1. Human Papillomavirus infection and cervical lesions in HIV infected women on antiretroviral treatment in Thailand
- Author
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Chureeratana Bowonwatanuwong, Panita Pathipvanich, Prattana Leenasirimakul, Kosit Tantinam, Rittha Lertkoonalak, Somboon Tansuphasawasdikul, Naruepon Yutthakasemsunt, Pacharee Kantipong, Prateung Liampongsabuddhi, Rattakarn Paramee, Nuananong Luekamlung, Isabelle Heard, Chaiwat Putiyanun, Nicole Ngo-Giang-Huong, Sinart Prommas, Rucha Kongpanichkul, Sophie Le Coeur, Sunida Panna, Aram Limtrakul, Diane Le Pluart, Nantasak Chotivanich, Virat Klinbuayaem, Pensiriwan Sang-a-gad, Céline Gallot, Sudanee Buranabanjasatean, Florence Brunet-Possenti, Tristan Delory, Myrtille Prouté, Guttiga Halue, Pakorn Wittayapraparat, Florence Fayard, Alexandre Blake, Samreung Rangdaeng, Wanmanee Matanasarawut, Naree Eiamsirikit, Métrey H. Tiv, Pornnapa Suriyachai, Prapap Yuthavisuthi, Kevin Zarca, Gonzague Jourdain, Fadia Dib, Tapnarong Jarupanich, Suchart Thongpaen, Nusra Puarattana-Aroonkorn, Thomas Althaus, Alice Desbiolles, Sookchai Theansavettrakul, Marc Lallemant, Apichat Chutanunta, Sukit Banchongkit, and Institut national d'études démographiques (INED)
- Subjects
Cross-sectional study ,[SDV]Life Sciences [q-bio] ,Uterine Cervical Neoplasms ,HIV Infections ,Logistic regression ,[SHS]Humanities and Social Sciences ,0302 clinical medicine ,HIV infected women ,Cytology ,vaccine ,Medicine ,030212 general & internal medicine ,Cervical lesions ,Prospective cohort study ,Papillomaviridae ,Cancer ,Colposcopy ,medicine.diagnostic_test ,HPV infection ,virus diseases ,Middle Aged ,Thailand ,female genital diseases and pregnancy complications ,Antiretroviral therapy ,Infectious Diseases ,Anti-Retroviral Agents ,030220 oncology & carcinogenesis ,Female ,Microbiology (medical) ,Cart ,Adult ,medicine.medical_specialty ,HPV ,Genotype ,03 medical and health sciences ,Internal medicine ,Humans ,Women ,Gynecology ,business.industry ,Human Papillomavirus (HPV) infection ,Papillomavirus Infections ,HIV ,medicine.disease ,Uterine Cervical Dysplasia ,Cross-Sectional Studies ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business - Abstract
International audience; OBJECTIVES: To estimate the prevalence and factors associated with Human Papillomavirus (HPV) infection, HPV genotypes and cytological/histological high-grade (HSIL+/CIN2+) lesions. METHODS: We conducted a cross-sectional study within a prospective cohort of HIV-infected women on combination antiretroviral therapy (cART). Cervical specimens were collected for cytology and HPV genotyping (Papillocheck(R)). Any women with High-Risk-HPV (HR-HPV), and/or potentially HR-HPV (pHR-HPV) and/or ASC-US or higher (ASC-US+) lesions were referred for colposcopy. Factors associated with HR-HPV infection and with HSIL+/CIN2+ lesions were investigated using mixed-effects logistic regression models. RESULTS: 829 women were enrolled: median age 40.4 years, on cART for a median of 6.9 years, median CD4 cell-count 536 cells/mm3, and 788 (96%) with HIV-viral load/=1 HR-HPV, of whom 38 (5%) HPV52, 22 (3%) HPV16, 9 (1%) HPV18; 21 (3%) had pHR-HPV, 34 (4%) low risk-HPV infection, and 56 (26%) had multiple genotypes. Younger age, low CD4 cell-counts and low education were independently associated with HR-HPV infection. 72 women (9%) had ASC-US+ and 28 (3%) HSIL+/CIN2+ lesions. HR-HPV infection was independently associated with HSIL+/CIN2+ lesions. CONCLUSION: The prevalence of HPV infection and of cervical lesions was low. The HPV genotype distribution supports the use of 9-valent vaccine in Thailand.
- Published
- 2017