contributed to an increase in successful pregnancies among SLE patients, fostering a safer, more promising reproductive landscape. However, despite advances, individuals with SLE continue to struggle with the complexities of family building. This review explores infertility and pregnancy outcomes in SLE, fertility preservation, the role of assisted reproductive technology, and considerations for tailoring these approaches to SLE patients. [ABSTRACT FROM AUTHOR]

This case review considers Theis J's judgment in Re Z (Surrogacy: Step-parent Adoption) [2024] EWFC 20, in which she refused a step-parent adoption order but made several other orders in relation to contact and the exercise of parental responsibility between the three adults involved. I posit that while the judgment probably represents the best possible outcome all round – especially the best interests of the child at its heart – it does not reflect the lived reality of most surrogacy agreements entered into in this country, or the experiences of those involved. It does, however, indicate that proposed reforms as recommended by the Law Commission of England and Wales and the Scottish Law Commission in 2023 would be welcome, especially as the intention behind them is precisely to protect against breakdowns in surrogacy arrangements such as sadly happened in this case. [ABSTRACT FROM AUTHOR]

Assisted reproduction often involves biological contributions by third parties such as egg/sperm donors, mitochondrial DNA donors, and surrogate mothers. However, these arrangements are also characterised by a biological relationship between the child and at least one intending parent. For example, one or both intending parents might use their own eggs/sperm in surrogacy, or an intending mother might conceive using donor sperm or gestate a donor embryo. What happens when this relationship is absent, as in the case of 'double‐donor surrogacy' arrangements (DDS)? Here, a child is conceived using both donor eggs and sperm, carried by a surrogate, and raised by the commissioning parents. In this paper, I critically examine proposals to allow DDS in the United Kingdom, and the intentionalist justification for treating this practice distinctly (morally and legally speaking) from private adoption. I argue that the intentionalist approach cannot plausibly justify such a distinction and that other approaches to moral parenthood are also unlikely to succeed. [ABSTRACT FROM AUTHOR]

The article examines the contested aspects of neoliberalism through cinematic narratives, addressing the issue of Assisted Reproductive Technology (ART) in India, a debated subject in socio-legal spheres. Existing literature extensively discusses the biopolitical and bioethical dimensions of commercialization and commodification, particularly concerning organ, egg, sperm donations, and gestational commercial surrogacy. This research endeavors to scrutinise and appraise the ethical quandaries emanating from the technological transformation of motherhood, as portrayed in fictional representations. These narratives shed light on the difficult situations faced by surrogates and egg donors, who are often driven by familial or socio-economic pressures to provide their reproductive services. Consequently, they become commodified within the context of India's In Vitro Fertilization (IVF) industry. Ergo, through the films I Am (2010) and Mimi (2021), this article probes into the intertwining socioeconomic situations of the large percentage of infertile women and claims that the positive discourse around the 'new Indian women' is inherently diluted and undermined. Additionally, the research emphasizes that ART—and more importantly, a new agency for single women—is reiterated within the political and socio-historical contexts of the films discussed. [ABSTRACT FROM AUTHOR]

Copyright of Community & Physician / Toplum ve Hekim is the property of Turk Tabipleri Birligi / Turkish Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Community & Physician / Toplum ve Hekim is the property of Turk Tabipleri Birligi / Turkish Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The development of artificial womb technology (AWT) is continuing to proceed and raises important ethical and theological questions for Christians. While there has been extensive secular discourse on artificial wombs in recent years, there has been minimal Christian engagement with this topic. There are broadly two primary uses of artificial womb technology: first, ectogestation, which is a form of enhanced neonatal care, where only some of the gestation period takes place in an artificial womb, and second, ectogenesis, where the entire period of gestation occurs in an artificial womb. It is plausible that some form of ectogestation in the latter weeks or months of pregnancy could be possible within a decade or so, while ectogenesis for humans remains far more speculative. Ectogestation is likely to significantly reduce maternal and neonatal morbidity and mortality, and so there is a strong prima facie case for supporting its development. Ectogenesis, however, may bring several challenges, including the further commodification of children, and the potential pathologizing of pregnancy and childbirth. Its long-term effects on those created through this process are also unknown. If it becomes ubiquitous, we may also find the central theological significance of pregnancy and birth diminished. The dilemma for Christians is that the development of seemingly unproblematic ectogestation is likely to normalize the use of artificial gestation, and, in time, pave the way for ectogenesis. [ABSTRACT FROM AUTHOR]

Building on existing scholarship examining how audiences interpret reproductive experiences on film and television, we investigate how viewers make meaning of representations of motherhood, abortion, adoption, and surrogacy on the Hulu television miniseries Little Fires Everywhere. We recruited twenty-one participants to watch the series and conducted three virtual focus groups of seven women each. Based on the racial identities of the main characters in the series, we segmented these groups by race: one group each of white women, Black women, and Chinese American women. Focus groups were facilitated by moderators who matched the racial and ethnic backgrounds of each group. We asked participants about their overall reactions to the series, their impressions of various characters, and each reproductive health plotline. Participants expressed both tender and critical reactions to characters who endured motherhood, surrogacy and adoption, yet most participants were overtly critical of Lexie, the character who obtained an abortion. We argue that this is likely because the character of Lexie is written as largely unsympathetic, leaving audiences with little opportunity to form a parasocial relationship with her. We discuss the implications of this for cultural conversations and understandings of abortion more broadly.

The new, the engine that allows us to evolve. That is what we do by nature: we figure out how things work and we make new steps, over and over. We created vaccines to help prevent diseases and, in the future, maybe we are about to create a human being outside the womb. It is a sin, it is a legal thing, it is moral? Are we guilty of considering ourselves gods? Medically assisted human reproduction is a piece of a puzzle, of an engine that can separate us or bring us together, that can raise or erase family boundaries, give us rights or put us on the wall of morality. Assisted reproductive technologies are medical procedures and their role is, first of all, to help people who experience some difficulties or who suffer an inability to have biological children of their own. But the access to the experience of pregnancy is expanded by the big new development to the potential of those reproductive technologies. And, as always, there is a price for that, for everything that we create or update, and those challenges go far beyond medicine, science or pure technique and we are forced to wonder about moral, religious or legal limitations.

The selection of the primary endpoint in a clinical trial plays a critical role in determining the trial's success. Ideally, the primary endpoint is the clinically most relevant outcome, also termed the true endpoint. However, practical considerations, like extended follow-up, may complicate this choice, prompting the proposal to replace the true endpoint with so-called surrogate endpoints. Evaluating the validity of these surrogate endpoints is crucial, and a popular evaluation framework is based on the proportion of treatment effect explained (PTE). While methodological advancements in this area have focused primarily on estimation methods, interpretation remains a challenge hindering the practical use of the PTE. We review various ways to interpret the PTE. These interpretations—two causal and one non-causal—reveal connections between the PTE principal surrogacy, causal mediation analysis, and the prediction of trial-level treatment effects. A common limitation across these interpretations is the reliance on unverifiable assumptions. As such, we argue that the PTE is only meaningful when researchers are willing to make very strong assumptions. These challenges are also illustrated in an analysis of three hypothetical vaccine trials. [ABSTRACT FROM AUTHOR]

When the primary endpoints in randomized clinical trials require long term follow-up or are costly to measure, it is often desirable to assess treatment effects on surrogate instead of clinical endpoints. Prior to adopting a surrogate endpoint for such purposes, the extent of its surrogacy on the primary endpoint must be assessed. There is a rich statistical literature on assessing surrogacy in the overall population, much of which is based on quantifying the proportion of treatment effect on the primary endpoint that is explained by the treatment effect on the surrogate endpoint. However, the surrogacy of an endpoint may vary across different patient subgroups according to baseline demographic characteristics, and limited methods are currently available to assess overall surrogacy in the presence of potential surrogacy heterogeneity. In this paper, we propose methods that incorporate covariates for baseline information, such as age, to improve overall surrogacy assessment. We use flexible semi-non-parametric modeling strategies to adjust for covariate effects and derive a robust estimate for the proportion of treatment effect of the covariate-adjusted surrogate endpoint. Simulation results suggest that the adjusted surrogate endpoint has greater proportion of treatment effect compared to the unadjusted surrogate endpoint. We apply the proposed method to data from a clinical trial of infliximab and assess the adequacy of the surrogate endpoint in the presence of age heterogeneity. [ABSTRACT FROM AUTHOR]

Within feminism there is no unified perspective on surrogate pregnancy (sp). Feminist disagreement generally translates into a debate between the defense of autonomy and the protection from exploitation and oppression. This formula, however, overlooks the common feminist framework of the debate, within which limiting oppression and promoting women's autonomy should be considered shared goals. I will advance the debate by analyzing these shared objectives by appealing to contemporary literature on personal autonomy. I will argue that the models of autonomy assumed by those who defend sp as a form of self-determination mask significant forms of oppression in contemporary contexts and that it is only by adopting a particular conception of autonomy that feminist proposals contrary to sp can be seen as hostile to autonomy. I conclude that reflecting and legislating on sp requires models of autonomy that are sensitive to different forms of oppression. [ABSTRACT FROM AUTHOR]

The European eel encounters challenges in achieving sexual maturation in captivity, which has been a concern for researchers. This study explores surrogate broodstock technology as an alternative approach for eel production. The present study aimed to evaluate zebrafish and European sea bass as potential recipients for European eel spermatogonia transplantation, given the abundance of eel type A spermatogonia (SPGA). Immature European eel testes were dissected and maintained at 4 °C or cryopreserved. SPGA were obtained by dissociation of fresh or post-thawed tissue, employing an enzymatic solution, and then labelled with fluorescent membrane marker PKH26. SPGA from fresh tissue were transplanted into wild-type zebrafish larvae and triploid European sea bass larvae, while SPGA from cryopreserved testis were transplanted into vasa::egfp transgenic zebrafish larvae. One-and-a-half months post-transplantation (mpt), fluorescent donor cells were not detected in the gonads of zebrafish or European sea bass. Molecular qPCR analyses at 1.5 or 6 mpt did not reveal European eel-specific gene expression in the gonads of any transplanted fish. The findings suggest that the gonadal microenvironments of zebrafish and European sea bass are unsuitable for the development of European eel spermatogonia, highlighting distinctive spermatogonial stem cell migration mechanisms within teleost species [ABSTRACT FROM AUTHOR]

So far, the Italian literature on the genesis and development of anti-gender mobilisation has focussed on right-wing and Vatican strategies, discourses, and alliances. However, in recent years debates around "gender theory" have prompted political and cultural conflicts inside Italian feminist, lesbian and secular left-wing movements and parties. These political fractures – mirrored also in the debate on TERF and "gender-critical" feminism - have become visible in the Italian public debate on the Zan Bill (an anti-homophobia provision rejected by Italian Parliament in 2021). Although "gender critical" feminists do not belong to the anti-gender movement - in Italy largely monopolised by right-wing and Catholic activists - I argue that the unexpected convergences towards the fight against "gender ideology" are relevant for, at least, two reasons. On one side, the idea of "gender theory" has reinforced its role as a keyword orienting Italian public discourse on sexual rights. On the other hand, criticism of various (although inconsistent) definitions of "gender theory" has broadened their cultural circulation outside conservative or religious groups, in both cases associated with processes of ideological colonisation. These two shifts can be considered to enact a relevant normalisation of anti-gender narratives within Italian public and political discourse fostered by media vulgarisation and popular understandings of the meaning of "gender". [ABSTRACT FROM AUTHOR]

Copyright of Church in the World / Crkva u Svijetu is the property of University of Split, Catholic Faculty of Theology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Identity is made up of a series of elements, including biological, gestational, and genetic factors that are relevant to the initial recording, potential modification, and restoration of family relations. While some countries, through their legislation, policies, and practices, have slowly moved toward the recognition of these elements and have made efforts to ensure that the right to identity is respected in a number of circumstances, it remains evident that access to personal information and origins is still a challenge for many persons, including those whose births have not been registered and/or who have been in care, have been adopted, were born following the resort to anonymous ARTs or surrogacy, or are in complex sociogeopolitical contexts. The registration of identity elements still does not mean that access to these is safeguarded. [ABSTRACT FROM AUTHOR]

The desire for parenthood among infertile individuals is often fulfilled by resorting to the ever-evolving Assisted Reproductive Techniques (ART). Since the birth of Durga, India's first baby born using ART in 1981, the lucrative fertility industry has grown exponentially in our country. The Government of India passed the Assisted Reproductive Technology (Regulatory) Act in 2021 to provide regulatory support to these services. The legislation offers clarity on various aspects of ART, including measures to safeguard children born through these procedures. The effective implementation of the ART Act is crucial to ensure that ART services become affordable, ethical, and socially acceptable in India. This article aims to discuss the controversies with ART services and issues that could compromise the wellbeing of children, while highlighting the provisions provided under the Act to address these. [ABSTRACT FROM AUTHOR]

Members of the Czech Parliament submitted the Amendment to the Civil Code and the Criminal Code that considers surrogacy as a specific form of human trafficking addressing the prohibited commercialization of the human body. The amendment aims to protect women, whose social status is often exploited, and children, who are reduced to commodities. The proposed changes seek to prevent the abuse of international surrogacy and reproductive tourism and, as a result, prohibit surrogacy even in an altruistic form between close relatives. Current Czech legislation tolerates surrogacy. Many social and ethical questions associated with this phenomenon deserve a societywide discussion. Foreign legislation oscillates from clearly regulated conditions for surrogacy, through regulations that tolerate surrogacy without further regulation, to the prohibition of this specific phenomenon. This paper discusses the legislative regulation of surrogate motherhood in the Czech Republic (CR), as it compares with foreign regulation, and focuses on parameters used to compare different legal systems. Detailed national legislation, but especially uniform international rules can contribute to the protection from potential abuse caused by surrogacy. While altruistic surrogacy can be morally acceptable, commercial surrogacy, especially in an international context, can lead to the aforementioned abuses. [ABSTRACT FROM AUTHOR]

Global biodiversity is declining at rates never seen before. At the same time, resources directed at conservation planning still fall orders of magnitude short. Thus, efficient allocation of resources is needed to prioritize regions that can shelter more biodiversity. A usual approach to identify priority areas for conservation is to map species distribution and use this information as input in spatial prioritization proceedings. Since data on common species are more readily available, final maps of priority areas for conservation are heavily biased towards this group, overlooking rare species. Thus, we created a ranking of priority maps for common and rare tree species, separately, aiming to comprehend if prioritizing areas for the conservation of common trees is enough to protect rare trees all at once. Additionally, we overlapped our priority maps with maps of current protected areas (PAs) to identify if the latter already cover areas designated in our models. Our results show that common tree species can act as surrogates for rare tree species since priority maps for both groups overlap with more than 70% of their area. Yet, most of the current PAs do not cover significant areas for protecting tree species, revealing an urgent need to expand or create new PAs to properly safeguard the local biodiversity. [ABSTRACT FROM AUTHOR]

Objectives Measurement of digital perfusion, sometimes coupled with a cold challenge, has been widely used as an objective outcome in trials evaluating drug therapies in RP, in addition to patient-reported outcomes or to establish the proof-of-concept in preliminary studies. However, whether digital perfusion is a valid surrogate for clinical outcomes in RP trials has never been explored. The principal aim of this study was to evaluate the potential surrogacy of digital perfusion, by combining individual-level and trial-level data. Methods We used individual data from a series of n -of-1 trials, and trial data from a network meta-analysis. We estimated individual-level surrogacy through coefficients of determination between digital perfusion and clinical outcomes (R 2ind). We further calculated the coefficients of determination between treatment effect on the clinical outcomes and on digital perfusion, at the individual level (R 2TEind) and at the trial level (R 2trial), using non-weighted linear regression, with their 95% CI calculated through bootstrapping. Results Results from 33 patients and 24 trials were included in the final analysis. At the individual level, there was no correlation between digital perfusion and clinical outcomes at rest and in response to various cooling tests (the highest R 2ind was 0.03 [−0.07, 0.09]), and R 2TEind was also very low 0.07 (0, 0.29). At the trial level, the highest value of R 2trial was 0.1 (0, 0.477). Conclusions Digital perfusion, at rest or in response to a cold challenge, and whatever the method used, does not fulfil the criteria of a valid surrogate for existing patient-reported outcomes in RP trials. [ABSTRACT FROM AUTHOR]

The present study investigated child behavior problems, parenting styles, coparenting, and couple relationship satisfaction in 67 European gay father families via surrogacy and 67 European heterosexual parent families via unassisted conception, all with children aged 1.5–10 years (M = 3.57 years, SD = 2.09). The two family groups were matched for child age and gender. In the gay father group only, the associations between family anti‐gay microaggressions, family/friend support, and other main variables also were explored. Children of gay fathers had fewer externalizing and internalizing problems compared to children of heterosexual parents. Also, gay fathers reported more effective parenting styles, greater coparenting quality, and higher couple relationship satisfaction compared to heterosexual parents. Overall, child externalizing problems (i.e., aggression, rule‐breaking) and internalizing problems (i.e., anxiety, depression) were more strongly associated with being raised in a heterosexual parent family, more authoritarian parenting, and lower positive coparenting. Specific to the gay father sample, anti‐gay microaggressions experienced by family members were associated with more child internalizing problems, lower positive coparenting, and lower social support from family and friends. These results refute concerns about possible detrimental effects on child development of surrogacy conception or of being raised by gay fathers. The results further suggest that family therapists treating child behavior problems should focus mainly on improving the coparenting relationship, reducing authoritarian/punitive parenting styles, and (for gay father families specifically) coping with anti‐gay microaggressions and lack of social support outside the nuclear family. [ABSTRACT FROM AUTHOR]

Building on existing scholarship examining how audiences interpret reproductive experiences on film and television, we investigate how viewers make meaning of representations of motherhood, abortion, adoption, and surrogacy on the Hulu television miniseries Little Fires Everywhere. We recruited twenty-one participants to watch the series and conducted three virtual focus groups of seven women each. Based on the racial identities of the main characters in the series, we segmented these groups by race: one group each of white women, Black women, and Chinese American women. Focus groups were facilitated by moderators who matched the racial and ethnic backgrounds of each group. We asked participants about their overall reactions to the series, their impressions of various characters, and each reproductive health plotline. Participants expressed both tender and critical reactions to characters who endured motherhood, surrogacy and adoption, yet most participants were overtly critical of Lexie, the character who obtained an abortion. We argue that this is likely because the character of Lexie is written as largely unsympathetic, leaving audiences with little opportunity to form a parasocial relationship with her. We discuss the implications of this for cultural conversations and understandings of abortion more broadly. [ABSTRACT FROM AUTHOR]

This paper examines how legal parenthood should be allocated in surrogacy under English law. I argue that we need to shift the focus of the discussion to the surrogate's negative intention to not be a parent as the key to move away from the current gestational model of motherhood. This has three main benefits that are explored in this paper. First, it respects surrogates' voices and construes them in terms of their autonomy and agency, rather than solely in terms of their vulnerability. Second, it provides a conceptually robust basis for recognising legal parenthood of the intended parents at birth, since the surrogate's negative intention is construed as the trigger for the application of specialised rules on parenthood. Third, it serves as a guiding principle in developing appropriate and comprehensive protections for the surrogate, including recognising the intended parents as the legal parents at birth, the parameters of the surrogate's right to withdraw consent, and further safeguarding requirements and checks before entering into a surrogacy agreement. Overall, focusing on the surrogate's negative intention allows us to view surrogacy in a nuanced way, away from false dichotomies, and contributes to a more compelling case in favour of actively facilitating surrogacy. [ABSTRACT FROM AUTHOR]

This article sheds light on the normative dimension of birth registration and explores how birth registration practices intertwine with traditional notions of child care. It shows that, while birth registration may appear a straightforward and factual procedure, it actually rests upon and perpetuates the notion that care 'naturally' stems from gestation and birth, and is by definition maternal. This normative dimension of birth registration becomes especially apparent when trans families and families created through surrogacy are denied registration in line with their lived experience. By delving into two case studies, namely the Swiss Federal Supreme Court's latest case-law on surrogacy and recent cases involving trans birthing men, this article shows that birth registration practices fail to recognise caring relationships in non-traditional families on their own terms. In the context of surrogacy, the understanding of care as 'naturally' arising from gestation and birth downgrades the relationship between the child and the intended mother by requiring her to pursue step-child adoption, despite having cared for the child since birth and sometimes being genetically connected. In a similar vein, birth registration practices tend to (mis)classify a caring relationship between a trans birthing man and his child as 'mother-child', thus rendering trans male care invisible. [ABSTRACT FROM AUTHOR]

Surrogacy is a form of family creation that raises many medical, ethical, and legal questions. This article examines how the European Court of Human Rights (ECtHR) deals with the issue of cross-border surrogacy and its legal consequences in its recent case law. It will demonstrated that the Strasbourg Court has developed a nuanced case law that leaves it in the first place to the national authorities to deal with the complex issue of surrogacy, whereby it is nevertheless clear that further to the Strasbourg case law even if legislators rule out the possibility of surrogacy on their territory, they will have to find solutions to "'regularise"' the de facto situation of the child, taking into account its best interests. [ABSTRACT FROM AUTHOR]

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Introduction: Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is rare condition that has a negative impact on quality of life because affected women lack a uterus and vagina, and are therefore unable to engage in sexual intercourse and experience natural pregnancy. This study evaluated perceptions of surrogacy in Vietnamese women with MRKH who have started families. Method: Women with MRKH who had undergone successful vaginal reconstruction, were married, and had started families participated in a semi-structured, in-depth, one-on-one online video interview with an experienced female psychologist. Openended questions were used to encourage participants to express their perceptions of surrogacy; prominent themes were discussed, compared, and combined. Results: Twenty women (mean age 31 years) agreed to participate. Key themes identified from interviews were the importance of having genetic offspring, consideration of surrogacy as a preferred solution to infertility, the barriers to surrogacy in Vietnam, lack of reproductive information and counselling, individuals concealing their health condition, the impact of religion on the possibility of surrogacy, the economic cost of surrogacy, and the difficulty in finding a surrogate under the restrictions imposed by Vietnamese law. Discussion: Based on the perceptions of women from MRKH from Vietnam, there is an opportunity to improve how infertility is managed in these people, including information about surrogacy. These data show that individuals with MRKH should be provided with information about the possibility of surrogacy, encouraged to be open and seek support, and be managed by a multidisciplinary team that includes psychological support; the provision of economic support for fertility treatments in women with MRKH should also be considered. [ABSTRACT FROM AUTHOR]