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4. Clinical utility of <scp>sFlt</scp> ‐1 and <scp>PlGF</scp> in screening, prediction, diagnosis and monitoring of pre‐eclampsia and fetal growth restriction

Author

Stepan, H, Galindo, A, Hund, M, Schlembach, D, Sillman, J, Surbek, D, and Vatish, M

Subjects
Reproductive Medicine, Radiological and Ultrasound Technology, embryonic structures, Obstetrics and Gynecology, 610 Medicine & health, Radiology, Nuclear Medicine and imaging, General Medicine
Abstract

Preeclampsia (PE) is characterized by placental and maternal endothelial dysfunction, and associated with fetal growth restriction (FGR), placental abruption, preterm delivery and stillbirth. The angiogenic factors soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) are altered in pregnancies complicated by placental-related disorders. In this review, we summarize existing literature examining the performance of maternal PlGF, sFlt-1 and sFlt-1/PlGF ratio for a) screening and diagnosing PE, b) predicting PE development in the short term, c) monitoring established PE and d) predicting other placental-related disorders. We also discuss the performance of PlGF and the sFlt-1/PlGF ratio for predicting PE in twin pregnancies. For first trimester screening, a more accurate way of identifying high-risk women than current practices is to combine PlGF levels with clinical risk factors and ultrasound markers. To support diagnosis of PE later in pregnancy, the sFlt-1/PlGF ratio has advantages over PlGF because it has a higher pooled sensitivity and specificity for diagnosing and monitoring PE. The sFlt-1/PlGF ratio has clinical value because it can rule out the development of PE in the subsequent 1-4 weeks after the test. Once diagnosis of PE is established, repeated measurement of sFlt-1 and PlGF can help monitor progression of the condition and may inform clinical decision-making around optimal time for delivery. The sFlt-1/PlGF ratio is useful for predicting FGR and preterm delivery, but the association between stillbirth and the angiogenic factors remains unclear. The sFlt-1/PlGF ratio can also be used to predict PE in twin pregnancies, although different sFlt-1/PlGF ratio cut-offs to those of singleton pregnancies should be applied for optimal performance. In summary, PlGF, sFlt-1 and the sFlt-1/PlGF ratio are useful for screening, diagnosing, predicting, and monitoring placental-related disorders in singleton and twin pregnancies; we propose further integration of these angiogenic factor tests in clinical practice. This article is protected by copyright. All rights reserved.

Published
2023

15. Preimplantation factor modulates oligodendrocytes by H19-induced demethylation of NCOR2

Author

Spinelli, M, Boucard, C, Ornaghi, S, Schoeberlein, A, Irene, K, Coman, D, Hyder, F, Zhang, L, Haesler, V, Bordey, A, Barnea, E, Paidas, M, Surbek, D, Mueller, M, Spinelli M., Boucard C., Ornaghi S., Schoeberlein A., Irene K., Coman D., Hyder F., Zhang L., Haesler V., Bordey A., Barnea E., Paidas M., Surbek D., Mueller M., Spinelli, M, Boucard, C, Ornaghi, S, Schoeberlein, A, Irene, K, Coman, D, Hyder, F, Zhang, L, Haesler, V, Bordey, A, Barnea, E, Paidas, M, Surbek, D, Mueller, M, Spinelli M., Boucard C., Ornaghi S., Schoeberlein A., Irene K., Coman D., Hyder F., Zhang L., Haesler V., Bordey A., Barnea E., Paidas M., Surbek D., and Mueller M.

Abstract

Failed or altered gliogenesis is a major characteristic of diffuse white matter injury in survivors of premature birth. The developmentally regulated long noncoding RNA (lncRNA) H19 inhibits S-adenosylhomocysteine hydrolase (SAHH) and contributes to methylation of diverse cellular components, such as DNA, RNA, proteins, lipids, and neurotransmitters. We showed that the pregnancy-derived synthetic PreImplantation Factor (sPIF) induces expression of the nuclear receptor corepressor 2 (NCOR2) via H19/SAHH-mediated DNA demethylation. In turn, NCOR2 affects oligodendrocyte differentiation markers. Accordingly, after hypoxic-ischemic brain injury in rodents, myelin protection and oligodendrocytes’ fate are in part modulated by sPIF and H19. Our results revealed an unexpected mechanism of the H19/SAHH axis underlying myelin preservation during brain recovery and its use in treating neurodegenerative diseases can be envisioned.

Published
2021

22. 'Evidence-based medicine' in der Geburtshilfe

Author

Rath, W., Winkler, M., Schneider, K. T. M., Bröcker, J., Thornton, J., Holzgreve, W., Schaub, A. F., Hösli, I., Hödel, M., Schloo, R., Tercanli, S., Rempen, A., Surbek, D. V., Berg, Dietrich, editor, Diedrich, Klaus, editor, and Rauskolb, Rüdiger, editor

Published
2000
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25. Clinical utility of sFlt‐1 and PlGF in screening, prediction, diagnosis and monitoring of pre‐eclampsia and fetal growth restriction.

Author

Stepan, H., Galindo, A., Hund, M., Schlembach, D., Sillman, J., Surbek, D., and Vatish, M.

Subjects
FETAL growth retardation, PLACENTAL growth factor, MEDICAL screening, MULTIPLE pregnancy, ABRUPTIO placentae, PLACENTA praevia, PREMATURE labor
Abstract

Pre‐eclampsia (PE) is characterized by placental and maternal endothelial dysfunction, and associated with fetal growth restriction (FGR), placental abruption, preterm delivery and stillbirth. The angiogenic factors soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF) are altered in pregnancies complicated by placenta‐related disorders. In this Review, we summarize the existing knowledge, examining the performance of maternal PlGF, sFlt‐1 and the sFlt‐1/PlGF ratio for screening PE, predicting development of PE in the short term, diagnosing PE, monitoring established PE and predicting other placenta‐related disorders in singleton pregnancy. We also discuss the performance of PlGF and the sFlt‐1/PlGF ratio for predicting PE in twin pregnancy. For first‐trimester screening in singleton pregnancy, a more accurate way of identifying high‐risk women than current practice is to combine maternal PlGF levels with clinical risk factors and ultrasound markers. Later in pregnancy, the sFlt‐1/PlGF ratio has advantages over PlGF because it has a higher pooled sensitivity and specificity for diagnosing and monitoring PE. It has clinical value because it can rule out the development of PE in the 1–4‐week period after the test. Once a diagnosis of PE is established, repeat measurement of sFlt‐1 and PlGF can help monitor progression of the condition and may inform clinical decision‐making regarding the optimal time for delivery. The sFlt‐1/PlGF ratio is useful for predicting FGR and preterm delivery, but the association between stillbirth and the angiogenic factors is unclear. The sFlt‐1/PlGF ratio can be used to predict PE in twin pregnancy, although different sFlt‐1/PlGF ratio cut‐offs from those for singleton pregnancy should be applied for optimal performance. In summary, PlGF, sFlt‐1 and the sFlt‐1/PlGF ratio are useful for screening, diagnosing, predicting and monitoring placenta‐related disorders in singleton and twin pregnancy. We propose that tests for these angiogenic factors are integrated more fully into clinical practice.© 2022 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Prevention of preterm delivery with vaginal progesterone in women with preterm labour (4P): randomised double-blind placebo-controlled trial

Author

de Tejada, Martinez B, Karolinski, A, Ocampo, M C, Laterra, C, Hösli, I, Fernández, D, Surbek, D, Huespe, M, Drack, G, Bunader, A, Rouillier, S, de Degani, López G, Seidenstein, E, Prentl, E, Antón, J, Krähenmann, F, Nowacki, D, Poncelas, M, Nassif, J C, Papera, R, Tuma, C, Espoile, R, Tiberio, O, Breccia, G, Messina, A, Peker, B, Schinner, E, Mol, B W, Kanterewicz, L, Wainer, V, Boulvain, M, Othenin-Girard, V, Bertolino, M V, and Irion, O

Published
2015
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34. Freie mitteilungen

Author

Robbiani, M. B., Huch, A., Mathèz-Loïc, F., Kotze, I., Major, A., Bouic, P., Paul, L., Schneider, H., Odendaal, H. J., Glanzmann, P., Dürig, P., Nägeli, E., Hänggi, W., Koller, A., Surbek, D., Almendral, A. C., Surbek, D., Koller, A., Frei, R., and Pavic, N.

Published
1995
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50. Influenza- und Pertussisimpfung in der Schwangerschaft

Author

Berger, Christoph, Niederer-Loher, A, Bouvier Gallacchi, M, Brügger, D, Martinez de Tejada, B, Spaar Zographos, A, Surbek, D, and University of Zurich

Subjects
10036 Medical Clinic, 610 Medicine & health
Published
2019

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