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Background: The correlation between depression, anxiety and thyroid function is widely recognized. These conditions exhibit numerous similar symptoms, which complicates the process of diagnosing and treating them. The aim of this study is to determine the frequency of Anxiety Symptoms in Individuals with Hypothyroidism at a Specialized Medical Facility. Materials and Methods: A comprehensive assessment was conducted on 100 individuals who had been diagnosed with hypothyroidism. The evaluation involved the utilization of the Hamilton Depression Rating Scale (HDRS) and the Hamilton Anxiety Scale (HAM-A). The study included participants of all genders, ranging in age from 18 to 45 years, who had confirmed diagnoses of hypothyroidism and provided their explicit written consent. Results: Out of the participants, 73% were females and 27% were males. Among the total sample, 63% displayed different levels of depression based on the HDR Scale, while 65% exhibited varying degrees of anxiety according to the HAM-A scales. When considering males, the most prevalent symptoms in line with the HDR scales were feelings of depression (74.07%) and anxiety (85.18%). Conversely, among females, the most frequent symptoms were somatic symptoms related to the gastrointestinal system (69.86%). Analyzing the HAM-A scales, the primary symptom for males was depressed mood (92.59%), whereas for females, it was anxious mood (93.15%). Conclusion: There is significant prevalence of depression and anxiety among the patients with hypothyroidism.

Introduction: Atrial fibrillation is one of the commonest arrhythmias with an overall prevalence estimated to be 0.4-1% in the general population. The objective of this study was to find out the prevalence of atrial fibrillation among patients admitted to the Department of Internal Medicine in a tertiary care centre. Methods: A descriptive cross-sectional study was conducted among patients admitted to the Department of Internal Medicine of a tertiary care centre from 01 March 2021 to 01 March 2022. Ethical approval was obtained from the Institutional Review Committee (Reference number: IRC-478/2021). Convenience sampling method was used. Data were collected from the hospital records using a semi-structured study proforma including demography, clinical presentation, laboratory investigations, electrocardiogram, 2-dimension echocardiography, and CHA2DS2VASc score. Point estimate and 95% Confidence Interval were calculated. Results: Among 27,980 patients, atrial fibrillation was found in 185 (0.66%) (0.58-0.77, 95% Confidence Interval). Among them 66 (35.67%) were in the age group of 61-70 years and 97 (52.43%) were females. Dyspnea was present in 149 (80.54%), palpitation in 137 (74.05%) and pedal edema in 117 (63.27%). Valvular atrial fibrillation was seen in 101 (54.59%) and non-valvular atrial fibrillation was seen in 84 (45.41%) patients. Conclusions: The prevalence of atrial fibrillation was found to be similar when compared to other studies conducted in similar settings.

Introduction: Acute ischemic stroke is the second most common cause of death after ischemic heart disease worldwide and Nepal's top five diseases based on Disability-Adjusted Life Years. Dyslipidemia is a major risk factor for coronary heart disease but has an unclear role in the pathogenesis of ischemic stroke. The objective of this study was to find the prevalence of dyslipidemia in acute non-cardioembolic ischemic stroke patients at a tertiary care centre. Methods: A descriptive cross-sectional study was conducted among 76 patients with acute noncardioembolic ischemic stroke admitted in the Neuromedicine unit of a tertiary care centre from August 2017 to July 2018. Ethical approval was obtained from the Institutional Review Committee of the same institute (Reference number: 478/2020). Patients underwent baseline investigations, including fasting lipid profile and Computed Tomography Scan/Magnetic Resonance Imaging head. Data were analysed using Statistical Package for the Social Sciences version 21.0. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: The prevalence of dyslipidemia among the acute non-cardioembolic ischemic stroke patients was 35 (46.05%) (35.05–57.05 at 95% Confidence Interval) where high total cholesterol was diagnosed in 11 (31.43%), high triglycerides in 25 (71.43%), high low-density-lipoprotein in 10 (28.57%), and low high-density-lipoprotein in 11 (31.43%) patients. Conclusions: The prevalence of dyslipidemia among acute non-cardioembolic ischemic stroke patients at our tertiary care centre is higher than the similar studies done in similar settings.