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14 results on '"Suppini, Noemi"'

1. Emerging Nanomedicine Approaches in Targeted Lung Cancer Treatment.

Author

Alexandru, Isaic, Davidescu, Lavinia, Motofelea, Alexandru Cătălin, Ciocarlie, Tudor, Motofelea, Nadica, Costachescu, Dan, Marc, Monica Steluta, Suppini, Noemi, Șovrea, Alina Simona, Coșeriu, Răzvan-Lucian, Bondor, Daniela-Andreea, Bobeică, Laura-Gabriela, and Crintea, Andreea

Subjects
LUNG cancer, NANOMEDICINE, NANOPARTICLES, CELLULAR signal transduction, CANCER treatment
Abstract

Lung cancer, the leading cause of cancer-related deaths worldwide, is characterized by its aggressive nature and poor prognosis. As traditional chemotherapy has the disadvantage of non-specificity, nanomedicine offers innovative approaches for targeted therapy, particularly through the development of nanoparticles that can deliver therapeutic agents directly to cancer cells, minimizing systemic toxicity and enhancing treatment efficacy. VEGF and VEGFR are shown to be responsible for activating different signaling cascades, which will ultimately enhance tumor development, angiogenesis, and metastasis. By inhibiting VEGF and VEGFR signaling pathways, these nanotherapeutics can effectively disrupt tumor angiogenesis and proliferation. This review highlights recent advancements in nanoparticle design, including lipid-based, polymeric, and inorganic nanoparticles, and their clinical implications in improving lung cancer outcomes, exploring the role of nanomedicine in lung cancer diagnoses and treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Large Lung Consolidation: A Rare Presentation of Pulmonary Sarcoidosis

Author

Marc, Monica Steluta, primary, Pescaru, Camelia Corina, additional, Costin, Emanuela Oana, additional, Crisan, Alexandru Florian, additional, Maritescu, Adelina, additional, Pescaru, Andrei, additional, Suppini, Noemi, additional, Olteanu, Gheorghe Emilian, additional, Traila, Daniel, additional, Oancea, Cristian, additional, and Manolescu, Diana, additional

Published
2023
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7. Large Lung Consolidation: A Rare Presentation of Pulmonary Sarcoidosis.

Author

Marc, Monica Steluta, Pescaru, Camelia Corina, Costin, Emanuela Oana, Crisan, Alexandru Florian, Maritescu, Adelina, Pescaru, Andrei, Suppini, Noemi, Olteanu, Gheorghe Emilian, Traila, Daniel, Oancea, Cristian, and Manolescu, Diana

Subjects
SARCOIDOSIS, LUNGS, DIAGNOSTIC imaging, LUNG cancer, DIFFERENTIAL diagnosis, GRANULOMA
Abstract

Sarcoidosis is a complex inflammatory disease of uncertain origin, characterized by non-necrotizing epithelioid cell granulomas (NNEGs) affecting multiple organ systems. Although many different clinical and pathological phenotypes can be present, with different organs involved, the lung is the most common site described. In this case report, we (a) present and discuss the broad differential diagnosis of a patient presenting with a solitary lung mass with clinical and imaging features of lung cancer that ultimately was confirmed with a rare manifestation of stage II pulmonary sarcoidosis, and (b) analyze and compare similar cases from the literature. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Lung Function Assessment by Impulse Oscillometry in Adults

Author

Porojan-Suppini, Noemi, Fira-Mladinescu, Ovidiu, Marc, Monica, Tudorache, Emanuela, and Oancea, Cristian

Subjects
oscillometry, respiratory resistance, respiratory impedance, Review, respiratory system, Corrigendum, pulmonary function tests, respiratory tract diseases
Abstract

Over the past decades, impulse oscillometry (IOS) has gained ground in the battery of pulmonary function tests. Performing the test requires minimal cooperation of the patient; therefore, it is a useful tool, especially in evaluating lung mechanics in children, elderly patients, and those who cannot perform spirometry. Oscillometry has also been used in both clinical and research departments. Studies were published mainly in asthma regarding detection of bronchodilator response and the therapeutic response to different drugs. Furthermore, it has been shown to be a sensitive technique to evaluate disease control. Other studied diseases were COPD, interstitial lung diseases, small airway disease, impairment of lung function due to exposure to occupational hazards or smoking, central airways obstruction, cystic fibrosis, monitoring lung mechanics during mechanical ventilation and sleep, neuromuscular diseases, lung transplant, and graft function. The aim of this review is to present the utility of oscillometry on the previously mentioned clinical fields.

Published
2020

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