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Your search keyword '"Surgical staging, MRI"' showing total 3 results
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3 results on '"Surgical staging, MRI"'

1. Dedicated MRI staging versus surgical staging of peritoneal metastases in colorectal cancer patients considered for CRS-HIPEC; the DISCO randomized multicenter trial

Author

M. P. Engbersen, C. J. V. Rijsemus, J. Nederend, A. G. J. Aalbers, I. H. J. T. de Hingh, V. Retel, D. M. J. Lambregts, E. J. R. J. Van der Hoeven, D. Boerma, M. J. Wiezer, M. De Vries, E. V. E. Madsen, A. R. M. Brandt-Kerkhof, S. Van Koeverden, P. R. De Reuver, R. G. H. Beets-Tan, N. F. M. Kok, and M. J. Lahaye

Subjects
Colorectal peritoneal metastases, CRS-HIPEC, Surgical staging, MRI, RCT, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Selecting patients with peritoneal metastases from colorectal cancer (CRCPM) who might benefit from cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is challenging. Computed tomography generally underestimates the peritoneal tumor load. Diagnostic laparoscopy is often used to determine whether patients are amenable for surgery. Magnetic resonance imaging (MRI) has shown to be accurate in predicting completeness of CRS. The aim of this study is to determine whether MRI can effectively reduce the need for surgical staging. Methods The study is designed as a multicenter randomized controlled trial (RCT) of colorectal cancer patients who are deemed eligible for CRS-HIPEC after conventional CT staging. Patients are randomly assigned to either MRI based staging (arm A) or to standard surgical staging with or without laparoscopy (arm B). In arm A, MRI assessment will determine whether patients are eligible for CRS-HIPEC. In borderline cases, an additional diagnostic laparoscopy is advised. The primary outcome is the number of unnecessary surgical procedures in both arms defined as: all surgeries in patients with definitely inoperable disease (PCI > 24) or explorative surgeries in patients with limited disease (PCI

Published
2021
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2. Dedicated MRI staging versus surgical staging of peritoneal metastases in colorectal cancer patients considered for CRS-HIPEC; the DISCO randomized multicenter trial.

Author

Engbersen, M. P., Rijsemus, C. J. V., Nederend, J., Aalbers, A. G. J., de Hingh, I. H. J. T., Retel, V., Lambregts, D. M. J., Van der Hoeven, E. J. R. J., Boerma, D., Wiezer, M. J., De Vries, M., Madsen, E. V. E., Brandt-Kerkhof, A. R. M., Van Koeverden, S., De Reuver, P. R., Beets-Tan, R. G. H., Kok, N. F. M., and Lahaye, M. J.

Subjects
*CYTOREDUCTIVE surgery, *COLORECTAL cancer, *CLINICAL trial registries, *CANCER patients, *MAGNETIC resonance imaging, *HYPERTHERMIC intraperitoneal chemotherapy
Abstract

Background: Selecting patients with peritoneal metastases from colorectal cancer (CRCPM) who might benefit from cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is challenging. Computed tomography generally underestimates the peritoneal tumor load. Diagnostic laparoscopy is often used to determine whether patients are amenable for surgery. Magnetic resonance imaging (MRI) has shown to be accurate in predicting completeness of CRS. The aim of this study is to determine whether MRI can effectively reduce the need for surgical staging.Methods: The study is designed as a multicenter randomized controlled trial (RCT) of colorectal cancer patients who are deemed eligible for CRS-HIPEC after conventional CT staging. Patients are randomly assigned to either MRI based staging (arm A) or to standard surgical staging with or without laparoscopy (arm B). In arm A, MRI assessment will determine whether patients are eligible for CRS-HIPEC. In borderline cases, an additional diagnostic laparoscopy is advised. The primary outcome is the number of unnecessary surgical procedures in both arms defined as: all surgeries in patients with definitely inoperable disease (PCI > 24) or explorative surgeries in patients with limited disease (PCI < 15). Secondary outcomes include correlations between surgical findings and MRI findings, cost-effectiveness, and quality of life (QOL) analysis.Conclusion: This randomized trial determines whether MRI can effectively replace surgical staging in patients with CRCPM considered for CRS-HIPEC.Trial Registration: Registered in the clinical trials registry of U.S. National Library of Medicine under NCT04231175 . [ABSTRACT FROM AUTHOR]

Published
2021
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3. Dedicated MRI staging versus surgical staging of peritoneal metastases in colorectal cancer patients considered for CRS-HIPEC; the DISCO randomized multicenter trial

Author

Max J. Lahaye, M. P. Engbersen, J. Nederend, I.H.J.T. de Hingh, E. J. R. J. Van der Hoeven, A. R. M. Brandt-Kerkhof, Marinus J. Wiezer, S. Van Koeverden, M. W. de Vries, Nils Kok, P.R. de Reuver, D. Boerma, Valesca P. Retèl, Doenja M. J. Lambregts, Regina G. H. Beets-Tan, Arend G. J. Aalbers, C. J. V. Rijsemus, E. V. E. Madsen, School Office GROW, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Faculteit FHML Centraal, Health Technology & Services Research, Radiology & Nuclear Medicine, and Surgery

Subjects
Cancer Research, Colorectal cancer, CARCINOMATOSIS, 030230 surgery, law.invention, Study Protocol, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, Randomized controlled trial, LAPAROSCOPY, law, Surgical oncology, Laparoscopy, RC254-282, Peritoneal Neoplasms, INDEX, Netherlands, medicine.diagnostic_test, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cytoreduction Surgical Procedures, Combined Modality Therapy, Magnetic Resonance Imaging, Tumor Burden, Oncology, 030220 oncology & carcinogenesis, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Hyperthermic intraperitoneal chemotherapy, Radiology, HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY, Colorectal Neoplasms, RCT, MRI, medicine.medical_specialty, Colorectal peritoneal metastases, Surgical staging, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, Multicenter trial, Genetics, medicine, MANAGEMENT, Humans, COMPUTED-TOMOGRAPHY, CRS-HIPEC, Neoplasm Staging, business.industry, Magnetic resonance imaging, medicine.disease, Clinical trial, Surgical staging, MRI, CYTOREDUCTIVE SURGERY, Sample Size, Quality of Life, Tomography, X-Ray Computed, business
Abstract

Background Selecting patients with peritoneal metastases from colorectal cancer (CRCPM) who might benefit from cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is challenging. Computed tomography generally underestimates the peritoneal tumor load. Diagnostic laparoscopy is often used to determine whether patients are amenable for surgery. Magnetic resonance imaging (MRI) has shown to be accurate in predicting completeness of CRS. The aim of this study is to determine whether MRI can effectively reduce the need for surgical staging. Methods The study is designed as a multicenter randomized controlled trial (RCT) of colorectal cancer patients who are deemed eligible for CRS-HIPEC after conventional CT staging. Patients are randomly assigned to either MRI based staging (arm A) or to standard surgical staging with or without laparoscopy (arm B). In arm A, MRI assessment will determine whether patients are eligible for CRS-HIPEC. In borderline cases, an additional diagnostic laparoscopy is advised. The primary outcome is the number of unnecessary surgical procedures in both arms defined as: all surgeries in patients with definitely inoperable disease (PCI > 24) or explorative surgeries in patients with limited disease (PCI Conclusion This randomized trial determines whether MRI can effectively replace surgical staging in patients with CRCPM considered for CRS-HIPEC. Trial registration Registered in the clinical trials registry of U.S. National Library of Medicine under NCT04231175.

Published
2021

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