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3 results on '"Suphat Korkiatithaweechai"'

1. Controlled Release of Diclofenac from Matrix Polymer of Chitosan and Oxidized Konjac Glucomannan

Author

Nongnuj Muangsin, Narong Praphairaksit, Pornpusadee Umsarika, and Suphat Korkiatithaweechai

Subjects
drug delivery system, diclofenac sodium, chitosan, oxidized konjac glucomannan, Biology (General), QH301-705.5
Abstract

The controlled release of diclofenac sodium (DFNa) from a chitosan-oxidized konjac glucomannan (CTS-OKG) polymer film was studied. Konjac glucomannan (KGM) was initially oxidized by sodium periodate and then cross-linked to CTS via imine bonds (–C=N–) to form the new CTS-OKG copolymer. The DFNa loaded CTS-OKG polymers were characterized by Fourier transformed infrared spectroscopy (FT-IR) and X-ray diffractometry (XRD). Finally, the release profiles of DFNa from the CTS-OKG polymer matrices were evaluated in a simulated gastrointestinal fluid system comprised of two hours in simulated gastric fluid (SGF; pH 1.2) followed by 24 h in simulated intestinal fluid (SIF; pH 7.4). A 1:2:1 (w/w/w) ratio of CTS:OKG:DFNa prepared at room temperature for 3 hours gave the highest % encapsulation efficiency (EE) of 95.6 ± 0.6 and resulted in a minimal release of DFNa ( < 1% over 2 h) in SGF (pH 1.2) and a significantly improved sustained release in SIF (pH 7.4) with ~6% and 19% release over 8 and 24 h, respectively), some 15- and five-fold lower than that of the two commercial DFNa preparations, Diclosian and Voltaren. This formulation may be used for further study as a long term intestine controlled release drug model (at least 3 days).

Published
2011
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2. Autonomic healing of thermoplastic elastomer composed of triblock copolymer

Author

Takumi Sako, Masayuki Yamaguchi, Suphat Korkiatithaweechai, and Ritsuko Watanabe

Subjects
triblock copolymer, Materials science, Mechanical Engineering, viscoelastic properties, thermoplastic elastomer, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Microstructure, 01 natural sciences, Chemical reaction, 0104 chemical sciences, Hildebrand solubility parameter, chemistry.chemical_compound, Polybutadiene, chemistry, Mechanics of Materials, Copolymer, self-healing, General Materials Science, Polystyrene, Composite material, Thermoplastic elastomer, 0210 nano-technology, Dissolution
Abstract

In this paper, we demonstrated that commercially available triblock copolymers such as polystyrene-b-polybutadiene-b-polystyrene (SBS) and polystyrene-b-polyisoprene-b-polystyrene (SIS), used as thermoplastic elastomers, exhibit autonomic self-healing behavior at room temperature without any chemical reaction even after cutting into two separate pieces. The healing efficiency is improved by immediate recombination after cutting, and is attributed to the destruction of the microstructure, i.e.、 polystyrene domains, leading to marked molecular mobility. Furthermore, quenched samples with obscure phase-separation exhibit good healing behavior. Finally, SBS has better healing efficiency than SIS because the solubility parameter of polybutadiene is closer to that of polystyrene than that of polyisoprene; to some extent, the solubility parameter is responsible for enhanced molecular motion owing to the mutual dissolution of both components.

Published
2016

3. Mechanical and Optical Properties of Polycarbonate Containing p-Terphenyl

Author

Masayuki Yamaguchi, Shogo Nobukawa, Azusa Miyagawa, and Suphat Korkiatithaweechai

Subjects
Materials science, Birefringence, Optical anisotropy, General Chemical Engineering, Intermolecular force, Modulus, General Chemistry, Industrial and Manufacturing Engineering, Spectral line, chemistry.chemical_compound, chemistry, visual_art, Terphenyl, visual_art.visual_art_medium, Molecule, Polycarbonate, Composite material
Abstract

Mechanical and optical properties of polycarbonate (PC) containing p-terphenyl (p-tPh) are studied. It is found from the dynamic mechanical spectra that the addition of p-tPh greatly enhances the modulus in the glassy state due to the antiplasticizing effect. Moreover, p-tPh molecules dissolved in PC show marked intermolecular orientation correlation with PC chains during hot-stretching. As a result, p-tPh orients to the stretching direction accompanying the orientation of PC chains. Because p-tPh shows a high level of optical anisotropy, the oriented p-tPh molecules enhance the orientation birefringence. The enhancement of both modulus and optical anisotropy leads to a thinner retardation film, which will be a great benefit in the industry.

Published
2013

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