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6 results on '"Sung-Yurb Park"'

2. Safety Assessment of Lactiplantibacillus (formerly Lactobacillus) plantarum Q180

Author

Hyunchae Joung, Byoung Kook Kim, Sung Yurb Park, Yoo Jin Kwon, Che Ok Jeon, Hye Su Jung, Jaeryang Chu, and Byung Hee Chun

Subjects
Genetics, Strain (chemistry), biology, General Medicine, biology.organism_classification, Applied Microbiology and Biotechnology, Genome, Plasmid, Mobile genetic elements, Insertion sequence, Gene, Lactobacillus plantarum, Prophage, Biotechnology
Abstract

The safety of the probiotic strain Q180, which exerts postprandial lipid-lowering effects, was bioinformatically and phenotypically evaluated. The genome of strain Q180 was completely sequenced, and single circular chromosome of 3,197,263 bp without any plasmid was generated. Phylogenetic and related analyses using16S rRNA gene and whole-genome sequences revealed that strain Q180 is a member of Lactiplantibacillus (Lp., formerly Lactobacillus) plantarum. Antimicrobial resistance (AMR) genes were bioinformatically analyzed using all Lp. plantarum genomes available in GenBank, which showed that AMR genes are present differently depending on Lp. plantarum strains. Bioinformatic analysis demonstrated that some mobile genetic elements such as prophages and insertion sequences were identified in the genome of strain Q180, but because they did not contain harmful genes such as AMR genes and virulence factor (VF)- and toxin-related genes, it was suggested that there is no transferability of harmful genes. The minimum inhibition concentrations of seven tested antibiotics suggested by the European Food Safety Authority guidelines were slightly lower than or equal to the microbiological cut-off values for Lp. plantarum. Strain Q180 did not show hemolytic and gelatinase activities and biogenic amine-producing ability. Taken together, this study demonstrated the safety of strain Q180 in terms of absence of AMR genes and VF- and toxin-related genes as a probiotic strain.

Published
2021
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3. Immunostimulatory Effect of Heat-Killed Probiotics on RAW264.7 Macrophages

Author

Hye-Ji Noh, Jung Min Park, Yoo Jin Kwon, Kyunghwan Kim, Sung Yurb Park, Insu Kim, Jong Hyun Lim, Byoung Kook Kim, and Byung-Yong Kim

Subjects
Mice, Hot Temperature, RAW 264.7 Cells, Macrophages, Probiotics, Animals, Cytokines, General Medicine, Nitric Oxide, Applied Microbiology and Biotechnology, Biotechnology
Abstract

Probiotics modulate the gut microbiota, which in turn regulate immune responses to maintain balanced immune homeostasis in the host. However, it is unclear how probiotic bacteria regulate immune responses. In this study we investigated the immunomodulatory effects of heat-killed probiotics, including

Published
2022

5. Safety Assessment of

Author

Yoo Jin, Kwon, Byung Hee, Chun, Hye Su, Jung, Jaeryang, Chu, Hyunchae, Joung, Sung Yurb, Park, Byoung Kook, Kim, and Che Ok, Jeon

Subjects
Biogenic Amines, Whole Genome Sequencing, Virulence Factors, Probiotics, Prophages, Drug Resistance, Bacterial, DNA Transposable Elements, Computational Biology, Microbial Sensitivity Tests, Genome, Bacterial, Phylogeny, Lactobacillus plantarum
Abstract

The safety of the probiotic strain Q180, which exerts postprandial lipid-lowering effects, was bioinformatically and phenotypically evaluated. The genome of strain Q180 was completely sequenced, and single circular chromosome of 3,197,263 bp without any plasmid was generated. Phylogenetic and related analyses using16S rRNA gene and whole-genome sequences revealed that strain Q180 is a member of

Published
2021

6. Complete Genome Sequencing and Comparative Genomic Analysis of Streptococcus thermophilus CKDB027, a Promising Probiotic Bacterial Strain

Author

Myung-Soo Kim, Bonggyu Min, Byung-Yong Kim, Sung-Yurb Park, Sung Sun Park, Byoung-Kook Kim, Insu Kim, and Yoo-Jin Kwon

Subjects
Whole genome sequencing, Genetics, Streptococcus thermophilus, Probiotic, biology, law, Comparative genomic analysis, biology.organism_classification, Bacterial strain, law.invention
Published
2021
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