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Acute decompensated heart failure (ADHF) is a challenging medical emergency with high mortality and its prevalence is increasing in India. There is paucity of data on ADHF in the country.Indian College of Cardiology National Heart Failure Registry (ICCNHFR) is an on-going observational registry on ADHF contributed by 22 hospitals across India; and we present the in-hospital and 30-day outcomes of ADHF patients enrolled from August 2018 to July 2019. Major objective included capturing demographics, comorbid conditions, aetiology, prescription patterns and assessing clinical outcomes.Of 5269 patients (mean age: 61.90 ± 13.85 years) enrolled in this study, males were predominant (67.09%). Mean duration of hospitalization was 5.74 ± 4.74 days. Ischemic heart disease was the most common (75.44%) aetiology. Abnormal electrocardiogram readings were found in most patients (89.86%). LVEF of ˂40% was found in 68.29% of patients. In-hospital mortality rates were 6.98%. The 30-day cumulative mortality was 12.35% and 30-day rehospitalization rate was 7.98%. At discharge, all guideline-based medical therapy (GDMT) were prescribed only to 24.99% of patients and 23.72% adhered to the prescription until 30 days. Older age, high serum creatinine levels and poor LVEF contributed to high mortality and rehospitalization.Patients with ADHF were younger and predominantly males. Usage of GDMT in ADHF patients was low (24.99%) and the in-hospital mortality was high. Older age, high serum creatinine levels, poor LVEF contributed for 30-day mortality and rehospitalization. This data on ADHF, could help in developing strategies to improve outcomes for HF patients in India.

Objective: To analyze the data of the cardiac comorbidities, investigational modalities, laboratory parameters, and outcomes of patients with COVID-19 related to cardiovascular system hospitalized in our center. Methods: Confirmed cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 infection by positive result on polymerase chain reaction testing of a nasopharyngeal sample, who were admitted to Indraprastha Apollo Hospital, Delhi, were included in the study. Demographics, baseline comorbidities, and test results related to cardiovascular diseases were collected and analyzed. Results: The study included 1012 patients, admitted in our institute with a COVID-19 positive report. The mean age of the patients was 54.6 ± 6.8 years. The male to female ratio was 1.7:1. The demographic characteristics included diabetes in 38%, hypertensives 45%, history of coronary artery disease 22%, and chronic kidney disease 30%. A total of 426 patients were all treated on HCQS. A total of 7 patients were primigravida with full term pregnancy. The patients were also stratified according to age and demographic characteristics were noted. The total number deceased were 41 with 971 patients making complete recovery. The results showed no change in QTc interval in survivors and nonsurvivors. D-dimer, ferritin, and LDH were raised in all nonsurvivors compared to survivors. Even thrombocytopenia and low albumin levels were noted in nonsurvivors. Conclusions: The study revealed no significant change in QTc interval in survivors and nonsurvivors on HCQS. Critically ill patients showed the trends of being underweight, low albumin levels, thrombocytopenia, raised D-dimer, lactate dehydrogenase (LDH), and ferritin levels. Further studies on larger numbers are needed to confirm these findings.

Current guidelines for acute coronary syndrome are derived from the data in randomized clinical trials and metanalysis conducted in patients. These patients are generally of younger age. The data of acute coronary syndrome in octogenarians is mainly derived from registries. This mid and long-term data regarding medical therapy or interventions in octogenarians is low in number with smaller subsets of patients. Most of the physicians are reluctant to use the same guidelines in these elderly patients due to increased chances of complications. This article reviews the available data and literature in acute coronary syndrome in octogenarians and provides management perspectives for these elderly patients.

Current guidelines for acute coronary syndrome are derived from the data in randomized clinical trials and metanalysis conducted in patients. These patients are generally of younger age. The data of acute coronary syndrome in octogenarians is mainly derived from registries. This mid- and long-term data regarding medical therapy or interventions in octogenarians is low in number with smaller subsets of patients. Most of the physicians are reluctant to use the same guidelines in these elderly patients due to increased chances of complications. This article reviews the available data and literature in acute coronary syndrome in octogenarians and provides management perspectives for these elderly patients. Literature has proved that early invasive protocols seem to be just as feasible in the elderly as in the general population. In order to mitigate any pharmacological side effects, it is imperative to correct the dosages to age- adjusted renal function.