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Abstract Metal‐semiconductor interfaces are crucial components of optoelectronic and electrical devices, the performance of which hinges on intricate dynamics involving charge transport and mechanical interaction at the interface. Nevertheless, structural changes upon photoexcitation and subsequent carrier transportation at the interface, which crucially impact hot carrier stability and lifetime, remain elusive. To address this long‐standing problem, they investigated the electron dynamics and resulting structural changes at the Au/TiO2 interface using ultrafast electron diffraction (UED). The analysis of the UED data reveals that interlayer electron transfer from metal to semiconductor generates a strong coupling between the two layers, offering a new way for ultrafast heat transfer through the interface and leading to a coherent structural vibration that plays a critical role in propagating mechanical stress. These findings provide insights into the relationship between electron transfer and interfacial mechanical and thermal properties.

Existing state-of-the-art stair climbing robots require precise control through many sensors and actuators to climb various stairs. In this study, we propose WAVES, a stair-climbing robot that can climb a variety of stairs with minimal electronic components and control. WAVES’ stair climbing ability is due to its soft part on the bottom, which adapts passively to the shape of the stairs. The soft parts were fabricated into a compliant mesh shape and could be freely deformed according to the shape of the stairs. We used the ratio of horizontal and vertical reaction forces that occur when the soft part is deformed as an index to determine stability, and the simulation results showed that the arc shape has the smallest horizontal reaction force ratio of 0.224 (honeycomb: 0.303, spoke: 0.276). Also, to determine the appropriate strength of the soft parts, we calculated the maximum compressive force that each section of the soft part should withstand. Based on the calculation results, we made the gap between arc patterns closer where the strong compressive force is applied. In conclusion, before applying soft parts to the robot, the diagonal length of the stairs it could climb was 328.7 mm–350 mm, but after applying soft materials, it can climb all stairs under 400 mm.

Abstract Understanding the degradation mechanism of organic light-emitting diodes (OLED) is essential to improve device performance and stability. OLED failure, if not process-related, arises mostly from chemical instability. However, the challenges of sampling from nanoscale organic layers and interfaces with enough analytical information has hampered identification of degradation products and mechanisms. Here, we present a high-resolution diagnostic method of OLED degradation using an Orbitrap mass spectrometer equipped with a gas cluster ion beam to gently desorb nanometre levels of materials, providing unambiguous molecular information with 7-nm depth resolution. We chemically depth profile and analyse blue phosphorescent and thermally-activated delayed fluorescent (TADF) OLED devices at different degradation levels. For OLED devices with short operational lifetimes, dominant chemical degradation mainly relate to oxygen loss of molecules that occur at the interface between emission and electron transport layers (EML/ETL) where exciton distribution is maximised, confirmed by emission zone measurements. We also show approximately one order of magnitude increase in lifetime of devices with slightly modified host materials, which present minimal EML/ETL interfacial degradation and show the method can provide insight for future material and device architecture development.

Summary: The 2019 coronavirus pandemic resulted in a massive global healthcare crisis, highlighting the necessity to develop effective and reproducible platforms capable of rapidly and accurately detecting SARS-CoV-2. In this study, we developed an electrolyte-gated indium-gallium-zinc-oxide (IGZO) thin-film transistor with sequential surface modification to realize the low limit of detection (LoD

Abstract Despite the growing interest in dynamic behaviors at the frequency domain, there exist very few studies on molecular orientation-dependent transient responses of organic mixed ionic–electronic conductors. In this research, we investigated the effect of ion injection directionality on transient electrochemical transistor behaviors by developing a model mixed conductor system. Two polymers with similar electrical, ionic, and electrochemical characteristics but distinct backbone planarities and molecular orientations were successfully synthesized by varying the co-monomer unit (2,2’-bithiophene or phenylene) in conjunction with a novel 1,4-dithienylphenylene-based monomer. The comprehensive electrochemical analysis suggests that the molecular orientation affects the length of the ion-drift pathway, which is directly correlated with ion mobility, resulting in peculiar OECT transient responses. These results provide the general insight into molecular orientation-dependent ion movement characteristics as well as high-performance device design principles with fine-tuned transient responses.

Abstract Ultra-flexible organic photovoltaics (OPVs) are promising candidates for next-generation power sources owing to their low weight, transparency, and flexibility. However, obtaining ultra-flexibility under extreme repetitive mechanical stress while maintaining optical transparency remains challenging because of the intrinsic brittleness of transparent electrodes. Here, we introduce strain-durable ultra-flexible semitransparent OPVs with a thickness below 2 μm. The conformal surface coverage of nanoscale thin metal electrodes (

A tray-type spatial power combiner is proposed at Ka-band using an $H$ -plane expanded waveguide with side-ridges and a dipole transition array. In order to overcome the small size of the Ka-band standard waveguide and accommodate as many as trays (six trays in this work), the $H$ -plane of the waveguide is expanded by three times using two-stepped waveguide transition. A circular post is employed to effectively suppress higher-order modes in the expanded waveguide. In addition, a side-ridged waveguide is proposed to reduce non-uniformity in the field and power distribution along the expanded $H$ -plane which seriously degrades power combining efficiency. It boosts the electric field close to the waveguide sidewalls by adding the metallic ridges which reduces the waveguide height at the sides. It is shown from the simulation that the proposed side-ridged waveguide can evenly distribute the electromagnetic power and reduce the magnitude imbalances between the trays. In addition, a capacitive iris is introduced in the ridges to improve the phase balance as well. The $H$ -plane expanded waveguide with side-ridges was fabricated and the measurement showed an insertion loss as low as 0.2 dB at Ka-band. Then, six trays consisting of dipole transition and microstrip line on the dielectric substrate was accommodated between the $H$ -plane expanded waveguides with side-ridges. The overall power combining system exhibited the measured insertion loss of 1.2 dB (back-to-back loss) at Ka-band. This result belongs to the excellent performance in terms of insertion loss and the number of the trays among the tray-type spatial power combiners reported at Ka-band.

This paper presents a high-frequency model of a brushless DC motor to predict its radiated emission (RE) through high-frequency simulations of electromagnetic fields. The main RE noise path of the device-under-test (DUT) motor is specified as the stator winding, and its accurate high-frequency model in a full-wave EM simulator is proven by a two-port T-network. We analyze the induced surface current distribution according to the air ventilation hole shapes of the rotor housing and calculate the radiated electric field intensity using the high-frequency model of the DUT motor. The expected difference in the radiated electric field intensity by the hole configuration from the simulation model is verified experimentally.

In this paper, a wideband ultra-low-profile solar cell–integrated antenna with a high form factor is presented. A copper indium gallium selenide-based solar cell was used for the proposed design. The solar cell was cut with a rectangular-shaped narrow slit to construct a built-in solar cell antenna with dimensions of 50 mm × 20 mm × 0.571 mm (0.382λo × 0.152λo × 0.0043λo at 2.28 GHz). The slit area needed to achieve a high form factor was only 0.5 mm × 18 mm. A coaxial-to-microstrip-line transition type of feeding structure was used to excite the antenna. An RF decoupler circuit was also designed under the second substrate to maintain the independent functioning of both devices. The simulated and measured results are in good agreement. Furthermore, the proposed design demonstrated a −10 dB impedance bandwidth of 42.45% with an ultra-low-profile structure of 0.0043λo at 2.28 GHz, and the maximum gain was 2.84 dBi in the impedance bandwidth range. In addition, the antenna has a high form factor of 99.1%, with no optical blockage.

Abstract Recently, biocompatible optical sources have been surfacing for new-rising biomedical applications, allowing them to be used for multi-purpose technologies such as biological sensing, optogenetic modulation, and phototherapy. Especially, vertical-cavity surface-emitting laser (VCSEL) is in the spotlight as a prospective candidate for optical sources owing to its low-driving current performance, low-cost, and package easiness in accordance with two-dimensional (2D) arrays structure. In this study, we successfully demonstrated the actualization of biocompatible thin-film 930 nm VCSELs transferred onto a Polydimethylsiloxane (PDMS) carrier. The PDMS feature with biocompatibility as well as biostability makes the thin-film VCSELs well-suited for biomedical applications. In order to integrate the conventional VCSEL onto the PDMS carrier, we utilized a double-transfer technique that transferred the thin-film VCSELs onto foreign substrates twice, enabling it to maintain the p-on-n polarity of the conventional VCSEL. Additionally, we employed a surface modification-assisted bonding (SMB) using an oxygen plasma in conjunction with silane treatment when bonding the PDMS carrier with the substrate-removed conventional VCSELs. The threshold current and maximum output power of the fabricated 930 nm thin-film VCSELs are 1.08 mA and 7.52 mW at an injection current of 13.9 mA, respectively.

Biocompatible field-effect-transistor-based biosensors have drawn attention for the development of next-generation human-friendly electronics. High-performance electronic devices must achieve low-voltage operation, long-term operational stability, and biocompatibility. Herein, we propose an electrolyte-gated thin-film transistor made of large-area solution-processed indium–gallium–zinc oxide (IGZO) semiconductors capable of directly interacting with live cells at physiological conditions. The fabricated transistors exhibit good electrical performance operating under sub-0.5 V conditions with high on-/off-current ratios (>107) and transconductance (>1.0 mS) over an extended operational lifetime. Furthermore, we verified the biocompatibility of the IGZO surface to various types of mammalian cells in terms of cell viability, proliferation, morphology, and drug responsiveness. Finally, the prolonged stable operation of electrolyte-gated transistor devices directly integrated with live cells provides the proof-of-concept for solution-processed metal oxide material-based direct cellular interfaces.

Abstract Inflammatory bowel disease (IBD) refers to disorders involving chronic inflammation of the gastrointestinal tract. Well-established treatments for IBD have not yet to be suggested. To address this gap, we investigated the effects of co-administration of Lactobacillus gasseri (L. gasseri) KBL697 and infliximab (IFX), the first approved tumor necrosis factor (TNF)-alpha inhibitor, on the dextran sodium sulfate-induced colitis mouse model. 2 × 109 colony-forming units/g of L. gasseri KBL697 were administered to seven-week-old female C57BL/6J mice daily by oral gavage. On day three, IFX (5 mg/kg) suspended in 1 × PBS (200 µL) was intravenously injected in the IFX-treated group and all mice were sacrificed on day nine. Co-administration of L. gasseri KBL697 and IFX improved colitis symptoms in mice, including body weight, disease activity index, colon length, and histology score. Additionally, pro-inflammatory cytokines, such as interferon-gamma, interleukin (IL)-2, IL-6, IL-17A, and TNF were significantly decreased, while IL-10, an anti-inflammatory cytokine, was increased. Expression levels of tight junction genes and CD4 + CD25 + Foxp3 + T regulatory cells in the mesenteric lymph nodes were synergistically upregulated with the combined treatment. Furthermore, co-administered mice displayed altered cecum microbial diversity and composition with increases in the genus Prevotella. Related changes in the predicted amino and nucleic acid metabolic pathways were also evident, along with increased acetate and butyrate level. Therefore, the synergistic effect of L. gasseri KBL697 and IFX co-administration is a possible method of prevention and treatment for IBD.

A TM01 mode transducer based on dipole antenna is proposed to design a broadband and low-loss radial power combiner at Ka-band (26.5–40 GHz). It is an essential component in the radial power combiners to convert the electromagnetic modes between rectangular and circular waveguides. The latter feeds the cylindrical cavity in TM01 mode of which the fields exhibit a circular symmetry. The proposed TM01 mode transducer consists of the dipole antenna, microstrip, and probe on a dielectric substrate. It is an in-line mode transducer. In other words, the rectangular and circular waveguides are aligned along the same axis of wave propagation. Therefore, it does not require the waveguide components such as tee junctions, steps, and bends which are normally used in the traditional mode transducers and increase the complexity, size, and loss of entire power combiner. The eight-way radial junction is also designed using a cylindrical cavity, where the rectangular waveguides are placed along the circumference of the cylindrical cavity. The dimensions of each component are determined based on the full-wave electromagnetic simulations. The designed eight-way radial power combiner consisting of the TM01 mode transducer and radial junction is fabricated in four-split blocks by mechanical machining. In the measurements, the proposed power combiner exhibits a broadband and low-loss performance under a compact size while maintaining the magnitude and phase balances between the eight ports.

Nano-electronic devices and materials hold considerable promise due to their inherent structural and material benefits, such as device miniaturization, increased integration density, and reduced power consumption [...]

The low ionic conductivity and unstable interface of electrolytes/electrodes are the key issues hindering the application progress of lithium-ion batteries (LiBs). In this work, a cross-linked gel polymer electrolyte (C-GPE) based on epoxidized soybean oil (ESO) was synthesized by in situ thermal polymerization using lithium bis(fluorosulfonyl)imide (LiFSI) as an initiator. Ethylene carbonate/diethylene carbonate (EC/DEC) was beneficial for the distribution of the as-prepared C-GPE on the anode surface and the dissociation ability of LiFSI. The resulting C-GPE-2 exhibited a wide electrochemical window (of up to 5.19 V vs. Li+/Li), an ionic conductivity (σ) of 0.23 × 10−3 S/cm at 30 °C, a super-low glass transition temperature (Tg), and good interfacial stability between the electrodes and electrolyte. The battery performance of the as-prepared C-GPE-2 based on a graphite/LiFePO4 cell showed a high specific capacity of ca. 161.3 mAh/g (an initial Coulombic efficiency (CE) of ca. 98.4%) with a capacity retention rate of ca. 98.5% after 50 cycles at 0.1 C and an average CE of about ca. 98.04% at an operating voltage range of 2.0~4.2 V. This work provides a reference for designing cross-linking gel polymer electrolytes with high ionic conductivity, facilitating the practical application of high-performance LiBs.

Fully coupled integrated load analyses (ILAs) to evaluate not only the load response but also the structural integrity are required to design a floating offshore wind turbine, since there has been no firmly established approach for obtaining the structural responses of a FOWT substructure in the time domain. This study aimed to explore if a direct strength analysis (DSA) technique that has been widely used for ships and offshore structures can adequately evaluate the FOWT substructure. In this study, acceleration and nacelle thrust were used for the dominant load parameters for DSA. The turbine thrust corresponding to the 50-year return period was taken from the literature. The acceleration response amplitude operator (RAO) was obtained through frequency response hydrodynamic analysis. The short-term sea states defined by the wave scatter diagram (WSD) of the expected installation area was represented by the JONSWAP wave spectrum. To account for the multi-directionality of the short-crested waves, the 0th order moments of the wave spectrum were corrected. The probabilities of each short-term sea state and each wave incidence angle were applied to derive the long-term acceleration for each return period. DSA cases were generated by combining the long-term acceleration and nacelle thrust to maximize the forces in the surge, sway, and heave directions. Linear spring elements were placed under the three outer columns of the substructure to provide soft constraints for hive, roll, and pitch motions. Nonlinear spring elements with initial tension were placed on the three fairlead chain stoppers (FCSs) to simulate the station-keeping ability of the mooring lines; they provided initial tension in the slacked position and an increased tension in the taut position. The structural strength evaluation of the coarse mesh finite element model with an element size same as the stiffener spacing showed that high stresses exceeding the permissible stresses occurred in the unstable members of the substructure. The high stress areas were re-evaluated using a fine mesh finite element model with an element size of 50 mm × 50 mm. The scope of structural reinforcement was identified from the fine mesh analyses. It was found that the DSA can be properly utilized for the substructure strength assessment of a FOWT.

In the medical field, it is delicate to anticipate good performance in using deep learning due to the lack of large-scale training data and class imbalance. In particular, ultrasound, which is a key breast cancer diagnosis method, is delicate to diagnose accurately as the quality and interpretation of images can vary depending on the operator’s experience and proficiency. Therefore, computer-aided diagnosis technology can facilitate diagnosis by visualizing abnormal information such as tumors and masses in ultrasound images. In this study, we implemented deep learning-based anomaly detection methods for breast ultrasound images and validated their effectiveness in detecting abnormal regions. Herein, we specifically compared the sliced-Wasserstein autoencoder with two representative unsupervised learning models autoencoder and variational autoencoder. The anomalous region detection performance is estimated with the normal region labels. Our experimental results showed that the sliced-Wasserstein autoencoder model outperformed the anomaly detection performance of others. However, anomaly detection using the reconstruction-based approach may not be effective because of the occurrence of numerous false-positive values. In the following studies, reducing these false positives becomes an important challenge.

Summary: Sensitive detection of near-infrared (NIR) light is applicable to variety of optical, chemical, and biomedical sensors. Of these diverse applications, NIR photodetectors have been used as a key component for photoplethysmography (PPG) sensors. In particular, because NIR organic photodetectors (OPDs) enable fabrication of stretchable and skin-conformal PPG sensors, they are attaining tremendously increasing interest in both academia and industry. Herein, we report strain-durable and highly sensitive NIR OPDs using an organic bulk heterojunction (BHJ) layer. For effective suppression of dark current, we employed BHJ combination consisting of PTB7-Th:Y6 which forms high energy barrier against transport-injected holes. The optimized OPDs exhibited high specific detectivity up to 2.2 × 1012 Jones at 800 nm. By constructing the devices on the parylene substrates, we successfully demonstrated stretchable NIR OPDs and high-performance skin-conformal PPG sensors.

Abstract Sol–gel indium–gallium–zinc oxide (IGZO) semiconductors are developed as active components of thin‐film transistors (TFTs) because of their high electron mobility, cost‐effective large‐area fabrication, and applicability for flexible substrates. Controlling oxygen vacancies (Vo) in the IGZO semiconductor channel is always problematic for reliable and long‐term operation. Surplus interfacial charges inside the IGZO channel cause negative shifts in threshold voltages (Vth), resulting in depletion‐mode operation and involuntary high current output. The room temperature and rapid (

There has been growing interest in the use of the sol-gel approach to form high-quality dielectric materials. Their tailored properties allow for developing functional electronic devices in a scalable and rapid manner. According to physicochemical principles, the displacement and response behavior of charges under an applied external field can manifest in unique dielectric properties, providing useful information to improve the process, design, and quality of electronic devices. Therefore, a systematic and in-depth investigation of the fundamentals of sol-gel dielectrics is necessary. In this Research Update, we present recent advances in various sol-gel-processed dielectric materials and their applications to functional electronic devices. A brief introduction to sol-gel chemistry to form oxide dielectric films and the basis of physical mechanisms under electrical fields are discussed. Along with the dielectric properties, recent achievements of proof-of-concept experiments and their various applications to functional electronic devices are introduced. It is expected that further innovations in solution-processed metal oxide dielectrics will achieve cost-effective high-performance functional electronics in the near future.

This paper proposes a pseudo-haptic interface that depicts the virtual weights of dumbbells in a virtual gymnasium. When a user performs a dumbbell biceps curl, he/she fixes the elbow joint as a standard joint and lifts the dumbbell, with its movement trajectory represented as a circular arc. The trajectories and velocity of dumbbell bicep curls differ depending on human physiological characteristics. Therefore, the proposed system provides an adaptable exercise area and force visualization of virtual dumbbells using a velocity-based pseudo-haptic interface and computer vision-based tracking method. The system recognizes the position and rotation of joints related to a dumbbell biceps curl with the implementation of density-based spatial clustering of applications with noise (a clustering algorithm) and resizes the radius and angle of an integrated force circular gauge. Furthermore, when a user lifts a dumbbell, the system recognizes, using linear regression, the current position and lifting force of the virtual dumbbell and visualizes the current lifting force with a guided movement trajectory to match the lifting force. Experimental results show that the proposed pseudo-haptic interface increased weight perception and usability by up to 30% compared to conventional methods (p < 0.05).

Human urine samples are non-invasive, readily available, and contain several components that can provide useful indicators of the health status of patients. Hence, urine is a desirable and important template to aid in the diagnosis of common clinical conditions. Conventional methods such as dipstick tests, urine culture, and urine microscopy are commonly used for urinalysis. Among them, the dipstick test is undoubtedly the most popular owing to its ease of use, low cost, and quick response. Despite these advantages, the dipstick test has limitations in terms of sensitivity, selectivity, reusability, and quantitative evaluation of diseases. Various biosensor technologies give it the potential for being developed into point-of-care (POC) applications by overcoming these limitations of the dipstick test. Here, we present a review of the biosensor technologies available to identify urine-based biomarkers that are typically detected by the dipstick test and discuss the present limitations and challenges that future development for their translation into POC applications for urinalysis.

Human norovirus (HuNoV) is an important enteric virus that can cause large gastroenteritis outbreaks via the fecal-oral route from contaminated water and produce. Real-time quantitative reverse transcription PCR (RT-qPCR) is the only method to apply the routine detection of HuNoV in various samples, however, inhibitors present in the samples can affect the accuracy and sensitivity of RT-qPCR results. Here, we suggest an inhibitor-removal treatment for two types of noroviruses using two commercial kits. Two types of water sample (surface and seawater) and four types of produce (green onions, lettuces, radishes, and strawberries) were evaluated. The recovery efficiencies of noroviruses in water samples clearly increased in surface and seawater samples with the inhibitor-removal treatment compared to untreated samples. Moreover, murine norovirus-1 was well recovered from the four types of produce with the inhibitor-removal treatment. The mean recovery efficiencies of HuNoV genogroup II genotype 4 in lettuces and strawberries were also increased in the treated samples. Therefore, we suggest that the inhibitor-removal treatment could be useful for improving the accuracy and sensitivity of RT-qPCR methods for noroviruses in water and produce.

Abstract Background We investigated the characteristics of adolescents who committed suicide in South Korea, and how these characteristics differed by gender. Method Data from middle and high school students who committed suicide between 2014 and 2016 were analyzed. We evaluated differences in suicide method and place, personal characteristics, and school life characteristics by gender using the Chi square test and t test. Results Jumping from a high place was the most common suicide method for both male and female students. A significantly greater proportion of female adolescents had experienced depressive symptoms, previous self-injury, previous suicide attempts, and had problems with school attendance and peers. Additionally, they were more likely to be classified as high risk according to a school-based mental health screening test and to utilize professional mental health treatment services. Conclusion Our results demonstrate that adolescents who committed suicide exhibited gender differences in personal characteristics and school life. These characteristics might aid in the development of adolescent suicide policies and intervention programs.

We confirmed that Lactobacillus paracasei (L. paracasei) strains (KBL382, 384, 385) exhibited strong protective effects in an in vivo dextran sodium sulfate-induced colitis model. L. paracasei treatment significantly improved colitis symptoms. Among tested strains, L. paracasei KBL382-treated mice exhibited significantly lower levels of cytokines interferon gamma, interleukin (IL)-4, IL-6, tumor necrosis factor, and IL-17A. On the other hand, higher levels of anti-inflammatory cytokine IL-10 and CD4 + CD25 + Foxp3+ T regulatory cell populations in mesenteric lymph nodes were observed in mice group with L. paracasei. L. paracasei treatment clearly increased zonula occluden-1, claudin 3, and mucin 4 levels, which improved the tight junction and mucus thickness. L. paracasei-treated mice showed significantly higher bacterial diversity and changed the composition of cecal microbiota. Therefore, we suggest that L. paracasei could be a useful tool in the treatment of inflammatory bowel diseases via immunomodulation and the improvement of gut microbiota.

Polymer electrolytes (PEs) based on poly(ethylene oxide) (PEO) have gained increasing interest in lithium-ion batteries (LIBs) and are expected to solve the safety issue of commercial liquid electrolytes due to their excellent thermal and mechanical stability, suppression of lithium dendrites and shortened battery assembly process. However, challenges, such as high interfacial resistance between electrolyte and electrodes and poor ionic conductivity (σ) at room temperature (RT), still limit the use of PEO-based PEs. In this work, an in situ PEO-based polymer electrolyte consisting of polyethylene glycol dimethacrylate (PEGDMA) 1000, lithium bis(fluorosulfonyl)imide (LiFSI) and DMF is cured on a LiFePO4 (LFP) cathode to address the above-mentioned issues. As a result, optimized PE shows a promising σ and lithium-ion transference number (tLi+) of 6.13 × 10−4 S cm−1 and 0.63 at RT and excellent thermal stability up to 136 °C. Moreover, the LiFePO4//Li cell assembled by in situ PE exhibits superior discharge capacity (141 mAh g−1) at 0.1 C, favorable Coulombic efficiency (97.6%) after 100 cycles and promising rate performance. This work contributes to modifying PEO-based PE to force the interfacial contact between the electrolyte and the electrode and to improve LIBs’ performance.

When driving the piezoelectric transducer (PT: piezo transducer), which is a key device, it is important for the ultrasonic system (using ultrasonic waves of 20 kHz or higher) to operate at a resonant frequency that can maximize the conversion of mechanical energy (vibration) from electrical energy. The resonant frequency of the PT changes during the actual operation according to the load fluctuations and environmental conditions. Therefore, to maintain a stable output in an ultrasonic system, it is essential to track the resonant frequency in a short time. In particular, fast resonant frequency tracking (RFT: resonant frequency tracking) is an important factor in the medical ultrasonic system, i.e., the system applied in this thesis. The reason is that in the case of a medical ultrasonic system, heat-induced skin necrosis, etc., may cause the procedure to be completed within a short period of time. Therefore, tracking the RFT time for maximum power transfer is an important factor; in this thesis, we propose a new high-speed RFT method. The proposed method finds the whole system resonance frequency by using the transient phenomenon (underdamped response characteristic) that appears in an impedance system, such as an ultrasonic generator, and uses this to derive the mechanical resonance frequency of the PT. To increase the accuracy of the proposed method, parameter fluctuations of the pressure of the PT, the equivalent circuit impedance analysis of the PT, and a MATLAB simulation were performed. Through this, the correlation between the resonance frequency of the ultrasonic system, including the LC filter with nonlinear characteristics and the mechanical resonance frequency of the PT, was analyzed. Based on the analyzed results, a method for tracking the mechanical resonance frequency that can transfer the maximum output to the PT is proposed in this thesis. Experiments show that using the proposed high-speed RFT method, the ultrasonic system can track the mechanical resonance frequency of the PT with high accuracy in a short time.

Macrophage metabolic pathways show changes in response to various external stimuli. Especially, increased lipopolysaccharide, an important bacterial component and Toll-like receptor 4 agonist, can induce activity in various macrophage metabolic pathways, including energy production and biosynthesis, as well as high immune responses due to increase in differentiated M1 macrophages. In this study, we confirmed that Lactobacillus paracasei (L. paracasei) KBL382, KBL384 and KBL385, isolated from the feces of healthy Koreans, can modulate various enzymes and membrane transporters related to glycolysis or macrophage polarization including hypoxia-inducible factor 1-alpha (HIF1A), inducible nitric oxide synthase (iNOS) and arginase in stimulated macrophages at the mRNA level, using the in vitro rodent bone‐marrow‐derived macrophage (BMDM) model. All L. paracasei exhibited significant down-regulatory effects on mRNAs for glycolysis-related enzymes, including lactate dehydrogenase A, solute carrier family 2 member 1, and triosephosphate isomerase. Moreover, L. paracasei treatment could lead to significant reductions in HIF1A or iNOS mRNA, and induced arginase mRNA in the BMDM model. Therefore, further extensive studies should be performed to support the application of L. paracasei, such as in probiotics or therapeutics, in controlling abnormal immune responses related to macrophage.

The pinewood nematode (PWN), Bursaphelenchus xylophilus, is a causative agent of pine wilt disease (PWD). To date, although several molecular diagnostic methods have been developed, rapid on-site diagnostic tools for detecting PWN in pinewood are limited. In this study, a point of care diagnostic (POCD) method for detecting PWN in pinewood using recombinase polymerase amplification (RPA) assay was developed. This method comprises quick gDNA extraction buffer (DAP buffer) for the direct extraction of gDNA of PWN from pinewood and a battery-mounted portable optical isothermal device (POID) for the detection of PWD in the field. The RPA assay can distinguish between the PWN and its conspecies which exist in pinewood and can complete diagnostic procedures within 25 min in the field. Moreover, the RPA assay can detect PWN in old wood samples in both natural and stored conditions. The POCD-RPA assay to detect PWN will be useful for epidemiological investigations in the field as well as for quarantine processes in the wood trade.

The lack of understanding of mixed transport in ion-permeable conjugated polymer films hinders the advance of organic electrochemical transistors for bioelectronics. Here, the authors elucidate the structure-property-performance relationships for conventional and crystallized PEDOT:PSS films.

Follicular helper T (TFH) cells promote germinal centre (GC) response for efficient generation of protective antibodies during humoral immunity. Here the authors show that deficiency of the translational repressor, Capicua/CIC, enhances TFH differentiation and GC responses potentially via the derepression of Etv5.

Background Similar to other combat sports, mixed martial arts (MMA) includes divisional weight classes. The purpose of our research was to further investigate the amount of weight professional MMA fighters lost prior to weighing in for competition, their methods used to cut weight, and their sources of advice on how to cut weight. Methods This survey was administered to 92 male professional MMA athletes. The survey questions included duration of overall weight loss prior to competition, methods of weight-cutting, and their sources of advice regarding weight cutting. Results When comparing the number of methods of weight cutting with the source of advice, those who received their advice from social media used slightly more methods of weight cutting (M = 4.86, SD = 1.27) than those who did not (M = 4.02, SD = 1.55); t(90) = − 2.53, p

Gut microbiota play an important role in immune responses and energy metabolism. In this study, we evaluated whether administration of Lactobacillus fermentum (L. fermentum) KBL375 isolated from healthy Korean feces improves the atopic dermatitis using the house dust mite (Dermatophagoides farinae)-induced atopic dermatitis (AD) mouse model. Administration of L. fermentum KBL375 significantly decreased dermatitis score, ear and dorsal thickness, and serum immunoglobulin E level in AD-induced mice. Significant reductions in mast cells and eosinophils were discovered in skin tissues from L. fermentum KBL375-treated mice. T helper 2 cell-related cytokines interleukin (IL)-4, IL-5, IL-13, and IL-31 significantly decreased, and anti-inflammatory cytokine IL-10 or transforming growth factor-β increased in skin tissues from L. fermentum KBL375-treated mice. In addition to phenotypic changes in skin tissues, L. fermentum KBL375 treatment induced an increase in the CD4+CD25+Foxp3+ cell population in mesenteric lymph nodes. Taxonomic and functional analyses of gut microbiota showed significantly higher cecum bacterial diversities and abundances including genus Bilophila, Dorea, and Dehalobacterium in L. fermentum KBL375-treated mice. Metabolic analysis of the cecum also showed significant changes in the levels of various amino acids including methionine, phenylalanine, serine, and tyrosine, as well as short chain fatty acids such as acetate, butyrate, and propionate in AD-induced mice due to L. fermentum KBL375 treatment. These altered metabolites in AD-induced mice returned to the levels similar to those in control mice when treated with L. fermentum KBL375. Therefore, L. fermentum KBL375 could be useful for AD treatment by modulating the immune system and inducing various metabolites.

The rapid advances in human-friendly and wearable photoplethysmography (PPG) sensors have facilitated the continuous and real-time monitoring of physiological conditions, enabling self-health care without being restricted by location. In this paper, we focus on state-of-the-art skin-compatible PPG sensors and strategies to obtain accurate and stable sensing of biological signals adhered to human skin along with light-absorbing semiconducting materials that are classified as silicone, inorganic, and organic absorbers. The challenges of skin-compatible PPG-based monitoring technologies and their further improvements are also discussed. We expect that such technological developments will accelerate accurate diagnostic evaluation with the aid of the biomedical electronic devices.

Follicular helper T (TFH) cells mediate germinal center reactions to generate high affinity antibodies against specific pathogens, and their excessive production is associated with the pathogenesis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE). ETV5, a member of the ETS transcription factor family, promotes TFH cell differentiation in mice. In this study, we examined the role of ETV5 in the pathogenesis of lupus in mice and humans. T cell-specific deletion of Etv5 alleles ameliorated TFH cell differentiation and autoimmune phenotypes in lupus mouse models. Further, we identified SPP1 as an ETV5 target that promotes TFH cell differentiation in both mice and humans. Notably, extracellular osteopontin (OPN) encoded by SPP1 enhances TFH cell differentiation by activating the CD44-AKT signaling pathway. Furthermore, ETV5 and SPP1 levels were increased in CD4+ T cells from patients with SLE and were positively correlated with disease activity. Taken together, our findings demonstrate that ETV5 is a lupus-promoting transcription factor, and secreted OPN promotes TFH cell differentiation. [ABSTRACT FROM AUTHOR]