1. Efficacy of adjunctive modalities during tooth extraction for the prevention of osteoradionecrosis: A systematic review and meta‐analysis.
- Author
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Quah, Bernadette, Yong, Chee Weng, Lai, Clement Wei Ming, and Islam, Intekhab
- Subjects
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ANTIBIOTICS , *PLATELET-rich fibrin , *MEDICAL information storage & retrieval systems , *OSTEORADIONECROSIS , *HEAD & neck cancer , *TREATMENT effectiveness , *CANCER patients , *META-analysis , *DESCRIPTIVE statistics , *DISEASE prevalence , *SYSTEMATIC reviews , *PENTOXIFYLLINE , *ODDS ratio , *MEDLINE , *COMBINED modality therapy , *VITAMIN E , *MEDICAL databases , *DENTAL extraction , *HYPERBARIC oxygenation , *ONLINE information services , *PHOTOBIOMODULATION therapy - Abstract
Background: Jaw osteoradionecrosis (ORN) is a complication in patients with previous head and neck radiotherapy. Its incidence increases with dental extractions. Hence, this review aimed to evaluate the efficacy of adjunctive treatment modalities undertaken at the time of extraction in previous head and neck radiotherapy patients in preventing ORN. Methods: A systematic review was conducted, where studies with data on ORN incidence after extraction with or without adjunctive interventions were included. Meta‐analyses were conducted to estimate the pooled prevalence of ORN per intervention and the pooled odds ratio for incidence of ORN between interventions. Results: In total, 1520 patients in 29 studies were included. Interventions identified were hyperbaric oxygen (HBO), pentoxifylline‐tocopherol (PENTO), antibiotics (ABX), platelet‐rich fibrin and photobiomodulation. The pooled prevalence of ORN for HBO (4.6%), PENTO (3.4%) and ABX (3.8%) was significantly lower than the Control (17.6%). For studies with direct comparisons between groups, HBO had lower but not significant odds of developing ORN than the Control (OR 0.27) and ABX (OR 0.57). Conclusions: HBO, PENTO and ABX may reduce the incidence of ORN compared to no intervention. Given that all three have similar incidences of ORN, ABX may be the most cost‐effective and accessible adjunctive modality. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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