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Ectopically located parathyroid adenoma is one of the major causes of persistent and recurrent hyperparathyroidism and hypercalcemia. Approximately 0.3–8% of parathyroid adenoma is found in an ectopic location. Ectopic parathyroid adenomas are uncommon causes of persistent hypercalcemia and can be present at uncommon locations, including the hypoglossal nerve, the posterior triangle of the neck, axilla, and pericardium 3. A high index of suspicion is warranted when we see persistently elevated levels of parathyroid hormones (PTHs) and calcium levels post parathyroidectomy. Here, we present a patient who persistently had elevated calcium and PTH levels after parathyroidectomy.

Primary hyperparathyroidism is a common endocrinology anomaly which involves head and neck region. The diagnosis and treatment of parathyroid adenoma however still remains a challenge. Giant parathyroid adenomas are rare and involve more surgical expertise. Retrospective study was carried in Departments of ENT and Endocrinology, SMS Medical College and Hospital, Jaipur. Records of patients operated between 2010 and 2019 were evaluated and analysed for size and site of parathyroid adenomas, biochemical parameters, intra-operative findings and postoperative course. Tumours with size > 3 cm were termed as giant parathyroid adenomas and this is a rarity in literature. Records of 79 patients were found to be complete. Out of these 9 had giant parathyroid adenomas: 4 left inferior, 2 right inferior, 1 ectopic location (superior mediastinum) and 1 each in left and right superior glands. The size, symptomatology and biochemical parameters are discussed in light of available literature. Giant parathyroid adenomas are a rare entity and their behaviour are same as of non giant parathyroid adenomas. In the view of literature published on pub Med, this is found to be largest case series on parathyroid Adenoma considering size more than 3 cm.

Thymic masses are one of the most common tumors in the anterior mediastinum. Nevertheless, because the thymus originates in the third and fourth pharyngeal pouches and descends into the anterior mediastinum, ectopic thymic tissue may be found anywhere from the angle of the mandible to the superior mediastinum. Ectopic cervical thymoma (ECT) is an extremely rare tumor that originates from ectopic thymic tissue trapped during the migration of the embryonic thymus and is often misdiagnosed as a thyroid tumor or other neck masses. Herein, we report an unusual case of ectopic cervical thymoma associated to myasthenia gravis (MG).

Aortic arch is part of the pars thoracic aorta, located in the superior mediastinum. Its function is to carry oxygenated blood to all parts of the body in systemic circulation. From five different studies, all of them showed variations of the aortic arch branching patterns. This article discusses the variation of aortic arch branching patterns using the Natsis classification. The study found that the variations in the branching pattern are mainly of type I and type II.

This is a rare case of a 55 year-old immunocompetent female who developed Methicillin sensitive Staphylococcus aureus sternoclavicular septic arthritis. The infection was not limited to the joint space but extended into adjacent bones and superior mediastinum. However the patient was successfully treated without surgical intervention and preservation of joint function was obtained with only intravenous antibiotic therapy.

Background Germ cell tumors prefer gonadal regions, but they can be expected in extragonadal sites such as the anterior mediastinum, which is the commonly involved region after gonads. Amongst germ cell tumors, teratomas are the rarer subtypes which develop in the anterior mediastinum. Case presentation The authors present two adult patients, a male and a female, both complaining of chronic chest pain and cough. Chest CT scans were performed revealing characteristic CT features of mature teratomas in the anterior mediastinum which were extending to the superior mediastinum in both patients. Conclusion Germ cell tumors are involving the mediastinum; however, amongst all germ cell tumors, teratoma is the least common type arising in the mediastinum, and a chest CT scan considered the imaging investigation of choice. Surgery is the best option and patients may have a very good prognosis.

Over the past decade there has been tremendous development in the clinical application of minimally invasive esophagectomy (MIE) for the treatment of squamous esophageal carcinoma. The major challenges in the performance of MIE include limitations in visualization and manipulation within the confined, rigid thoracic cavity; the need for adequate patient positioning and anesthetic techniques to accommodate the surgical exposure; and changes in the surgical steps for achieving radical nodal dissection, especially for the superior mediastinum. The surgical procedure for MIE is more and more standardized, and there is an increasing practice of MIE worldwide. Randomized trials and meta-analyses have confirmed the advantages of MIE over open esophagectomy, including a significantly lower rate of complications and shorter hospital stays. The recent application of robotics technologies for MIE has further enhanced the quality and safety of the surgical dissection, while intraoperative nerve monitoring has contributed to a lower rate of recurrent laryngeal nerve palsy. With the application of new technologies, we expect further improvement in surgical outcomes for MIE in the treatment of squamous esophageal cancer.

This review provides an overview of comprehensive knowledge regarding the anatomy of the fasciae and fascial spaces of the maxillofacial and the anterior neck regions, principally from the standpoint of oral surgery, whose descriptions have long been puzzling and descriptively much too complex. The maxillofacial and the anterior neck regions are divided into four portions: the portions superficial and deep to the superficial layer of the deep cervical fascia (SfDCF) including its rostral extension to the face, the intermediate portion sandwiched by the splitting SfDCF, and the superficial portion peculiar to the face where the deep structures open on the body surface to form the oral cavity. Different fascial spaces are contained in each of the portions, although the spaces belonging to the portion of the same depth communicate freely with each other. The spaces of the superficial portions are adjacent to the oral cavity and constitute the starting point of deep infections from that cavity. The spaces of the intermediate portion lie around the mandible and occupy the position connecting the superficial and deep portions. Among these spaces, the submandibular and prestyloid spaces play an important role as relay stations conveying the infections into the deep portion. The spaces of the deep portion lie near the cervical viscera and communicate inferiorly with the superior mediastinum, among which the poststyloid space plays a role as a reception center of the infections and conveys the infections into the superior mediastinum particularly by way of the retrovisceral space and the carotid sheath.

Mediastinal glomus tumors are rarely recognized, and only seven cases have been reported in the literature. Here, we describe a rare mediastinal glomus tumor and review the characteristics of this rare clinical case. The patient was a 50-year-old female who presented with coughing for 3 months. Her chest computed tomography scan demonstrated a localized tumor in the posterior superior mediastinum. Intraoperatively, we found a longitudinal rupture of the membranous trachea above the carina. We completely resected the tumor and repaired the tracheal rupture under a thoracoscopy using a pedicled muscle flap. The tissue was diagnosed as a mediastinal glomus tumor according to its histological and immunophenotypic characteristics.

This cervicothoracic approach gives an excellent access to the supraclavicular area, as well as the superior mediastinum and upper sulcus, while sparing the entire musculature of the neck. This technique is built on a division of the sternal manubrium through an L-shaped incision, thus respecting the sternoclavicular joint. The resection of the first costal cartilage allows mobilization of an osteomuscular flap that is progressively elevated.

Surgery of large mediastinal tumors is a great challenge for the surgeons due to wide number of organs that may be involved despite the narrow space. Any treatment plan should be thoroughly planned step-by-step since the diagnosis to assess the features of the tumor and its relationship with the surrounding organs. Radicality is main goal of the surgeons even if this includes the sacrifice of some structure and the reconstruction of others. Cooperation with the anesthesiologist and surgeons of other speciality is often necessary especially in case of infiltrating tumors. Evolution of the surgical technique end of the peri-operative management as well as the availability of new-generation prosthesis and the increasingly widespread of extracorporeal circulation (ECC) have turned this kind of surgery into a feasible, safe and effective procedure. The cornerstones of this surgery are a detailed preoperative assessment, the ability to prevent any potential complication and involve a multidisciplinary equipe.

Background. Primary hyperparathyroidism is caused by the excessive growth of parathormone secretion, its consequence being hypercalcemia. The parathyroid adenoma is responsible for over half of primary hyperparathyroidism cases. The mandibular tumor can be the initial sign in the case of primary hyperparathyroidism.Case presentation. We present the case of a 33 year old patient with history of a mandibular operated tumor, repetitive pathological fractures and hypercalcemia manifestations. The level of the parathormone at the first measurement indicated a very high value. The parathyroid scintigraphy with 99mTc-MIBI (methoxy-isobutyl-isonitrile) evidenced a high uptake of the tracerin the superior mediastinum, suggestive for an ectopic parathyroid adenoma. The histopathological examination after surgery leads to the diagnosis of parathyroid adenoma. The association between the primary hyperparathyroidism, the mandibular tumour, the clinical history and the nuclear imaging lead to the diagnosis of primary hyperparathyroidism – Jaw tumor syndrome.Conclusion. The hyperparathyroidism-Jaw tumor syndrome has a special clinical importance because of the severe and progressive symptomatology, and because of the risk of developing neoplasia of parathyroid glands, which have a reserved prognosis.

The thymus is the main organ in the (anterior) (pre-vascular) mediastinum, playing a central role in the maintenance of both cellular and humoral immunity. The function of the thymus has been long underlooked due to its involution starting during young adulthood and unawareness regarding its immunological function. A variety of primary tumors and inflammatory/reactive/disreactive processes occur in the mediastinum and may involve the anterior-superior compartment and the thymus. Maldevelopment processes also take place in the pre-vascular compartment mediastinum. Although infective diseases do not currently represent the main processes in western countries, they may represent a diagnostic challenge in developing countries. The purpose of this review is to provide a short overview of the main thymic cellular components, their tumors, pseudotumors, in order to provide insights into their clinical setting and the features which assist pathologists in their differential diagnosis (DD). Specific differential diagnostic points are provided, both for “solid” tumors as well as for haematological malignancies, together with a morphological overview of cases of concern that occur in the anterior mediastinum. The main immunohistochemical characteristics of neoplastic/non-neoplastic pathology and updated specific references are also provided.

Understanding the anatomy of the superior mediastinum can be helpful in correctly diagnosing diseases in this location. Because structures are closely packed in the superior mediastinum, diseases in this space may be difficult to diagnose. The anatomic boundaries of the superior mediastinum are show

Address for Correspondence: Dr. Deepa Somanath, Assistant Professor, Dept. of Anatomy, Sri Manakula Vinayagar Medical College, Madagadipet, Puducherry605 107, India. E-Mail: deepa.somanath@gmail.com *1 Assistant Professor, Dept. of Anatomy, Sri Manakula Vinayagar Medical College, Puducherry, India. 2 Post Graduate Student, Dept. of Anatomy, Sri Manakula Vinayagar Medical College, Puducherry, India. Arterial variations in the branching pattern of arch of aorta are uncommon and may occur as a result of developmental changes in the fusion and absorption of various pharyngeal arch arteries into the aortic sac. The present case report describes a finding in a male cadaver aged between 6065 years about the origin of left vertebral artery directly from the arch of aorta. Such variations should be kept in mind during surgical procedures in the superior mediastinum.

Mediastinum is one of most the enigmatic areas of the human body and its pathology can be equally riveting. The mediastinum is broadly divided into four regions: Anterior mediastinum; Superior mediastinum; Middle or visceral mediastinum and Posterior or paravertebral mediastinum. All these compartments contain vascular, lymphatic, neural, capsular and solid organ structures, which may be affected by various disease processes and tumours. Mediastinal masses can be silent for a long time and present suddenly as a life-threatening situation, which can be confusing to the untrained mind. These include symptoms of sudden airway obstruction, bronchospasm, venous engorgement and sometimes, even sudden death. While a lot has been published regarding their anaesthetic and surgical management, there is paucity of literature on emergency or intensive care management. This narrative review proposes to highlight the varied acute presentations of mediastinal tumours and their critical care management. Keywords : Airway obstruction; Bronchospasm; Emergency; Mediastinum; Mass

Haemangiomas are most common non-malignant vascular tumours of infancy. Here, we describe an antenatally detected mass over the neck causing compressive respiratory compromise at birth requiring resuscitative measures at birth. The mass showed increased vascularity on Contrast Enhanced Computed Tomography (CECT) with extension upto superior mediastinum. Surgical excision was required following failure to medical measures with steroids and propranolol. Histopathology confirmed it to be a venous haemangioma. This case highlights that these benign lesions may reach large sizes and antenatal detection may help in planning effective delivery and resuscitative measures.

As a preliminary work the macroscopic and macroscopic study of thymus of pig was carried out. 2 male and 2 female pigs weighing 80±10 kgs were used. The thymus of these animals was procured in the slaughter house where it is sacrificed for edible purpose. It was a large bilobed structure situated in the superior mediastinum. Tissue from the thymus was processed and stained with H&E. Lobules were observed. Cortex and medulla could be differentiated. Two to three Hassall's corpuscles were observed and the distribution was uniform. Key Word: Thymus, Hassall's corpuscles, cortex, medulla.

Ectopic adrenocorticotropic hormone (ACTH) secretion is associated with a heterogeneous spectrum of neuroendocrine tumours (NETs) as well as non-NET tumours. Both ectopic ACTH secretion (EAS) and NETs are relatively uncommon. Large cell neuroendocrine carcinoma (LCNEC) is considered to be a poorly differentiated NET, and is very rarely associated with EAS. Only case reports of EAS associated with LCNEC have been documented. We present a case of disseminated LCNEC associated with EAS. The LCNEC was diagnosed on bone marrow trephine biopsy, and the likely but unproven primary was a NET arising from the superior mediastinum, which also caused superior vena cava (SVC) syndrome at presentation.

Thyroglossal duct cyst is a congenital lesion in the anterior side of neck which results from embryonic remnant of the descending thyroglossal duct. It may get enlarge by infection, inflammation or mucous retention but can be found anywhere in the midline from the base of the tongue to thyroid gland. Most commonly it is present infrahyoid only. In this case, it is present at an unusual site at suprasternal region. A young male presented in the OPD with a single, non-tender swelling in the midline at suprasternal region, almost reaching upto superior mediastinum. After radiological examination and histopathological excision biopsy, it came out to be thyroglossal cyst. No recurrence had occurred.

Thymoma is a rare case presenting in the paediatric age group. Only 30 cases have been reported so far. Our case is a 14 month old female, presented with respiratory distress. CT scan showed gross widening of superior mediastinum with a homogeneous opacity. Immunohistochemistry was suggestive of thymoma. She underwent excision of the thymic mass and is well at present.J Nepal Paediatr Soc 2015;35(1):76-78

Background Surgical stabilization of the sternoclavicular joint (SCJ) is infrequent, and cardiothoracic surgery assistance is often recommended. Patient safety and surgeon efficiency may be improved by greater understanding of the anatomic relationships near the SCJ. The purpose of this study is to determine the distances from the SCJ to critical structures in the superior mediastinum. Materials and methods Distances from the posterior SCJ to adjacent mediastinal structures were recorded using contrast computed tomography scans of 49 consecutive patients. Patient sex, height, body mass index, side, age, and thickness of the sternum and medial clavicle were also recorded. Results The mean distance to the nearest anatomic structure deep to the clavicular region of the SCJ was 6.6 mm and was 12.5 mm for the sternal region. The clavicle was an average thickness of 18 mm, and the sternum was an average thickness of 17 mm. The closest structure was the brachiocephalic vein. An artery was identified as the closest structure in 21.2% of patients. Distance differences between the right and left sides were noted, but sex had no bearing on distance to structures. Conclusion Multiple mediastinal structures are close to the SCJ. The most frequent structure at risk of injury deep to the SCJ is the brachiocephalic vein. Such knowledge may improve patient safety.